메뉴 건너뛰기




Volumn 3, Issue 11, 2014, Pages e967147-1-e967147-5

Novel immune checkpoint blocker approved for the treatment of advanced melanoma

Author keywords

CTLA4; ipilimumab; Keytruda ; nivolumab; PD 1; Yervoy

Indexed keywords

CD134 ANTIGEN; DURVALUMAB; GLYCOPROTEIN GP 100; IMMUNOMODULATING AGENT; IMMUNOSUPPRESSIVE AGENT; IPILIMUMAB; LENALIDOMIDE; MPDL 3280A; NIVOLUMAB; PEMBROLIZUMAB; PROGRAMMED DEATH 1 LIGAND 1;

EID: 84921398753     PISSN: 21624011     EISSN: 2162402X     Source Type: Journal    
DOI: 10.4161/21624011.2014.967147     Document Type: Editorial
Times cited : (32)

References (133)
  • 1
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • 22437870
    • D.M.Pardoll. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 2012; 12:252-64; PMID:22437870; http://dx.doi.org/10.1038/nrc3239
    • (2012) Nat Rev Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 3
    • 84902590227 scopus 로고    scopus 로고
    • Immune checkpoints: a therapeutic target in triple negative breast cancer
    • 24843833
    • A.Chawla, A.V.Philips, G.Alatrash, E.Mittendorf. Immune checkpoints: a therapeutic target in triple negative breast cancer. Oncoimmunology 2014; 3:e28325; PMID:24843833; http://dx.doi.org/10.4161/onci.28325
    • (2014) Oncoimmunology , vol.3 , pp. 28325
    • Chawla, A.1    Philips, A.V.2    Alatrash, G.3    Mittendorf, E.4
  • 4
    • 84894499071 scopus 로고    scopus 로고
    • Immune checkpoint blockade: the hope for immunotherapy as a treatment of lung cancer?
    • 24565586
    • J.R.Brahmer. Immune checkpoint blockade: the hope for immunotherapy as a treatment of lung cancer? Semin Oncol 2014; 41:126-32; PMID:24565586; http://dx.doi.org/10.1053/j.seminoncol.2013.12.014
    • (2014) Semin Oncol , vol.41 , pp. 126-132
    • Brahmer, J.R.1
  • 5
    • 78449243489 scopus 로고    scopus 로고
    • Immune checkpoint proteins: a new therapeutic paradigm for cancer–preclinical background: CTLA-4 and PD-1 blockade
    • 21074057
    • J.Weber. Immune checkpoint proteins: a new therapeutic paradigm for cancer–preclinical background: CTLA-4 and PD-1 blockade. Semin Oncol 2010; 37:430-9; PMID:21074057; http://dx.doi.org/10.1053/j.seminoncol.2010.09.005
    • (2010) Semin Oncol , vol.37 , pp. 430-439
    • Weber, J.1
  • 6
    • 84884700351 scopus 로고    scopus 로고
    • Immunological checkpoint inhibitors enter adolescence
    • 24035406
    • A.K.Nowak. Immunological checkpoint inhibitors enter adolescence. Lancet Oncol 2013; 14:1035-7; PMID:24035406; http://dx.doi.org/10.1016/S1470-2045(13)70401-7
    • (2013) Lancet Oncol , vol.14 , pp. 1035-1037
    • Nowak, A.K.1
  • 8
    • 77955138291 scopus 로고    scopus 로고
    • Trial watch: ipilimumab success in melanoma provides boost for cancer immunotherapy
    • 20671754
    • Trial watch: ipilimumab success in melanoma provides boost for cancer immunotherapy. Nat Rev Drug Discov 2010; 9:584; PMID:20671754; http://dx.doi.org/10.1038/nrd3245
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 584
  • 9
    • 75249083669 scopus 로고    scopus 로고
    • Immunity unleashed in melanoma
    • 20152761
    • M.K.Erdmann. Immunity unleashed in melanoma. Lancet Oncol 2010; 11:108-9; PMID:20152761; http://dx.doi.org/10.1016/S1470-2045(09)70400-0
    • (2010) Lancet Oncol , vol.11 , pp. 108-109
    • Erdmann, M.K.1
  • 10
    • 75249100054 scopus 로고    scopus 로고
    • Ipilimumab monotherapy in patients with pretreated advanced melanoma: a randomised, double-blind, multicentre, phase 2, dose-ranging study
    • 20004617
    • J.D.Wolchok, B.Neyns, G.Linette, S.Negrier, J.Lutzky, L.Thomas, W.Waterfield, D.Schadendorf, M.Smylie, T.GuthrieJr, Ipilimumab monotherapy in patients with pretreated advanced melanoma: a randomised, double-blind, multicentre, phase 2, dose-ranging study. Lancet Oncol 2010; 11:155-64; PMID:20004617; http://dx.doi.org/10.1016/S1470-2045(09)70334-1
    • (2010) Lancet Oncol , vol.11 , pp. 155-164
    • Wolchok, J.D.1    Neyns, B.2    Linette, G.3    Negrier, S.4    Lutzky, J.5    Thomas, L.6    Waterfield, W.7    Schadendorf, D.8    Smylie, M.9    Guthrie, T.10
  • 13
    • 0028867420 scopus 로고
    • Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
    • 7584144
    • E.A.Tivol, F.Borriello, A.N.Schweitzer, W.P.Lynch, J.A.Bluestone, A.H.Sharpe. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 1995; 3:541-7; PMID:7584144; http://dx.doi.org/10.1016/1074-7613(95)90125-6
    • (1995) Immunity , vol.3 , pp. 541-547
    • Tivol, E.A.1    Borriello, F.2    Schweitzer, A.N.3    Lynch, W.P.4    Bluestone, J.A.5    Sharpe, A.H.6
  • 15
    • 84906510279 scopus 로고    scopus 로고
    • Distinct immunological mechanisms of CTLA-4 and PD-1 blockade revealed by analyzing TCR usage in blood lymphocytes
    • 25083336
    • L.Robert, C.Harview, R.Emerson, X.Wang, S.Mok, B.Homet, B.Comin-Anduix, R.C.Koya, H.Robins, P.C.Tumeh, Distinct immunological mechanisms of CTLA-4 and PD-1 blockade revealed by analyzing TCR usage in blood lymphocytes. Oncoimmunology 2014; 3:e29244; PMID:25083336; http://dx.doi.org/10.4161/onci.29244
    • (2014) Oncoimmunology , vol.3 , pp. 29244
    • Robert, L.1    Harview, C.2    Emerson, R.3    Wang, X.4    Mok, S.5    Homet, B.6    Comin-Anduix, B.7    Koya, R.C.8    Robins, H.9    Tumeh, P.C.10
  • 16
    • 84899106840 scopus 로고    scopus 로고
    • Local CTLA4 blockade effectively restrains experimental pancreatic adenocarcinoma growth in vivo
    • 24701377
    • L.C.Sandin, F.Eriksson, P.Ellmark, A.S.Loskog, T.H.Totterman, S.M.Mangsbo. Local CTLA4 blockade effectively restrains experimental pancreatic adenocarcinoma growth in vivo. Oncoimmunology 2014; 3:e27614; PMID:24701377; http://dx.doi.org/10.4161/onci.27614
    • (2014) Oncoimmunology , vol.3 , pp. 27614
    • Sandin, L.C.1    Eriksson, F.2    Ellmark, P.3    Loskog, A.S.4    Totterman, T.H.5    Mangsbo, S.M.6
  • 17
    • 84908354848 scopus 로고    scopus 로고
    • Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial
    • 25034862
    • C.Robert, A.Ribas, J.D.Wolchok, F.S.Hodi, O.Hamid, R.Kefford, J.S.Weber, A.M.Joshua, W.J.Hwu, T.C.Gangadhar, Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial. Lancet 2014; 384:1109-17; PMID:25034862; http://dx.doi.org/10.1016/S0140-6736(14)60958-2
    • (2014) Lancet , vol.384 , pp. 1109-1117
    • Robert, C.1    Ribas, A.2    Wolchok, J.D.3    Hodi, F.S.4    Hamid, O.5    Kefford, R.6    Weber, J.S.7    Joshua, A.M.8    Hwu, W.J.9    Gangadhar, T.C.10
  • 18
    • 84907543029 scopus 로고    scopus 로고
    • Efficacy and safety of the anti-PD-1 monoclonal antibody MK-3475 in 411 patients (pts) with melanoma (MEL)
    • A.Ribas, F.S.Hodi, R.Kefford, O.Hamid, A.Daud, J.D.Wolchok, Efficacy and safety of the anti-PD-1 monoclonal antibody MK-3475 in 411 patients (pts) with melanoma (MEL). ASCO Meeting Abstr 2014; 32:LBA9000.
