Epidural injections in prevention of surgery for spinal pain: Systematic review and meta-analysis of randomized controlled trials

Spine Journal

Volumn 15, Issue 2, 2015, Pages 348-362

  Bicket, Mark C ^a   Horowitz, Joshua M ^a,b   Benzon, Honorio T ^c   Cohen, Steven P ^b,d  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d WALTER REED ARMY MEDICAL CENTER   (United States)

Author keywords

Back pain; Epidural steroid injection; Low back pain; Meta analysis; Radicular pain; Surgery; Systematic review

Indexed keywords

ANALGESIC AGENT; STEROID;

ANALGESIA; EPIDURAL ANESTHESIA; HUMAN; INTERVERTEBRAL DISK HERNIA; LUMBAR SPINAL STENOSIS; META ANALYSIS; POSTOPERATIVE PAIN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SECONDARY ANALYSIS; SPINAL PAIN; STEROID THERAPY; SYSTEMATIC REVIEW; VERTEBRAL CANAL STENOSIS; EPIDURAL DRUG ADMINISTRATION; LOW BACK PAIN; TREATMENT OUTCOME;

HUMANS; INJECTIONS, EPIDURAL; LOW BACK PAIN; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TREATMENT OUTCOME;

EID: 84921436968     PISSN: 15299430     EISSN: 18781632     Source Type: Journal    
DOI: 10.1016/j.spinee.2014.10.011     Document Type: Review

References (71)

