Short-term pretreatment with atorvastatin attenuates left ventricular dysfunction, Reduces infarct size and apoptosis in acute myocardial infarction rats

International Journal of Clinical and Experimental Medicine

Volumn 7, Issue 12, 2014, Pages 4799-4808

  Chen, Tie Long ^a   Zhu, Guang Li ^a   He, Xiao Long ^a   Wang, Jian An ^b   Wang, Y ^a,c   Qi, Guo An ^a  

^a Department of Cardiology Hangzhou Hospital of TCM ^*  (China)

^b THE SECOND AFFILIATED HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c ZHEJIANG CHINESE MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Atorvastatin; Bcl 2; Fas; Left ventricular function; Myocardial infarction

Indexed keywords

ATORVASTATIN; CASPASE 3; CASPASE 8; FAS ANTIGEN; FAS LIGAND; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2;

ACUTE HEART INFARCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN INFARCTION SIZE; CONTROLLED STUDY; CORONARY ARTERY LIGATION; DOWN REGULATION; HEART FUNCTION; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART LEFT VENTRICLE FAILURE; HEART LEFT VENTRICLE PRESSURE; MALE; NICK END LABELING; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; UPREGULATION; WESTERN BLOTTING;

RATTUS;

EID: 84921459807     PISSN: None     EISSN: 19405901     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Abbate A, Bussani R, Amin MS, Vetrovec GW and Baldi A. Acute myocardial infarction and heart failure: role of apoptosis. Int J Biochem Cell Biol 2006; 38: 1834-1840.
2. Krijnen PA, Nijmeijer R, Meijer CJ, Visser CA, Hack CE and Niessen HW. Apoptosis in myocardial ischaemia and infarction. J Clin Pathol 2002; 55: 801-811.
3. Amann U, Kirchberger I, Heier M, Goluke H, von Scheidt W, Kuch B, Peters A and Meisinger C. Long-term survival in patients with different combinations of evidence-based medications after incident acute myocardial infarction: results from the MONICA/KORA Myocardial Infarction Registry. Clin Res Cardiol 2014; 103: 655-664.
4. Bauer T, Gitt AK, Junger C, Zahn R, Koeth O, Towae F, Schwarz AK, Bestehorn K, Senges J, Zeymer U; Acute Coronary Syndromes Registry (ACOS) investigators. Guideline-recommended secondary prevention drug therapy after acute myocardial infarction: predictors and outcomes of nonadherence. Eur J Cardiovasc Prev Rehabil 2010; 17: 576-581.
5. Klungel OH, Heckbert SR, de Boer A, Leufkens HG, Sullivan SD, Fishman PA, Veenstra DL and Psaty BM. Lipid-lowering drug use and cardiovascular events after myocardial infarction. Ann Pharmacother 2002; 36: 751-757.
6. Jones PH and Farmer JA. Adjunctive interventions in myocardial infarction: the role of statin therapy. Curr Atheroscler Rep 2008; 10: 142-148.
7. Sposito AC, Santos SN, de Faria EC, Abdalla DS, da Silva LP, Soares AA, Japiassu AV, Quinaglia e Silva JC, Ramires JA and Coelho OR. Timing and dose of statin therapy define its impact on inflammatory and endothelial responses during myocardial infarction. Arterioscler Thromb Vasc Biol 2011; 31: 1240-1246.
8. Li L, Su Q, Wang Y, Dai R, Lu Y, Su B and Zhao Y. Effect of atorvastatin (Lipitor) on myocardial apoptosis and caspase-8 activation following coronary microembolization. Cell Biochem Biophys 2011; 61: 399-406.
9. Nafasi L, Rahmani R, Shafiee A, Salari A, Abdollahi A and Meysamie A. Can a high reloading dose of atorvastatin prior to percutaneous coronary intervention reduce periprocedural myocardial infarction? Curr Med Res Opin 2014; 30: 381-386.