    • (2014) ASCO Meeting Abstr , vol.32 , pp. 9000
    • Ribas, A.1    Hodi, F.S.2    Kefford, R.3    Hamid, O.4    Daud, A.5    Wolchok, J.D.6
  • 19
    • 84904628107 scopus 로고    scopus 로고
    • Nivolumab: a review of its use in patients with malignant melanoma
    • 25022950
    • E.D.Deeks. Nivolumab: a review of its use in patients with malignant melanoma. Drugs 2014; 74:1233-9; PMID:25022950; http://dx.doi.org/10.1007/s40265-014-0234-4
    • (2014) Drugs , vol.74 , pp. 1233-1239
    • Deeks, E.D.1
  • 20
    • 84906908933 scopus 로고    scopus 로고
    • Improved survival ends nivolumab trial early
    • 25185170
    • Improved survival ends nivolumab trial early. Cancer Discov 2014; 4:979-80; PMID:25185170; http://dx.doi.org/10.1158/2159-8290.CD-NB2014-104
    • (2014) Cancer Discov , vol.4 , pp. 979-980
  • 24
    • 84886943622 scopus 로고    scopus 로고
    • Re-orienting the immune system: durable tumor regression and successful re-induction therapy using anti-PD1 antibodies
    • 23734322
    • E.J.Lipson. Re-orienting the immune system: durable tumor regression and successful re-induction therapy using anti-PD1 antibodies. Oncoimmunology 2013; 2:e23661; PMID:23734322; http://dx.doi.org/10.4161/onci.23661
    • (2013) Oncoimmunology , vol.2 , pp. 23661
    • Lipson, E.J.1
  • 25
    • 84906517328 scopus 로고    scopus 로고
    • PD-L1 expression and tumor-infiltrating lymphocytes: revisiting the antitumor immune response potential in breast cancer
    • 25083339
    • K.A.Schalper. PD-L1 expression and tumor-infiltrating lymphocytes: revisiting the antitumor immune response potential in breast cancer. Oncoimmunology 2014; 3:e29288; PMID:25083339; http://dx.doi.org/10.4161/onci.29288
    • (2014) Oncoimmunology , vol.3 , pp. 29288
    • Schalper, K.A.1
  • 26
    • 84886945566 scopus 로고    scopus 로고
    • The immune checkpoint regulator PD-L1 is a specific target for naturally occurring CD4 T cells
    • 23734334
    • S.Munir, G.H.Andersen, I.M.Svane, M.H.Andersen. The immune checkpoint regulator PD-L1 is a specific target for naturally occurring CD4 T cells. Oncoimmunology 2013; 2:e23991; PMID:23734334; http://dx.doi.org/10.4161/onci.23991
    • (2013) Oncoimmunology , vol.2 , pp. 23991
    • Munir, S.1    Andersen, G.H.2    Svane, I.M.3    Andersen, M.H.4
  • 29
    • 84919434353 scopus 로고    scopus 로고
    • Clinical evaluation of compounds targeting PD-1PD-L1 pathway for cancer immunotherapy
    • 24917416
    • J.Lu, L.Lee-Gabel, M.C.Nadeau, T.M.Ferencz, S.A.Soefje. Clinical evaluation of compounds targeting PD-1PD-L1 pathway for cancer immunotherapy. J Oncol Pharm Pract 2014; PMID:24917416
    • (2014) J Oncol Pharm Pract
    • Lu, J.1    Lee-Gabel, L.2    Nadeau, M.C.3    Ferencz, T.M.4    Soefje, S.A.5
  • 30
    • 84890933630 scopus 로고    scopus 로고
    • Update on immune checkpoint inhibitors in lung cancer
    • 24357746
    • B.C.Creelan. Update on immune checkpoint inhibitors in lung cancer. Cancer Control 2014; 21:80-9; PMID:24357746
    • (2014) Cancer Control , vol.21 , pp. 80-89
    • Creelan, B.C.1
  • 31
    • 84874830056 scopus 로고    scopus 로고
    • Biomarkers for immunostimulatory monoclonal antibodies in combination strategies for melanoma and other tumor types
    • 23460532
    • P.A.Ascierto, M.Kalos, D.A.Schaer, M.K.Callahan, J.D.Wolchok. Biomarkers for immunostimulatory monoclonal antibodies in combination strategies for melanoma and other tumor types. Clin Cancer Res 2013; 19:1009-20; PMID:23460532; http://dx.doi.org/10.1158/1078-0432.CCR-12-2982
    • (2013) Clin Cancer Res , vol.19 , pp. 1009-1020
    • Ascierto, P.A.1    Kalos, M.2    Schaer, D.A.3    Callahan, M.K.4    Wolchok, J.D.5
  • 33
    • 84922634440 scopus 로고    scopus 로고
    • A phase 1 study to evaluate the safety and tolerability of MEDI4736, an anti-PD-L1 antibody, in combination with tremelimumab in patients with advanced solid tumors
    • M.K.Callahan, P.A.Ott, K.Odunsi, S.V.Bertolini, L.S.Pan, R.R.Venhaus, A phase 1 study to evaluate the safety and tolerability of MEDI4736, an anti-PD-L1 antibody, in combination with tremelimumab in patients with advanced solid tumors. ASCO Meeting Abstr 2014; 32:TPS3120.
