Comparison of Akt/mTOR/4E-BP1 pathway signal activation and mutations of PIK3CA in Merkel cell polyomavirus-positive and Merkel cell polyomavirus-negative carcinomas

Human Pathology

Volumn 46, Issue 2, 2015, Pages 210-216

  Iwasaki, Takeshi ^a   Matsushita, Michiko ^a   Nonaka, Daisuke ^b   Kuwamoto, Satoshi ^a   Kato, Masako ^a   Murakami, Ichiro ^a   Nagata, Keiko ^a   Nakajima, Hideki ^c   Sano, Shigetoshi ^c   Hayashi, Kazuhiko ^a  

^a TOTTORI UNIVERSITY   (Japan)

^b CHRISTIE HOSPITAL   (United Kingdom)

^c KOCHI MEDICAL SCHOOL   (Japan)

Author keywords

Akt mTOR 4E BP1 pathway; Merkel cell carcinoma; Merkel cell polyomavirus; PIK3CA; Squamous cell carcinoma

Indexed keywords

INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; PROTEIN KINASE B; PROTEIN TSC1; TUBERIN; UNCLASSIFIED DRUG; VIRUS LARGE T ANTIGEN; EIF4EBP1 PROTEIN, HUMAN; MTOR PROTEIN, HUMAN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOPROTEIN; PIK3CA PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TARGET OF RAPAMYCIN KINASE;

ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; GENE MUTATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MALE; MERKEL CELL POLYOMAVIRUS; MERKEL CELL TUMOR; MOLECULAR PATHOLOGY; MUTATOR GENE; NONHUMAN; PIK3CA GENE; POLYOMAVIRUS INFECTION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SKIN CARCINOGENESIS; VIRUS GENOME; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; MUTATION; PATHOLOGY; PHYSIOLOGY; SKIN TUMOR; VIROLOGY; VIRUS INFECTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CARCINOMA, MERKEL CELL; FEMALE; HUMANS; MALE; MERKEL CELL POLYOMAVIRUS; MUTATION; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHOPROTEINS; POLYOMAVIRUS INFECTIONS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SKIN NEOPLASMS; TOR SERINE-THREONINE KINASES; TUMOR VIRUS INFECTIONS;

EID: 84920933347     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2014.07.025     Document Type: Article

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