Systematic mechanism-orientated approach to chronic pancreatitis pain

World Journal of Gastroenterology

Volumn 21, Issue 1, 2015, Pages 47-59

  Bouwense, Stefan A W ^a   De Vries, Marjan ^a   Schreuder, Luuk T W ^a   Olesen, Soren S ^b   Frokjær, Jens B ^b   Drewes, Asbjorn M ^b,c   Van Goor, Harry ^a   Wilder Smith, Oliver H G ^a,c  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b AALBORG UNIVERSITY HOSPITAL   (Denmark)

^c AALBORG UNIVERSITY   (Denmark)

Author keywords

Central sensitization; Chronic pancreatitis; Electroencephalograpy; Magnetic resonance imaging; Pain; Pain treatment; Quantitative sensory testing

Indexed keywords

KETAMINE; NORADRENALIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT; ANALGESIC AGENT;

ANALGESIA; ARTICLE; CENTRAL NERVOUS SYSTEM; CHRONIC PAIN; CHRONIC PANCREATITIS; CLINICAL PRACTICE; DIAGNOSTIC TEST; ELECTROENCEPHALOGRAPHY; EVENT RELATED POTENTIAL; EVOKED RESPONSE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; HYPERALGESIA; NOCICEPTION; QUANTITATIVE SENSORY TESTING; VISCERAL PAIN; ANIMAL; CLINICAL PATHWAY; COMPLICATION; DRUG EFFECTS; PAIN MEASUREMENT; PAIN THRESHOLD; PANCREATITIS, CHRONIC; PATHOPHYSIOLOGY; PREDICTIVE VALUE; PROCEDURES; TREATMENT OUTCOME;

ANALGESICS; ANIMALS; CENTRAL NERVOUS SYSTEM; CHRONIC PAIN; CRITICAL PATHWAYS; HUMANS; PAIN MANAGEMENT; PAIN MEASUREMENT; PAIN PERCEPTION; PAIN THRESHOLD; PANCREATITIS, CHRONIC; PREDICTIVE VALUE OF TESTS; TREATMENT OUTCOME;

EID: 84920897226     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v21.i1.47     Document Type: Article

References (88)

