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Volumn 64, Issue 2, 2015, Pages 292-302

Higher proportion of viral basal core promoter mutant increases the risk of liver cirrhosis in hepatitis B carriers

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ADVERSE OUTCOME; ARTICLE; CASE CONTROL STUDY; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; LIVER CIRRHOSIS; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; PROMOTER REGION; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; RISK FACTOR; VIRAL GENETICS; VIRUS CORE; VIRUS MUTANT; BLOOD; CLASSIFICATION; COMPLICATION; GENETICS; HETEROZYGOTE; IMMUNOLOGY; ISOLATION AND PURIFICATION; MIDDLE AGED; MUTATION; VIROLOGY;

EID: 84920940527     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2014-306977     Document Type: Article
Times cited : (104)

References (38)
  • 1
    • 79960721213 scopus 로고    scopus 로고
    • Fighting against viral hepatitis: Lessons from Taiwan
    • Chen DS. Fighting against viral hepatitis: lessons from Taiwan. Hepatology 2011;54:381-92.
    • (2011) Hepatology , vol.54 , pp. 381-392
    • Chen, D.S.1
  • 2
    • 0027422748 scopus 로고
    • From hepatitis to hepatoma: Lessons from type B viral hepatitis
    • Chen DS. From hepatitis to hepatoma: lessons from type B viral hepatitis. Science 1993;262:369-70.
    • (1993) Science , vol.262 , pp. 369-370
    • Chen, D.S.1
  • 3
    • 0348047588 scopus 로고    scopus 로고
    • Hepatitis B virus genotypes and hepatocellular carcinoma in Taiwan
    • Kao JH. Hepatitis B virus genotypes and hepatocellular carcinoma in Taiwan. Intervirology 2003;46:400-7.
    • (2003) Intervirology , vol.46 , pp. 400-407
    • Kao, J.H.1
  • 4
    • 59749096640 scopus 로고    scopus 로고
    • Hepatitis B virus infection
    • Liaw YF, Chu CM. Hepatitis B virus infection. Lancet 2009;373:582-92.
    • (2009) Lancet , vol.373 , pp. 582-592
    • Liaw, Y.F.1    Chu, C.M.2
  • 5
    • 84983726731 scopus 로고    scopus 로고
    • Recent advances in the research of hepatitis B virus-related hepatocellular carcinoma: Epidemiologic and molecular biological aspects
    • Kao JH, Chen PJ, Chen DS. Recent advances in the research of hepatitis B virus-related hepatocellular carcinoma: epidemiologic and molecular biological aspects. Adv Cancer Res 2010;108:21-72.
    • (2010) Adv Cancer Res , vol.108 , pp. 21-72
    • Kao, J.H.1    Chen, P.J.2    Chen, D.S.3
  • 6
    • 29944436855 scopus 로고    scopus 로고
    • Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level
    • Chen CJ, Yang HI, Su J, et al . Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level. JAMA 2006;295:65-73.
    • (2006) JAMA , vol.295 , pp. 65-73
    • Chen, C.J.1    Yang, H.I.2    Su, J.3
  • 7
    • 33644858331 scopus 로고    scopus 로고
    • Predicting cirrhosis risk based on the level of circulating hepatitis B viral load
    • Iloeje UH, Yang HI, Su J, et al. Predicting cirrhosis risk based on the level of circulating hepatitis B viral load. Gastroenterology 2006;130:678-86.
    • (2006) Gastroenterology , vol.130 , pp. 678-686
    • Iloeje, U.H.1    Yang, H.I.2    Su, J.3
  • 8
    • 84984578046 scopus 로고    scopus 로고
    • Serum hepatitis B surface antigen levels help predict disease progression in patients with low hepatitis B virus loads
    • Tseng TC, Liu CJ, Yang HC, et al. Serum hepatitis B surface antigen levels help predict disease progression in patients with low hepatitis B virus loads. Hepatology 2013;57:441-50.
