Subclinical hypothyroidism in children

Indian Pediatrics

Volumn 51, Issue 11, 2014, Pages 889-895

  Shriraam, M ^a   Sridhar, M ^a  

^a Apollo Childrens Hospital   (India)

Author keywords

Goiter; Hypothyroidism; Thyroid function tests

Indexed keywords

ANTITHYROID AGENT; THYROTROPIN; THYROXINE;

ALGORITHM; CHILD; CHILDHOOD DISEASE; CLINICAL FEATURE; COCHRANE LIBRARY; DISEASE COURSE; EMBASE; EVIDENCE BASED PRACTICE; HORMONE SUBSTITUTION; HUMAN; INTERVENTION STUDY; MEDLINE; REVIEW; SUBCLINICAL HYPOTHYROIDISM; THYROTROPIN BLOOD LEVEL; BLOOD; FEMALE; GOITER; HYPOTHYROIDISM; MALE; THYROID FUNCTION TEST;

FEMALE; GOITER; HUMANS; HYPOTHYROIDISM; MALE; THYROID FUNCTION TESTS; THYROTROPIN; THYROXINE;

EID: 84921412247     PISSN: 00196061     EISSN: 09747559     Source Type: Journal    
DOI: 10.1007/s13312-014-0522-9     Document Type: Review

References (39)

