메뉴 건너뛰기




Volumn 14, Issue 12, 2014, Pages 1-12

Shared Neurobiological Pathways Between Type 2 Diabetes and Depressive Symptoms: a Review of Morphological and Neurocognitive Findings

Author keywords

Biological mechanisms; Brain; Depression; Depressive symptoms; Hippocampus; Morphological and structural abnormalities; MRI; Neurocognitive deficits; Neurogenesis; Neuroplasticity; Prefrontal cortex; Type 2 diabetes; Volumetric

Indexed keywords

ADRENERGIC SYSTEM; BODY COMPOSITION; BRAIN REGION; COGNITIVE DEFECT; COMORBIDITY; DEPRESSION; GRAY MATTER; HIPPOCAMPUS; HUMAN; HYPERACTIVITY; MAJOR DEPRESSION; NERVE CELL PLASTICITY; NEUROBIOLOGY; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEAR MAGNETIC RESONANCE IMAGING; PREFRONTAL CORTEX; QUALITY OF LIFE; REVIEW; COGNITION; COMPLICATION; METABOLISM; NEUROIMAGING; PATHOPHYSIOLOGY; PSYCHOLOGY; VASCULAR ENDOTHELIUM;

EID: 84920872265     PISSN: 15344827     EISSN: 15390829     Source Type: Journal    
DOI: 10.1007/s11892-014-0560-7     Document Type: Review
Times cited : (16)

References (69)
  • 1
    • 0035374580 scopus 로고    scopus 로고
    • The prevalence of comorbid depression in adults with diabetes: a meta-analysis
    • PID: 11375373, COI: 1:STN:280:DC%2BD3M3pt1GitA%3D%3D
    • Anderson RJ, Freedland KE, Clouse RE, Lustman PJ. The prevalence of comorbid depression in adults with diabetes: a meta-analysis. Diabetes Care. 2001;24:1069–78.
    • (2001) Diabetes Care , vol.24 , pp. 1069-1078
    • Anderson, R.J.1    Freedland, K.E.2    Clouse, R.E.3    Lustman, P.J.4
  • 2
    • 0027199350 scopus 로고
    • Prevalence of depression in adults with diabetes: an epidemiological evaluation
    • PID: 8375247, COI: 1:STN:280:DyaK3szoslSruw%3D%3D
    • Gavard JA, Lustman PJ, Clouse RE. Prevalence of depression in adults with diabetes: an epidemiological evaluation. Diabetes Care. 1993;16:1167–78.
    • (1993) Diabetes Care , vol.16 , pp. 1167-1178
    • Gavard, J.A.1    Lustman, P.J.2    Clouse, R.E.3
  • 4
    • 0033927080 scopus 로고    scopus 로고
    • Depression and poor glycemic control: a meta-analytic review of the literature
    • PID: 10895843, COI: 1:STN:280:DC%2BD3M%2FhtlGgtA%3D%3D
    • Lustman PJ, Anderson RJ, Freedland KE, de Groot M, Carney RM, Clouse RE. Depression and poor glycemic control: a meta-analytic review of the literature. Diabetes Care. 2000;23:934–42.
    • (2000) Diabetes Care , vol.23 , pp. 934-942
    • Lustman, P.J.1    Anderson, R.J.2    Freedland, K.E.3    de Groot, M.4    Carney, R.M.5    Clouse, R.E.6
  • 6
    • 0034722749 scopus 로고    scopus 로고
    • Depression and diabetes. Impact of depressive symptoms on adherence, function, and costs
    • PID: 11088090, COI: 1:STN:280:DC%2BD3M%2FmvFOksQ%3D%3D
    • Ciechanowski PS, Katon WJ, Russo JE. Depression and diabetes. Impact of depressive symptoms on adherence, function, and costs. Arch Intern Med. 2000;160:3278–85.
    • (2000) Arch Intern Med , vol.160 , pp. 3278-3285
    • Ciechanowski, P.S.1    Katon, W.J.2    Russo, J.E.3
  • 7
    • 0031039184 scopus 로고    scopus 로고
    • The effects of psychiatric disorders and symptoms on quality of life in patients with type I and type II diabetes
    • PID: 9062437, COI: 1:STN:280:DyaK2s3hs1Wmuw%3D%3D
    • Jacobson AM, de Groot M, Samson JA. The effects of psychiatric disorders and symptoms on quality of life in patients with type I and type II diabetes. Qual Life Res. 1997;6(1):11–20.
