Comparative evaluation of therapy with l-thyroxine versus no treatment in children with idiopathic and mild subclinical hypothyroidism

Hormone Research in Paediatrics

Volumn 77, Issue 6, 2012, Pages 376-381

  Wasniewska, Malgorzata ^a   Corrias, Andrea ^b   Aversa, Tommaso ^a   Valenzise, Mariella ^a   Mussa, Alessandro ^b   De Martino, Lucia ^c   Lombardo, Fortunato ^a   De Luca, Filippo ^a   Salerno, Mariacarolina ^c  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Idiopathic subclinical hypothyroidism; L Thyroxine therapy; Mild subclinical hypothyroidism; Subclinical hypothyroidism

Indexed keywords

LEVOTHYROXINE; THYROTROPIN; THYROXINE;

ADOLESCENT; ARTICLE; CHILD; CONTROLLED STUDY; DISEASE COURSE; FEMALE; HUMAN; IDIOPATHIC DISEASE; MAJOR CLINICAL STUDY; MALE; PRESCHOOL CHILD; PREVALENCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; SCHOOL CHILD; SUBCLINICAL HYPOTHYROIDISM; THYROID FUNCTION; TREATMENT DURATION; TREATMENT OUTCOME;

ADOLESCENT; ASYMPTOMATIC DISEASES; CHILD; CHILD, PRESCHOOL; FEMALE; HORMONE REPLACEMENT THERAPY; HUMANS; HYPOTHYROIDISM; MALE; SEVERITY OF ILLNESS INDEX; THYROID FUNCTION TESTS; THYROTROPIN; THYROXINE; TREATMENT OUTCOME;

EID: 84864335050     PISSN: 16632818     EISSN: 16632826     Source Type: Journal    
DOI: 10.1159/000339156     Document Type: Article

References (17)

1. Surks MI, Ortiz E, Daniels GH, Sawin CT, Col NF, Cobin RH, Franklyn JA, Hershman JM, Burman KD, Denke MA, Gorman C, Cooper RS, Weissman NJ: Subclinical thyroid disease: scientific review and guidelines for diagnosis and management. JAMA 2004; 291: 228-238. (Pubitemid 38082818)
2. Chu JW, Crapo LM: The treatment of subclinical hypothyroidism is seldom necessary. J Clin Endocrinol Metab 2001; 86: 4591-4599. (Pubitemid 33020490)
3. McDermott MT, Ridgway EC: Subclinical hypothyroidism is mild thyroid failure and should be treated. J Clin Endocrinol Metab 2001; 86: 4585-4590. (Pubitemid 33020489)
4. Wu T, Flowers JW, Tudiver F, Wilson JL, Punyasavatsut N: Subclinical thyroid disorders and cognitive performance among adolescents in the United States. BMC Pediatr 2006; 6: 12.
5. Villar HCCE, Saconato H, Valente O, Atallah AN: Thyroid hormone replacement for subclinical hypothyroidism. Cochrane Database Syst Rev 2007; 18:CD003419.
6. Kaplowitz PB: Subclinical hypothyroidism in children: normal variation or sign of a failing thyroid gland. Int J Pediatr Endocrinol 2010; 2010: 281453.
7. Wasniewska M, Salerno M, Cassio A, Corrias A, Aversa T, Zirilli G, Capalbo D, Bal M, Mussa A, De Luca F: Prospective evaluation of the natural course of idiopathic subclinical hypothyroidism in childhood and adolescence. Eur J Endocrinol 2009; 160: 417-421.
8. Cerbone M, Bravaccio C, Capalbo D, Polizzi M, Wasniewska M, Cioffi D, Improda N, Valenzise M, Bruzzese D, De Luca F, Salerno M: Linear growth and intellectual outcome in children with long-term idiopathic subclinical hypothyroidism. Eur J Endocrinol 2011; 164: 591-597.
9. Cacciari E, Milani S, Balsamo A, and Directive Councils of SIEDP/ISPED for 1996-1997 and 2002-2003: Italian cross-sectional growth charts for height, weight and BMI (2-20 years). J Endocrinol Invest 2006; 29: 581-593. (Pubitemid 44446267)
10. Lazar L, Frunklin RB, Battat E, Lebenthal Y, Philip M, Meyerovitch J: Natural history of thyroid function tests over 5 years in a large pediatric cohort. J Clin Endocrinol Metab 2009; 94: 1678-1682.
11. O'Grady MJ, Cody D: Subclinical hypothyroidism in childhood. Arch Dis Child 2011; 96: 280-284.
12. Radetti G, Maselli M, Buzi F, Corrias A, Mussa A, Cambiaso P, Salerno M, Cappa M, Baiocchi M, Gastaldi R, Minerba L, Loche S: The natural history of the normal/mild elevated TSH serum levels in children and adolescents with Hashimoto's thyroiditis and isolated hyperthyrotropinemia: a 3-year follow-up. Clin Endocrinol 2012; 76: 394-398.
13. Diez JJ, Iglesias P: Spontaneous subclinical hypothyroidism in patients older than 55 years: an analysis of natural course and risk factors for the development of overt thyroid failure. J Clin Endocrinol Metab 2004; 89: 4890-4897. (Pubitemid 39391424)
14. Tonacchera M, Perri A, De Marco G, Agretti P, Banco ME, Di Cosmo C, Grasso L, Vitti P, Chiovato L, Pinchera A: Low prevalence of thyrotropin receptor mutations in a large series of subjects with sporadic and familial non-autoimmune subclinical hypothyroidism. J Clin Endocrinol Metab 2004; 89: 5787-5793. (Pubitemid 39518472)
15. Nicoletti A, Bal M, De Marco G, Baldazzi L, Agretti P, Menabò S, Ballarini E, Cicognani A, Tonacchera M, Cassio A: Thyrotropinstimulating hormone receptor gene analysis in pediatric patients with non-autoimmune subclinical hypothyroidism. J Clin Endocrinol Metab 2009; 94: 4187-4194.
16. Rapa A, Monzani A, Moia S, Vivenza D, Bellone S, Petri A, Teofoli F, Cassioi A, Cesaretti G, Corrias A, de Sanctis V, Di Maio S, Volta C, Wasniewska M, Tatò L, Bona G: Subclinical hypothyroidism in children and adolescents: a wide range of clinical, biochemical, and genetic factors involved. J Clin Endocrinol Metab 2009; 94: 2414-2420.
17. Celebiro D, Gelmini G, Cordella D, Bonomi M, Winkler F, Biebermann H, de Marco A, Marelli F, Libri DV, Antonica F, Vigone MC, Cappa M, Mian C, Santorio A, Beck-Peccoz P, Radetti G, Weber G, Persani L: Frequent TSH receptor genetic alterations with variable signaling impairment in a large series of children with non-autoimmune isolated hyperthyrotropinemia. J Clin Endocrinol Metab 2012; 97:E156-E160.