Androgens and opiates: Testosterone interaction with morphine self-administration in male rats

NeuroReport

Volumn 25, Issue 7, 2014, Pages 521-526

  Cooper, Sarah E ^a,b   Wood, Ruth I ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Anabolic agents; Operant conditioning; Opioid analgesics; Progressive ratio

Indexed keywords

MORPHINE; TESTOSTERONE; ANDROGEN; NARCOTIC AGENT;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG SELF ADMINISTRATION; INSTRUMENTAL CONDITIONING; LOCOMOTION; MALE; MOTIVATION; NEUROCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; RAT; REARING; REINFORCEMENT; REWARD; SEDATION; ANIMAL; DOSE RESPONSE; DRUG EFFECTS; DRUG INTERACTION; LONG EVANS RAT; MOTOR ACTIVITY;

ANDROGENS; ANIMALS; CONDITIONING, OPERANT; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; MALE; MORPHINE; MOTOR ACTIVITY; NARCOTICS; RATS; RATS, LONG-EVANS; REINFORCEMENT SCHEDULE; REWARD; SELF ADMINISTRATION; TESTOSTERONE;

EID: 84921294567     PISSN: 09594965     EISSN: 1473558X     Source Type: Journal    
DOI: 10.1097/WNR.0000000000000125     Document Type: Article

References (25)

1. McDougall C (2004). Cracking down on steroid use. Men's Health. Available at: http://www.menshealth.com/fitness/steroid-use-0?fullpage =true. [Accessed 11 July 2013].
2. Arvary D, Pope HG. Anabolic-androgenic steroids as a gateway to opioid dependence. N Engl J Med 2000; 342:1532.
3. Kanayama G, Cohane GH,Weiss RD, Pope HG. Past anabolic-androgenic steroid use among men admitted for substance abuse treatment: an underrecognized problem? J Clin Psychiatry 2003; 64:156-160.
4. Tennant F, Black DL, Voy RO. Anabolic steroid dependence with opioid-type features. N Engl J Med 1988; 319:578.
5. Thiblin I, Lindquist O, Rajs J. Cause and manner of death among users of anabolic androgenic steroids. J Forensic Sci 2000; 45:16-23.
6. Wines JD, Gruber AJ, Pope HG, Lukas SE. Nalbuphine hydrochloride dependence in anabolic steroid users. Am J Addict 1999; 8:161-164.
7. Kashkin KB, Kleber HD. Hooked on hormones? An anabolic steroid addiction hypothesis. JAMA 1989; 262:3166-3170.
8. Kanayama G, Brower KJ, Wood RI, Hudson JI, Pope HG Jr. Anabolicandrogenic steroid dependence: an emerging disorder. Addiction 2009; 104:1966-1978.
9. Craft RM, Mogil JS, Aloisi AM. Sex differences in pain and analgesia: the role of gonadal hormones. Eur J Pain 2004; 8:397-411.
10. Peters KD, Wood RI. Androgen dependence in hamsters: overdose, tolerance, and potential opioidergic mechanisms. Neuroscience 2005; 130:971-981.
11. Célérier E, Yazdi MT, Castañé A, Ghozland S, Nyberg F, Maldonado R. Effects of nandrolone on acute morphine responses, tolerance and dependence in mice. Eur J Pharmacol 2003; 465:69-81.
12. Philipova T, Ivanova T, Pavlova E, Kasakov L, Vlaskovska M. Nandrolone modulates the non-opioid and opioid analgesia and tolerance/ dependence: role of sexual dimorphism. Arch Physiol Biochem 2003; 111:429-436.
13. Nyberg F, Hallberg M. Interactions between opioids and anabolic androgenic steroids: implications for the development of addictive behavior. Int Rev Neurobiol 2012; 102:189-206.
14. Li N, He S, Parrish C, Delich J, Grasing K. Differences in morphine and cocaine reinforcement under fixed and progressive ratio schedules; effects of extinction, reacquisition and schedule design. Behav Pharmacol 2003; 14:619-630.
15. Clark AS, Blasberg ME, Brandling-Bennett EM. Stanozolol, oxymetholone, and testosterone cypionate effects on the rat estrous cycle. Physiol Behav 1998; 63:287-295.
16. Wood RI. Anabolic steroid dependence? Insights from animals and humans. Front Neuroendocrinol 2008; 29:490-506.
17. Johnston LD, O'Malley PM, Bachman JG, Schulenberg JE. Monitoring the future national results on drug use: 2012 overview, key findings on adolescent drug use. Ann Arbor, MI: Institute for Social Research, University of Michigan; 2013.
18. Williams JT, Christie MJ, Manzoni O. Cellular and synaptic adaptations mediating opioid dependence. Physiol Rev 2001; 81:299-343.
19. Tsutsui KT, Wood RI, Craft RM. Anabolic-androgenic steroid effects on nociception and morphine antinociception in male rats. Pharmacol Biochem Behav 2011; 99:500-508.
20. Patti CL, Frussa-Filho R, Silva RH, Carvalho RC, Kameda SR, Takatsu-Coleman AL, et al. Behavioral characterization of morphine effects on motor activity in mice. Pharmacol Biochem Behav 2005; 81:923-927.
21. Oberlander JG, Henderson LP. The Sturm und Drang of anabolic steroid use: angst, anxiety, and aggression. Trends Neurosci 2012; 35:382-392.
22. Azorlosa JL, Simmons EL. Context-specific morphine withdrawal: Evidence that rearing reflects withdrawal, not exploration. Psychobiology 1999; 27:557-560.
23. Guarino G, Spampinato S. Nandrolone decreases mu opioid receptor expression in SH-SY5Y human neuroblastoma cells. Neuroreport 2008; 19:1131-1135.
24. Menard CS, Hebert TJ, Dohanich GP, Harlan RE. Androgenic-anabolic steroids modify beta-endorphin immunoreactivity in the rat brain. Brain Res 1995; 669:255-262.
25. Harlan RE, Brown HE, Lynch CS, D'Souza D, Garcia MM. Androgenicanabolic steroids blunt morphine-induced c-fos expression in the rat striatum: possible role of beta-endorphin. Brain Res 2000; 853:99-104.