Immunoregulatory Neuropeptides

The Wiley-Blackwell Handbook of Psychoneuroimmunology

Volumn , Issue , 2013, Pages 144-160

  Ganea, Doina ^a   Skarica, Mario ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adaptive immunity; Anti inflammatory NP; Antimicrobial peptide; Central nervous system (CNS); Immune system; Immunomodulatory neuropeptides; Innate immunity; Vasoactive intestinal peptide (VIP)

Indexed keywords

EID: 84920941899     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781118314814.ch7     Document Type: Chapter

References (49)

1. Bedoui, S., Miyake, S., Straub, R. H., von Horsten, S., and Yamamura, T. (2004). More sympathy for autoimmunity with neuropeptideY? Trends in Immunology, 25(10), 508-512.
2. Bellinger, D. L., Millar, B. A., Perez, S., Carter, J., Wood, C., ThyagaRajan, S., et al. (2008). Sympathetic modulation of immunity: relevance to disease. Cellular Immunology, 252(1-2), 27-56.
3. Brogden, K. A., Guthmiller, J. M., Salzet, M., and Zasloff, M. (2005). The nervous system and innate immunity: the neuropeptide connection. Nature Immunology, 6(6), 558-564.
4. Brzoska, T., Luger, T. A., Maaser, C., Abels, C., and Bohm, M. (2008). Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases. Endocrine Reviews, 29(5), 581-602.
5. Catania, A., Colombo, G., Rossi, C., Carlin, A., Sordi, A., Lonati, C., et al. (2006). Antimicrobial properties of alpha-MSH and related synthetic melanocortins. Scientific World Journal, 6, 1241-1246.
6. Chen, G., Hao, J., Xi, Y., Wang, W., Wang, Z., Li, N., et al. (2008). The therapeutic effect of vasoactive intestinal peptide on experimental arthritis is associated with CD4+CD25+ T regulatory cells. Scandinavian Journal of Immunology, 68(6), 572-578.
7. Chorny, A., Gonzalez-Rey, E., Fernandez-Martin, A., Pozo, D., Ganea, D., and Delgado, M. (2005). Vasoactive intestinal peptide induces regulatory dendritic cells with therapeutic effects on autoimmune disorders. Proceedings of the National Academy of Sciences of the USA, 102(38), 13562-13567.
8. Dantzer, R., O’Connor, J. C., Freund, G. G., Johnson, R. W., and Kelley, K. W. (2008). From inflammation to sickness and depression: when the immune system subjugates the brain. Nature Reviews Neuroscience, 9(1), 46-56.
9. Delgado, M., Anderson, P., Garcia-Salcedo, J. A., Caro, M., and Gonzalez-Rey, E. (2009). Neuropeptides kill African trypanosomes by targeting intracellular compartments and inducing autophagic-like cell death. Cell Death and Differentiation, 16(3), 406-416.
10. Delgado, M., Chorny, A., Gonzalez-Rey, E., and Ganea, D. (2005). Vasoactive intestinal peptide generates CD4+CD25+ regulatory T cells in vivo. Journal of Leukocyte Biology, 78(6), 1327-1338.
11. Delgado, M., and Ganea, D. (2008). Anti-inflammatory neuropeptides: a new class of endogenous immunoregulatory agents. Brain, Behavior, Immunity, 22(8), 1146-1151.
12. Delgado, M. and Ganea, D. (2011). Vasoactive intestinal peptide: a neuropeptide with pleiotropic immune functions. Amino Acids. 2011 Dec 3. DOI: 10.1007/s00726-011-1184-8
13. Delgado, M., Pozo, D., and Ganea, D. (2004). The significance of vasoactive intestinal peptide in immunomodulation. Pharmacological Reviews, 56(2), 249-290.
14. Delgado, M., Toscano, M. G., Benabdellah, K., Cobo, M., O’Valle, F., Gonzalez-Rey, E., et al. (2008). In vivo delivery of lentiviral vectors expressing vasoactive intestinal peptide complementary DNA as gene therapy for collagen-induced arthritis. Arthritis and Rheumatism, 58(4), 1026-1037.
15. Dello Russo, C., Lisi, L., Navarra, P., and Tringali, G. (2009). Diverging effects of cortistatin and somatostatin on the production and release of prostanoids from rat cortical microglia and astrocytes. J Neuroimmunology, 213(1-2), 78-83.