    • (1997) Qual Life Res , vol.6 , Issue.1 , pp. 11-20
    • Jacobson, A.M.1    de Groot, M.2    Samson, J.A.3
  • 8
    • 77953509680 scopus 로고    scopus 로고
    • Role of motivation in the relationship between depression, self-care and glycemic control in adults with type 2 diabetes
    • PID: 20179250
    • Egede L, Osborn C. Role of motivation in the relationship between depression, self-care and glycemic control in adults with type 2 diabetes. Diabetes Educ. 2010;36(2):276–83.
    • (2010) Diabetes Educ , vol.36 , Issue.2 , pp. 276-283
    • Egede, L.1    Osborn, C.2
  • 9
    • 12144287613 scopus 로고    scopus 로고
    • Behavioral and clinical factors associated with depression among individuals with diabetes
    • PID: 15047648
    • Katon W, Von Korff M, Ciechanowski P, Russo J, Lin E, et al. Behavioral and clinical factors associated with depression among individuals with diabetes. Diabetes Care. 2004;27:914–20.
    • (2004) Diabetes Care , vol.27 , pp. 914-920
    • Katon, W.1    Von Korff, M.2    Ciechanowski, P.3    Russo, J.4    Lin, E.5
  • 10
    • 33644789513 scopus 로고    scopus 로고
    • The association of comorbid depression with mortality in patients with type 2 diabetes
    • PID: 16249537
    • Katon W, Rutter C, Simon G, Lin EB, Ludman E, et al. The association of comorbid depression with mortality in patients with type 2 diabetes. Diabetes Care. 2005;28:2668–72.
    • (2005) Diabetes Care , vol.28 , pp. 2668-2672
    • Katon, W.1    Rutter, C.2    Simon, G.3    Lin, E.B.4    Ludman, E.5
  • 11
    • 0028843716 scopus 로고
    • Health care costs of primary care patients with recognized depression
    • PID: 7575105, COI: 1:STN:280:DyaK28%2FgtlCltg%3D%3D
    • Simon G, von Korff M, Barlow W. Health care costs of primary care patients with recognized depression. Arch Gen Psychiatry. 1995;52:850–6.
    • (1995) Arch Gen Psychiatry , vol.52 , pp. 850-856
    • Simon, G.1    von Korff, M.2    Barlow, W.3
  • 14
    • 84856735196 scopus 로고    scopus 로고
    • The course of depressive symptoms in primary care patients with type 2 diabetes: results from the Diabetes, Depression, Type D Personality Zuidoost-Brabant (DiaDDZoB) study
    • PID: 22198261, COI: 1:STN:280:DC%2BC387ovVKjtw%3D%3D
    • Nefs G, Pouwer F, Denollet J, Pop V. The course of depressive symptoms in primary care patients with type 2 diabetes: results from the Diabetes, Depression, Type D Personality Zuidoost-Brabant (DiaDDZoB) study. Diabetologia. 2012;55:608–16.
    • (2012) Diabetologia , vol.55 , pp. 608-616
    • Nefs, G.1    Pouwer, F.2    Denollet, J.3    Pop, V.4
  • 15
    • 78649326062 scopus 로고    scopus 로고
    • Type 2 diabetes as a risk factor for the onset of depression: a systematic review and meta-analysis
    • PID: 20711716, COI: 1:STN:280:DC%2BC3cbnsVWmsQ%3D%3D
    • Nouwen A, Winkley K, Twisk J, Lloyd CE, Peyrot M, Ismail K, et al. Type 2 diabetes as a risk factor for the onset of depression: a systematic review and meta-analysis. Diabetologia. 2010;53:2480–6.
    • (2010) Diabetologia , vol.53 , pp. 2480-2486
    • Nouwen, A.1    Winkley, K.2    Twisk, J.3    Lloyd, C.E.4    Peyrot, M.5    Ismail, K.6
  • 16
    • 37849031273 scopus 로고    scopus 로고
    • Does depression increase the risk of developing type 2 diabetes?
    • Cosgrove MP, Sargeant LA, Griffin SJ. Does depression increase the risk of developing type 2 diabetes? Occup Med. 2008;58:7–14.