    • (2014) ASCO Meeting Abstr , vol.32 , pp. 3120
    • Callahan, M.K.1    Ott, P.A.2    Odunsi, K.3    Bertolini, S.V.4    Pan, L.S.5    Venhaus, R.R.6
  • 36
    • 84896698630 scopus 로고    scopus 로고
    • Cutaneous melanoma
    • 24054424
    • A.M.Eggermont, A.Spatz, C.Robert. Cutaneous melanoma. Lancet 2014; 383:816-27; PMID:24054424; http://dx.doi.org/10.1016/S0140-6736(13)60802-8
    • (2014) Lancet , vol.383 , pp. 816-827
    • Eggermont, A.M.1    Spatz, A.2    Robert, C.3
  • 37
    • 84860490666 scopus 로고    scopus 로고
    • Intensifying tumour immunity through combination therapy
    • 22326921
    • G.Dranoff. Intensifying tumour immunity through combination therapy. Lancet Oncol 2012; 13:440-2; PMID:22326921; http://dx.doi.org/10.1016/S1470-2045(12)70051-7
    • (2012) Lancet Oncol , vol.13 , pp. 440-442
    • Dranoff, G.1
  • 38
    • 84890285105 scopus 로고    scopus 로고
    • Inhibiting the inhibitors: checkpoints blockade in solid tumors
    • 24244910
    • D.Mavilio, E.Lugli. Inhibiting the inhibitors: checkpoints blockade in solid tumors. Oncoimmunology 2013; 2:e26535; PMID:24244910; http://dx.doi.org/10.4161/onci.26535
    • (2013) Oncoimmunology , vol.2 , pp. 26535
    • Mavilio, D.1    Lugli, E.2
  • 39
    • 84880279552 scopus 로고    scopus 로고
    • Combination checkpoint blockade–taking melanoma immunotherapy to the next level
    • 23724866
    • J.L.Riley. Combination checkpoint blockade–taking melanoma immunotherapy to the next level. N Engl J Med 2013; 369:187-9; PMID:23724866; http://dx.doi.org/10.1056/NEJMe1305484
    • (2013) N Engl J Med , vol.369 , pp. 187-189
    • Riley, J.L.1
  • 40
    • 84908327768 scopus 로고    scopus 로고
    • Melanoma: immune checkpoint blockade story gets better
    • 25034863
    • S.Bhatia, J.A.Thompson. Melanoma: immune checkpoint blockade story gets better. Lancet 2014; 384:1078-9; PMID:25034863; http://dx.doi.org/10.1016/S0140-6736(14)61140-5
    • (2014) Lancet , vol.384 , pp. 1078-1079
    • Bhatia, S.1    Thompson, J.A.2
  • 41
    • 81155155667 scopus 로고    scopus 로고
    • Treatment of advanced melanoma with immunological checkpoint block
    • 21938386
    • K.Margolin. Treatment of advanced melanoma with immunological checkpoint block. Curr Oncol Rep 2011; 13:430-2; PMID:21938386; http://dx.doi.org/10.1007/s11912-011-0195-7
    • (2011) Curr Oncol Rep , vol.13 , pp. 430-432
    • Margolin, K.1
  • 42
    • 84908127484 scopus 로고    scopus 로고
    • Melanoma: smart therapeutic strategies in immuno-oncology
    • 24590131
    • A.M.Eggermont, C.Robert. Melanoma: smart therapeutic strategies in immuno-oncology. Nat Rev Clin Oncol 2014; 11:181-2; PMID:24590131; http://dx.doi.org/10.1038/nrclinonc.2014.36
    • (2014) Nat Rev Clin Oncol , vol.11 , pp. 181-182
    • Eggermont, A.M.1    Robert, C.2
  • 44
    • 84899069873 scopus 로고    scopus 로고
    • The immune landscape of human tumors: implications for cancer immunotherapy
    • 24800163
    • G.Bindea, B.Mlecnik, H.K.Angell, J.Galon. The immune landscape of human tumors: implications for cancer immunotherapy. Oncoimmunology 2014; 3:e27456; PMID:24800163; http://dx.doi.org/10.4161/onci.27456
    • (2014) Oncoimmunology , vol.3 , pp. 27456
    • Bindea, G.1    Mlecnik, B.2    Angell, H.K.3    Galon, J.4
  • 45
    • 84899104459 scopus 로고    scopus 로고
    • Harnessing the immune system to provide long-term survival in patients with melanoma and other solid tumors
    • 24719793
    • A.Eggermont, C.Robert, J.C.Soria, L.Zitvogel. Harnessing the immune system to provide long-term survival in patients with melanoma and other solid tumors. Oncoimmunology 2014; 3:e27560; PMID:24719793; http://dx.doi.org/10.4161/onci.27560
    • (2014) Oncoimmunology , vol.3 , pp. 27560
    • Eggermont, A.1    Robert, C.2    Soria, J.C.3    Zitvogel, L.4
  • 46
    • 84934758039 scopus 로고    scopus 로고
    • Phase III, open-label study of nivolumab (anti-PD-1; BMS-936558, ONO-4538) as monotherapy or combined with ipilimumab in advanced or metastatic solid tumors
    • M.K.Callahan, J.C.Bendell, E.Chan, M.Morse, R.N.Pillai, P.Bono, Phase III, open-label study of nivolumab (anti-PD-1; BMS-936558, ONO-4538) as monotherapy or combined with ipilimumab in advanced or metastatic solid tumors. ASCO Meeting Abstr 2014; 32:TPS3114.
    • (2014) ASCO Meeting Abstr , vol.32 , pp. 3114
    • Callahan, M.K.1    Bendell, J.C.2    Chan, E.3    Morse, M.4    Pillai, R.N.5    Bono, P.6
  • 47
    • 84912134974 scopus 로고    scopus 로고
    • Phase I open-label, multiple ascending dose trial of MSB0010718C, an anti-PD-L1 monoclonal antibody, in advanced solid malignancies
    • C.R.Heery, G.H.O’Sullivan Coyne, R.A.Madan, J.Schlom, A.von Heydebreck, J.-M.Cuillerot, Phase I open-label, multiple ascending dose trial of MSB0010718C, an anti-PD-L1 monoclonal antibody, in advanced solid malignancies. ASCO Meeting Abstr 2014; 32:3064.
    • (2014) ASCO Meeting Abstr , vol.32 , pp. 3064
    • Heery, C.R.1    O’Sullivan Coyne, G.H.2    Madan, R.A.3    Schlom, J.4    von Heydebreck, A.5    Cuillerot, J.-M.6
  • 48
    • 84938602784 scopus 로고    scopus 로고
    • A multicohort trial of the safety and efficacy of the PD-1 inhibitor MK-3475 in patients with hematologic malignancies
    • G.Garcia-Manero, G.Martinelli, J.F.Zeidner, D.Avigan, K.C.Anderson, V.Ribrag, A multicohort trial of the safety and efficacy of the PD-1 inhibitor MK-3475 in patients with hematologic malignancies. ASCO Meeting Abstr 2014; 32:TPS3116.
    • (2014) ASCO Meeting Abstr , vol.32 , pp. 3116
    • Garcia-Manero, G.1    Martinelli, G.2    Zeidner, J.F.3    Avigan, D.4    Anderson, K.C.5    Ribrag, V.6
  • 50
    • 84880715077 scopus 로고    scopus 로고
    • Survival and long-term follow-up of the phase I trial of nivolumab (Anti-PD-1; BMS-936558; ONO-4538) in patients (pts) with previously treated advanced non-small cell lung cancer (NSCLC)
    • J.R.Brahmer, L.Horn, S.J.Antonia, D.R.Spigel, L.Gandhi, L.V.Sequist, Survival and long-term follow-up of the phase I trial of nivolumab (Anti-PD-1; BMS-936558; ONO-4538) in patients (pts) with previously treated advanced non-small cell lung cancer (NSCLC). ASCO Meeting Abstr 2013; 31:8030.
    • (2013) ASCO Meeting Abstr , vol.31 , pp. 8030
    • Brahmer, J.R.1    Horn, L.2    Antonia, S.J.3    Spigel, D.R.4    Gandhi, L.5    Sequist, L.V.6
  • 51
    • 84912130561 scopus 로고    scopus 로고
    • Nivolumab (anti-PD-1, BMS-936558, ONO-4538) in patients (pts) with advanced non-small-cell lung cancer (NSCLC): survival and clinical activity by subgroup analysis
    • J.R.Brahmer, L.Horn, L.Gandhi, D.R.Spigel, S.J.Antonia, N.A.Rizvi, Nivolumab (anti-PD-1, BMS-936558, ONO-4538) in patients (pts) with advanced non-small-cell lung cancer (NSCLC): survival and clinical activity by subgroup analysis. ASCO Meeting Abstr 2014; 32:8112.
