Early maternal separation induces alterations of colonic epithelial permeability and morphology

Pediatric Surgery International

Volumn 30, Issue 12, 2014, Pages 1217-1222

  Li, Bo ^a   Lee, Carol ^a   Zani, Augusto ^a   Zani Ruttenstock, Elke ^a   Ip, Wan ^a   Chi, Lijun ^a   Olguin, Paul Delgado ^a,b,c   Gonska, Tanja ^a   Pierro, Agostino ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c HEART AND STROKE FOUNDATION OF CANADA   (Canada)

Author keywords

Intestinal epithelial permeability; Maternal separation; Necrotizing enterocolitis; Ussing chamber

Indexed keywords

FLUORESCEIN ISOTHIOCYANATE DEXTRAN; HORSERADISH PEROXIDASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE PERMEABILITY; CELL STRUCTURE; COLON MUCOSA; COLONIC MORPHOLOGY; CONTROLLED STUDY; GROWTH CHAMBER; ILEUM MUCOSA; INFANT; INTESTINE EPITHELIUM; INTESTINE FUNCTION; INTESTINE MUCOSA PERMEABILITY; MATERNAL DEPRIVATION; MORPHOLOGY; MOUSE; NEWBORN; NONHUMAN; PERINATAL PERIOD; PERMEABILITY BARRIER; PRIORITY JOURNAL; TISSUE SECTION; ANIMAL; BREEDING; C57BL MOUSE; COLON; CYTOLOGY; FEMALE; INTESTINE MUCOSA; METABOLISM; PHYSIOLOGY; PREGNANCY;

ANIMALS; ANIMALS, NEWBORN; CELL MEMBRANE PERMEABILITY; COLON; FEMALE; INTESTINAL MUCOSA; MATERNAL DEPRIVATION; MICE; MICE, INBRED C57BL; PREGNANCY; PREGNANCY, ANIMAL;

EID: 84920940658     PISSN: 01790358     EISSN: 14379813     Source Type: Journal    
DOI: 10.1007/s00383-014-3611-x     Document Type: Article

References (23)

1. Longstaffe S (1979) Maternal deprivation masking as mental retardation in children. Can Fam Phys 25:1365–1367
2. McIntosh J, Anisman H, Merali Z (1999) Short- and long-periods of neonatal maternal separation differentially affect anxiety and feeding in adult rats: gender-dependent effects. Brain Res Dev Brain Res 113:97–106
3. Zani A, Cananzi M, Fascetti-Leon F et al (2014) Amniotic fluid stem cells improve survival and enhance repair of damaged intestine in necrotising enterocolitis via a COX-2 dependent mechanism. Gut 63:300–309
4. Zani A, Ghionzoli M, Lauriti G et al (2010) Does intestinal permeability lead to organ failure in experimental necrotizing enterocolitis? Pediatr Surg Int 26:85–89
5. Gareau MG, Jury J, Yang PC et al (2006) Neonatal maternal separation causes colonic dysfunction in rat pups including impaired host resistance. Pediatr Res 59:83–88
6. Moussaoui N, Braniste V, Ait-Belgnaoui A et al (2014) Changes in intestinal glucocorticoid sensitivity in early life shape the risk of epithelial barrier defect in maternal-deprived rats. PLoS One 9:e88382
7. Gareau MG, Jury J, Perdue MH (2007) Neonatal maternal separation of rat pups results in abnormal cholinergic regulation of epithelial permeability. Am J Physiol Gastrointest Liver Physiol 293:G198–G203
8. Zani A, Cordischi L, Cananzi M et al (2008) Assessment of a neonatal rat model of necrotizing enterocolitis. Eur J Pediatr Surg 18:423–426
9. Radulescu A, Zhang HY, Yu X et al (2010) Heparin-binding epidermal growth factor-like growth factor overexpression in transgenic mice increases resistance to necrotizing enterocolitis. J Pediatr Surg 45:1933–1939
10. Barker N, van Es JH, Kuipers J et al (2007) Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449:1003–1007
11. Barker N, Clevers H (2010) Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells. Gastroenterology 138:1681–1696
12. Estienne M, Claustre J, Clain-Gardechaux G et al (2010) Maternal deprivation alters epithelial secretory cell lineages in rat duodenum: role of CRF-related peptides. Gut 59:744–751
13. Catassi C, Bonucci A, Coppa GV et al (1995) Intestinal permeability changes during the first month: effect of natural versus artificial feeding. J Pediatr Gastroenterol Nutr 21:383–386
14. Taylor SN, Basile LA, Ebeling M et al (2009) Intestinal permeability in preterm infants by feeding type: mother’s milk versus formula. Breastfeed Med 4:11–15
15. Boudry G, Morise A, Seve B et al (2011) Effect of milk formula protein content on intestinal barrier function in a porcine model of LBW neonates. Pediatr Res 69:4–9
16. Rouwet EV, Heineman E, Buurman WA et al (2002) Intestinal permeability and carrier-mediated monosaccharide absorption in preterm neonates during the early postnatal period. Pediatr Res 51:64–70
17. McCracken VJ, Lorenz RG (2001) The gastrointestinal ecosystem: a precarious alliance among epithelium, immunity and microbiota. Cell Microbiol 3:1–11
18. Puiman P, Stoll B (2008) Animal models to study neonatal nutrition in humans. Curr Opin Clin Nutr Metab Care 11:601–606
19. Sanderson IR, Walker WA (1993) Uptake and transport of macromolecules by the intestine: possible role in clinical disorders (an update). Gastroenterology 104:622–639
20. Shen XJ, Rawls JF, Randall T et al (2010) Molecular characterization of mucosal adherent bacteria and associations with colorectal adenomas. Gut Microbes 1:138–147
21. Gareau MG, Jury J, MacQueen G et al (2007) Probiotic treatment of rat pups normalises corticosterone release and ameliorates colonic dysfunction induced by maternal separation. Gut 56:1522–1528
22. Neu J (2007) Gastrointestinal development and meeting the nutritional needs of premature infants. Am J Clin Nutr 85:629S–634S
23. Turner JR (2009) Intestinal mucosal barrier function in health and disease. Nat Rev Immunol 9:799–809