An altered pattern of myocardial histopathological and molecular changes underlies the different characteristics of type-1 and type-2 diabetic cardiac dysfunction

Journal of Diabetes Research

Volumn 2015, Issue , 2015, Pages

  Radovits, Tamás ^a,b   Korkmaz, Sevil ^a   Mátyás, Csaba ^b   Oláh, Attila ^b   Németh, Balázs Tamás ^b   Páli, Szabolcs ^a,b   Hirschberg, Kristóf ^a   Zubarevich, Alina ^a   Gwanmesia, Patricia Neh ^a   Li, Shiliang ^a   Loganathan, Sivakkanan ^a   Barnucz, Enik ^a,b   Merkely, Béla ^b   Szabó, Gábor ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; ATRIAL NATRIURETIC FACTOR; CASPASE 12; COLLAGEN TYPE 1; COLLAGEN TYPE 3; COPPER ZINC SUPEROXIDE DISMUTASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIN 1; EOSIN; GLUTATHIONE REDUCTASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HEMATOXYLIN; MANGANESE SUPEROXIDE DISMUTASE; MESSENGER RNA; MYOSIN HEAVY CHAIN ALPHA; MYOSIN HEAVY CHAIN BETA; PROTEIN C JUN; STREPTOZOCIN; TRANSFORMING GROWTH FACTOR BETA; 3-NITROTYROSINE; TRANSFORMING GROWTH FACTOR BETA1; TYROSINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CLINICAL ASSESSMENT; COMPARATIVE STUDY; CONTROLLED STUDY; DIABETIC CARDIOMYOPATHY; DISEASE ASSOCIATION; HEART FUNCTION; HEART HYPERTROPHY; HEART LEFT VENTRICLE PRESSURE; HEART LEFT VENTRICLE VOLUME; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART MUSCLE FIBROSIS; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MOLECULAR BIOLOGY; NICK END LABELING; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ONCOGENE C FOS; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STAINING; SYSTOLIC DYSFUNCTION; UPREGULATION; WESTERN BLOTTING; ZUCKER DIABETIC FATTY RAT; ANALOGS AND DERIVATIVES; ANIMAL; CARDIAC MUSCLE; CHEMISTRY; COMPLICATION; DIABETES MELLITUS; EXPERIMENTAL DIABETES MELLITUS; FIBROSIS; GENE EXPRESSION REGULATION; HEART; HEART DISEASE; HEART LEFT VENTRICLE FUNCTION; HEMODYNAMICS; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT; TUNEL ASSAY; ZUCKER RAT;

ANIMALS; APOPTOSIS; DIABETES COMPLICATIONS; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; FIBROSIS; GENE EXPRESSION REGULATION; HEART; HEART DISEASES; HEMODYNAMICS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MALE; MYOCARDIUM; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; RATS, ZUCKER; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA1; TYROSINE; VENTRICULAR FUNCTION, LEFT;

EID: 84921416847     PISSN: 23146745     EISSN: 23146753     Source Type: Journal    
DOI: 10.1155/2015/728741     Document Type: Article

References (31)