1. A.D. Woolf, and B. Pfleger Burden of major musculoskeletal conditions Bull World Health Organ 81 2003 646 656
2. W.T. Crow, and D.R. Willis Estimating cost of care for patients with acute low back pain: a retrospective review of patient records J Am Osteopath Assoc 109 2009 229 233
3. L. Manchikanti, V. Pampati, F.J. Falco, and J.A. Hirsch Growth of spinal interventional pain management techniques: analysis of utilization trends and Medicare expenditures 2000 to 2008 Spine 38 2013 157 168
4. S.S. Rajaee, H.W. Bae, L.E. Kanim, and R.B. Delamarter Spinal fusion in the United States: analysis of trends from 1998 to 2008 Spine 37 2012 67 76
5. J.K. Freburger, G.M. Holmes, R.P. Agans, A.M. Jackman, J.D. Darter, and A.S. Wallace The rising prevalence of chronic low back pain Arch Intern Med 169 2009 251 258
6. Social Security Administration Office of Policy Annual statistical report on the social security disability insurance program, 2011 SSA Publication No. 13-11827 2012 Social Security Administration Washington, DC
7. R.B. Keller, S.J. Atlas, D.N. Soule, D.E. Singer, and R.A. Deyo Relationship between rates and outcomes of operative treatment for lumbar disc herniation and spinal stenosis J Bone Joint Surg Am 81 1999 752 762
8. J. Friedly, L. Chan, and R. Deyo Geographic variation in epidural steroid injection use in Medicare patients J Bone Joint Surg Am 90 2008 1730 1737
9. C. Price, N. Arden, L. Coglan, and P. Rogers Cost-effectiveness and safety of epidural steroids in the management of sciatica Health Technol Assess 9 2005 1 58
10. J. Karppinen, A. Malmivaara, M. Kurunlahti, E. Kyllönen, T. Pienimäki, and P. Nieminen Periradicular infiltration for sciatica: a randomized controlled trial Spine 26 2001 1059 1067
11. D.K. Whynes, R.A. McCahon, A. Ravenscroft, and J. Hardman Cost effectiveness of epidural steroid injections to manage chronic lower back pain BMC Anesthesiol 12 2012 26
12. S. Rasmussen, D.S. Krum-Møller, L.R. Lauridsen, S.E. Jensen, H. Mandøe, and C. Gerlif Epidural steroid following discectomy for herniated lumbar disc reduces neurological impairment and enhances recovery: a randomized study with two-year follow-up Spine 33 2008 2028 2033
13. M. Juniper, T.K. Le, and D. Mladsi The epidemiology, economic burden, and pharmacological treatment of chronic low back pain in France, Germany, Italy, Spain and the UK: a literature-based review Expert Opin Pharmacother 10 2009 2581 2592
14. R.W. Teasell Compensation and chronic pain Clin J Pain 17 2001 S46 S64
15. R.H. Dworkin, D.C. Turk, J.T. Farrar, J.A. Haythornthwaite, M.P. Jensen, and N.P. Katz Core outcome measures for chronic pain clinical trials: IMMPACT recommendations Pain 113 2005 9 19
16. K.D. Riew, Y. Yin, L. Gilula, K.H. Bridwell, L.G. Lenke, and C. Lauryssen The effect of nerve-root injections on the need for operative treatment of lumbar radicular pain. A prospective, randomized, controlled, double-blind study J Bone Joint Surg Am 82-A 2000 1589 1593
17. K.D. Riew, J.B. Park, Y.S. Cho, L. Gilula, A. Patel, and L.G. Lenke Nerve root blocks in the treatment of lumbar radicular pain. A minimum five-year follow-up J Bone Joint Surg Am 88 2006 1722 1725
18. N.K. Arden, C. Price, I. Reading, J. Stubbing, J. Hazelgrove, and C.C. Dunne A multicentre randomized controlled trial of epidural corticosteroid injections for sciatica: the WEST study Rheumatology (Oxford) 44 2005 1399 1406
19. K. Bush, and S. Hillier A controlled study of caudal epidural injections of triamcinolone plus procaine for the management of intractable sciatica Spine 16 1991 572 575
20. S. Carette, R. Leclaire, S. Marcoux, F. Morin, G.A. Blaise, and A. St-Pierre Epidural corticosteroid injections for sciatica due to herniated nucleus pulposus N Engl J Med 336 1997 1634 1640
21. S.P. Cohen, R.L. White, C. Kurihara, T.M. Larkin, A. Chang, and S.R. Griffith Epidural steroids, etanercept, or saline in subacute sciatica: a multicenter, randomized trial Ann Intern Med 156 2012 551 559
22. J.M. Cuckler, P.A. Bernini, S.W. Wiesel, R.E. Booth Jr., R.H. Rothman, and G.T. Pickens The use of epidural steroids in the treatment of lumbar radicular pain. A prospective, randomized, double-blind study J Bone Joint Surg Am 67 1985 63 66
23. T.F. Dilke, H.C. Burry, and R. Grahame Extradural corticosteroid injection in management of lumbar nerve root compression Br Med J 2 1973 635 637
24. A. Ghahreman, R. Ferch, and N. Bogduk The efficacy of transforaminal injection of steroids for the treatment of lumbar radicular pain Pain Med 11 2010 1149 1168
25. Y. Hegihara, S. Ogata, H. Hirayama, T. Koyama, and E. Watanabe Why use steroids in lumbar selective nerve root block? A randomized control study Chiba Med J 85 2009 71 76