1. Steer ML, Waxman I, Freedman S. Chronic pancreatitis. N Engl J Med 1995; 332: 1482-1490 [PMID: 7739686 DOI: 10.1056/NEJM199506013322206]
2. Amann ST, Yadav D, Barmada MM, O'Connell M, Kennard ED, Anderson M, Baillie J, Sherman S, Romagnuolo J, Hawes RH, Alkaade S, Brand RE, Lewis MD, Gardner TB, Gelrud A, Money ME, Banks PA, Slivka A, Whitcomb DC. Physical and mental quality of life in chronic pancreatitis: a case-control study from the North American Pancreatitis Study 2 cohort. Pancreas 2013; 42: 293-300 [PMID: 23357924 DOI: 10.1097/ MPA.0b013e31826532e7]
3. Bang UC, Benfield T, Hyldstrup L, Bendtsen F, Beck Jensen JE. Mortality, cancer, and comorbidities associated with chronic pancreatitis: a Danish nationwide matched-cohort study. Gastroenterology 2014; 146: 989-994 [PMID: 24389306]
4. Cervero F, Laird JM. Visceral pain. Lancet 1999; 353: 2145-2148 [PMID: 10382712 DOI: 10.1016/S0140-6736(99)01306-9]
5. Jadad AR, Browman GP. The WHO analgesic ladder for cancer pain management. Stepping up the quality of its evaluation. JAMA 1995; 274: 1870-1873 [PMID: 7500538 DOI: 10.1001/jama.1995.03530230056031]
6. Issa Y, van Santvoort HC, van Goor H, Cahen DL, Bruno MJ, Boermeester MA. Surgical and endoscopic treatment of pain in chronic pancreatitis: a multidisciplinary update. Dig Surg 2013; 30: 35-50 [PMID: 23635532 DOI: 10.1159/000350153]
7. Buscher HC, van Goor H, Wilder-Smith OH. Effect of thoracoscopic splanchnic denervation on pain processing in chronic pancreatitis patients. Eur J Pain 2007; 11: 437-443 [PMID: 16843020 DOI: 10.1016/j.ejpain.2006.06.001]
8. Andrén-Sandberg A, Hoem D, Gislason H. Pain management in chronic pancreatitis. Eur J Gastroenterol Hepatol 2002; 14: 957-970 [PMID: 12352215 DOI: 10.1097/00042737-200209000-00006]
9. Drewes AM, Krarup AL, Detlefsen S, Malmstrom ML, Dimcevski G, Funch-Jensen P. Pain in chronic pancreatitis: the role of neuropathic pain mechanisms. Gut 2008; 57: 1616-1627 [PMID: 18566105 DOI: 10.1136/gut.2007.146621]
10. Drewes AM, Gratkowski M, Sami SA, Dimcevski G, Funch-Jensen P, Arendt-Nielsen L. Is the pain in chronic pancreatitis of neuropathic origin? Support from EEG studies during experimental pain. World J Gastroenterol 2008; 14: 4020-4027 [PMID: 18609686 DOI: 10.3748/wjg.14.4020]
11. Bouwense SA, Buscher HC, van Goor H, Wilder-Smith OH. S-ketamine modulates hyperalgesia in patients with chronic pancreatitis pain. Reg Anesth Pain Med 2011; 36: 303-307 [PMID: 21490522 DOI: 10.1097/AAP.0b013e3182177022]
12. Bouwense SA, Olesen SS, Drewes AM, Poley JW, van Goor H, Wilder-Smith OH. Effects of pregabalin on central sensitization in patients with chronic pancreatitis in a randomized, controlled trial. PLoS One 2012; 7: e42096 [PMID: 22879908 DOI: 10.1371/journal.pone.0042096]
13. Buscher HC, Wilder-Smith OH, van Goor H. Chronic pancreatitis patients show hyperalgesia of central origin: a pilot study. Eur J Pain 2006; 10: 363-370 [PMID: 16087373 DOI: 10.1016/j.ejpain.2005.06.006]
14. Moore RA, Straube S, Wiffen PJ, Derry S, McQuay HJ. Pregabalin for acute and chronic pain in adults. Cochrane Database Syst Rev 2009; (3): CD007076 [PMID: 19588419]
15. Olesen SS, Bouwense SA, Wilder-Smith OH, van Goor H, Drewes AM. Pregabalin reduces pain in patients with chronic pancreatitis in a randomized, controlled trial. Gastroenterology 2011; 141: 536-543 [PMID: 21683078 DOI: 10.1053/j.gastro.2011.04.003]