10. Song XJ, Yang CY, Liu B, Wei Q, Korkor MT, Liu JY and Yang P. Atorvastatin inhibits myocardial cell apoptosis in a rat model with post-myocardial infarction heart failure by downregulating ER stress response. Int J Med Sci 2011; 8: 564-572.
11. Wang H, Yang YJ, Qian HY, Zhang Q, Gao LJ, Li P, Wang TJ and Wang SD. Statin administration does not improve the mobilization of very small embryonic-like stem cells (VSELs) in contrast to resveratrol treatment in a murine model of acute myocardial infarction. Physiol Res 2012; 61: 543-549.
12. Wouters CW, Meijer P, Janssen CI, Frederix GW, Oyen WJ, Boerman OC, Smits P and Rongen GA. Atorvastatin does not affect ischaemia-inducedphosphatidylserine exposition in humans in-vivo. J Atheroscler Thromb 2012; 19: 285-291.
13. Wouters CW, Wever KE, Bronckers I, Hopman MT, Smits P, Thijssen DH and Rongen GA. Short-term statin treatment does not prevent ischemia and reperfusion-induced endothelial dysfunction in humans. J Cardiovasc Pharmacol 2012; 59: 22-28.
14. Tong J, Ding J, Shen X, Chen L, Bian Y, Ma G, Yao Y and Yang F. Mesenchymal stem cell transplantation enhancement in myocardial infarction rat model under ultrasound combined with nitric oxide microbubbles. PLoS One 2013; 8: e80186.
15. Huang BS, Ahmad M, White RA, Marc Y, Llorens-Cortes C and Leenen FH. Inhibition of brain angiotensin III attenuates sympathetic hyperactivity and cardiac dysfunction in rats post-myocardial infarction. Cardiovasc Res 2013; 97: 424-431.
16. Jiang C, Li Y, Jiang X, Yao N, Gao M, Zhang X, Wang J, Wang X, Sun Z, Zhang J and Ni Y. Hypericin as a marker for determination of myocardial viability in a rat model of myocardial infarction. Photochem Photobiol 2014; 90: 867-872.
17. Liu C, Liu Y and Yang Z. Myocardial infarction induces cognitive impairment by increasing the production of hydrogen peroxide in adult rat hippocampus. Neurosci Lett 2014; 560: 112-116.
18. Tian XF, Cui MX, Yang SW, Zhou YJ and Hu DY. Cell death, dysglycemia and myocardial infarction. Biomed Rep 2013; 1: 341-346.
19. Doggrell SA. Is atorvastatin superior to other statins? Analysis of the clinical trials with atorvastatin having cardiovascular endpoints. Rev Recent Clin Trials 2006; 1: 143-153.
20. Jose MA, Anandkumar S, Narmadha MP and Sandeep M. A comparative effect of atorvastatin with other statins in patients of hyperlipidemia. Indian J Pharmacol 2012; 44: 261-263.
21. Pradines B, Torrentino-Madamet M, Fontaine A, Henry M, Baret E, Mosnier J, Briolant S, Fusai T and Rogier C. Atorvastatin is 10-fold more active in vitro than other statins against Plasmodium falciparum. Antimicrob Agents Chemother 2007; 51: 2654-2655.
22. Cunningham SM, Rush JE and Freeman LM. Short-term effects of atorvastatin in normal dogs and dogs with congestive heart failure due to myxomatous mitral valve disease. J Vet Intern Med 2013; 27: 985-989.
23. Tentzeris I, Rohla M, Jarai R, Farhan S, Freynhofer MK, Unger G, Nurnberg M, Geppert A, Wessely E, Wojta J and Huber K. Influence of high-dose highly efficient statins on short-termmortality in patients undergoing percutaneous coronary intervention with stenting for acute coronary syndromes. Am J Cardiol 2014; 113: 1099-1104.
24. Toso A, Leoncini M, Maioli M, Gallopin M, Tedeschi D, Amato M and Bellandi F. Short-term high-dose atorvastatin for periprocedural myocardial infarction prevention in patients with renal dysfunction. J Cardiovasc Med (Hagerstown) 2011; 12: 318-321.