26. L. Klenerman, R. Greenwood, H.T. Davenport, D.C. White, and S. Peskett Lumbar epidural injections in the treatment of sciatica Br J Rheumatol 23 1984 35 38
27. J. Kraemer, J. Ludwig, U. Bickert, V. Owczarek, and M. Traupe Lumbar epidural perineural injection: a new technique Eur Spine J 6 1997 357 361
28. J.A. Mathews, S.B. Mills, V.M. Jenkins, S.M. Grimes, M.J. Morkel, and W. Mathews Back pain and sciatica: controlled trials of manipulation, traction, sclerosant and epidural injections Br J Rheumatol 26 1987 416 423
29. W. Snoek, H. Weber, and B. Jørgensen Double blind evaluation of extradural methyl prednisolone for herniated lumbar discs Acta Orthop Scand 48 1977 635 641
30. S. Tafazal, L. Ng, N. Chaudhary, and P. Sell Corticosteroids in peri-radicular infiltration for radicular pain: a randomised double blind controlled trial. One year results and subgroup analysis Eur Spine J 18 2009 1220 1225
31. J.P. Valat, B. Giraudeau, S. Rozenberg, P. Goupille, P. Bourgeois, and V. Micheau-Beaugendre Epidural corticosteroid injections for sciatica: a randomised, double blind, controlled clinical trial Ann Rheum Dis 6 2003 639 643
32. J. Wilson-MacDonald, G. Burt, D. Griffin, and C. Glynn Epidural steroid injection for nerve root compression. A randomised, controlled trial J Bone Joint Surg Br 87 2005 352 355
33. T. Iversen, T.K. Solberg, B. Romner, T. Wilsgaard, J. Twisk, and A. Anke Effect of caudal epidural steroid or saline injection in chronic lumbar radiculopathy: multicentre, blinded, randomised controlled trial BMJ 343 2011 d5278
34. F.E. Sayegh, E.I. Kenanidis, K.A. Papavasiliou, M.E. Potoupnis, J.M. Kirkos, and G.A. Kapetanos Efficacy of steroid and nonsteroid caudal epidural injections for low back pain and sciatica: a prospective, randomized, double-blind clinical trial Spine 34 2009 1441 1447
35. A.D. Furlan, V. Pennick, C. Bombardier, M. van Tulder Editorial Board, Cochrane Back Review Group 2009 Updated method guidelines for systematic reviews in the Cochrane Back Review Group Spine 34 2009 1929 1941
36. A. Liberati, D.G. Altman, J. Tetzlaff, C. Mulrow, P.C. Gøtzsche, and J.P. Ioannidis The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration Ann Intern Med 151 2009 W65 W94
37. J. Aronsohn, K. Chapman, M. Soliman, T. Shah, S. Costandi, and R. Michael Percutaneous microdiscectomy versus epidural injection for management of chronic spinal pain Proc West Pharmacol Soc 53 2010 16 19
38. L.L. Brown A double-blind, randomized, prospective study of epidural steroid injection vs. The mild® procedure in patients with symptomatic lumbar spinal stenosis Pain Pract 12 2012 333 341
39. B.C. Reeves, J.J. Deeks, J.P.T. Higgins, and G.A. Wells Including non-randomized studies J.P.T. Higgins, S. Green, Cochrane handbook for systematic reviews of interventions 2008 John Wiley & Sons Chichester, UK 391 432
40. J.P.T. Higgins, D.G. Altman, and J.A.C. Sterne Assessing risk of bias in included studies J.P.T. Higgins, S. Green, Cochrane handbook for systematic reviews of interventions 2008 John Wiley & Sons Chichester, UK 187 241
41. M.B. Bicket, A. Gupta, C.H. Brown, and S.P. Cohen Epidural injections for spinal pain: a systematic review and meta-analysis evaluating the "control" injections in randomized controlled trials Anesthesiology 119 2013 907 931
42. D. Atkins, D. Best, P.A. Briss, M. Eccles, Y. Falck-Ytter, and S. Flottorp Grading quality of evidence and strength of recommendations BMJ 328 2004 1490
43. N. Henschke, R.W. Ostelo, M.W. van Tulder, J.W. Vlaeyen, S. Morley, and W.J. Assendelft Behavioural treatment for chronic low-back pain Cochrane Database Syst Rev 2010 CD002014
44. G.H. Guyatt, A.D. Oxman, G.E. Vist, R. Kunz, Y. Falck-Ytter, and P. Alonso-Coello GRADE: an emerging consensus on rating quality of evidence and strength of recommendations BMJ 336 2008 924 926
45. M. Hopwood, and S. Abram Factors associated with failure of lumbar steroids Reg Anesth 18 1993 238 243
46. L. Manchikanti, R. Buenaventura, K.N. Manhcikanti, X. Ruan, S. Gupta, and H.S. Smith Effectiveness of therapeutic lumbar transforaminal epidural steroid injections in managing lumbar spinal pain Pain Physician 15 2012 E199 E245
47. A. Stout Epidural steroid injections for low back pain Phys Med Rehabil Clin N Am 21 2010 825 834
48. O. Airaksinen, J. Brox, C. Cedraschi, J. Hildebrandt, J. Klaber-Moffett, and F. Kovacs European guidelines for the management of chronic nonspecific low back pain Eur Spine J 15 2006 S192 S300
49. F. Ferrante, S. Wilson, C. Iacobo, E.J. Orav, A.G. Rocco, and S. Lipson Clinical classification as a predictor of therapeutic outcome after cervical epidural steroid injection Spine 18 1993 730 736
50. R. Benyamin, L. Manchikanti, A.T. Parr, S. Diwan, V. Singh, and F.J. Falco The effectiveness of lumbar interlaminar epidural injections in the managing chronic low back and lower extremity pain Pain Physician 15 2012 E363 E404
