Long noncoding RNA MALAT1 promotes brain metastasis by inducing epithelial-mesenchymal transition in lung cancer

Journal of Neuro-Oncology

Volumn 121, Issue 1, 2015, Pages 101-108

  Shen, Liqin ^a   Chen, Lei ^a   Wang, Yongsheng ^b   Jiang, Xiaochun ^c   Xia, Hongping ^c   Zhuang, Zhixiang ^a  

^a THE SECOND AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^b MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^c WANNAN MEDICAL COLLEGE   (China)

Author keywords

Brain metastasis; Epithelial mesenchymal transition; LncRNA; Lung cancer; MALAT1

Indexed keywords

LONG UNTRANSLATED RNA; MALAT1 LONG NON-CODING RNA, HUMAN;

ANIMAL; BRAIN TUMOR; C57BL MOUSE; CANCER TRANSPLANTATION; CELL MOTION; EPITHELIAL MESENCHYMAL TRANSITION; GENE SILENCING; GENETICS; HUMAN; KAPLAN MEIER METHOD; METABOLISM; NON SMALL CELL LUNG CANCER; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SECONDARY; TUMOR CELL LINE; TUMOR INVASION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; BRAIN NEOPLASMS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL MOVEMENT; EPITHELIAL-MESENCHYMAL TRANSITION; GENE SILENCING; HUMANS; KAPLAN-MEIER ESTIMATE; MICE, INBRED C57BL; NEOPLASM INVASIVENESS; NEOPLASM TRANSPLANTATION; RNA, LONG NONCODING;

EID: 84921032534     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-014-1613-0     Document Type: Article

References (21)

1. Nolte SM, Venugopal C, McFarlane N, Morozova O, Hallett RM, O’Farrell E, Manoranjan B, Murty NK, Klurfan P, Kachur E (2013) A cancer stem cell model for studying brain metastases from primary lung cancer. J Natl Cancer Inst 105:551–562
2. Heon S, Yeap BY, Britt GJ, Costa DB, Rabin MS, Jackman DM, Johnson BE (2010) Development of central nervous system metastases in patients with advanced non-small cell lung cancer and somatic EGFR mutations treated with gefitinib or erlotinib. Clin Cancer Res 16:5873–5882
3. Xia M, Hu M (2010) The role of microRNA in tumor invasion and metastasis. J Cancer Mol 5:33–39
4. Potti A, Mukherjee S, Petersen R, Dressman HK, Bild A, Koontz J, Kratzke R, Watson MA, Kelley M, Ginsburg GS (2006) A genomic strategy to refine prognosis in early-stage non–small-cell lung cancer. N Engl J Med 355:570–580
5. Yanaihara N, Caplen N, Bowman E, Seike M, Kumamoto K, Yi M, Stephens RM, Okamoto A, Yokota J, Tanaka T (2006) Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell 9:189–198
6. Chen H-Y, Yu S-L, Chen C-H, Chang G-C, Chen C-Y, Yuan A, Cheng C-L, Wang C-H, Terng H-J, Kao S-F (2007) A five-gene signature and clinical outcome in non–small-cell lung cancer. N Engl J Med 356:11–20
7. Nguyen DX, Chiang AC, Zhang XH-F, Kim JY, Kris MG, Ladanyi M, Gerald WL, Massague J (2009) WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis. Cell 138:51–62
8. Gutschner T, Diederichs S (2012) The hallmarks of cancer: a long noncoding RNA point of view. RNA Biol 9:703–719
9. Tano K, Akimitsu N (2012) Long noncoding RNAs in cancer progression. Frontiers in genetics 3:219
10. Eißmann M, Gutschner T, Hämmerle M, Günther S, Caudron-Herger M, Groß M, Schirmacher P, Rippe K, Braun T, Diederichs S (2012) Loss of the abundant nuclear noncoding RNA MALAT1 is compatible with life and development. RNA Biol 9:1076–1087
11. Schmidt LH, Spieker T, Koschmieder S, Humberg J, Jungen D, Bulk E, Hascher A, Wittmer D, Marra A, Hillejan L (2011) The long noncoding MALAT-1 RNA indicates a poor prognosis in non-small cell lung cancer and induces migration and tumor growth. J Thorac Oncol 6:1984–1992
12. Gutschner T, Hämmerle M, Eißmann M, Hsu J, Kim Y, Hung G, Revenko A, Arun G, Stentrup M, Groß M, Zörnig M, MacLeod AR, Spector DL, Diederichs S (2013) The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells. Cancer Res 73:1180–1189. doi:10.1158/0008-5472.can-12-2850
13. Grinberg-Rashi H, Ofek E, Perelman M, Skarda J, Yaron P, Hajdúch M, Jacob-Hirsch J, Amariglio N, Krupsky M, Simansky DA (2009) The expression of three genes in primary non–small cell lung cancer is associated with metastatic spread to the brain. Clin Cancer Res 15:1755–1761
14. Berkhout B, Jeang K-T (2007) RISCy business: microRNAs, pathogenesis, and viruses. J Biol Chem 282:26641–26645
15. Yu S-L, Chen H-Y, Chang G-C, Chen C-Y, Chen H-W, Singh S, Cheng C-L, Yu C-J, Lee Y-C, Chen H-S, Su T-J, Chiang C-C, Li H-N, Hong Q-S, Su H-Y, Chen C-C, Chen W-J, Liu C-C, Chan W-K, Chen WJ, Li K-C, Chen JJW, Yang P-C (2008) MicroRNA signature predicts survival and relapse in lung cancer. Cancer Cell 13:48–57
16. Arora S, Ranade AR, Tran NL, Nasser S, Sridhar S, Korn RL, Ross JT, Dhruv H, Foss KM, Sibenaller Z (2011) MicroRNA-328 is associated with (non-small) cell lung cancer (NSCLC) brain metastasis and mediates NSCLC migration. Int J Cancer 129:2621–2631
17. Ji P, Diederichs S, Wang W, Böing S, Metzger R, Schneider PM, Tidow N, Brandt B, Buerger H, Bulk E (2003) MALAT-1, a novel noncoding RNA, and thymosin β4 predict metastasis and survival in early-stage non-small cell lung cancer. Oncogene 22:8031–8041
18. Gutschner T, Hämmerle M, Diederichs S (2013) MALAT1—a paradigm for long noncoding RNA function in cancer. J Mol Med 91:791–801
19. Tie J, Pan Y, Zhao L, Wu K, Liu J, Sun S, Guo X, Wang B, Gang Y, Zhang Y (2010) MiR-218 inhibits invasion and metastasis of gastric cancer by targeting the Robo1 receptor. PLoS Genet 6:e1000879
20. Tano K, Mizuno R, Okada T, Rakwal R, Shibato J, Masuo Y, Ijiri K, Akimitsu N (2010) MALAT-1 enhances cell motility of lung adenocarcinoma cells by influencing the expression of motility-related genes. FEBS Lett 584:4575–4580
21. Tripathi V, Shen Z, Chakraborty A, Giri S, Freier SM, Wu X, Zhang Y, Gorospe M, Prasanth SG, Lal A, Prasanth KV (2013) Long noncoding RNA MALAT1 controls cell cycle progression by regulating the expression of oncogenic transcription factor B-MYB. PLoS Genet 9:e1003368. doi:10.1371/journal.pgen.1003368