16. Woolf CJ, Salter MW. Neuronal plasticity: increasing the gain in pain. Science 2000; 288: 1765-1769 [PMID: 10846153 DOI: 10.1126/science.288.5472.1765]
17. Coderre TJ, Katz J, Vaccarino AL, Melzack R. Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence. Pain 1993; 52: 259-285 [PMID: 7681556 DOI: 10.1016/0304-3959(93)90161-H]
18. Wilder-Smith OH. A Paradigm-Shift in Pain Medicine. USA: River Publishers, 2013
19. Schaible HG, Vanegas H. How do we manage chronic pain? Baillieres Best Pract Res Clin Rheumatol 2000; 14: 797-811 [PMID: 11092803 DOI: 10.1053/berh.2000.0114]
20. Neziri AY, Bersinger NA, Andersen OK, Arendt-Nielsen L, Mueller MD, Curatolo M. Correlation between altered central pain processing and concentration of peritoneal fluid inflammatory cytokines in endometriosis patients with chronic pelvic pain. Reg Anesth Pain Med 2014; 39: 181-184 [PMID: 24694998 DOI: 10.1097/AAP.0000000000000068]
21. Yarnitsky D, Granot M, Nahman-Averbuch H, Khamaisi M, Granovsky Y. Conditioned pain modulation predicts duloxetine efficacy in painful diabetic neuropathy. Pain 2012; 153: 1193-1198 [PMID: 22480803]
22. Lindblom K. Technique and results in myelography and disc puncture. Acta radiol 1950; 34: 321-330 [PMID: 14799269 DOI: 10.3109/00016925009135278]
23. Lindblom U, Tapper DN. Terminal properties of a vibrotactile sensor. Exp Neurol 1967; 17: 1-15 [PMID: 4959818 DOI: 10.1016/0014-4886(67)90117-3]
24. Geber C, Klein T, Azad S, Birklein F, Gierthmühlen J, Huge V, Lauchart M, Nitzsche D, Stengel M, Valet M, Baron R, Maier C, Tölle T, Treede RD. Test-retest and interobserver reliability of quantitative sensory testing according to the protocol of the German Research Network on Neuropathic Pain (DFNS): a multi-centre study. Pain 2011; 152: 548-556 [PMID: 21237569 DOI: 10.1016/j.pain.2010.11.013]
25. Olesen SS, van Goor H, Bouwense SA, Wilder-Smith OH, Drewes AM. Reliability of static and dynamic quantitative sensory testing in patients with painful chronic pancreatitis. Reg Anesth Pain Med 2012; 37: 530-536 [PMID: 22854397 DOI: 10.1097/AAP.0b013e3182632c40]
26. Pavlakoviæ G, Petzke F. The role of quantitative sensory testing in the evaluation of musculoskeletal pain conditions. Curr Rheumatol Rep 2010; 12: 455-461 [PMID: 20857243 DOI: 10.1007/s11926-010-0131-0]
27. Bouwense SA, Olesen SS, Drewes AM, Frokjær JB, van Goor H, Wilder-Smith OH. Is altered central pain processing related to disease stage in chronic pancreatitis patients with pain? An exploratory study. PLoS One 2013; 8: e55460 [PMID: 23405154]
28. Olesen SS, Brock C, Krarup AL, Funch-Jensen P, Arendt-Nielsen L, Wilder-Smith OH, Drewes AM. Descending inhibitory pain modulation is impaired in patients with chronic pancreatitis. Clin Gastroenterol Hepatol 2010; 8: 724-730 [PMID: 20304100 DOI: 10.1016/j.cgh.2010.03.005]
29. Kirschbaum WR, Stehle HC. Electroencephalographic studies of patients with peptic ulcer and functional gastric disorders. Electroencephalogr Clin Neurophysiol 1953; 5: 513-520 [PMID: 13107597 DOI: 10.1016/0013-4694(53)90027-3]
30. Frokjaer JB, Olesen SS, Graversen C, Andresen T, Lelic D, Drewes AM. Neuroimaging of the human visceral pain system-A methodological review. Scand J Pain 2011; 2: 95-104 [DOI: 10.1016/j.sjpain.2011.02.006]
31. Niedermeyer E, Krauss GL, Peyser CE. The electroencephalogram and mental activation. Clin Electroencephalogr 1989; 20: 215-227 [PMID: 2791311 DOI: 10.1177/155005948902000409]
