Lack of efficacy of mitoxantrone in primary progressive Multiple Sclerosis irrespective of pharmacogenetic factors: A multi-center, retrospective analysis

Journal of Neuroimmunology

Volumn 278, Issue , 2015, Pages 277-279

  Grey Née Cotte, Steffi ^a   Salmen Née Stroet, Anke ^a   von Ahsen, Nico ^b   Starck, Michaela ^c,h   Winkelmann, Alexander ^d   Zettl, Uwe K ^d   Comabella, Manuel ^e   Montalban, Xavier ^e   Zipp, Frauke ^f   Fleischer, Vinzenz ^f   Kruse, Niels ^g   Gold, Ralf ^a   Chan, Andrew ^a  

^a ST JOSEF HOSPITAL   (Germany)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

^c Marianne Strauss Hospital   (Germany)

^d UNIVERSITY OF ROSTOCK   (Germany)

^e UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^f UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^g UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^h Medizinisches Labor Bremen   (Germany)

Author keywords

Escalation therapy; Immunosuppression; Multi drug resistance transporter; Pharmacogenetics

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; MITOXANTRONE; MULTIDRUG RESISTANCE PROTEIN 1; ABC TRANSPORTER; ABCB1 PROTEIN, HUMAN; ABCG2 PROTEIN, HUMAN; ANALGESIC AGENT; MULTIDRUG RESISTANCE PROTEIN; TUMOR PROTEIN;

ABCB1 GENE; ABCG2 GENE; ADULT; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG INDICATION; DRUG RESPONSE; FEMALE; GENE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; PHARMACOGENETICS; RETROSPECTIVE STUDY; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT DURATION; CLINICAL TRIAL; GENETICS; MIDDLE AGED; MULTICENTER STUDY; MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE;

ADULT; ANALGESICS; ATP-BINDING CASSETTE TRANSPORTERS; FEMALE; HUMANS; MALE; MIDDLE AGED; MITOXANTRONE; MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE; NEOPLASM PROTEINS; P-GLYCOPROTEINS; PHARMACOGENETICS; RETROSPECTIVE STUDIES;

EID: 84920896770     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2014.11.017     Document Type: Article

References (11)

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