-
1
-
-
0027418515
-
Interferon β-1b is effective in relapsing-remitting multiple sclerosis. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial
-
The IFNB Multiple Sclerosis Study Group. Interferon β-1b is effective in relapsing-remitting multiple sclerosis. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. Neurology 1993;43:655-61.
-
(1993)
Neurology
, vol.43
, pp. 655-661
-
-
-
2
-
-
0029082566
-
Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: Results of a phase III multicenter, double-blind, placebo-controlled trial
-
Johnson KP, Brooks BR, Cohen JA, et al. Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: results of a phase III multicenter, double-blind, placebo-controlled trial. Neurology 1995;45:1268-76.
-
(1995)
Neurology
, vol.45
, pp. 1268-1276
-
-
Johnson, K.P.1
Brooks, B.R.2
Cohen, J.A.3
-
3
-
-
0008678962
-
Intramuscular interferon β-1a for disease progression in relapsing multiple sclerosis
-
Jacobs LD, Cookfair DL, Rudick RA, et al. Intramuscular interferon β-1a for disease progression in relapsing multiple sclerosis. Ann Neurol 1996;39:285-94.
-
(1996)
Ann Neurol
, vol.39
, pp. 285-294
-
-
Jacobs, L.D.1
Cookfair, D.L.2
Rudick, R.A.3
-
4
-
-
0031057970
-
Randomised placebo-controlled trial of monthly intravenous immunoglobulin therapy in relapsing-remitting multiple sclerosis
-
Fazekas F, Deisenhammer F, Strasser-Fuchs S, et al. Randomised placebo-controlled trial of monthly intravenous immunoglobulin therapy in relapsing-remitting multiple sclerosis. Lancet 1997;349:589-93.
-
(1997)
Lancet
, vol.349
, pp. 589-593
-
-
Fazekas, F.1
Deisenhammer, F.2
Strasser-Fuchs, S.3
-
5
-
-
0345601517
-
Randomised double-blind placebo-controlled study of interferon β-1a in relapsing/remitting multiple sclerosis
-
PRISMS Study Group. Randomised double-blind placebo-controlled study of interferon β-1a in relapsing/remitting multiple sclerosis. Lancet 1998;352:1498-504.
-
(1998)
Lancet
, vol.352
, pp. 1498-1504
-
-
-
6
-
-
0029279166
-
Outcomes assessment in multiple sclerosis clinical trials: A critical analysis
-
Whitaker JN, McFarland HF, Rudge P, et al. Outcomes assessment in multiple sclerosis clinical trials: a critical analysis. Multiple Sclerosis 1995;1:37-47.
-
(1995)
Multiple Sclerosis
, vol.1
, pp. 37-47
-
-
Whitaker, J.N.1
McFarland, H.F.2
Rudge, P.3
-
8
-
-
0032995935
-
Assessing relapses in treatment trials of relapsing and remitting multiple sclerosis: Can we do better?
-
Liu C, Blumhardt LD. Assessing relapses in treatment trials of relapsing and remitting multiple sclerosis: can we do better? Multiple Sclerosis 1999;5:22-8.
-
(1999)
Multiple Sclerosis
, vol.5
, pp. 22-28
-
-
Liu, C.1
Blumhardt, L.D.2
-
9
-
-
0024504359
-
The natural history of multiple sclerosis: A geographically based study. 1. Clinical course and disability
-
Weinshenker BG, Bass B, Rice GPA, et al. The natural history of multiple sclerosis: a geographically based study. 1. Clinical course and disability. Brain 1989;112:133-46.
-
(1989)
Brain
, vol.112
, pp. 133-146
-
-
Weinshenker, B.G.1
Bass, B.2
Rice, G.P.A.3
-
10
-
-
0027537209
-
Prognostic factors in a multiple sclerosis incidence cohort with 25 years of follow-up
-
Runmarker B, Andersen O. Prognostic factors in a multiple sclerosis incidence cohort with 25 years of follow-up. Brain 1993;116:117-34.
-
(1993)
Brain
, vol.116
, pp. 117-134
-
-
Runmarker, B.1
Andersen, O.2
-
11
-
-
0344832127
-
Are placebo-controlled clinical trials still ethical in multiple sclerosis?