32. Jensen O, Bonnefond M, VanRullen R. An oscillatory mechanism for prioritizing salient unattended stimuli. Trends Cogn Sci 2012; 16: 200-206 [PMID: 22436764 DOI: 10.1016/j.tics.2012.03.002]
33. de Vries M, Wilder-Smith OH, Jongsma ML, van den Broeke EN, Arns M, van Goor H, van Rijn CM. Altered resting state EEG in chronic pancreatitis patients: toward a marker for chronic pain. J Pain Res 2013; 6: 815-824 [PMID: 24379694 DOI: 10.2147/JPR.S50919]
34. Olesen SS, Hansen TM, Graversen C, Steimle K, Wilder-Smith OH, Drewes AM. Slowed EEG rhythmicity in patients with chronic pancreatitis: evidence of abnormal cerebral pain processing? Eur J Gastroenterol Hepatol 2011; 23: 418-424 [PMID: 21399506 DOI: 10.1097/MEG.0b013e3283457b09]
35. van den Broeke EN, Wilder-Smith OH, van Goor H, Vissers KC, van Rijn CM. Patients with persistent pain after breast cancer treatment show enhanced alpha activity in spontaneous EEG. Pain Med 2013; 14: 1893-1899 [PMID: 24034712 DOI: 10.1111/pme.12216]
36. Peterson NN, Schroeder CE, Arezzo JC. Neural generators of early cortical somatosensory evoked potentials in the awake monkey. Electroencephalogr Clin Neurophysiol 1995; 96: 248-260 [PMID: 7750450 DOI: 10.1016/0168-5597(95)00006-E]
37. Sur S, Sinha VK. Event-related potential: An overview. Ind Psychiatry J 2009; 18: 70-73 [PMID: 21234168 DOI: 10.4103/0972-6748.57865]
38. Nissen TD, Brock C, Graversen C, Coen SJ, Hultin L, Aziz Q, Lykkesfeldt J, Drewes AM. Translational aspects of rectal evoked potentials: a comparative study in rats and humans. Am J Physiol Gastrointest Liver Physiol 2013; 305: G119-G128 [PMID: 23703652 DOI: 10.1152/ajpgi.00403.2012]
39. Garcia-Larrea L . Objective pain diagnostics: clinical neurophysiology. Neurophysiol Clin 2012; 42: 187-197 [PMID: 22632867 DOI: 10.1016/j.neucli.2012.03.001]
40. Kramer JL, Haefeli J, Jutzeler CR. An objective measure of stimulus-evoked pain. J Neurosci 2012; 32: 12981-12982 [PMID: 22993414 DOI: 10.1523/JNEUROSCI.3175-12.2012]
41. De Broucker T, Willer JC. [Comparative study of the nociceptive reflex and late components of the evoked somatosensory potential during stimulation of the sural nerve in healthy subjects]. Rev Electroencephalogr Neurophysiol Clin 1985; 15: 149-153 [PMID: 4070727]
42. Baumgärtner U, Treede RD. Are there nociceptive-specific brain potentials? J Neurophysiol 2009; 102: 3073-3074; author reply 3075-3076 [PMID: 19889859 DOI: 10.1152/ jn.00588.2009]
43. Mouraux A, Iannetti GD. Nociceptive laser-evoked brain potentials do not reflect nociceptive-specific neural activity. J Neurophysiol 2009; 101: 3258-3269 [PMID: 19339457 DOI: 10.1152/jn.91181.2008]
44. Turner R . Magnetic resonance imaging of brain function. Am J Physiol Imaging 1992; 7: 136-145 [PMID: 1343210]
45. Nucifora PG, Verma R, Lee SK, Melhem ER. Diffusiontensor MR imaging and tractography: exploring brain microstructure and connectivity. Radiology 2007; 245: 367-384 [PMID: 17940300 DOI: 10.1148/radiol.2452060445]
46. Detre JA, Leigh JS, Williams DS, Koretsky AP. Perfusion imaging. Magn Reson Med 1992; 23: 37-45 [PMID: 1734182 DOI: 10.1002/mrm.1910230106]
47. Tracey I, Johns E. The pain matrix: reloaded or reborn as we image tonic pain using arterial spin labelling. Pain 2010; 148: 359-360 [PMID: 20080346 DOI: 10.1016/j.pain.2009.11.009]