    • (2008) Occup Med , vol.58 , pp. 7-14
    • Cosgrove, M.P.1    Sargeant, L.A.2    Griffin, S.J.3
  • 18
    • 82855165012 scopus 로고    scopus 로고
    • Depression and type 2 diabetes: inflammatory mechanisms of a psychoneuroendocrine co-morbidity
    • PID: 22020230, COI: 1:CAS:528:DC%2BC3MXhsFSkt7rE, Well written review paper that highlights several biological mechanisms associated with T2D and depression with a particular emphasis on cellular and molecular research
    • Stuart MJ, Baune BT. Depression and type 2 diabetes: inflammatory mechanisms of a psychoneuroendocrine co-morbidity. Neurosci Biobehav Rev. 2012;36:658–76. Well written review paper that highlights several biological mechanisms associated with T2D and depression with a particular emphasis on cellular and molecular research.
    • (2012) Neurosci Biobehav Rev , vol.36 , pp. 658-676
    • Stuart, M.J.1    Baune, B.T.2
  • 19
    • 1442275317 scopus 로고    scopus 로고
    • Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes
    • PID: 14988310
    • Pickup JC. Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care. 2004;27:813–23.
    • (2004) Diabetes Care , vol.27 , pp. 813-823
    • Pickup, J.C.1
  • 20
    • 33646423317 scopus 로고    scopus 로고
    • Depression as a risk factor for the onset of type 2 diabetes. A meta-analysis
    • PID: 16520921, COI: 1:STN:280:DC%2BD283jsVWisw%3D%3D
    • Knol MJ, Twisk JWR, Beekman ATF, Heine RJ, Snoek FJ, Pouwer F. Depression as a risk factor for the onset of type 2 diabetes. A meta-analysis. Diabetologia. 2006;49:837–45.
    • (2006) Diabetologia , vol.49 , pp. 837-845
    • Knol, M.J.1    Twisk, J.W.R.2    Beekman, A.T.F.3    Heine, R.J.4    Snoek, F.J.5    Pouwer, F.6
  • 21
    • 30544445602 scopus 로고    scopus 로고
    • Cytokines sing the blues: inflammation and the pathogenesis of depression
    • PID: 16316783, COI: 1:CAS:528:DC%2BD28XmsVylsg%3D%3D
    • Raison CL, Capuron L, Miller AH. Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends Immunol. 2006;27:24–31.
    • (2006) Trends Immunol , vol.27 , pp. 24-31
    • Raison, C.L.1    Capuron, L.2    Miller, A.H.3
  • 22
    • 33947653784 scopus 로고    scopus 로고
    • Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans: a meta-analysis of monoamine depletion studies
    • PID: 17389902, COI: 1:CAS:528:DC%2BD2sXjsV2isr8%3D
    • Ruhe HG, Mason NS, Schene AH. Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans: a meta-analysis of monoamine depletion studies. Mol Psychiatry. 2007;12:331–59.
    • (2007) Mol Psychiatry , vol.12 , pp. 331-359
    • Ruhe, H.G.1    Mason, N.S.2    Schene, A.H.3
  • 23
    • 37249094173 scopus 로고    scopus 로고
    • From inflammation to sickness and depression: when the immune system subjugates the brain
    • COI: 1:CAS:528:DC%2BD2sXhsVGjsbfJ
    • Dantzer R, O’Connor JC, Freund GC, Johnson RW, Kelley KW. From inflammation to sickness and depression: when the immune system subjugates the brain. Nature. 2008;9:46–7.
    • (2008) Nature , vol.9 , pp. 46-47
    • Dantzer, R.1    O’Connor, J.C.2    Freund, G.C.3    Johnson, R.W.4    Kelley, K.W.5
  • 24
    • 84886949470 scopus 로고    scopus 로고
    • Diabetes, depressive symptoms, and inflammation in older adults: results from the Health, Aging, and Body Composition Study
    • PID: 24182629, First empirical study to confirm that previously hypothesized markers of inflammation are elevated in participants with both T2D and self-reported depressive symptoms to a greater degree than participants with either disorder alone or people without T2D and depressive symptoms
    • Doyle TA, de Groot M, Harris T, Schwartz F, Strotmeyer ES, Johnson KC, et al. Diabetes, depressive symptoms, and inflammation in older adults: results from the Health, Aging, and Body Composition Study. J Psychosom Res. 2013;75:419–24. First empirical study to confirm that previously hypothesized markers of inflammation are elevated in participants with both T2D and self-reported depressive symptoms to a greater degree than participants with either disorder alone or people without T2D and depressive symptoms.