-
Thompson AJ, Polman C, Hohlfeld R, eds. London: Martin Dunitz
-
Noseworthy JH. Are placebo-controlled clinical trials still ethical in multiple sclerosis? In: Thompson AJ, Polman C, Hohlfeld R, eds. Multiple sclerosis: clinical challenges and controversies. London: Martin Dunitz, 1997:177-93.
-
(1997)
Multiple Sclerosis: Clinical Challenges and Controversies
, pp. 177-193
-
-
Noseworthy, J.H.1
-
12
-
-
0031675392
-
Interferons in the treatment of multiple sclerosis. Do they prevent the progression of the disease?
-
Rice G, Ebers G. Interferons in the treatment of multiple sclerosis. Do they prevent the progression of the disease? Arch Neurol 1998;55:1578-80.
-
(1998)
Arch Neurol
, vol.55
, pp. 1578-1580
-
-
Rice, G.1
Ebers, G.2
-
13
-
-
0029161628
-
Interferon β-1b in the treatment of multiple sclerosis: Final outcome of the randomized controlled trial
-
The IFNB Multiple Sclerosis Study Group and the University of British Columbia MS/MRI Analysis Group. Interferon β-1b in the treatment of multiple sclerosis: final outcome of the randomized controlled trial. Neurology 1995;45:1277-85.
-
(1995)
Neurology
, vol.45
, pp. 1277-1285
-
-
-
14
-
-
8544249096
-
Impact of interferon β-1a on neurologic disability in relapsing multiple sclerosis
-
Rudick RA, Goodkin DE, Jacobs LD, et al. Impact of interferon β-1a on neurologic disability in relapsing multiple sclerosis. Neurology 1997;49:358-63.
-
(1997)
Neurology
, vol.49
, pp. 358-363
-
-
Rudick, R.A.1
Goodkin, D.E.2
Jacobs, L.D.3
-
15
-
-
0021035886
-
Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)
-
Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 1983;33:1444-52.
-
(1983)
Neurology
, vol.33
, pp. 1444-1452
-
-
Kurtzke, J.F.1
-
16
-
-
0031747230
-
Summary measure statistic for assessing the outcome of treatment trials in relapsing-remitting multiple sclerosis
-
Liu C, Li Wan Po A, Blumhardt LD. Summary measure statistic for assessing the outcome of treatment trials in relapsing-remitting multiple sclerosis. J Neurol Neurosurg Psychiatry 1998;64:726-9.
-
(1998)
J Neurol Neurosurg Psychiatry
, vol.64
, pp. 726-729
-
-
Liu, C.1
Li Wan Po, A.2
Blumhardt, L.D.3
-
17
-
-
0025728367
-
The natural history of multiple sclerosis: A geographically based study. 4. Applications to planning and interpretation of clinical therapeutic trials
-
Weinshenker BG, Rice GPA, Noseworthy JH, et al. The natural history of multiple sclerosis: a geographically based study. 4. Applications to planning and interpretation of clinical therapeutic trials. Brain 1991;114:1057-67.
-
(1991)
Brain
, vol.114
, pp. 1057-1067
-
-
Weinshenker, B.G.1
Rice, G.P.A.2
Noseworthy, J.H.3
-
18
-
-
0028270611
-
Design strategies in multiple sclerosis clinical trials
-
Ellison GW, Myers LW, Leake BD, et al. Design strategies in multiple sclerosis clinical trials. Ann Neurol 1994;36:S108-12.
-
(1994)
Ann Neurol
, vol.36
-
-
Ellison, G.W.1
Myers, L.W.2
Leake, B.D.3
-
19
-
-
0030813139
-
Clinical outcome measures and rating scales in multiple sclerosis trials
-
Wingerchuk DM, Noseworthy JH, Weinshenker BG. Clinical outcome measures and rating scales in multiple sclerosis trials. Mayo Clin Proc 1997;72:1070-9.
-
(1997)
Mayo Clin Proc
, vol.72
, pp. 1070-1079
-
-
Wingerchuk, D.M.1
Noseworthy, J.H.2
Weinshenker, B.G.3
-
20
-
-
0024796845
-
The natural history of multiple sclerosis: A geographically based study. 2. Predictive value of the early clinical course
-
Weinshenker BG, Bass B, Rice GPA, et al. The natural history of multiple sclerosis: a geographically based study. 2. Predictive value of the early clinical course. Brain 1989;112:1419-28.