    • (2014) ASCO Meeting Abstr , vol.32 , pp. 8112
    • Brahmer, J.R.1    Horn, L.2    Gandhi, L.3    Spigel, D.R.4    Antonia, S.J.5    Rizvi, N.A.6
  • 52
    • 84930697267 scopus 로고    scopus 로고
    • Differential expression of LKB1, PD-L1, and PD-L2 in KRAS-mutant non-small cell lung cancer in never-smokers
    • A.Calles, X.Liao, L.M.Sholl, M.Butaney, S.J.Rodig, G.J.Freeman, Differential expression of LKB1, PD-L1, and PD-L2 in KRAS-mutant non-small cell lung cancer in never-smokers. ASCO Meeting Abstr 2014; 32:8032.
    • (2014) ASCO Meeting Abstr , vol.32 , pp. 8032
    • Calles, A.1    Liao, X.2    Sholl, L.M.3    Butaney, M.4    Rodig, S.J.5    Freeman, G.J.6
  • 53
    • 84911864007 scopus 로고    scopus 로고
    • A phase III, randomized, open-label trial of nivolumab (anti-PD-1; BMS-936558, ONO-4538) versus investigator's choice chemotherapy (ICC) as first-line therapy for stage IV or recurrent PD-L1+ non-small cell lung cancer (NSCLC)
    • D.P.Carbone, M.A.Socinski, A.C.Chen, P.Bhagavatheeswaran, M.Reck, L.Paz-Ares. A phase III, randomized, open-label trial of nivolumab (anti-PD-1; BMS-936558, ONO-4538) versus investigator's choice chemotherapy (ICC) as first-line therapy for stage IV or recurrent PD-L1+ non-small cell lung cancer (NSCLC). ASCO Meeting Abstr 2014; 32:TPS8128.
    • (2014) ASCO Meeting Abstr , vol.32 , pp. 8128
    • Carbone, D.P.1    Socinski, M.A.2    Chen, A.C.3    Bhagavatheeswaran, P.4    Reck, M.5    Paz-Ares, L.6
  • 54
    • 84907614647 scopus 로고    scopus 로고
    • Safety and clinical activity of MK-3475 in previously treated patients (pts) with non-small cell lung cancer (NSCLC)
    • E.B.Garon, N.B.Leighl, N.A.Rizvi, G.R.Blumenschein, A.S.Balmanoukian, J.P.Eder, Safety and clinical activity of MK-3475 in previously treated patients (pts) with non-small cell lung cancer (NSCLC). ASCO Meeting Abstr 2014; 32:8020.
    • (2014) ASCO Meeting Abstr , vol.32 , pp. 8020
    • Garon, E.B.1    Leighl, N.B.2    Rizvi, N.A.3    Blumenschein, G.R.4    Balmanoukian, A.S.5    Eder, J.P.6
  • 55
    • 84880709088 scopus 로고    scopus 로고
    • Clinical activity, safety, and biomarkers of MPDL3280A, an engineered PD-L1 antibody in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC)
    • D.R.Spigel, S.N.Gettinger, L.Horn, R.S.Herbst, L.Gandhi, M.S.Gordon, Clinical activity, safety, and biomarkers of MPDL3280A, an engineered PD-L1 antibody in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC). ASCO Meeting Abstr 2013; 31:8008.
    • (2013) ASCO Meeting Abstr , vol.31 , pp. 8008
    • Spigel, D.R.1    Gettinger, S.N.2    Horn, L.3    Herbst, R.S.4    Gandhi, L.5    Gordon, M.S.6
  • 56
    • 84905107303 scopus 로고    scopus 로고
    • PD-L1 expression in primary clear cell renal cell carcinomas (ccRCCs) and their metastases
    • M.Callea, E.M.Genega, M.Gupta, S.Cheng, A.P.Fay, J.Song, PD-L1 expression in primary clear cell renal cell carcinomas (ccRCCs) and their metastases. ASCO Meeting Abstr 2014; 32:4585.
    • (2014) ASCO Meeting Abstr , vol.32 , pp. 4585
    • Callea, M.1    Genega, E.M.2    Gupta, M.3    Cheng, S.4    Fay, A.P.5    Song, J.6
  • 57
    • 84905107303 scopus 로고    scopus 로고
    • PD-L1 expression in primary clear cell renal cell carcinomas (ccRCCs) and their metastases
    • M.Callea, E.M.Genega, M.Gupta, A.P.Fay, J.Song, I.Carvo, PD-L1 expression in primary clear cell renal cell carcinomas (ccRCCs) and their metastases. ASCO Meeting Abstr 2014; 32:467.
    • (2014) ASCO Meeting Abstr , vol.32 , pp. 467
    • Callea, M.1    Genega, E.M.2    Gupta, M.3    Fay, A.P.4    Song, J.5    Carvo, I.6
  • 58
    • 84921742040 scopus 로고    scopus 로고
    • Immunomodulatory activity of nivolumab in previously treated and untreated metastatic renal cell carcinoma (mRCC): biomarker-based results from a randomized clinical trial
    • T.K.Choueiri, M.N.Fishman, B.J.Escudier, J.J.Kim, H.M.Kluger, W.M.Stadler, Immunomodulatory activity of nivolumab in previously treated and untreated metastatic renal cell carcinoma (mRCC): biomarker-based results from a randomized clinical trial. ASCO Meeting Abstr 2014; 32:5012.
    • (2014) ASCO Meeting Abstr , vol.32 , pp. 5012
    • Choueiri, T.K.1    Fishman, M.N.2    Escudier, B.J.3    Kim, J.J.4    Kluger, H.M.5    Stadler, W.M.6
  • 59
    • 84880706331 scopus 로고    scopus 로고
    • Survival, safety, and response duration results of nivolumab (Anti-PD-1; BMS-936558; ONO-4538) in a phase I trial in patients with previously treated metastatic renal cell carcinoma (mRCC): long-term patient follow-up
    • C.G.Drake, D.F.McDermott, M.Sznol, T.K.Choueiri, H.M.Kluger, J.D.Powderly, Survival, safety, and response duration results of nivolumab (Anti-PD-1; BMS-936558; ONO-4538) in a phase I trial in patients with previously treated metastatic renal cell carcinoma (mRCC): long-term patient follow-up. ASCO Meeting Abstr 2013; 31:4514.
    • (2013) ASCO Meeting Abstr , vol.31 , pp. 4514
    • Drake, C.G.1    McDermott, D.F.2    Sznol, M.3    Choueiri, T.K.4    Kluger, H.M.5    Powderly, J.D.6
  • 60
    • 84938595611 scopus 로고    scopus 로고
    • PD-L1 expression in non-clear cell renal cell carcinoma and benign kidney tumors
    • A.P.Fay, M.Callea, K.P.Gray, T.H.Ho, J.Song, I.Carvo, PD-L1 expression in non-clear cell renal cell carcinoma and benign kidney tumors. ASCO Meeting Abstr 2014; 32:4526.
    • (2014) ASCO Meeting Abstr , vol.32 , pp. 4526
    • Fay, A.P.1    Callea, M.2    Gray, K.P.3    Ho, T.H.4    Song, J.5    Carvo, I.6
  • 62
    • 84938648665 scopus 로고    scopus 로고
    • PD-L1 specific tumor infiltrating lymphocytes occur frequently in melanoma and HNSCC patients
    • N.Junker, M.Donia, R.Andersen, M.H.Andersen, I.M.Svane. PD-L1 specific tumor infiltrating lymphocytes occur frequently in melanoma and HNSCC patients. ASCO Meeting Abstr 2014; 32:11083.
    • (2014) ASCO Meeting Abstr , vol.32 , pp. 11083
    • Junker, N.1    Donia, M.2    Andersen, R.3    Andersen, M.H.4    Svane, I.M.5
  • 63
    • 84907521155 scopus 로고    scopus 로고
    • A phase Ib study of MK-3475 in patients with human papillomavirus (HPV)-associated and non-HPV-associated head and neck (HN) cancer
    • T.Y.Seiwert, B.Burtness, J.Weiss, I.Gluck, J.P.Eder, S.I.Pai, A phase Ib study of MK-3475 in patients with human papillomavirus (HPV)-associated and non-HPV-associated head and neck (HN) cancer. ASCO Meeting Abstr 2014; 32:6011.