    • (2013) J Psychosom Res , vol.75 , pp. 419-424
    • Doyle, T.A.1    de Groot, M.2    Harris, T.3    Schwartz, F.4    Strotmeyer, E.S.5    Johnson, K.C.6
  • 25
    • 84873599522 scopus 로고    scopus 로고
    • Endocrine and inflammatory profiles in type 2 diabetic patients with and without major depressive disorder
    • PID: 23410093, COI: 1:CAS:528:DC%2BC3sXotVKgtro%3D, Provides corroborating evidence that previously hypothesized markers of inflammation are elevated in participants with both T2D and clinically diagnosed MDD as well as the first reported evidence that 24-hour urine free cortisol levels are higher among participants with both disorders compared to participants with T2D alone
    • Alvarez A, Faccioli J, Guinzbourg M, Castex MM, Bayon C, Masson W. Endocrine and inflammatory profiles in type 2 diabetic patients with and without major depressive disorder. BMC Res Notes. 2013;6:61. Provides corroborating evidence that previously hypothesized markers of inflammation are elevated in participants with both T2D and clinically diagnosed MDD as well as the first reported evidence that 24-hour urine free cortisol levels are higher among participants with both disorders compared to participants with T2D alone.
    • (2013) BMC Res Notes , vol.6 , pp. 61
    • Alvarez, A.1    Faccioli, J.2    Guinzbourg, M.3    Castex, M.M.4    Bayon, C.5    Masson, W.6
  • 26
    • 8844231080 scopus 로고    scopus 로고
    • Neuroplasticity: from MRI to depressive symptoms
    • PID: 15550349, COI: 1:CAS:528:DC%2BD2cXhtVSktrjP
    • Fossati P, Radtchenko A, Boyer P. Neuroplasticity: from MRI to depressive symptoms. Eur Neuropsychopharmacol. 2004;14(5):S503–10.
    • (2004) Eur Neuropsychopharmacol , vol.14 , Issue.5 , pp. S503-S510
    • Fossati, P.1    Radtchenko, A.2    Boyer, P.3
  • 27
    • 84856196205 scopus 로고    scopus 로고
    • Diabetes as a chronic metabolic stressor: causes, consequences and clinical complications
    • PID: 21320489, COI: 1:CAS:528:DC%2BC38XhsVersLw%3D
    • Reagan L. Diabetes as a chronic metabolic stressor: causes, consequences and clinical complications. Exp Neurol. 2012;233(1):68–78.
    • (2012) Exp Neurol , vol.233 , Issue.1 , pp. 68-78
    • Reagan, L.1
  • 28
    • 84879705689 scopus 로고    scopus 로고
    • Effects of diabetes on hippocampal neurogenesis: links to cognition and depression
    • PID: 23680701, COI: 1:CAS:528:DC%2BC3sXhsFCqt7rP
    • Ho N, Sommers MS, Lucki I. Effects of diabetes on hippocampal neurogenesis: links to cognition and depression. Neurosci Biobehav Rev. 2013;37:1346–62.
    • (2013) Neurosci Biobehav Rev , vol.37 , pp. 1346-1362
    • Ho, N.1    Sommers, M.S.2    Lucki, I.3
  • 29
    • 57749179191 scopus 로고    scopus 로고
    • The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression
    • COI: 1:CAS:528:DC%2BD1MXhvVOjsro%3D
    • Maes M, Yirmyia R, Noraberg J, Brene S, Hibbein J, Perini G, et al. The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression. Metab Brain Dysfunct. 2009;24:27–53.
    • (2009) Metab Brain Dysfunct , vol.24 , pp. 27-53
    • Maes, M.1    Yirmyia, R.2    Noraberg, J.3    Brene, S.4    Hibbein, J.5    Perini, G.6
  • 30
    • 79952591317 scopus 로고    scopus 로고
    • A new chapter in the field of memory: adult hippocampal neurogenesis
    • PID: 21395854
    • Koehl M, Abrous DN. A new chapter in the field of memory: adult hippocampal neurogenesis. Eur J Neurosci. 2011;33:1101–14.
    • (2011) Eur J Neurosci , vol.33 , pp. 1101-1114
    • Koehl, M.1    Abrous, D.N.2
  • 32
    • 33745941592 scopus 로고    scopus 로고
    • The inflammatory consequences of psychologic stress: relationship to insulin resistance, obesity, atherosclerosis and diabetes, type II
    • PID: 16781084, COI: 1:CAS:528:DC%2BD28XntFShtLk%3D
    • Black P. The inflammatory consequences of psychologic stress: relationship to insulin resistance, obesity, atherosclerosis and diabetes, type II. Med Hypotheses. 2006;67:879–91.