48. Napadow V, LaCount L, Park K, As-Sanie S, Clauw DJ, Harris RE. Intrinsic brain connectivity in fibromyalgia is associated with chronic pain intensity. Arthritis Rheum 2010; 62: 2545-2555 [PMID: 20506181 DOI: 10.1002/art.27497]
49. Abdallah AA, Krige JE, Bornman PC. Biliary tract obstruction in chronic pancreatitis. HPB (Oxford) 2007; 9: 421-428 [PMID: 18345288 DOI: 10.1080/13651820701774883]
50. st century. Part I: classification, pathophysiology, anatomic considerations and treatment. JOP 2004; 5: 8-24 [PMID: 14730118]
51. Barreto SG, Saccone GT. Pancreatic nociception - revisiting the physiology and pathophysiology. Pancreatology 2012; 12: 104-112 [PMID: 22487519 DOI: 10.1016/j.pan.2012.02.010]
52. Demir IE, Tieftrunk E, Maak M, Friess H, Ceyhan GO. Pain mechanisms in chronic pancreatitis: of a master and his fire. Langenbecks Arch Surg 2011; 396: 151-160 [PMID: 21153480 DOI: 10.1007/s00423-010-0731-1]
53. Vijungco JD, Prinz RA. Management of biliary and duodenal complications of chronic pancreatitis. World J Surg 2003; 27: 1258-1270 [PMID: 14534824 DOI: 10.1007/s00268-003-7246-7]
54. Bouwense SA, Buscher HC, van Goor H, Wilder-Smith OH. Has central sensitization become independent of nociceptive input in chronic pancreatitis patients who fail thoracoscopic splanchnicectomy? Reg Anesth Pain Med 2011; 36: 531-536 [PMID: 22005656 DOI: 10.1097/AAP.0b013e31822e0d4a]
55. Ceyhan GO, Bergmann F, Kadihasanoglu M, Altintas B, Demir IE, Hinz U, Müller MW, Giese T, Büchler MW, Giese NA, Friess H. Pancreatic neuropathy and neuropathic pain - a comprehensive pathomorphological study of 546 cases. Gastroenterology 2009; 136: 177-186.e1 [PMID: 18992743]
56. Demir IE, Schorn S, Schremmer-Danninger E, Wang K, Kehl T, Giese NA, Algül H, Friess H, Ceyhan GO. Perineural mast cells are specifically enriched in pancreatic neuritis and neuropathic pain in pancreatic cancer and chronic pancreatitis. PLoS One 2013; 8: e60529 [PMID: 23555989 DOI: 10.1371/journal.pone.0060529]
57. Ceyhan GO, Demir IE, Maak M, Friess H. Fate of nerves in chronic pancreatitis: Neural remodeling and pancreatic neuropathy. Best Pract Res Clin Gastroenterol 2010; 24: 311-322 [PMID: 20510831 DOI: 10.1016/j.bpg.2010.03.001]
58. Bockman DE, Buchler M, Malfertheiner P, Beger HG. Analysis of nerves in chronic pancreatitis. Gastroenterology 1988; 94: 1459-1469 [PMID: 3360267]
59. Poulsen JL, Olesen SS, Malver LP, Frokjær JB, Drewes AM. Pain and chronic pancreatitis: a complex interplay of multiple mechanisms. World J Gastroenterol 2013; 19: 7282-7291 [PMID: 24259959 DOI: 10.3748/wjg.v19.i42.7282]
60. Friess H, Zhu ZW, di Mola FF, Kulli C, Graber HU, Andren-Sandberg A, Zimmermann A, Korc M, Reinshagen M, Büchler MW. Nerve growth factor and its high-affinity receptor in chronic pancreatitis. Ann Surg 1999; 230: 615-624 [PMID: 10561084 DOI: 10.1097/00000658-199911000-00002]
61. Zhu ZW, Friess H, Wang L, Zimmermann A, Büchler MW. Brain-derived neurotrophic factor (BDNF) is upregulated and associated with pain in chronic pancreatitis. Dig Dis Sci 2001; 46: 1633-1639 [PMID: 11508661 DOI: 10.1023/A:1010684916863]
62. Anand P, Aziz Q, Willert R, van Oudenhove L. Peripheral and central mechanisms of visceral sensitization in man. Neurogastroenterol Motil 2007; 19: 29-46 [PMID: 17280584]
63. Dimcevski G, Sami SA, Funch-Jensen P, Le Pera D, Valeriani M, Arendt-Nielsen L, Drewes AM. Pain in chronic pancreatitis: the role of reorganization in the central nervous system. Gastroenterology 2007; 132: 1546-1556 [PMID: 17408654 DOI: 10.1053/j.gastro.2007.01.037]