    • (2013) Hepatology , vol.57 , pp. 441-450
    • Tseng, T.C.1    Liu, C.J.2    Yang, H.C.3
  • 9
    • 84983726112 scopus 로고    scopus 로고
    • High levels of hepatitis B surface antigen increase risk of hepatocellular carcinoma in patients with low HBV load
    • e3; quiz e13-4
    • Tseng TC, Liu CJ, Yang HC, et al. High levels of hepatitis B surface antigen increase risk of hepatocellular carcinoma in patients with low HBV load. Gastroenterology 2012;142:1140-9 e3; quiz e13-4.
    • (2012) Gastroenterology , vol.142 , pp. 1140-1149
    • Tseng, T.C.1    Liu, C.J.2    Yang, H.C.3
  • 10
    • 84984585959 scopus 로고    scopus 로고
    • Risk stratification of hepatocellular carcinoma in hepatitis B virus e antigen-negative carriers by combining viral biomarkers
    • Tseng TC, Liu CJ, Chen CL, et al. Risk stratification of hepatocellular carcinoma in hepatitis B virus e antigen-negative carriers by combining viral biomarkers. J Infect Dis 2013;208:584-93.
    • (2013) J Infect Dis , vol.208 , pp. 584-593
    • Tseng, T.C.1    Liu, C.J.2    Chen, C.L.3
  • 11
    • 84984549253 scopus 로고    scopus 로고
    • Basal core promoter mutations of hepatitis B virus increase the risk of hepatocellular carcinoma in hepatitis B carriers
    • Kao JH, Chen PJ, Lai MY, et al. Basal core promoter mutations of hepatitis B virus increase the risk of hepatocellular carcinoma in hepatitis B carriers. Gastroenterology 2003;124:327-34.
    • (2003) Gastroenterology , vol.124 , pp. 327-334
    • Kao, J.H.1    Chen, P.J.2    Lai, M.Y.3
  • 12
    • 51049117284 scopus 로고    scopus 로고
    • Associations between hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma
    • Yang HI, Yeh SH, Chen PJ, et al. Associations between hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma. J Natl Cancer Inst 2008;100:1134-43.
    • (2008) J Natl Cancer Inst , vol.100 , pp. 1134-1143
    • Yang, H.I.1    Yeh, S.H.2    Chen, P.J.3
  • 13
    • 84984559412 scopus 로고    scopus 로고
    • Role of hepatitis B viral load and basal core promoter mutation in hepatocellular carcinoma in hepatitis B carriers
    • Liu CJ, Chen BF, Chen PJ, et al. Role of hepatitis B viral load and basal core promoter mutation in hepatocellular carcinoma in hepatitis B carriers. J Infect Dis 2006;193:1258-65.
    • (2006) J Infect Dis , vol.193 , pp. 1258-1265
    • Liu, C.J.1    Chen, B.F.2    Chen, P.J.3
  • 14
    • 84984569467 scopus 로고    scopus 로고
    • Role of hepatitis B virus precore/core promoter mutations and serum viral load on noncirrhotic hepatocellular carcinoma: A case-control study
    • Liu CJ, Chen BF, Chen PJ, et al. Role of hepatitis B virus precore/core promoter mutations and serum viral load on noncirrhotic hepatocellular carcinoma: a case-control study. J Infect Dis 2006;194:594-9.
    • (2006) J Infect Dis , vol.194 , pp. 594-599
    • Liu, C.J.1    Chen, B.F.2    Chen, P.J.3
  • 15
    • 38349105023 scopus 로고    scopus 로고
    • Temporal relationship between hepatitis B virus enhancer II/basal core promoter sequence variation and risk of hepatocellular carcinoma
    • Chou YC, Yu MW, Wu CF, et al . Temporal relationship between hepatitis B virus enhancer II/basal core promoter sequence variation and risk of hepatocellular carcinoma. Gut 2008;57:91-7.
    • (2008) Gut , vol.57 , pp. 91-97
    • Chou, Y.C.1    Yu, M.W.2    Wu, C.F.3
  • 16
    • 84858698728 scopus 로고    scopus 로고
    • Quantitative dynamics of hepatitis B basal core promoter and precore mutants before and after HBeAg seroconversion
    • Nie H, Evans AA, London WT, et al. Quantitative dynamics of hepatitis B basal core promoter and precore mutants before and after HBeAg seroconversion. J Hepatol 2012;56:795-802.
