TGF-β2 secretion from RPE decreases with polarization and becomes apically oriented

Cytokine

Volumn 71, Issue 2, 2015, Pages 394-396

  Hirsch, Louis ^a   Nazari, Hossein ^a   Sreekumar, Parameswaran G ^b   Kannan, Ram ^b   Dustin, Laurie ^a   Zhu, Danhong ^a   Barron, Ernesto ^b   Hinton, David R ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b DOHENY EYE INSTITUTE   (United States)

Author keywords

Embryonic stem cell; Polarity; Proliferative vitreoretinopathy; Retinal pigment epithelium; TGF

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; ISOPROTEIN;

APICAL MEMBRANE; ARTICLE; CELL POLARITY; CONTROLLED STUDY; CYTOKINE RELEASE; EMBRYONIC STEM CELL; FETUS; HUMAN; HUMAN CELL; PIGMENT EPITHELIUM; CELL CULTURE; CELL TRANSPLANTATION; CYTOLOGY; IMMUNOLOGY; METABOLISM; PATHOLOGY; RETINA; RETINAL PIGMENT EPITHELIUM; STEM CELL; VITREORETINOPATHY;

CELL TRANSPLANTATION; CELLS, CULTURED; EMBRYONIC STEM CELLS; HUMANS; PROTEIN ISOFORMS; RETINA; RETINAL PIGMENT EPITHELIUM; STEM CELLS; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; VITREORETINOPATHY, PROLIFERATIVE;

EID: 84921019547     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2014.11.014     Document Type: Article

References (15)

1. Rizzolo L.J. Polarity and the development of the outer blood-retinal barrier. Histol Histopathol 1997, 12:1057-1067.
2. Parapuram S.K., Chang B., Li L., et al. Differential effects of TGFbeta and vitreous on the transformation of retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 2009, 50:5965-5974.
3. Connor T.B., Roberts A.B., Sporn M.B., et al. Correlation of fibrosis and transforming growth factor-beta type 2 levels in the eye. J Clin Invest 1989, 83:1661-1666.
4. Kannan R., Sreekumar P.G., Hinton D.R. VEGF and PEDF secretion in ARPE-19 and fhRPE cells. Invest Ophthalmol Vis Sci 2011, 52:9047.
5. Kvanta A. Expression and secretion of transforming growth factor-beta in transformed and nontransformed retinal pigment epithelial cells. Ophthal Res 1994, 26:361-367.
6. Zamiri P., Masli S., Kitaichi N., Taylor A.W., Streilein J.W. Thrombospondin plays a vital role in the immune privilege of the eye. Invest Ophthalmol Vis Sci 2005, 46:908-919.
7. Bharti K., Rao M., Hull S.C., et al. Developing cellular therapies for retinal degenerative diseases. Invest Ophthalmol Vis Sci 2014, 55:1191-1202.
8. Sonoda S., Spee C., Barron E., Ryan S.J., Kannan R., Hinton D.R. A protocol for the culture and differentiation of highly polarized human retinal pigment epithelial cells. Nat Protocols 2009, 4:662-673.
9. Zhu D., Deng X., Spee C., et al. Polarized secretion of PEDF from human embryonic stem cell-derived RPE promotes retinal progenitor cell survival. Invest Ophthalmol Vis Sci 2011, 52:1573-1585.
10. Li R., Wen R., Banzon T., Maminishkis A., Miller S.S. CNTF mediates neurotrophic factor secretion and fluid absorption in human retinal pigment epithelium. PloS one 2011, 6:e23148.
11. Sugita S., Futagami Y., Smith S.B., Naggar H., Mochizuki M. Retinal and ciliary body pigment epithelium suppress activation of T lymphocytes via transforming growth factor beta. Exp Eye Res 2006, 83:1459-1471.
12. Diniz B., Thomas P., Thomas B., et al. Subretinal implantation of retinal pigment epithelial cells derived from human embryonic stem cells: improved survival when implanted as a monolayer. Invest Ophthalmol Vis Sci 2013, 54:5087-5096.
13. Saika S., Yamanaka O., Okada Y., et al. TGF beta in fibroproliferative diseases in the eye. Front Biosci 2009, 1:376-390.
14. Cordeiro M.F., Bhattacharya S.S., Schultz G.S., Khaw P.T. TGF-beta1, -beta2, and -beta3 in vitro: biphasic effects on Tenon's fibroblast contraction, proliferation, and migration. Invest Ophthalmol Vis Sci 2000, 41:756-763.
15. Carrington L., McLeod D., Boulton M. IL-10 and antibodies to TGF-beta2 and PDGF inhibit RPE-mediated retinal contraction. Invest Ophthalmol Vis Sci 2000, 41:1210-1216.