25. Song L, Yang YJ, Dong QT, Qian HY, Gao RL, Qiao SB, Shen R, He ZX, Lu MJ, Zhao SH, Geng YJ and Gersh BJ. Atorvastatin enhance efficacy of mesenchymal stem cells treatment for swine myocardial infarction via activation of nitric oxide synthase. PLoS One 2013; 8: e65702.
26. Birnbaum Y, Ashitkov T, Uretsky BF, Ballinger S and Motamedi M. Reduction of infarct size by short-term pretreatment with atorvastatin. Cardiovasc Drugs Ther 2003; 17: 25-30.
27. Sola S, Mir MQ, Lerakis S, Tandon N and Khan BV. Atorvastatin improves left ventricular systolic function and serum markers of inflammation in nonischemic heart failure. J Am Coll Cardiol 2006; 47: 332-337.
28. Clunn GF, Sever PS and Hughes AD. Calcium channel regulation in vascular smooth muscle cells: synergistic effects of statins and calcium channel blockers. Int J Cardiol 2010; 139: 2-6.
29. Zhang L, Zhang L, Li YH, Zhang HY, Chen ML, Gao MM, Hu AH, Yang HS and Yang HS. High-dose glucose-insulin-potassium treatment reduces myocardial apoptosis in patients with acute myocardial infarction. Eur J Clin Invest 2005; 35: 164-170.
30. Kim MJ, Lee JH, Park SY, Hong KW, Kim CD, Kim KY and Lee WS. Protection from apoptotic cell death by cilostazol, phosphodiesterase type III inhibitor, via cAMP-dependent protein kinase activation. Pharmacol Res 2006; 54: 261-267.
31. Kang S, Yang YJ, Wu YL, Chen YT, Li L and Tian Y. Myocardium and microvessel endothelium apoptosis at day 7 following reperfused acute myocardial infarction. Microvasc Res 2010; 79: 70-79.
32. Ruixing Y, Dezhai Y and Jiaquan L. Effects of cardiotrophin-1 on hemodynamics and cardiomyocyte apoptosis in rats with acute myocardial infarction. J Med Invest 2004; 51: 29-37.
33. Sun H, Guo T, Liu L, Yu Z, Xu W, Chen W, Shen L, Wang J and Dou X. Ischemic postconditioning inhibits apoptosis after acute myocardial infarction in pigs. Heart Surg Forum 2010; 13: E305-310.
34. Yu W, Liu Q and Zhu S. Carvacrol protects against acute myocardial infarction of rats via anti-oxidative and anti-apoptotic pathways. Biol Pharm Bull 2013; 36: 579-584.
35. Levine B, Sinha S and Kroemer G. Bcl-2 family members: dual regulators of apoptosis and autophagy. Autophagy 2008; 4: 600-606.
36. Sakamaki J, Daitoku H, Ueno K, Hagiwara A, Yamagata K and Fukamizu A. Arginine methylation of BCL-2 antagonist of cell death (BAD) counteracts its phosphorylation and inactivation by Akt. Proc Natl Acad Sci U S A 2011; 108: 6085-6090.
37. Chang G, Zhang P, Ye L, Lu K, Wang Y, Duan Q, Zheng A, Qin S and Zhang D. Protective effects of sitagliptin on myocardial injury and cardiac function in an ischemia/reperfusion rat model. Eur J Pharmacol 2013; 718: 105-113.
38. Chang J, Zhang G, Zhang L, Hou YP, Liu XL and Zhang L. High admission glucose levels increase Fas apoptosis and mortality in patients with acute ST-elevation myocardial infarction: a prospective cohort study. Cardiovasc Diabetol 2013; 12: 171.
39. Lu C, Ren D, Wang X, Ha T, Liu L, Lee EJ, Hu J, Kalbfleisch J, Gao X, Kao R, Williams D and Li C. Toll-like receptor 3 plays a role in myocardial infarction and ischemia/reperfusion injury. Biochim Biophys Acta 2014; 1842: 22-31.
40. Zidar N, Jera J, Maja J and Dusan S. Caspases in myocardial infarction. Adv Clin Chem 2007; 44: 1-33.
41. Abbate A, Biondi-Zoccai GG and Baldi A. Pathophysiologic role of myocardial apoptosis in post-infarction left ventricular remodeling. J Cell Physiol 2002; 193: 145-153.