-
(1989)
Brain
, vol.112
, pp. 1419-1428
-
-
Weinshenker, B.G.1
Bass, B.2
Rice, G.P.A.3
-
21
-
-
85046517932
-
Reply to correspondence by Simonian NA, McAllister A, Hull J. Summary measure statistic for assessing the outcome of treatment trials in relapsing-remitting multiple sclerosis
-
Liu C, Blumhardt LD, Li Wan Po A. Reply to correspondence by Simonian NA, McAllister A, Hull J. Summary measure statistic for assessing the outcome of treatment trials in relapsing-remitting multiple sclerosis. J Neurol Neurosurg Psychiatry 1999;66:553-4.
-
(1999)
J Neurol Neurosurg Psychiatry
, vol.66
, pp. 553-554
-
-
Liu, C.1
Blumhardt, L.D.2
Li Wan Po, A.3
-
22
-
-
0029902571
-
Meta-analysis of the placebo-treated groups in clinical trials of progressive MS
-
Weinshenker BG, Issa M, Baskerville J. Meta-analysis of the placebo-treated groups in clinical trials of progressive MS. Neurology 1996:46:1613-19.
-
(1996)
Neurology
, vol.46
, pp. 1613-1619
-
-
Weinshenker, B.G.1
Issa, M.2
Baskerville, J.3
-
23
-
-
0032494783
-
Interferon β therapy for multiple sclerosis
-
Goodkin DE. Interferon β therapy for multiple sclerosis. Lancet 1998;352:1486-7.
-
(1998)
Lancet
, vol.352
, pp. 1486-1487
-
-
Goodkin, D.E.1
-
24
-
-
0001113985
-
Some aspects of the natural history of disseminated sclerosis
-
McAlpine D, Compston N. Some aspects of the natural history of disseminated sclerosis. Q J Med 1952;82:135-67.
-
(1952)
Q J Med
, vol.82
, pp. 135-167
-
-
McAlpine, D.1
Compston, N.2
-
25
-
-
0029873865
-
Long-term and short-term outcome of multiple sclerosis. A 3 year follow up study
-
Weinshenker BG, Issa M, Baskerville J. Long-term and short-term outcome of multiple sclerosis. A 3 year follow up study. Arch Neurol 1996;53:353-8.
-
(1996)
Arch Neurol
, vol.53
, pp. 353-358
-
-
Weinshenker, B.G.1
Issa, M.2
Baskerville, J.3
-
26
-
-
0024431267
-
Exacerbation rates and adherence to disease type with a prospectively followed-up population with multiple sclerosis. Implications for clinical trials
-
Goodkin DE, Hertsgaard D, Rudick RA. Exacerbation rates and adherence to disease type with a prospectively followed-up population with multiple sclerosis. Implications for clinical trials. Arch Neurol 1989;46:1107-12.
-
(1989)
Arch Neurol
, vol.46
, pp. 1107-1112
-
-
Goodkin, D.E.1
Hertsgaard, D.2
Rudick, R.A.3
-
27
-
-
0031226430
-
Recommendations from the clinical outcome assessment task force of the National Multiple Sclerosis Society
-
Rudick RA, Antel J, Confavreux C, et al. Recommendations from the clinical outcome assessment task force of the National Multiple Sclerosis Society. Ann Neurol 1997;42: 379-82.
-
(1997)
Ann Neurol
, vol.42
, pp. 379-382
-
-
Rudick, R.A.1
Antel, J.2
Confavreux, C.3
-
28
-
-
0032919071
-
Development of a multiple sclerosis functional composite as a clinical trial outcome measure
-
Cutter GR, Baier ML, Rudick RA, et al. Development of a multiple sclerosis functional composite as a clinical trial outcome measure. Brain 1999;122:871-82.
-
(1999)
Brain
, vol.122
, pp. 871-882
-
-
Cutter, G.R.1
Baier, M.L.2
Rudick, R.A.3
-
29
-
-
0032870663
-
The Guy's neurological disability scale (GNDS): A new disability measure for multiple sclerosis
-
Sharrack B, Hughes RAC. The Guy's neurological disability scale (GNDS): a new disability measure for multiple sclerosis. Multiple Sclerosis 1999;5:223-33.
-
(1999)
Multiple Sclerosis
, vol.5
, pp. 223-233
-
-
Sharrack, B.1
Hughes, R.A.C.2
-
30
-
-
9544238232
-
Clinical outcomes assessment in multiple sclerosis
-
Rudick RA, Antel J, Confavreux C, et al. Clinical outcomes assessment in multiple sclerosis. Ann Neurol 1996;40:469-79.
