Identification of the key molecules involved in chronic copper exposure-aggravated memory impairment in transgenic mice of Alzheimer's disease using proteomic analysis

Journal of Alzheimer's Disease

Volumn 44, Issue 2, 2015, Pages 455-469

  Yu, Jun ^a,b   Luo, Xiaobin ^e   Xu, Hua ^a   Ma, Quan ^b   Yuan, Jianhui ^b   Li, Xuling ^b,f   Chang, Raymond Chuen Chung ^c   Qu, Zhongsen ^d   Huang, Xinfeng ^b   Zhuang, Zhixiong ^b   Liu, Jianjun ^b   Yang, Xifei ^b  

^a JINAN UNIVERSITY   (China)

^b SHENZHEN CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

^d SHANGHAI JIAO TONG UNIVERSITY   (China)

^e Shen Zhen Kai Tuo Biotech ^*  (China)

^f SHENZHEN UNIVERSITY   (China)

Author keywords

Alzheimer's disease; copper; memory impairment; two dimensional fluorescence difference gel electrophoresis

Indexed keywords

4 AMINOBUTYRATE AMINOTRANSFERASE; ACTIN; BRAIN PROTEIN; CHAPERONIN CONTAINING TCP1; COLLAPSIN RESPONSE MEDIATOR PROTEIN; COLLAPSIN RESPONSE MEDIATOR PROTEIN 2; COMPLEXIN 1; COMPLEXIN 2; COPPER; COPPER SULFATE; CYTOCHROME C OXIDASE; ELONGATION FACTOR TU; GLUTAMATE DEHYDROGENASE; GLUTATHIONE TRANSFERASE M1; GLYOXALASE; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; HEMOGLOBIN BETA CHAIN; LYASE; MALATE DEHYDROGENASE; ORNITHINE OXOACID AMINOTRANSFERASE; PEROXIREDOXIN 5; PROTEIN DISULFIDE ISOMERASE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; PYRUVATE KINASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); RHO GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR 1; STATHMIN; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; VOLTAGE DEPENDENT ANION CHANNEL 2; AMYLOID PRECURSOR PROTEIN; APP PROTEIN, HUMAN; MAPT PROTEIN, HUMAN; PRESENILIN 1; PSEN1 PROTEIN, HUMAN; TAU PROTEIN;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN MITOCHONDRION; COGNITION; CONTROLLED STUDY; DISEASE EXACERBATION; DOWN REGULATION; EXPERIMENTAL BEHAVIORAL TEST; HIPPOCAMPUS; LONG TERM EXPOSURE; MASS SPECTROMETRY; MEMORY; MEMORY DISORDER; MOUSE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEOMICS; TRANSGENIC MOUSE; TWO DIMENSIONAL DIFFERENCE GEL ELECTROPHORESIS; UPREGULATION; WESTERN BLOTTING; WILD TYPE; ANIMAL; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; GENETICS; HUMAN; MAZE TEST; METABOLISM; PHYSIOLOGY; PSYCHOLOGY; SPATIAL MEMORY;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BLOTTING, WESTERN; COGNITION; COPPER SULFATE; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; HUMANS; MASS SPECTROMETRY; MAZE LEARNING; MEMORY DISORDERS; MICE, TRANSGENIC; PRESENILIN-1; PROTEOMICS; SPATIAL MEMORY; TAU PROTEINS;

EID: 84921445917     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-141776     Document Type: Article

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