    • (2012) J Hepatol , vol.56 , pp. 795-802
    • Nie, H.1    Evans, A.A.2    London, W.T.3
  • 17
    • 84984562157 scopus 로고    scopus 로고
    • Distinct evolution and predictive value of hepatitis B virus precore and basal core promoter mutations in interferon-induced hepatitis B e antigen seroconversion
    • Yang HC, Chen CL, Shen YC, et al. Distinct evolution and predictive value of hepatitis B virus precore and basal core promoter mutations in interferon-induced hepatitis B e antigen seroconversion. Hepatology 2013;57:934-43.
    • (2013) Hepatology , vol.57 , pp. 934-943
    • Yang, H.C.1    Chen, C.L.2    Shen, Y.C.3
  • 18
    • 84983727403 scopus 로고    scopus 로고
    • Serum hepatitis B virus-DNA levels correlate with long-term adverse outcomes in spontaneous hepatitis B e antigen seroconverters
    • Tseng TC, Liu CJ, Chen CL, et al. Serum hepatitis B virus-DNA levels correlate with long-term adverse outcomes in spontaneous hepatitis B e antigen seroconverters. J Infect Dis 2012;205:54-63.
    • (2012) J Infect Dis , vol.205 , pp. 54-63
    • Tseng, T.C.1    Liu, C.J.2    Chen, C.L.3
  • 19
    • 84984552614 scopus 로고    scopus 로고
    • Serum hepatitis B surface antigen levels predict surface antigen loss in hepatitis B e antigen seroconverters
    • e2
    • Tseng TC, Liu CJ, Su TH, et al. Serum hepatitis B surface antigen levels predict surface antigen loss in hepatitis B e antigen seroconverters. Gastroenterology 2011;141:517-25 e2.
    • (2011) Gastroenterology , vol.141 , pp. 517-525
    • Tseng, T.C.1    Liu, C.J.2    Su, T.H.3
  • 20
    • 84900549965 scopus 로고    scopus 로고
    • Hepatitis B surface antigen level complements viral load in predicting viral reactivation in spontaneous HBeAg seroconverters
    • Tseng TC, Liu CJ, Su TH, et al. Hepatitis B surface antigen level complements viral load in predicting viral reactivation in spontaneous HBeAg seroconverters. J Gastroenterol Hepatol 2014. doi:10.1111/jgh.12502
    • (2014) J Gastroenterol Hepatol
    • Tseng, T.C.1    Liu, C.J.2    Su, T.H.3
  • 21
    • 84983726125 scopus 로고    scopus 로고
    • Young chronic hepatitis B patients with nucleos(t)ide analogue-induced hepatitis B e antigen seroconversion have a higher risk of HBV reactivation
    • Tseng TC, Liu CJ, Su TH, et al. Young chronic hepatitis B patients with nucleos(t)ide analogue-induced hepatitis B e antigen seroconversion have a higher risk of HBV reactivation. J Infect Dis 2012;206:1521-31.
    • (2012) J Infect Dis , vol.206 , pp. 1521-1531
    • Tseng, T.C.1    Liu, C.J.2    Su, T.H.3
  • 22
    • 70349240414 scopus 로고    scopus 로고
    • Chronic hepatitis B: Update 2009
    • Lok AS, McMahon BJ. Chronic hepatitis B: update 2009. Hepatology 2009;50:661-2.
    • (2009) Hepatology , vol.50 , pp. 661-662
    • Lok, A.S.1    McMahon, B.J.2
  • 23
    • 84865376141 scopus 로고    scopus 로고
    • Asian-Pacific consensus statement on the management of chronic hepatitis B: A 2012 update
    • Liaw YF, Kao JH, Piratvisuth T, et al. Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2012 update. Hepatol Int 2012;6:531-61.