    • (2014) ASCO Meeting Abstr , vol.32 , pp. 6011
    • Seiwert, T.Y.1    Burtness, B.2    Weiss, J.3    Gluck, I.4    Eder, J.P.5    Pai, S.I.6
  • 64
    • 84905753981 scopus 로고    scopus 로고
    • Efficacy and safety of anti-PD-1 antibody (Nivolumab: BMS-936558, ONO-4538) in patients with platinum-resistant ovarian cancer
    • J.Hamanishi, M.Mandai, T.Ikeda, M.Minami, A.Kawaguchi, N.Matsumura, Efficacy and safety of anti-PD-1 antibody (Nivolumab: BMS-936558, ONO-4538) in patients with platinum-resistant ovarian cancer. ASCO Meeting Abstr 2014; 32:5511.
    • (2014) ASCO Meeting Abstr , vol.32 , pp. 5511
    • Hamanishi, J.1    Mandai, M.2    Ikeda, T.3    Minami, M.4    Kawaguchi, A.5    Matsumura, N.6
  • 65
    • 84905698694 scopus 로고    scopus 로고
    • Inhibition of PD-L1 by MPDL3280A and clinical activity in pts with metastatic urothelial bladder cancer (UBC)
    • T.Powles, N.J.Vogelzang, G.D.Fine, J.P.Eder, F.S.Braiteh, Y.Loriot, Inhibition of PD-L1 by MPDL3280A and clinical activity in pts with metastatic urothelial bladder cancer (UBC). ASCO Meeting Abstr 2014; 32:5011.
    • (2014) ASCO Meeting Abstr , vol.32 , pp. 5011
    • Powles, T.1    Vogelzang, N.J.2    Fine, G.D.3    Eder, J.P.4    Braiteh, F.S.5    Loriot, Y.6
  • 66
    • 84938648666 scopus 로고    scopus 로고
    • Programmed death receptor ligand-1 (PD-L1) expression in a thymoma (T) tissue microarray (TMA)
    • S.K.Padda, J.Riess, E.J.Schwartz, L.Tian, H.E.Kohrt, J.W.Neal, Programmed death receptor ligand-1 (PD-L1) expression in a thymoma (T) tissue microarray (TMA). ASCO Meeting Abstr 2014; 32:7606.
    • (2014) ASCO Meeting Abstr , vol.32 , pp. 7606
    • Padda, S.K.1    Riess, J.2    Schwartz, E.J.3    Tian, L.4    Kohrt, H.E.5    Neal, J.W.6
  • 67
    • 84938648667 scopus 로고    scopus 로고
    • Immune checkpoints expression in MSI versus MSS colorectal cancers and their potential therapeutic implications
    • N.J.Llosa, F.Housseau, E.C.Wick, L.Hechenbleikner, M.Cruise, R.Anders, Immune checkpoints expression in MSI versus MSS colorectal cancers and their potential therapeutic implications. ASCO Meeting Abstr 2014; 32:3620.
    • (2014) ASCO Meeting Abstr , vol.32 , pp. 3620
    • Llosa, N.J.1    Housseau, F.2    Wick, E.C.3    Hechenbleikner, L.4    Cruise, M.5    Anders, R.6
  • 70
    • 84860436621 scopus 로고    scopus 로고
    • Combined immunotherapy with granulocyte-macrophage colony-stimulating factor-transduced allogeneic prostate cancer cells and ipilimumab in patients with metastatic castration-resistant prostate cancer: a phase 1 dose-escalation trial
    • 22326922
    • A.J.van den Eertwegh, J.Versluis, H.P.van den Berg, S.J.Santegoets, R.J.van Moorselaar, T.M.van der Sluis, H.E.Gall, T.C.Harding, K.Jooss, I.Lowy, Combined immunotherapy with granulocyte-macrophage colony-stimulating factor-transduced allogeneic prostate cancer cells and ipilimumab in patients with metastatic castration-resistant prostate cancer: a phase 1 dose-escalation trial. Lancet Oncol 2012; 13:509-17; PMID:22326922; http://dx.doi.org/10.1016/S1470-2045(12)70007-4
    • (2012) Lancet Oncol , vol.13 , pp. 509-517
    • van den Eertwegh, A.J.1    Versluis, J.2    van den Berg, H.P.3    Santegoets, S.J.4    van Moorselaar, R.J.5    van der Sluis, T.M.6    Gall, H.E.7    Harding, T.C.8    Jooss, K.9    Lowy, I.10
  • 71
    • 84902449791 scopus 로고    scopus 로고
    • Combined OX40 ligation plus CTLA-4 blockade: more than the sum of its parts
    • 25050194
    • S.N.Linch, W.L.Redmond. Combined OX40 ligation plus CTLA-4 blockade: more than the sum of its parts. Oncoimmunology 2014; 3:e28245; PMID:25050194; http://dx.doi.org/10.4161/onci.28245
    • (2014) Oncoimmunology , vol.3 , pp. 28245
    • Linch, S.N.1    Redmond, W.L.2
  • 72
    • 84904609350 scopus 로고    scopus 로고
    • Blockade of PD-1 immunosuppression boosts CAR T-cell therapy
    • 24353912
    • L.B.John, M.H.Kershaw, P.K.Darcy. Blockade of PD-1 immunosuppression boosts CAR T-cell therapy. Oncoimmunology 2013; 2:e26286; PMID:24353912; http://dx.doi.org/10.4161/onci.26286
    • (2013) Oncoimmunology , vol.2 , pp. 26286
    • John, L.B.1    Kershaw, M.H.2    Darcy, P.K.3
  • 76
    • 84883230583 scopus 로고    scopus 로고
    • Blockade of the PD-1 pathway enhances the efficacy of adoptive cell therapy against cancer
    • 23524510
    • W.Peng, G.Lizee, P.Hwu. Blockade of the PD-1 pathway enhances the efficacy of adoptive cell therapy against cancer. Oncoimmunology 2013; 2:e22691; PMID:23524510; http://dx.doi.org/10.4161/onci.22691
    • (2013) Oncoimmunology , vol.2 , pp. 22691
    • Peng, W.1    Lizee, G.2    Hwu, P.3
  • 77
    • 84867544962 scopus 로고    scopus 로고
    • PD-1 blockade enhances T-cell migration to tumors by elevating IFN-gamma inducible chemokines
    • 22915761
    • W.Peng, C.Liu, C.Xu, Y.Lou, J.Chen, Y.Yang, H.Yagita, W.W.Overwijk, G.Lizée, L.Radvanyi, PD-1 blockade enhances T-cell migration to tumors by elevating IFN-gamma inducible chemokines. Cancer Res 2012; 72:5209-18; PMID:22915761; http://dx.doi.org/10.1158/0008-5472.CAN-12-1187
    • (2012) Cancer Res , vol.72 , pp. 5209-5218
    • Peng, W.1    Liu, C.2    Xu, C.3    Lou, Y.4    Chen, J.5    Yang, Y.6    Yagita, H.7    Overwijk, W.W.8    Lizée, G.9    Radvanyi, L.10
  • 80
    • 84860455345 scopus 로고    scopus 로고
    • Ipilimumab and a poxviral vaccine targeting prostate-specific antigen in metastatic castration-resistant prostate cancer: a phase 1 dose-escalation trial
    • 22326924
    • R.A.Madan, M.Mohebtash, P.M.Arlen, M.Vergati, M.Rauckhorst, S.M.Steinberg, K.Y.Tsang, D.J.Poole, H.L.Parnes, J.J.Wright, Ipilimumab and a poxviral vaccine targeting prostate-specific antigen in metastatic castration-resistant prostate cancer: a phase 1 dose-escalation trial. Lancet Oncol 2012; 13:501-8; PMID:22326924; http://dx.doi.org/10.1016/S1470-2045(12)70006-2