1. Surks MI, Ortiz GH, Sawin CT. Subclinical thyroid disease: Scientific review and guidelines for diagnosis and management. JAMA. 2004;291:228–38.
2. Canaris GJ, Manowitz NR, Mayor G, Ridgway EC. The Colorado thyroid disease prevalence study. Arch Intern Med. 2000;160:526–34.
3. Paoli-Valeri M, Maman-Alvardo D, Jiménez-Lopez V. Frequency of subclinical hypothyroidism among healthy children and those with neurological conditions in the state of Mérida, Venezuela. Invest Clin. 2003;44:209–18.
4. Wu T, Flowers JW, Tudiver F. Subclinical thyroid disorders and cognitive performance among adolescents in the United States. BMC Pediatr. 2006;6:12.
5. Aijaz NJ, Flaherty EM, Preston T. Neurocognitive function in children with compensated hypothyroidism: lack of short term effects on or off thyroxin. BMC Endocr Disord. 2006;6:2.
6. Scobbo RR, Vondohlen TW, Hassan M, Islam S. Serum TSH variability in normal individuals: the influence of time of sample collection. W V Med J. 2004;100:138–42.
7. Sarkar R. TSH comparison between chemiluminescence (Architect) and electrochemiluminescence (Cobas) immunassays: An Indian population perspective. Indian J Clin Biochem. 2014;29:189–95.
8. Marwaha RK, Tandon N, Desai AK, Kanwar R, Aggarwal R, Sastry A, et al. Reference range of thyroid hormones in healthy school-age children: Country-wide data from India. Clin Biochem. 2010;43:51–6.
9. Marwaha RK, Tandon N, Desai A, Kanwar R, Grewal K, Aggarwal R, et al. Reference range of thyroid hormones in normal Indian school-age children. Clin Endocrinol(Oxf). 2008;68:369–74.
10. Palmieri EA, Fazio S, Lombardi G. Subclinical hypothyroidism and cardiovascular risk: A reason to treat? Treat Endocrinol. 2004;3:233–44.
11. Papi G, Uberti ED, Betterle C. Subclinical Hypothryoidism. Curr Opin Endocrinol Diabetes Obes. 2007;14:197–208.
12. Cooper DS. Clinical practice. Subclinical hypothyroidism. N Engl J Med. 2001; 345:260–5.
13. Narumi S, Muroya K, Abe Y, Yasui M, Asakura Y, Adachi M, et al. TSHR mutations as a cause of congenital hypothyroidism in Japan: A population-based genetic epidemiology study. J Clin Endocrinol Metab. 2009;94:1317–23.
14. Nicoletti A, Bal M, De Marco G, Baldazzi L, Agretti P, Menabo S, et al. Thyrotropin-stimulating hormone receptor gene analysis in pediatric patients with nonautoimmune subclinical hypothyroidism. J Clin Endocrinol Metab. 2009;94:4187–94.
15. De Marco G, Agretti P, Montanelli, Dicosmo C, Bagattini B, De Servi M, et al. Identification and functional analysis of novel dual oxidase 2 (DUOX2) mutations in children with congenital or subclinical hypothyroidism. J Clin Endocrinol Metab. 2011;96:e1335–9.
16. Grandone A, Perrone L, Cirillo G, Di Sessa A, Corona AM, Amato A, et al. Impact of phosphodiesterase 8B gene rs4704397 variation on thyroid homeostasis in childhood obesity. Eur J Endocrinol. 2012;166:255–60.
17. Turkkahraman D, Alper OM, Aydin F, Yildiz A, Pehlivanoglu S, Luleci G, et al. Final diagnosis in children with subclinical hypothyroidism and mutation analysis of the thyroid peroxidise gene (TPO). J Pediatr Endocrinol Metab. 2009;22:845–51.
18. Rubello D, Pozzan GB, Casara D, Girelli ME, Boccato S, Rigon F, et al. Natural course of subclinical hypothyroidism in Down’s syndrome: Prospective study results and therapeutic considerations. J Endocrinol Invest. 1995;18:35–40.
19. Schaub RL, Hale DE, Rose SR. The spectrum of thyroid abnormalities in individuals with 18q deletions. J Clin Endocrinol Metab. 2005;90:2259–63.
20. Persani L, Borgato S, Romoli R, Asteria C, Pizzocaro A, Beck-Peccoz P. Changes in the degree of sialylation of carbohydrate chains modify the biological properties of circulating thyrotropin isoforms in various physiological and pathological states. J Clin Endocrinol Metab. 1998;83:2486–92.
21. Lazar L, Frumkin RB, Battat E, Lebenthal Y, Phillip M, Meyerovitch J. Natural history of thyroid function tests over 5 years in a large pediatric cohort. J Clin Endocrinol Metab. 2009;94:1678–82.
22. Marwaha RK, Tandon N, Garg MK, Desai A, Kanwar R, Sastry A, et al. Thyroid status two decades after salt iodization: country-wide data in school children from India. Clin Endocrinol (Oxf). 2012;76:905–10.
23. Das S, Bhansali A, Dutta P, Aggarwal A, Bansal MP, Garg D, et al. Persistence of goitre in the post-iodization phase: micronutrient deficiency or thyroid autoimmunity? Indian J Med Res. 2011;133:103–9.
24. Xiao Chen X, Feng Qin Y, Lian Zhou X, Lai Yang R, Hua Shi Y, Qing Mao H, et al. Diagnosis and treatment of subclinical hypothyroidism detected by neonatal screening. World J Pediatr. 2011;7:350–4.
25. Torun E, Cindemir E, Özgen IT, Öktem F. Subclinical hypothyroidism in obese children. Dicle MedJ. 2013;40:5–8.
26. Cebeci AN, Güven A, Yýldýz M. Profile of hypothyroidism in Down’s syndrome. J Clin Res Pediatr Endocrinol. 2013;5:116–20.
27. Soliman GZA, Bahagt NM, EL-mofty Z. Prevalence of thyroid disorder in Egyptian children with type I diabetes mellitus and the prevalence of thyroid antibodies among them. Thyroid Disorders Ther. 2013;2:1.
28. Zulewski H, Müller B, Exer P, Miserez AR. Estimation of tissue hypothyroidism by a new clinical score: Evaluation of patients with various grades of hypothyroidism and controls. J Clin Endocrinol Metab. 1997;82:771–6.
29. Gopalakrishnan S, Chugh PK, Chhillar M. Goitrous autoimmune thyroiditis in a pediatric population: A longitudinal study. Pediatrics. 2008;122:e670–4.
30. Radetti G, Gottardi E, Bona G, Corrias A, Salardi S, Loche S, et al. The natural history of euthyroid Hashimoto’s thyroiditis in children. J Pediatr. 2006;149:827–32.
31. Wasniewska M, Salerno M, Cassio A, Corrias A, Aversa T, Zirilli G, et al. Prospective evaluation of the natural course of idiopathic subclinical hypothyroidism in childhood and adolescence. Eur J Endocrinol. 2009;160:417–21.
32. Radetti G, Maselli M, Buzi F, Corrias A, Mussa A, Cambiaso P, et al. The natural history of the normal/mild elevated TSH serum levels in children and adolescents with Hashimoto’s thyroiditis and isolated hyperthyro-tropinaemia: A 3-year follow-up. Clin Endocrinol (Oxf). 2012;76:394–8.
33. Zois C, Stavrou I, Svarna E, Seferiadis K, Tsatsoulis A. Natural course of autoimmune thyroiditis after elimination of iodine deficiency in northwestern Greece. Thyroid. 2006;16:289–93.
34. Jaruratanasirikul S, Leethanaporn K, Khuntigij P, Sriplung H. The clinical course of Hashimoto’s thryoiditis in children and adolescents: 6 years longitudinal follow-up. J Pediatr Endocrinol Metab. 2001;14:177–84.
35. Leonardi D, Polizzotti N, Carta A, Gelsomino R, Sava L, Vigneri R, et al. Longitudinal study of thyroid function in children with mild hyperthyrotropinemia at neonatal screening for congenital hypothyroidism. J Clin Endocrinol Metab. 2008;93:2679–85.
36. Moore DC. Natural course of subclinical hypothyroidism in childhood and adolescence. Arch Pediatr Adolesc Med. 1996;150:293–7.
37. Wasniewska M, Corrias A, Aversa T, Valenzise M, Mussa A, De Martino L, et al. Comparative evaluation of therapy with L-Thyroxine versus no treatment in children with idiopathic and mild subclinical hypothyroidism. Horm Res Paediatr. 2012;77:376–81.
38. Cetinkaya E, Aslan A, Vidinlisan S, Ocal G. Height improvement by L-thyroxine treatment in subclinical hypothyroidism. Pediatr Int. 2003;45:534–7.
39. Chase HP, Garg SK, Cockerham RS, Wilcox WD, Walravens PA. Thyroid hormone replacement and growth of children with subclinical hypothyroidism and diabetes. Diabet Med. 1990;7:299–303.