51. W.C. Jacobs, M. van Tulder, M. Arts, S.M. Rubinstein, M. van Middelkoop, and R. Ostelo Surgery versus conservative management of sciatica due to a lumbar herniated disc: a systematic review Eur Spine J 20 2011 513 522
52. S. May, and C. Comer Is surgery more effective than non-surgical treatment for spinal stenosis, and which non-surgical treatment is more effective? A systematic review Physiotherapy 99 2013 12 20
53. C.M. Bono, G. Ghiselli, T.J. Gilbert, D.S. Kreiner, C. Reitman, and J.T. Summers An evidence-based clinical guideline for the diagnosis and treatment of cervical radiculopathy from degenerative disorders Spine J 11 2011 64 72
54. R. Chou, J. Baisden, E.J. Carragee, D.K. Resnick, W.O. Shaffer, and J.D. Loeser Surgery for low back pain: a review of the evidence for an American Pain Society Clinical Practice Guideline Spine 34 2009 1094 1109
55. S.P. Cohen, M.C. Bicket, D. Jamison, I. Wilkinson, and J.P. Rathmell Epidural steroids: a comprehensive, evidence-based review Reg Anesth Pain Med 38 2013 175 200
56. W.E. Ackerman III, and M. Ahmad The efficacy of lumbar epidural steroid injections in patients with lumbar disc herniations Anesth Analg 104 2007 1217 1222
57. I. Kolsi, J. Delecrin, J.M. Berthelot, L. Thomas, A. Prost, and Y. Maugars Efficacy of nerve root versus interspinous injections of glucocorticoids in the treatment of disk-related sciatica. A pilot, prospective, randomized, double-blind study Joint Bone Spine 67 2000 113 118
58. J.H. Lee, J. Moon, and S.H. Lee Comparison of effectiveness according to different approaches of epidural steroid injection in lumbosacral herniated disk and spinal stenosis J Back Musculoskelet Rehabil 22 2009 83 89
59. N. Laiq, M.N. Khan, M.J. Iqbal, and S. Khan Comparison of epidural steroid injections with conservative management in patients with lumbar radiculopathy J Coll Physicians Surg Pak 19 2009 539 543
60. K. Radcliff, A. Hilibrand, J.D. Lurie, T.D. Tosteson, L. Delasotta, and J. Rihn The impact of epidural steroid injections on the outcomes of patients treated for lumbar disc herniation: a subgroup analysis of the SPORT trial J Bone Joint Surg Am 94 2012 1353 1358
61. K. Radcliff, C. Kepler, A. Hilibrand, J. Rihn, W. Zhao, and J. Lurie Epidural steroid injections are associated with less improvement in patients with lumbar spinal stenosis: a subgroup analysis of the spine patient outcomes research trial Spine 38 2013 279 291
62. J.N. Weinstein, T.D. Tosteson, J.D. Lurie, A.N. Tosteson, B. Hanscom, and J.S. Skinner Surgical vs. nonoperative treatment for lumbar disk herniation: the spine patient outcomes research trial (SPORT): a randomized trial JAMA 296 2006 2441 2450
63. J.N. Weinstein, T.D. Tosteson, J.D. Lurie, A.N. Tosteson, E. Blood, and B. Hanscom Surgical versus nonsurgical therapy for lumbar spinal stenosis N Engl J Med 358 2008 794 810
64. G.R. Buttermann Treatment of lumbar disc herniation: epidural steroid injection compared with discectomy. A prospective, randomized study J Bone Joint Surg Am 86-A 2004 670 679
65. P.C. Gerszten, M. Smuck, J.P. Rathmell, T.T Simopoulos, S.M. Bhagia, and C.K. Mocek Plasma disc decompression compared with fluoroscopy-guided transforaminal epidural steroid injections for symptomatic contained lumbar disc herniation: a prospective, randomized, controlled trial J Neurosurg 12 2010 357 371
66. S.T. Roberts, S.E. Willick, M.E. Rho, and J.D. Rittenberg Efficacy of lumbosacral transforaminal epidural steroid injections: a systematic review PM R 1 2009 657 668
67. J. MacVicar, W. King, M.H. Landers, and N. Bogduk The effectiveness of lumbar transforaminal injection of steroids: a comprehensive review with systematic analysis of the published data Pain Med 14 2013 14 28
68. R.Z. Pinto, C.G. Maher, M.L. Ferreira, M. Hancock, V.C. Oliveira, and A.J. McLachlan Epidural corticosteroid injections in the management of sciatica: a systematic review and meta-analysis Ann Intern Med 157 2012 865 877
69. T.M. Kerkering, M.L. Grifasi, A.W. Baffoe-Bonnie, E. Bansal, D.C. Garner, and J.A. Smith Early clinical observations in prospectively followed patients with fungal meningitis related to contaminated epidural steroid injections Ann Intern Med 158 2013 154 161
70. R. Lewis, N. Williams, H.E. Matar, N. Din, D. Fitzsimmons, and C. Phillips The clinical effectiveness and cost-effectiveness of management strategies for sciatica: systematic review and economic model Health Technol Assess 15 2011 1 578
71. D.R. Fitzgibbon, K.L. Posner, K.B. Domino, R.A. Caplan, L.A. Lee, and F.W. Cheney Chronic pain management: American Society of Anesthesiologists Closed Claims Project Anesthesiology 100 2004 98 105