16. Deng, S., Xi, Y., Wang, H., Hao, J., Niu, X., Li, W., et al. (2010). Regulatory effect of vasoactive intestinal peptide on the balance of Treg and Th17 in collagen-induced arthritis. Cellular Immunology, 265(2), 105-110.
17. Douglas, S. D., and Leeman, S. E. (2011). Neurokinin-1 receptor: functional significance in the immune system in reference to selected infections and inflammation. Annals of the New York Academy of Sciences, 1217, 83-95.
18. El Karim, I. A., Linden, G. J., Orr, D. F., and Lundy, F. T. (2008). Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites. J Neuroimmunology, 200(1-2), 11-16.
19. Fernandez-Martin, A., Gonzalez-Rey, E., Chorny, A., Ganea, D., and Delgado, M. (2006). Vasoactive intestinal peptide induces regulatory T cells during experimental autoimmune encephalomyelitis. European Journal of Immunology, 36(2), 318-326.
20. Fernandez-Martin, A., Gonzalez-Rey, E., Chorny, A., Martin, J., Pozo, D., Ganea, D., et al. (2006). VIP prevents experimental multiple sclerosis by downregulating both inflammatory and autoimmune components of the disease. Annals of the New York Academy of Sciences, 1070, 276-281.
21. Goetzl, E. J., Voice, J. K., Shen, S., Dorsam, G., Kong, Y., West, K. M., et al. (2001). Enhanced delayedtype hypersensitivity and diminished immediate-type hypersensitivity in mice lacking the inducible VPAC(2) receptor for vasoactive intestinal peptide. Proceedings of the National Academy of Sciences of the USA, 98(24), 13854-13859.
22. Gonzalez-Rey, E. and Delgado, M. (2006). Therapeutic treatment of experimental colitis with regulatory dendritic cells generated with vasoactive intestinal peptide. Gastroenterology, 131(6), 1799-1811.
23. Gonzalez-Rey, E., Fernandez-Martin, A., Chorny, A., and Delgado, M. (2006). Vasoactive intestinal peptide induces CD4+, CD25+ T regulatory cells with therapeutic effect in collagen-induced arthritis. Arthritis and Rheumatism, 54(3), 864-876.
24. Gonzalez-Rey, E., Fernandez-Martin, A., Chorny, A., Martin, J., Pozo, D., Ganea, D., et al. (2006). Therapeutic effect of vasoactive intestinal peptide on experimental autoimmune encephalomyelitis:down-regulation of inflammatory and autoimmune responses. American Journal of Pathology, 168(4), 1179-1188.
25. Gonzalez-Rey, E., Ganea, D., and Delgado, M. (2010). Neuropeptides: keeping the balance between pathogen immunity and immune tolerance. Current Opinion in Pharmacology, 10(4), 473-481.
26. Gravanis, A. and Margioris, A. N. (2005). The corticotropin-releasing factor (CRF) family of neuropeptides in inflammation: potential therapeutic applications. Current Medicinal Chemistry, 12(13), 1503-1512.
27. Hamidi, S. A., Szema, A. M., Lyubsky, S., Dickman, K. G., Degene, A., Mathew, S. M., et al. (2006). Clues to VIP function from knockout mice. Annals of the New York Academy of Sciences, 1070, 5-9.
28. Han, D., Tian, Y., Zhang, M., Zhou, Z., and Lu, J. (2007). Prevention and treatment of experimental autoimmune encephalomyelitis with recombinant adeno-associated virus-mediated alphamelanocyte- stimulating hormone-transduced PLP139-151-specific T cells. Gene Therapy, 14(5), 383-395.
29. Jimeno, R., Gomariz, R. P., Gutierrez-Canas, I., Martinez, C., Juarranz, Y., and Leceta, J. (2010). New insights into the role of VIP on the ratio of T-cell subsets during the development of autoimmune diabetes. Immunology and Cell Biology, 88(7), 734-745.
30. Leuchte, H. H., Baezner, C., Baumgartner, R. A., Bevec, D., Bacher, G., Neurohr, C., et al. (2008). Inhalation of vasoactive intestinal peptide in pulmonary hypertension. European Respiratory Journal, 32(5), 1289-1294.