1. S. Boudina and E. D. Abel, and quot;Diabetic cardiomyopathy revisited, and " Circulation, vol. 115, no. 25, pp. 3213-3223, 2007.
2. D. An and B. Rodrigues, and quot;Role of changes in cardiacmetabolism in development of diabetic cardiomyopathy, and " American Journal of Physiology-Heart and Circulatory Physiology, vol. 291, no. 4, pp. H1489-H1506, 2006.
3. D. A. Rees and J. C. Alcolado, and quot;Animal models of diabetes mellitus, and " Diabetic Medicine, vol. 22, no. 4, pp. 359-370, 2005.
4. R. S. Guleria, A. B. Singh, I. T. Nizamutdinova et al., and quot;Activation of retinoid receptor-mediated signaling ameliorates diabetesinduced cardiac dysfunction in Zucker diabetic rats, and " Journal of Molecular and Cellular Cardiology, vol. 57, no. 1, pp. 106-118, 2013.
5. L. S. Mansor, E. R. Gonzalez, M. A. Cole et al., and quot;Cardiac metabolism in a new ratmodel of type 2 diabetes using high-fat diet with low dose streptozotocin, and " Cardiovascular Diabetology, vol. 12, no. 1, article 136, 2013.
6. T. Radovits, S. Korkmaz, S. Loganathan et al., and quot;Comparative investigation of the left ventricular pressure-volume relationship in rat models of type 1 and type 2 diabetes mellitus, and " American Journal of Physiology-Heart and Circulatory Physiology, vol. 297, no. 1, pp. H125-H133, 2009.
7. M. Aragno, R. Mastrocola, G. Alloatti et al., and quot;Oxidative stress triggers cardiac fibrosis in the heart of diabetic rats, and " Endocrinology, vol. 149, no. 1, pp. 380-388, 2008.
8. L. Cai and Y. J. Kang, and quot;Cell death and diabetic cardiomyopathy, and " Cardiovascular Toxicology, vol. 3, no. 3, pp. 219-228, 2003.
9. K. Huynh, B. C. Bernardo, J. R. McMullen, and R. H. Ritchie, and quot;Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways, and " Pharmacology and Therapeutics, vol. 142, no. 3, pp. 375-415, 2014.
10. T. Radovits, T. Bömicke, G. Kökény et al., and quot;The phosphodiesterase-5 inhibitor vardenafil improves cardiovascular dysfunction in experimental diabetes mellitus, and " British Journal of Pharmacology, vol. 156, no. 6, pp. 909-919, 2009.
11. P. Pacher, T. Nagayama, P. Mukhopadhyay, S. Bátkai, and D. A. Kass, and quot;Measurement of cardiac function using pressurevolume conductance catheter technique in mice and rats, and " Nature Protocols, vol. 3, no. 9, pp. 1422-1434, 2008.
12. L. Liaudet, F. G. Soriano, E. Szabo et al., and quot;Protection against hemorrhagic shock in mice genetically deficient in poly(ADPribose) polymerase, and " Proceedings of the National Academy of Sciences of theUnited States of America, vol. 97, no. 18, pp. 10203-10208, 2000.
13. J. Kajstura, F. Fiordaliso, A. M. Andreoli et al., and quot;IGF-1 overexpression inhibits the development of diabetic cardiomyopathy and angiotensin II-mediated oxidative stress, and " Diabetes, vol. 50, no. 6, pp. 1414-1424, 2001.
14. D. Song, K. H. Kuo, R. Yao, S. R. Hutchings, and C. C. Y. Pang, and quot;Inducible nitric oxide synthase depresses cardiac contractile function in Zucker diabetic fatty rats, and " European Journal of Pharmacology, vol. 579, no. 1-3, pp. 253-259, 2008.
15. F. Fiordaliso, B. Li, R. Latini et al., and quot;Myocyte death in streptozotocin-induced diabetes in rats is angiotensin II-dependent, and " Laboratory Investigation, vol. 80, no. 4, pp. 513-527, 2000.
16. A. Frustaci, J. Kajstura, C. Chimenti et al., and quot;Myocardial cell death in human diabetes, and " Circulation Research, vol. 87, no. 12, pp. 1123-1132, 2000.