    • (2012) Hepatol Int , vol.6 , pp. 531-561
    • Liaw, Y.F.1    Kao, J.H.2    Piratvisuth, T.3
  • 24
    • 84984568841 scopus 로고    scopus 로고
    • A higher alanine aminotransferase level correlates with earlier hepatitis B e antigen seroconversion in lamivudine-treated chronic hepatitis B patients
    • Tseng TC, Liu CJ, Wang CC, et al. A higher alanine aminotransferase level correlates with earlier hepatitis B e antigen seroconversion in lamivudine-treated chronic hepatitis B patients. Liver Int 2008;28:1034-41.
    • (2008) Liver Int , vol.28 , pp. 1034-1041
    • Tseng, T.C.1    Liu, C.J.2    Wang, C.C.3
  • 25
    • 67149089048 scopus 로고    scopus 로고
    • Association of baseline viral factors with response to lamivudine therapy in chronic hepatitis B patients with high serum alanine aminotransferase levels
    • Tseng TC, Liu CJ, Wang CC, et al. Association of baseline viral factors with response to lamivudine therapy in chronic hepatitis B patients with high serum alanine aminotransferase levels. Antivir Ther 2009;14:203-10.
    • (2009) Antivir Ther , vol.14 , pp. 203-210
    • Tseng, T.C.1    Liu, C.J.2    Wang, C.C.3
  • 26
    • 0037299277 scopus 로고    scopus 로고
    • Correlation between ultrasonographic and pathologic diagnoses of hepatitis B and C virus-related cirrhosis
    • Hung CH, Lu SN, Wang JH, et al. Correlation between ultrasonographic and pathologic diagnoses of hepatitis B and C virus-related cirrhosis. J Gastroenterol 2003;38:153-7.
    • (2003) J Gastroenterol , vol.38 , pp. 153-157
    • Hung, C.H.1    Lu, S.N.2    Wang, J.H.3
  • 27
    • 0027173707 scopus 로고
    • Ultrasonographic changes of early liver cirrhosis in chronic hepatitis B: A longitudinal study
    • Lin DY, Sheen IS, Chiu CT, et al. Ultrasonographic changes of early liver cirrhosis in chronic hepatitis B: a longitudinal study. J Clin Ultrasound 1993;21:303-8.
    • (1993) J Clin Ultrasound , vol.21 , pp. 303-308
    • Lin, D.Y.1    Sheen, I.S.2    Chiu, C.T.3
  • 28
    • 67649199520 scopus 로고    scopus 로고
    • Long-term outcome of hepatitis B e antigen-negative hepatitis B surface antigen carriers in relation to changes of alanine aminotransferase levels over time
    • Tai DI, Lin SM, Sheen IS, et al. Long-term outcome of hepatitis B e antigen-negative hepatitis B surface antigen carriers in relation to changes of alanine aminotransferase levels over time. Hepatology 2009;49:1859-67.
    • (2009) Hepatology , vol.49 , pp. 1859-1867
    • Tai, D.I.1    Lin, S.M.2    Sheen, I.S.3
  • 29
    • 84984572980 scopus 로고    scopus 로고
    • Quantification and genotyping of hepatitis B virus in a single reaction by real-time PCR and melting curve analysis
    • Yeh SH, Tsai CY, Kao JH, et al. Quantification and genotyping of hepatitis B virus in a single reaction by real-time PCR and melting curve analysis. J Hepatol 2004;41:659-66.
    • (2004) J Hepatol , vol.41 , pp. 659-666
    • Yeh, S.H.1    Tsai, C.Y.2    Kao, J.H.3
  • 30
    • 70350131524 scopus 로고    scopus 로고
    • Hepatitis B virus core variants modify natural course of viral infection and hepatocellular carcinoma progression
    • Sung FY, Jung CM, Wu CF, et al. Hepatitis B virus core variants modify natural course of viral infection and hepatocellular carcinoma progression. Gastroenterology 2009;137:1687-97.
    • (2009) Gastroenterology , vol.137 , pp. 1687-1697
    • Sung, F.Y.1    Jung, C.M.2    Wu, C.F.3
  • 31
    • 84984584244 scopus 로고    scopus 로고
    • Serum hepatitis B surface antigen concentration correlates with HBV DNA level in patients with chronic hepatitis B
    • Su TH, Hsu CS, Chen CL, et al. Serum hepatitis B surface antigen concentration correlates with HBV DNA level in patients with chronic hepatitis B. Antivir Ther 2010;15:1133-9.
