GNAS mutations are associated with mucin production in low-grade appendiceal mucinous neoplasms, villous adenomas, and carcinomas

Human Pathology

Volumn 46, Issue 2, 2015, Pages 339-

  Zauber, Peter ^a   Marotta, Stephen ^a   Sabbath Solitare, Marlene ^a  

^a SAINT BARNABAS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; MUCIN; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN;

ADENOCARCINOMA; APPENDICEAL MUCINOUS NEOPLASM; APPENDIX TUMOR; GENE MUTATION; GNAS GENE; LETTER; TUMOR GENE; VILLOUS ADENOMA; COLLOID CARCINOMA; FEMALE; GENETICS; HUMAN; MALE;

ADENOCARCINOMA, MUCINOUS; APPENDICEAL NEOPLASMS; FEMALE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HUMANS; MALE;

EID: 84920911484     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2014.09.017     Document Type: Letter

References (5)

1. A.D. Singhi, J.M. Davison, and H.A. Choudry GNAS is frequently mutated in both low-grade and high-grade disseminated appendiceal mucinous neoplasms but does not affect survival Hum Pathol 45 2014 1737 1743
2. P. Zauber, E. Berman, S. Marotta, M. Sabbath-Solitare, and T. Bishop Ki-ras gene mutations are invariably present in low-grade mucinous tumors of the vermiform appendix Scand J Gastroenterol 46 2011 869 874
3. L.D. Wood, D.W. Parsons, and S. Jones The genomic landscapes of human breast and colorectal cancers Science 318 2007 1108 1113
4. C.A. Landis, S.B. Masters, A. Spada, A.M. Pace, H.R. Bourne, and L. Vallar GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours Nature 340 1989 692 696
5. G. Nishikawa, S. Sekine, and R. Ogawa Frequent GNAS mutations in low-grade appendiceal mucinous neoplasms Br J Cancer 108 2013 951 958