64. Arendt-Nielsen L, Laursen RJ, Drewes AM. Referred pain as an indicator for neural plasticity. Prog Brain Res 2000; 129: 343-356 [PMID: 11098702 DOI: 10.1016/S0079-6123(00)29026-2]
65. Drewes AM, Pedersen J, Liu W, Arendt-Nielsen L, Gregersen H. Controlled mechanical distension of the human oesophagus: sensory and biomechanical findings. Scand J Gastroenterol 2003; 38: 27-35 [PMID: 12608461 DOI: 10.1080/00365520310000401]
66. Drewes AM, Reddy H, Pedersen J, Funch-Jensen P, Gregersen H, Arendt-Nielsen L. Multimodal pain stimulations in patients with grade B oesophagitis. Gut 2006; 55: 926-932 [PMID: 16091554 DOI: 10.1136/gut.2005.067769]
67. Drewes AM, Frokjaer JB, Larsen E, Reddy H, Arendt-Nielsen L, Gregersen H. Pain and mechanical properties of the rectum in patients with active ulcerative colitis. Inflamm Bowel Dis 2006; 12: 294-303 [PMID: 16633051 DOI: 10.1097/01.MIB.0000209365.09189.04]
68. Faure C, Giguère L. Functional gastrointestinal disorders and visceral hypersensitivity in children and adolescents suffering from Crohn's disease. Inflamm Bowel Dis 2008; 14: 1569-1574 [PMID: 18521915 DOI: 10.1002/ibd.20506]
69. Galeazzi F, Lucà MG, Lanaro D, D'Incà R, D'Odorico A, Sturniolo GC, Mastropaolo G. Esophageal hyperalgesia in patients with ulcerative colitis: role of experimental stress. Am J Gastroenterol 2001; 96: 2590-2595 [PMID: 11569680 DOI: 10.1111/j.1572-0241.2001.04102.x]
70. Bernstein CN, Niazi N, Robert M, Mertz H, Kodner A, Munakata J, Naliboff B, Mayer EA. Rectal afferent function in patients with inflammatory and functional intestinal disorders. Pain 1996; 66: 151-161 [PMID: 8880836 DOI: 10.1016/0304-3959(96)03062-X]
71. Fass R, Naliboff B, Higa L, Johnson C, Kodner A, Munakata J, Ngo J, Mayer EA. Differential effect of long-term esophageal acid exposure on mechanosensitivity and chemosensitivity in humans. Gastroenterology 1998; 115: 1363-1373 [PMID: 9834263 DOI: 10.1016/S0016-5085(98)70014-9]
72. Mertz H, Fullerton S, Naliboff B, Mayer EA. Symptoms and visceral perception in severe functional and organic dyspepsia. Gut 1998; 42: 814-822 [PMID: 9691920 DOI: 10.1136/gut.42.6.814]
73. Bouwense SA, Ahmed Ali U, ten Broek RP, Issa Y, van Eijck CH, Wilder-Smith OH, van Goor H. Altered central pain processing after pancreatic surgery for chronic pancreatitis. Br J Surg 2013; 100: 1797-1804 [PMID: 24227367 DOI: 10.1002/bjs.9322]
74. Stawowy M, Drewes AM, Arendt-Nielsen L, Funch-Jensen P. Somatosensory changes in the referred pain area before and after cholecystectomy in patients with uncomplicated gallstone disease. Scand J Gastroenterol 2006; 41: 833-837 [PMID: 16785197 DOI: 10.1080/00365520500463332]
75. Wilder-Smith CH, Hill L, Wilkins J, Denny L. Effects of morphine and tramadol on somatic and visceral sensory function and gastrointestinal motility after abdominal surgery. Anesthesiology 1999; 91: 639-647 [PMID: 10485772 DOI: 10.1097/00000542-199909000-00013]
76. Olesen SS, Frokjær JB, Lelic D, Valeriani M, Drewes AM. Pain-associated adaptive cortical reorganisation in chronic pancreatitis. Pancreatology 2010; 10: 742-751 [PMID: 21273802 DOI: 10.1159/000321644]
77. Graversen C, Olesen SS, Olesen AE, Steimle K, Farina D, Wilder-Smith OH, Bouwense SA, van Goor H, Drewes AM. The analgesic effect of pregabalin in patients with chronic pain is reflected by changes in pharmaco-EEG spectral indices. Br J Clin Pharmacol 2012; 73: 363-372 [PMID: 21950372 DOI: 10.1111/j.1365-2125.2011.04104.x]
