Efficient backsplicing produces translatable circular mRNAs

RNA

Volumn 21, Issue 2, 2015, Pages 172-179

  Wang, Yang ^a,b   Wang, Zefeng ^b  

^a DALIAN MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Alternative splicing; Backsplicing; Circular RNA; Splicing factors; Translation

Indexed keywords

ADENOSINE; CIRCULAR MRNA; DOUBLE STRANDED RNA; GREEN FLUORESCENT PROTEIN; MESSENGER RNA; MESSENGER RNA PRECURSOR; THYMIDINE; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ALTERNATIVE RNA SPLICING; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DROSOPHILA; EUKARYOTE; EXON; HUMAN; HUMAN CELL; INTRON; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; RNA ANALYSIS; RNA STABILITY; RNA STRUCTURE; RNA TRANSCRIPTION; RNA TRANSLATION; ANIMAL; BIOSYNTHESIS; CONFORMATION; DROSOPHILA MELANOGASTER; GENETICS; HEK293 CELL LINE; PROTEIN SYNTHESIS;

EUKARYOTA;

ALTERNATIVE SPLICING; ANIMALS; DROSOPHILA MELANOGASTER; GREEN FLUORESCENT PROTEINS; HEK293 CELLS; HUMANS; NUCLEIC ACID CONFORMATION; PROTEIN BIOSYNTHESIS; RNA, MESSENGER;

EID: 84921368391     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.048272.114     Document Type: Article

References (27)

1. Burd CE, Jeck WR, Liu Y, Sanoff HK, Wang Z, Sharpless NE. 2010. Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk. PLoS Genet 6: e1001233.
2. Chen CY, Sarnow P. 1995. Initiation of protein synthesis by the eukaryotic translational apparatus on circular RNAs. Science 268: 415-417.
3. Choudhury R, Roy SG, Tsai YS, Tripathy A, Graves LM, Wang Z. 2014. The splicing activator DAZAP1 integrates splicing control into MEK/Erk-regulated cell proliferation and migration. Nat Commun 5: 3078.
4. Cocquerelle C, Daubersies P, Majerus MA, Kerckaert JP, Bailleul B. 1992. Splicing with inverted order of exons occurs proximal to large introns. EMBO J 11: 1095-1098.
5. De Conti L, Baralle M, Buratti E. 2013. Exon and intron definition in pre-mRNA splicing. Wiley Interdiscip Rev RNA 4: 49-60.
6. Fox-Walsh KL, Dou Y, Lam BJ, Hung SP, Baldi PF, Hertel KJ. 2005. The architecture of pre-mRNAs affects mechanisms of splice-site pairing. Proc Natl Acad Sci 102: 16176-16181.
7. Gallie DR. 1998. A tale of two termini: A functional interaction between the termini of an mRNA is a prerequisite for efficient translation initiation. Gene 216: 1-11.
8. Hansen TB, Jensen TI, Clausen BH, Bramsen JB, Finsen B, Damgaard CK, Kjems J. 2013. Natural RNA circles function as efficient microRNA sponges. Nature 495: 384-388.
9. Hentze MW, Preiss T. 2013. Circular RNAs: splicing's enigma variations. EMBO J 32: 923-925.
10. Jackson RJ, Hellen CU, Pestova TV. 2010. The mechanism of eukaryotic translation initiation and principles of its regulation. Nat Rev Mol Cell Biol 11: 113-127.
11. Jeck WR, Sorrentino JA, Wang K, Slevin MK, Burd CE, Liu J, Marzluff WF, Sharpless NE. 2013. Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA 19: 141-157.
12. Kornblihtt AR, Schor IE, Alló M, Dujardin G, Petrillo E, Muñoz MJ. 2013. Alternative splicing: a pivotal step between eukaryotic transcription and translation. Nat Rev Mol Cell Biol 14: 153-165.
13. Matera AG, Wang Z. 2014. A day in the life of the spliceosome. Nat Rev Mol Cell Biol 15: 108-121.
14. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, et al. 2013. Circular RNAs are a large class of animal RNAs with regulatory potency. Nature 495: 333-338.
15. Nigro JM, Cho KR, Fearon ER, Kern SE, Ruppert JM, Oliner JD, Kinzler KW, Vogelstein B. 1991. Scrambled exons. Cell 64: 607-613.
16. Pasman Z, Been MD, Garcia-Blanco MA. 1996. Exon circularization in mammalian nuclear extracts. RNA 2: 603-610.
17. Salzman J, Gawad C, Wang PL, Lacayo N, Brown PO. 2012. Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types. PLoS One 7: e30733.
18. Salzman J, Chen RE, Olsen MN, Wang PL, Brown PO. 2013. Cell-type specific features of circular RNA expression. PLoS Genet 9: e1003777.
19. Sharma S, Kohlstaedt LA, Damianov A, Rio DC, Black DL. 2008. Polypyrimidine tract binding protein controls the transition from exon definition to an intron defined spliceosome. Nat Struct Mol Biol 15: 183-191.
20. Wang Z, Burge CB. 2008. Splicing regulation: from a parts list of regulatory elements to an integrated splicing code. RNA 14: 802-813.
21. Wang Y, Wang Z. 2014. Systematical identification of splicing regulatory cis-elements and cognate trans-factors. Methods 65: 350-358.
22. Wang Y, Ma M, Xiao X, Wang Z. 2012. Intronic splicing enhancers, cognate splicing factors and context-dependent regulation rules. Nat Struct Mol Biol 19: 1044-1052.
23. Wang Y, Xiao X, Zhang J, Choudhury R, Robertson A, Li K, Ma M, Burge CB, Wang Z. 2013. A complex network of factors with overlapping affinities represses splicing through intronic elements. Nat Struct Mol Biol 20: 36-45.
24. Wang PL, Bao Y, Yee MC, Barrett SP, Hogan GJ, Olsen MN, Dinneny JR, Brown PO, Salzman J. 2014a. Circular RNA is expressed across the eukaryotic tree of life. PLoS One 9: e90859.
25. Wang Y, Chen D, Qian H, Tsai YS, Shao S, Liu Q, Dominguez D, Wang Z. 2014b. The splicing factor RBM4 controls apoptosis, proliferation, and migration to suppress tumor progression. Cancer Cell 26: 374-379.
26. Xiao X, Wang Z, Jang M, Burge CB. 2007. Coevolutionary networks of splicing cis-regulatory elements. Proc Natl Acad Sci 104: 18583-18588.
27. Zhang Y, Zhang XO, Chen T, Xiang JF, Yin QF, Xing YH, Zhu S, Yang L, Chen LL. 2013. Circular intronic long noncoding RNAs. Mol Cell 51: 792-806.