-
(1996)
Ann Neurol
, vol.40
, pp. 469-479
-
-
Rudick, R.A.1
Antel, J.2
Confavreux, C.3
-
31
-
-
0032494792
-
Placebo-controlled multicentre randomised trial of interferon β-1b in treatment of secondary progressive multiple sclerosis
-
European Study Group on Interferon β-1b in Secondary Progressive MS. Placebo-controlled multicentre randomised trial of interferon β-1b in treatment of secondary progressive multiple sclerosis. Lancet 1998;352:1491-7.
-
(1998)
Lancet
, vol.352
, pp. 1491-1497
-
-
-
32
-
-
0031002545
-
Axonal damage in acute multiple sclerosis lesions
-
Ferguson B, Matyszak MK, Esiri MM, et al. Axonal damage in acute multiple sclerosis lesions. Brain 1997;120:393-9.
-
(1997)
Brain
, vol.120
, pp. 393-399
-
-
Ferguson, B.1
Matyszak, M.K.2
Esiri, M.M.3
-
33
-
-
0032576752
-
Axonal transection in the lesions of multiple sclerosis
-
Trapp BD, Peterson J, Ransohoff RM, et al. Axonal transection in the lesions of multiple sclerosis. N Engl J Med 1998; 338:278-85.
-
(1998)
N Engl J Med
, vol.338
, pp. 278-285
-
-
Trapp, B.D.1
Peterson, J.2
Ransohoff, R.M.3
-
34
-
-
0031962941
-
Imaging axonal change of normal-appearing white matter in multiple sclerosis
-
Fu L, Matthews PM, De Stefano N, et al. Imaging axonal change of normal-appearing white matter in multiple sclerosis. Brain 1998;121:103-13.
-
(1998)
Brain
, vol.121
, pp. 103-113
-
-
Fu, L.1
Matthews, P.M.2
De Stefano, N.3
-
35
-
-
0032934804
-
Three dimensional MRI estimates of brain and spinal cord atrophy
-
Liu C, Edwards S, Gong Q, et al. Three dimensional MRI estimates of brain and spinal cord atrophy. J Neurol Neurosurg Psychiatry 1999;66:323-30.
-
(1999)
J Neurol Neurosurg Psychiatry
, vol.66
, pp. 323-330
-
-
Liu, C.1
Edwards, S.2
Gong, Q.3
-
36
-
-
0012527355
-
Studies on disseminated sclerosis: With special reference to symptomatology, course and progress
-
Müller R. Studies on disseminated sclerosis: with special reference to symptomatology, course and progress. Acta Med Scand 1949;133(suppl 222):1-214.
-
(1949)
Acta Med Scand
, vol.133
, Issue.222 SUPPL.
, pp. 1-214
-
-
Müller, R.1
-
37
-
-
0038150223
-
Prognosis and treatment of multiple sclerosis: Quantitative nosometric study
-
Alexander L, Berkeley AW, Alexander AM. Prognosis and treatment of multiple sclerosis: quantitative nosometric study. JAMA 1958;166:1943-9.
-
(1958)
JAMA
, vol.166
, pp. 1943-1949
-
-
Alexander, L.1
Berkeley, A.W.2
Alexander, A.M.3
-
38
-
-
0027410777
-
The significance of brain magnetic resonance imaging abnormalities at presentation with clinically isolated syndromes suggestive of multiple sclerosis. A 5 year follow up study
-
Morrisey SP, Miller DH, Kendall BE, et al. The significance of brain magnetic resonance imaging abnormalities at presentation with clinically isolated syndromes suggestive of multiple sclerosis. A 5 year follow up study. Brain 1993;116:135-46.
-
(1993)
Brain
, vol.116
, pp. 135-146
-
-
Morrisey, S.P.1
Miller, D.H.2
Kendall, B.E.3
-
39
-
-
0032905049
-
The psychometric properties of clinical rating scales used in multiple sclerosis
-
Sharrack B, Hughes RAC, Soudain S, et al. The psychometric properties of clinical rating scales used in multiple sclerosis. Brain 1999;122:141-59.
-
(1999)
Brain
, vol.122
, pp. 141-159
-
-
Sharrack, B.1
Hughes, R.A.C.2
Soudain, S.3
|