78. Mayer EA, Aziz Q, Coen S, Kern M, Labus JS, Lane R, Kuo B, Naliboff B, Tracey I. Brain imaging approaches to the study of functional GI disorders: a Rome working team report. Neurogastroenterol Motil 2009; 21: 579-596 [PMID: 19646070 DOI: 10.1111/j.1365-2982.2009.01304.x]
79. Moisset X, Bouhassira D, Denis D, Dominique G, Benoit C, Sabaté JM. Anatomical connections between brain areas activated during rectal distension in healthy volunteers: a visceral pain network. Eur J Pain 2010; 14: 142-148 [PMID: 19473859 DOI: 10.1016/j.ejpain.2009.04.011]
80. Willis WD, Westlund KN. Neuroanatomy of the pain system and of the pathways that modulate pain. J Clin Neurophysiol 1997; 14: 2-31 [PMID: 9013357 DOI: 10.1097/00004691-199701 000-00002]
81. Frokjær JB, Bouwense SA, Olesen SS, Lundager FH, Eskildsen SF, van Goor H, Wilder-Smith OH, Drewes AM. Reduced cortical thickness of brain areas involved in pain processing in patients with chronic pancreatitis. Clin Gastroenterol Hepatol 2012; 10: 434-438.e1 [PMID: 22155560 DOI: 10.1016/j.cgh.2011.11.024]
82. Bernstein CN, Frankenstein UN, Rawsthorne P, Pitz M, Summers R, McIntyre MC. Cortical mapping of visceral pain in patients with GI disorders using functional magnetic resonance imaging. Am J Gastroenterol 2002; 97: 319-327 [PMID: 11866268 DOI: 10.1111/j.1572-0241.2002.05464.x]
83. Buscher HC, Schipper EE, Wilder-Smith OH, Jansen JB, van Goor H. Limited effect of thoracoscopic splanchnicectomy in the treatment of severe chronic pancreatitis pain: a prospective long-term analysis of 75 cases. Surgery 2008; 143: 715-722 [PMID: 18549887 DOI: 10.1016/j.surg.2008.03.001]
84. Kosek E, Ordeberg G. Lack of pressure pain modulation by heterotopic noxious conditioning stimulation in patients with painful osteoarthritis before, but not following, surgical pain relief. Pain 2000; 88: 69-78 [PMID: 11098101 DOI: 10.1016/S0304-3959(00)00310-9]
85. Cruccu G, Anand P, Attal N, Garcia-Larrea L, Haanpää M, Jorum E, Serra J, Jensen TS. EFNS guidelines on neuropathic pain assessment. Eur J Neurol 2004; 11: 153-162 [PMID: 15009162 DOI: 10.1111/j.1468-1331.2004.00791.x]
86. Maier C, Baron R, Tölle TR, Binder A, Birbaumer N, Birklein F, Gierthmühlen J, Flor H, Geber C, Huge V, Krumova EK, Landwehrmeyer GB, Magerl W, Maihöfner C, Richter H, Rolke R, Scherens A, Schwarz A, Sommer C, Tronnier V, Uçeyler N, Valet M, Wasner G, Treede RD. Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): somatosensory abnormalities in 1236 patients with different neuropathic pain syndromes. Pain 2010; 150: 439-450 [PMID: 20627413 DOI: 10.1016/ j.pain.2010.05.002]
87. Rolke R, Baron R, Maier C, Tölle TR, Treede RD, Beyer A, Binder A, Birbaumer N, Birklein F, Bötefür IC, Braune S, Flor H, Huge V, Klug R, Landwehrmeyer GB, Magerl W, Maihöfner C, Rolko C, Schaub C, Scherens A, Sprenger T, Valet M, Wasserka B. Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): standardized protocol and reference values. Pain 2006; 123: 231-243 [PMID: 16697110 DOI: 10.1016/j.pain.2006.01.041]
88. Timmerman H, Wilder-Smith O, van Weel C, Wolff A, Vissers K. Detecting the neuropathic pain component in the clinical setting: a study protocol for validation of screening instruments for the presence of a neuropathic pain component. BMC Neurol 2014; 14: 94 [PMID: 24885108 DOI: 10.1186/1471-2377-14-94]