31. Li, J. M., Southerland, L., Hossain, M. S., Giver, C. R., Wang, Y., Darlak, K., et al. (2011). Absence of vasoactive intestinal peptide expression in hematopoietic cells enhances Th1 polarization and antiviral immunity in mice. Journal of Immunology, 187(2), 1057-1065.
32. Luger, T. A., Scholzen, T. E., Brzoska, T., and Bohm, M. (2003). New insights into the functions of alpha-MSH and related peptides in the immune system. Annals of the New York Academy of Sciences, 994, 133-140.
33. Maldonado, R. A. and von Andrian, U. H. (2010). How tolerogenic dendritic cells induce regulatory T cells. Advances in Immunology, 108, 111-165.
34. Odunayo, A., Dodam, J. R., Kerl, M. E., and DeClue, A. E. (2010). Immunomodulatory effects of opioids. J Journal of Veterinary Emergency and Critical Care (San Antonio), 20(4), 376-385.
35. Prasse, A., Zissel, G., Lutzen, N., Schupp, J., Schmiedlin, R., Gonzalez-Rey, E., et al. (2010). Inhaled vasoactive intestinal peptide exerts immunoregulatory effects in sarcoidosis. American Journal of Respiratory and Critical Care Medicine, 182(4), 540-548.
36. Rivest, S. (2009). Regulation of innate immune responses in the brain. Nature Reviews Immunology, 9(6), 429-439.
37. Sharma, V., Delgado, M., and Ganea, D. (2006). Granzyme B, a new player in activation-induced cell death, is down-regulated by vasoactive intestinal peptide in Th2 but not Th1 effectors. Journal of Immunology, 176(1), 97-110.
38. Snoek, S. A., Borensztajn, K. S., van den Wijngaard, R. M., and de Jonge, W. J. (2010). Neuropeptide receptors in intestinal disease: physiology and therapeutic potential. Current Pharmaceutical Design, 16(9), 1091-1105.
39. Stevens-Felten, S. Y. and Bellinger, D. L. (1997). Noradrenergic and peptidergic innervation of lymphoid organs. Chemical Immunology, 69, 99-131.
40. Taub, D. D. (2008). Novel connections between the neuroendocrine and immune systems: the ghrelin immunoregulatory network. Vitamins and Hormones, 77, 325-346.
41. Taylor, A. W. (2007). Ocular immunosuppressive microenvironment. Chemical Immunology and Allergy, 92, 71-85.
42. Toscano, M. G., Delgado, M., Kong, W., Martin, F., Skarica, M., and Ganea, D. (2010). Dendritic cells transduced with lentiviral vectors expressing VIP differentiate into VIP-secreting tolerogenic-like DCs. Molecular Therapy, 18(5), 1035-1045.
43. Tracey, K. J. (2010). Understanding immunity requires more than immunology. Nature Immunology, 11(7), 561-564.
44. Voice, J., Donnelly, S., Dorsam, G., Dolganov, G., Paul, S., and Goetzl, E. J. (2004). c-Maf and JunB mediation of Th2 differentiation induced by the type 2 G protein-coupled receptor (VPAC2) for vasoactive intestinal peptide. Journal of Immunology, 172(12), 7289-7296.
45. Voice, J. K., Dorsam, G., Lee, H., Kong, Y., and Goetzl, E. J. (2001). Allergic diathesis in transgenic mice with constitutive T cell expression of inducible vasoactive intestinal peptide receptor. FASEB Journal, 15(13), 2489-2496.
46. Wheway, J., Herzog, H., and Mackay, F. (2007). NPY and receptors in immune and inflammatory diseases. Current Topics in Medicinal Chemistry, 7(17), 1743-1752.
47. Wiesner, J. and Vilcinskas, A. (2010). Antimicrobial peptides: the ancient arm of the human immune system. Virulence, 1(5), 440-464.
48. Yadav, M., Rosenbaum, J., and Goetzl, E. J. (2008). Cutting edge: vasoactive intestinal peptide (VIP) induces differentiation of Th17 cells with a distinctive cytokine profile. Journal of Immunology, 180(5), 2772-2776.
49. Zudaire, E., Portal-Nunez, S., and Cuttitta, F. (2006). The central role of adrenomedullin in host defense. Journal of Leukocyte Biology, 80(2), 237-244.