    • (2012) Lancet Oncol , vol.13 , pp. 501-508
    • Madan, R.A.1    Mohebtash, M.2    Arlen, P.M.3    Vergati, M.4    Rauckhorst, M.5    Steinberg, S.M.6    Tsang, K.Y.7    Poole, D.J.8    Parnes, H.L.9    Wright, J.J.10
  • 81
    • 84880721353 scopus 로고    scopus 로고
    • Dendritic-cell-based therapeutic cancer vaccines
    • 23890062
    • K.Palucka, J.Banchereau. Dendritic-cell-based therapeutic cancer vaccines. Immunity 2013; 39:38-48; PMID:23890062; http://dx.doi.org/10.1016/j.immuni.2013.07.004
    • (2013) Immunity , vol.39 , pp. 38-48
    • Palucka, K.1    Banchereau, J.2
  • 85
    • 79957891364 scopus 로고    scopus 로고
    • PD-1 blockade by CT-011, anti-PD-1 antibody, enhances ex vivo T-cell responses to autologous dendritic cellmyeloma fusion vaccine
    • 21577144
    • J.Rosenblatt, B.Glotzbecker, H.Mills, B.Vasir, D.Tzachanis, J.D.Levine, R.M.Joyce, K.Wellenstein, W.Keefe, M.Schickler, PD-1 blockade by CT-011, anti-PD-1 antibody, enhances ex vivo T-cell responses to autologous dendritic cellmyeloma fusion vaccine. J Immunother 2011; 34:409-18; PMID:21577144; http://dx.doi.org/10.1097/CJI.0b013e31821ca6ce
    • (2011) J Immunother , vol.34 , pp. 409-418
    • Rosenblatt, J.1    Glotzbecker, B.2    Mills, H.3    Vasir, B.4    Tzachanis, D.5    Levine, J.D.6    Joyce, R.M.7    Wellenstein, K.8    Keefe, W.9    Schickler, M.10
  • 86
    • 84908299923 scopus 로고    scopus 로고
    • Updated survival, toxicity, and biomarkers of nivolumab withwithout peptide vaccine in patients naive to, or progressed on, ipilimumab (IPI)
    • J.S.Weber, R.R.Kudchadkar, G.T.Gibney, B.Yu, P.Cheng, A.J.Martinez, Updated survival, toxicity, and biomarkers of nivolumab withwithout peptide vaccine in patients naive to, or progressed on, ipilimumab (IPI). ASCO Meeting Abstr 2014; 32:3009.
    • (2014) ASCO Meeting Abstr , vol.32 , pp. 3009
    • Weber, J.S.1    Kudchadkar, R.R.2    Gibney, G.T.3    Yu, B.4    Cheng, P.5    Martinez, A.J.6
  • 89
    • 84904045263 scopus 로고    scopus 로고
    • A novel combinatorial cancer immunotherapy: poly-IC and blockade of the PD-1PD-L1 pathway
    • 25050210
    • T.Nagato, E.Celis. A novel combinatorial cancer immunotherapy: poly-IC and blockade of the PD-1PD-L1 pathway. Oncoimmunology 2014; 3:e28440; PMID:25050210; http://dx.doi.org/10.4161/onci.28440
    • (2014) Oncoimmunology , vol.3 , pp. 28440
    • Nagato, T.1    Celis, E.2
  • 93
    • 84904216679 scopus 로고    scopus 로고
    • Ipilimumab and radiation therapy for melanoma brain metastases
    • 24403263
    • A.W.Silk, M.F.Bassetti, B.T.West, C.I.Tsien, C.D.Lao. Ipilimumab and radiation therapy for melanoma brain metastases. Cancer Med 2013; 2:899-906; PMID:24403263; http://dx.doi.org/10.1002/cam4.140
    • (2013) Cancer Med , vol.2 , pp. 899-906
    • Silk, A.W.1    Bassetti, M.F.2    West, B.T.3    Tsien, C.I.4    Lao, C.D.5
  • 94
    • 84861398744 scopus 로고    scopus 로고
    • Abscopal effect in a patient with melanoma
    • author reply -6, 22621637
    • S.M.Hiniker, D.S.Chen, S.J.Knox. Abscopal effect in a patient with melanoma. N Engl J Med 2012; 366:2035; author reply -6; PMID:22621637; http://dx.doi.org/10.1056/NEJMc1203984
    • (2012) N Engl J Med , vol.366 , pp. 2035
    • Hiniker, S.M.1    Chen, D.S.2    Knox, S.J.3
  • 96
    • 84886944998 scopus 로고    scopus 로고
    • Exploiting the stress response to radiation to sensitize poorly immunogenic tumors to anti-CTLA-4 treatment
    • 23802063
    • S.Demaria, K.A.Pilones, S.C.Formenti, M.L.Dustin. Exploiting the stress response to radiation to sensitize poorly immunogenic tumors to anti-CTLA-4 treatment. Oncoimmunology 2013; 2:e23127; PMID:23802063; http://dx.doi.org/10.4161/onci.23127
    • (2013) Oncoimmunology , vol.2 , pp. 23127
    • Demaria, S.1    Pilones, K.A.2    Formenti, S.C.3    Dustin, M.L.4
  • 99
    • 84857789296 scopus 로고    scopus 로고
    • The secret ally: immunostimulation by anticancer drugs
    • 22301798
    • L.Galluzzi, L.Senovilla, L.Zitvogel, G.Kroemer. The secret ally: immunostimulation by anticancer drugs. Nat Rev Drug Discov 2012; 11:215-33; PMID:22301798; http://dx.doi.org/10.1038/nrd3626
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 215-233
    • Galluzzi, L.1    Senovilla, L.2    Zitvogel, L.3    Kroemer, G.4
  • 100
    • 84880747672 scopus 로고    scopus 로고
    • Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance
    • 23890065
    • L.Zitvogel, L.Galluzzi, M.J.Smyth, G.Kroemer. Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance. Immunity 2013; 39:74-88; PMID:23890065; http://dx.doi.org/10.1016/j.immuni.2013.06.014
    • (2013) Immunity , vol.39 , pp. 74-88
    • Zitvogel, L.1    Galluzzi, L.2    Smyth, M.J.3    Kroemer, G.4
  • 101
    • 84886944616 scopus 로고    scopus 로고
    • Combining checkpoint inhibitors and BRAF-targeted agents against metastatic melanoma
    • 23762807
    • Z.A.Cooper, D.T.Frederick, Z.Ahmed, J.A.Wargo. Combining checkpoint inhibitors and BRAF-targeted agents against metastatic melanoma. Oncoimmunology 2013; 2:e24320; PMID:23762807; http://dx.doi.org/10.4161/onci.24320
    • (2013) Oncoimmunology , vol.2 , pp. 24320
    • Cooper, Z.A.1    Frederick, D.T.2    Ahmed, Z.3    Wargo, J.A.4
  • 102
    • 84896730538 scopus 로고    scopus 로고
    • A phase I study of nivolumab (anti-PD-1; BMS-936558; ONO-4538) in combination with sunitinib, pazopanib, or ipilimumab in patients (pts) with metastatic renal cell carcinoma (mRCC)
    • A.Amin, M.S.Ernstoff, J.R.Infante, Heng DYC, B.I.Rini, E.R.Plimack, A phase I study of nivolumab (anti-PD-1; BMS-936558; ONO-4538) in combination with sunitinib, pazopanib, or ipilimumab in patients (pts) with metastatic renal cell carcinoma (mRCC). ASCO Meeting Abstr 2013; 31:TPS4593.