17. W. J. Paulus and C. Tschöpe, and quot;A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation, and " Journal of the American College of Cardiology, vol. 62, no. 4, pp. 263-271, 2013.
18. L. VanHeerebeek, N. Hamdani, M. L. Handoko et al., and quot;Diastolic stiffness of the failing diabetic heart: importance of fibrosis, advanced glycation end products, and myocyte resting tension, and " Circulation, vol. 117, no. 1, pp. 43-51, 2008.
19. D. T. Loo, and quot;In situ detection of apoptosis by the TUNEL assay: an overview of techniques, and " Methods in Molecular Biology, vol. 682, pp. 3-13, 2011.
20. E. Ramírez, M. Klett-Mingo, S. Ares-Carrasco et al., and quot;Eplerenone attenuated cardiac steatosis, apoptosis and diastolic dysfunction in experimental type-II diabetes, and " Cardiovascular Diabetology, vol. 12, no. 1, article 172, 2013.
21. W. Min, Z. W. Bin, Z. B. Quan, Z. J. Hui, and F. G. Sheng, and quot;The signal transduction pathway of PKC/NF-B/c-fos may be involved in the influence of high glucose on the cardiomyocytes of neonatal rats, and " Cardiovascular Diabetology, vol. 8, article 8, 2009.
22. W. Nadruz Jr., M. A. F. Corat, T. M. Marin, G. A. Guimarães Pereira, and K. G. Franchini, and quot;Focal adhesion kinase mediates MEF2 and c-Jun activation by stretch: role in the activation of the cardiac hypertrophic genetic program, and " Cardiovascular Research, vol. 68, no. 1, pp. 87-97, 2005.
23. E. J. Cox and S. A. Marsh, and quot;A systematic review of fetal genes as biomarkers of cardiac hypertrophy in rodent models of diabetes, and " PLoS ONE, vol. 9, no. 3, Article ID e92903, 2014.
24. S. Fredersdorf, C. Thumann, C. Ulucan et al., and quot;Myocardial hypertrophy and enhanced left ventricular contractility in Zucker diabetic fatty rats, and " Cardiovascular Pathology, vol. 13, no. 1, pp. 11-19, 2004.
25. Z. Xia, K. H. Kuo, P. R. Nagareddy et al., and quot;N-acetylcysteine attenuates PKC 2 overexpression and myocardial hypertrophy in streptozotocin-induced diabetic rats, and " Cardiovascular Research, vol. 73, no. 4, pp. 770-782, 2007.
26. A. Taye, M. M. Abouzied, and O. M. M. Mohafez, and quot;Tempol ameliorates cardiac fibrosis in streptozotocin-induced diabetic rats: role of oxidative stress in diabetic cardiomyopathy, and " Naunyn-Schmiedebergs Archives of Pharmacology, vol. 386, no. 12, pp. 1071-1080, 2013.
27. S. A. Marsh, P. C. Powell, A. Agarwal, L. J. DellItalia, and J. C. Chatham, and quot;Cardiovascular dysfunction in Zucker obese and Zucker diabetic fatty rats: role of hydronephrosis, and " American Journal of Physiology-Heart and Circulatory Physiology, vol. 293, no. 1, pp. H292-H298, 2007.
28. A. Daniels, D. Linz, M. Van Bilsen et al., and quot;Long-term severe diabetes only leads to mild cardiac diastolic dysfunction in Zucker diabetic fatty rats, and " European Journal of Heart Failure, vol. 14, no. 2, pp. 193-201, 2012.
29. H. Farhangkhoee, Z. A. Khan, H. Kaur, X. Xin, S. Chen, and S. Chakrabarti, and quot;Vascular endothelial dysfunction in diabetic cardiomyopathy: pathogenesis and potential treatment targets, and " Pharmacology and Therapeutics, vol. 111, no. 2, pp. 384-399, 2006.
30. B. Widyantoro, N. Emoto, K. Nakayama et al., and quot;Endothelial cell-derived endothelin-1 promotes cardiac fibrosis in diabetic hearts through stimulation of endothelial-to-mesenchymal transition, and " Circulation, vol. 121, no. 22, pp. 2407-2418, 2010.
31. A. González, S. Ravassa, J. Beaumont, B. Lopez, and J. Díez, and quot;New targets to treat the structural remodeling of the myocardium, and " Journal of theAmericanCollege of Cardiology, vol. 58, no. 18, pp. 1833-1843, 2011.