    • (2010) Antivir Ther , vol.15 , pp. 1133-1139
    • Su, T.H.1    Hsu, C.S.2    Chen, C.L.3
  • 32
    • 84984571825 scopus 로고    scopus 로고
    • Determinants of spontaneous surface antigen loss in hepatitis B e antigen-negative patients with a low viral load
    • Tseng TC, Liu CJ, Yang HC, et al. Determinants of spontaneous surface antigen loss in hepatitis B e antigen-negative patients with a low viral load. Hepatology 2012;55:68-76.
    • (2012) Hepatology , vol.55 , pp. 68-76
    • Tseng, T.C.1    Liu, C.J.2    Yang, H.C.3
  • 33
    • 7044272630 scopus 로고    scopus 로고
    • Hepatocellular carcinoma in cirrhosis: Incidence and risk factors
    • Fattovich G, Stroffolini T, Zagni I, et al . Hepatocellular carcinoma in cirrhosis: incidence and risk factors. Gastroenterology 2004;127:S35-50.
    • (2004) Gastroenterology , vol.127 , pp. S35-S50
    • Fattovich, G.1    Stroffolini, T.2    Zagni, I.3
  • 34
    • 84880932862 scopus 로고    scopus 로고
    • Prediction models of long-term Cirrhosis and hepatocellular carcinoma risk in chronic hepatitis B patients: Risk scores integrating host and virus profiles
    • Lee MH, Yang HI, Liu J, et al. Prediction models of long-term Cirrhosis and hepatocellular carcinoma risk in chronic hepatitis B patients: risk scores integrating host and virus profiles. Hepatology 2013;58:546-54.
    • (2013) Hepatology , vol.58 , pp. 546-554
    • Lee, M.H.1    Yang, H.I.2    Liu, J.3
  • 35
    • 84862664371 scopus 로고    scopus 로고
    • EASL clinical practice guidelines: Management of chronic hepatitis B virus infection
    • European Association for the Study of the Liver. EASL Clinical Practice Guidelines: management of chronic hepatitis B virus infection. J Hepatol 2012;57:167-85.
    • (2012) J Hepatol , vol.57 , pp. 167-185
    • European Association for the Study of the Liver1
  • 36
    • 84870825165 scopus 로고    scopus 로고
    • Basal core promoter mutation is associated with progression to cirrhosis rather than hepatocellular carcinoma in chronic hepatitis B virus infection
    • Chu CM, Lin CC, Chen YC, et al. Basal core promoter mutation is associated with progression to cirrhosis rather than hepatocellular carcinoma in chronic hepatitis B virus infection. Br J Cancer 2012;107:2010-15.
    • (2012) Br J Cancer , vol.107 , pp. 2010-2015
    • Chu, C.M.1    Lin, C.C.2    Chen, Y.C.3
  • 37
    • 80053583197 scopus 로고    scopus 로고
    • Hepatitis B virus core promoter mutations contribute to hepatocarcinogenesis by deregulating SKP2 and its target, p21
    • 21 e1-5
    • Huang Y, Tong S, Tai AW, et al. Hepatitis B virus core promoter mutations contribute to hepatocarcinogenesis by deregulating SKP2 and its target, p21. Gastroenterology 2011;141:1412-21, 21 e1-5.
    • (2011) Gastroenterology , vol.141 , pp. 1412-1421
    • Huang, Y.1    Tong, S.2    Tai, A.W.3
  • 38
    • 46249101267 scopus 로고    scopus 로고
    • The hepatitis B virus X protein induces paracrine activation of human hepatic stellate cells
    • Martin-Vilchez S, Sanz-Cameno P, Rodriguez-Munoz Y, et al. The hepatitis B virus X protein induces paracrine activation of human hepatic stellate cells. Hepatology 2008;47:1872-83.
    • (2008) Hepatology , vol.47 , pp. 1872-1883
    • Martin-Vilchez, S.1    Sanz-Cameno, P.2    Rodriguez-Munoz, Y.3


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