    • (2013) ASCO Meeting Abstr , vol.31 , pp. 4593
    • Amin, A.1    Ernstoff, M.S.2    Infante, J.R.3    Rini, B.I.4    Plimack, E.R.5
  • 103
    • 84914176528 scopus 로고    scopus 로고
    • Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with sunitinib or pazopanib in patients (pts) with metastatic renal cell carcinoma (mRCC)
    • A.Amin, E.R.Plimack, J.R.Infante, M.S.Ernstoff, B.I.Rini, D.F.McDermott, Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with sunitinib or pazopanib in patients (pts) with metastatic renal cell carcinoma (mRCC). ASCO Meeting Abstr 2014; 32:5010.
    • (2014) ASCO Meeting Abstr , vol.32 , pp. 5010
    • Amin, A.1    Plimack, E.R.2    Infante, J.R.3    Ernstoff, M.S.4    Rini, B.I.5    McDermott, D.F.6
  • 104
    • 84908269560 scopus 로고    scopus 로고
    • Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with platinum-based doublet chemotherapy (PT-DC) in advanced non-small cell lung cancer (NSCLC)
    • S.J.Antonia, J.R.Brahmer, S.N.Gettinger, L.Q.M.Chow, R.A.Juergens, F.A.Shepherd, Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with platinum-based doublet chemotherapy (PT-DC) in advanced non-small cell lung cancer (NSCLC). ASCO Meeting Abstr 2014; 32:8113.
    • (2014) ASCO Meeting Abstr , vol.32 , pp. 8113
    • Antonia, S.J.1    Brahmer, J.R.2    Gettinger, S.N.3    Chow, L.Q.M.4    Juergens, R.A.5    Shepherd, F.A.6
  • 105
    • 84916895694 scopus 로고    scopus 로고
    • Updated overall survival (OS) for BRF113220, a phase 1-2 study of dabrafenib (D) alone versus combined dabrafenib and trametinib (D+T) in pts with BRAF V600 mutation-positive (+) metastatic melanoma (MM)
    • K.Flaherty, A.Daud, J.S.Weber, J.A.Sosman, K.Kim, R.Gonzalez, Updated overall survival (OS) for BRF113220, a phase 1-2 study of dabrafenib (D) alone versus combined dabrafenib and trametinib (D+T) in pts with BRAF V600 mutation-positive (+) metastatic melanoma (MM). ASCO Meeting Abstr 2014; 32:9010.
    • (2014) ASCO Meeting Abstr , vol.32 , pp. 9010
    • Flaherty, K.1    Daud, A.2    Weber, J.S.3    Sosman, J.A.4    Kim, K.5    Gonzalez, R.6
  • 106
    • 84942196770 scopus 로고    scopus 로고
    • A phase III study to assess the safety and efficacy of pazopanib and MK-3475 in subjects with advanced renal cell carcinoma
    • D.F.McDermott, J.R.Infante, M.H.Voss, R.J.Motzer, J.B.A.G.Haanen, S.Chowdhury, A phase III study to assess the safety and efficacy of pazopanib and MK-3475 in subjects with advanced renal cell carcinoma. ASCO Meeting Abstr 2014; 32:TPS4604.
    • (2014) ASCO Meeting Abstr , vol.32 , pp. 4604
    • McDermott, D.F.1    Infante, J.R.2    Voss, M.H.3    Motzer, R.J.4    Haanen, J.B.A.G.5    Chowdhury, S.6
  • 107
    • 84938648668 scopus 로고    scopus 로고
    • An open-label, phase 1b, dose-escalation study (CA180-373) of dasatinib plus nivolumab, an investigational anti-programmed cell death 1 (PD-1) antibody, in patients (pts) with previously treated chronic myeloid leukemia (CML)
    • K.Porkka, M.J.Mauro, J.H.Lipton, F.-X.Mahon, L.C.Strauss, W.J.Geese, An open-label, phase 1b, dose-escalation study (CA180-373) of dasatinib plus nivolumab, an investigational anti-programmed cell death 1 (PD-1) antibody, in patients (pts) with previously treated chronic myeloid leukemia (CML). ASCO Meeting Abstr 2014; 32:TPS7119.
    • (2014) ASCO Meeting Abstr , vol.32 , pp. 7119
    • Porkka, K.1    Mauro, M.J.2    Lipton, J.H.3    Mahon, F.-X.4    Strauss, L.C.5    Geese, W.J.6
  • 108
    • 84907651085 scopus 로고    scopus 로고
    • Safety and response with nivolumab (anti-PD-1; BMS-936558, ONO-4538) plus erlotinib in patients (pts) with epidermal growth factor receptor mutant (EGFR MT) advanced NSCLC
    • N.A.Rizvi, L.Q.M.Chow, H.Borghaei, Y.Shen, C.Harbison, S.Alaparthy, Safety and response with nivolumab (anti-PD-1; BMS-936558, ONO-4538) plus erlotinib in patients (pts) with epidermal growth factor receptor mutant (EGFR MT) advanced NSCLC. ASCO Meeting Abstr 2014; 32:8022.
    • (2014) ASCO Meeting Abstr , vol.32 , pp. 8022
    • Rizvi, N.A.1    Chow, L.Q.M.2    Borghaei, H.3    Shen, Y.4    Harbison, C.5    Alaparthy, S.6
  • 109
    • 85027956453 scopus 로고    scopus 로고
    • Thunder and lightning: immunotherapy and oncolytic viruses collide
    • 21505424
    • A.Melcher, K.Parato, C.M.Rooney, J.C.Bell. Thunder and lightning: immunotherapy and oncolytic viruses collide. Mol Ther 2011; 19:1008-16; PMID:21505424; http://dx.doi.org/10.1038/mt.2011.65
    • (2011) Mol Ther , vol.19 , pp. 1008-1016
    • Melcher, A.1    Parato, K.2    Rooney, C.M.3    Bell, J.C.4
  • 112
  • 115
    • 84938579374 scopus 로고    scopus 로고
    • A phase 1 (Ph1) trial of MK-3475 combined with lenalidomide (Len) and low-dose dexamethasone (Dex) in patients (pts) with relapsedrefractory multiple myeloma (RRMM)
    • D.S.D.Siegel, P.Moreau, D.Avigan, K.C.Anderson, D.E.Reece, J.San Miguel, A phase 1 (Ph1) trial of MK-3475 combined with lenalidomide (Len) and low-dose dexamethasone (Dex) in patients (pts) with relapsedrefractory multiple myeloma (RRMM). ASCO Meeting Abstr 2014; 32:TPS3117.
    • (2014) ASCO Meeting Abstr , vol.32 , pp. 3117
    • Siegel, D.S.D.1    Moreau, P.2    Avigan, D.3    Anderson, K.C.4    Reece, D.E.5    San Miguel, J.6
  • 117
    • 84899051541 scopus 로고    scopus 로고
    • Novel insights into the mechanism of action of lenalidomide
    • 25340011
    • M.Semeraro, L.Galluzzi. Novel insights into the mechanism of action of lenalidomide. Oncoimmunology 2014; 3:e28386; PMID:25340011; http://dx.doi.org/10.4161/onci.28386
    • (2014) Oncoimmunology , vol.3 , pp. 28386
    • Semeraro, M.1    Galluzzi, L.2
  • 119
    • 84888340426 scopus 로고    scopus 로고
    • A phase I dose-escalation and cohort expansion study of lirilumab (anti-KIR; BMS-986015) administered in combination with nivolumab (anti-PD-1; BMS-936558; ONO-4538) in patients (Pts) with advanced refractory solid tumors
    • R.E.Sanborn, W.H.Sharfman, N.H.Segal, F.S.Hodi, J.D.Wolchok, W.J.Urba, A phase I dose-escalation and cohort expansion study of lirilumab (anti-KIR; BMS-986015) administered in combination with nivolumab (anti-PD-1; BMS-936558; ONO-4538) in patients (Pts) with advanced refractory solid tumors. ASCO Meeting Abstr 2013; 31:TPS3110.
    • (2013) ASCO Meeting Abstr , vol.31 , pp. 3110
    • Sanborn, R.E.1    Sharfman, W.H.2    Segal, N.H.3    Hodi, F.S.4    Wolchok, J.D.5    Urba, W.J.6
  • 120
    • 84907521154 scopus 로고    scopus 로고
    • A phase I dose escalation and cohort expansion study of lirilumab (anti-KIR; BMS-986015) in combination with nivolumab (anti-PD-1; BMS-936558, ONO-4538) in advanced solid tumors
    • N.H.Segal, F.S.Hodi, R.E.Sanborn, T.Gajewski, J.D.Wolchok, W.J.Urba, A phase I dose escalation and cohort expansion study of lirilumab (anti-KIR; BMS-986015) in combination with nivolumab (anti-PD-1; BMS-936558, ONO-4538) in advanced solid tumors. ASCO Meeting Abstr 2014; 32:TPS3115.
    • (2014) ASCO Meeting Abstr , vol.32 , pp. 3115
    • Segal, N.H.1    Hodi, F.S.2    Sanborn, R.E.3    Gajewski, T.4    Wolchok, J.D.5    Urba, W.J.6
  • 121
    • 84886945638 scopus 로고    scopus 로고
    • Current trends of anticancer immunochemotherapy
    • 23894726
    • E.Vacchelli, N.Prada, O.Kepp, L.Galluzzi. Current trends of anticancer immunochemotherapy. Oncoimmunology 2013; 2:e25396; PMID:23894726; http://dx.doi.org/10.4161/onci.25396
    • (2013) Oncoimmunology , vol.2 , pp. 25396
    • Vacchelli, E.1    Prada, N.2    Kepp, O.3    Galluzzi, L.4
  • 122
    • 84904024273 scopus 로고    scopus 로고
    • Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy
    • 24714771
    • J.M.Taube, A.Klein, J.R.Brahmer, H.Xu, X.Pan, J.H.Kim, L.Chen, D.M.Pardoll, S.L.Topalian, R.A.Anders. Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy. Clin Cancer Res 2014; 20:5064-74; PMID:24714771; http://dx.doi.org/10.1158/1078-0432.CCR-13-3271
    • (2014) Clin Cancer Res , pp. 5064-5074
    • Taube, J.M.1    Klein, A.2    Brahmer, J.R.3    Xu, H.4    Pan, X.5    Kim, J.H.6    Chen, L.7    Pardoll, D.M.8    Topalian, S.L.9    Anders, R.A.10
  • 123
    • 84890280934 scopus 로고    scopus 로고
    • Identification of new prognostic biomarkers for Stage III metastatic melanoma patients
    • 24228228
    • H.Kakavand, R.A.Scolyer, J.F.Thompson, G.J.Mann. Identification of new prognostic biomarkers for Stage III metastatic melanoma patients. Oncoimmunology 2013; 2:e25564; PMID:24228228; http://dx.doi.org/10.4161/onci.25564
    • (2013) Oncoimmunology , vol.2 , pp. 25564
    • Kakavand, H.1    Scolyer, R.A.2    Thompson, J.F.3    Mann, G.J.4
  • 124
    • 84902603313 scopus 로고    scopus 로고
    • Immune response markers in sentinel nodes may predict melanoma progression
    • 25050216
    • M.Rodolfo, C.Castelli, L.Rivoltini. Immune response markers in sentinel nodes may predict melanoma progression. Oncoimmunology 2014; 3:e28498; PMID:25050216; http://dx.doi.org/10.4161/onci.28498
    • (2014) Oncoimmunology , vol.3 , pp. 28498
    • Rodolfo, M.1    Castelli, C.2    Rivoltini, L.3
  • 128
    • 84885840329 scopus 로고    scopus 로고
    • Immune correlates of melanoma survival in adoptive cell therapy
    • 23525606
    • A.F.Lee, P.A.Sieling, D.J.Lee. Immune correlates of melanoma survival in adoptive cell therapy. Oncoimmunology 2013; 2:e22889; PMID:23525606; http://dx.doi.org/10.4161/onci.22889
    • (2013) Oncoimmunology , vol.2 , pp. 22889
    • Lee, A.F.1    Sieling, P.A.2    Lee, D.J.3
  • 129
    • 84922097884 scopus 로고    scopus 로고
    • Evaluation of immune-related response criteria (irRC) in patients (pts) with advanced melanoma (MEL) treated with the anti-PD-1 monoclonal antibody MK-3475
    • F.S.Hodi, A.Ribas, A.Daud, O.Hamid, C.Robert, R.Kefford, Evaluation of immune-related response criteria (irRC) in patients (pts) with advanced melanoma (MEL) treated with the anti-PD-1 monoclonal antibody MK-3475. ASCO Meeting Abstr 2014; 32:3006.
    • (2014) ASCO Meeting Abstr , vol.32 , pp. 3006
    • Hodi, F.S.1    Ribas, A.2    Daud, A.3    Hamid, O.4    Robert, C.5    Kefford, R.6
  • 130
    • 80455173518 scopus 로고    scopus 로고
    • Hemophilia A induced by ipilimumab
    • 22047582
    • J.Delyon, C.Mateus, T.Lambert. Hemophilia A induced by ipilimumab. N Engl J Med 2011; 365:1747-8; PMID:22047582; http://dx.doi.org/10.1056/NEJMc1110923
    • (2011) N Engl J Med , vol.365 , pp. 1747-1748
    • Delyon, J.1    Mateus, C.2    Lambert, T.3
  • 131
    • 67650491041 scopus 로고    scopus 로고
    • Anti-CTLA4 antibody-induced lupus nephritis
    • 19587352
    • F.Fadel, El K.Karoui, B.Knebelmann. Anti-CTLA4 antibody-induced lupus nephritis. N Engl J Med 2009; 361:211-2; PMID:19587352; http://dx.doi.org/10.1056/NEJMc0904283
    • (2009) N Engl J Med , vol.361 , pp. 211-212
    • Fadel, F.1    Karoui, K.2    Knebelmann, B.3
  • 132
    • 84875785905 scopus 로고    scopus 로고
    • Hepatotoxicity with combination of vemurafenib and ipilimumab
    • 23550685
    • A.Ribas, F.S.Hodi, M.Callahan, C.Konto, J.Wolchok. Hepatotoxicity with combination of vemurafenib and ipilimumab. N Engl J Med 2013; 368:1365-6; PMID:23550685; http://dx.doi.org/10.1056/NEJMc1302338
    • (2013) N Engl J Med , vol.368 , pp. 1365-1366
    • Ribas, A.1    Hodi, F.S.2    Callahan, M.3    Konto, C.4    Wolchok, J.5
  • 133
    • 84890281406 scopus 로고    scopus 로고
    • Adverse events to monoclonal antibodies used for cancer therapy: focus on hypersensitivity responses
    • 24251081
    • B.A.Baldo. Adverse events to monoclonal antibodies used for cancer therapy: focus on hypersensitivity responses. Oncoimmunology 2013; 2:e26333; PMID:24251081; http://dx.doi.org/10.4161/onci.26333
    • (2013) Oncoimmunology , vol.2 , pp. 26333
    • Baldo, B.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.