    • (2006) Med Hypotheses , vol.67 , pp. 879-891
    • Black, P.1
  • 33
    • 0042234050 scopus 로고    scopus 로고
    • The inflammatory response is an integral part of the stress response: implications for atherosclerosis, insulin resistance, type II diabetes and metabolic syndrome X
    • PID: 12946657, COI: 1:CAS:528:DC%2BD3sXmslegsb8%3D
    • Black PH. The inflammatory response is an integral part of the stress response: implications for atherosclerosis, insulin resistance, type II diabetes and metabolic syndrome X. Brain Behav Immun. 2003;17(5):350–64.
    • (2003) Brain Behav Immun , vol.17 , Issue.5 , pp. 350-364
    • Black, P.H.1
  • 34
    • 33846234579 scopus 로고    scopus 로고
    • Protective and damaging effects of stress mediators: central role of the brain
    • PID: 17290796
    • McEwen BS. Protective and damaging effects of stress mediators: central role of the brain. Dialogues Clin Neurosci. 2006;8:367–81.
    • (2006) Dialogues Clin Neurosci , vol.8 , pp. 367-381
    • McEwen, B.S.1
  • 35
    • 38049123500 scopus 로고    scopus 로고
    • Volumetric neuroimaging investigations in mood disorders: bipolar disorder versus major depressive disorder
    • PID: 18199239
    • Konarski JZ, McIntyre RS, Kennedy SH, Rafi-Tari S, Soczynska JK, Ketter TA, et al. Volumetric neuroimaging investigations in mood disorders: bipolar disorder versus major depressive disorder. Bipolar Disord. 2008;10:1–37.
    • (2008) Bipolar Disord , vol.10 , pp. 1-37
    • Konarski, J.Z.1    McIntyre, R.S.2    Kennedy, S.H.3    Rafi-Tari, S.4    Soczynska, J.K.5    Ketter, T.A.6
  • 36
    • 76649131622 scopus 로고    scopus 로고
    • Volumetric MRI studies of the hippocampus in major depressive disorder: meanings of inconsistency and directions for future research
    • PID: 19347777
    • Eker C, Gonul AS. Volumetric MRI studies of the hippocampus in major depressive disorder: meanings of inconsistency and directions for future research. World J Biol Psychiatry. 2010;11:19–35.
    • (2010) World J Biol Psychiatry , vol.11 , pp. 19-35
    • Eker, C.1    Gonul, A.S.2
  • 37
    • 33646832026 scopus 로고    scopus 로고
    • An update on regional brain volume differences associated with mood disorders
    • Campbell S, MacQueen G. An update on regional brain volume differences associated with mood disorders. Curr Opin Psychiatr. 2006;19(1):25–33.
    • (2006) Curr Opin Psychiatr , vol.19 , Issue.1 , pp. 25-33
    • Campbell, S.1    MacQueen, G.2
  • 39
    • 34548854760 scopus 로고    scopus 로고
    • Caloric restriction increases learning consolidation and facilitates synaptic plasticity through mechanisms dependent on NR28 subunits of the NMDA receptor
    • PID: 17881524, COI: 1:CAS:528:DC%2BD2sXhtFahsbfO
    • Fontan-Lozano A, Saez-Cassanelli JL, Inda MC, de los Santos-Artaga M, Sierra-Dominguez SA, Lopez-Lluch G, et al. Caloric restriction increases learning consolidation and facilitates synaptic plasticity through mechanisms dependent on NR28 subunits of the NMDA receptor. J Neurosci. 2007;27:10185–95.
    • (2007) J Neurosci , vol.27 , pp. 10185-10195
    • Fontan-Lozano, A.1    Saez-Cassanelli, J.L.2    Inda, M.C.3    de los Santos-Artaga, M.4    Sierra-Dominguez, S.A.5    Lopez-Lluch, G.6
  • 40
    • 0035968544 scopus 로고    scopus 로고
    • Episodic-like memory in animals: psychological criteria, neural mechanisms and the value of episodic-like tasks to investigate animal models of neurodegenerative disease
    • PID: 11571036, COI: 1:STN:280:DC%2BD3MrisVektA%3D%3D
    • Morris RG. Episodic-like memory in animals: psychological criteria, neural mechanisms and the value of episodic-like tasks to investigate animal models of neurodegenerative disease. Philos Trans R Soc Lond B Biol Sci. 2001;356:1453–65.
    • (2001) Philos Trans R Soc Lond B Biol Sci , vol.356 , pp. 1453-1465
    • Morris, R.G.1
  • 41
    • 84878757053 scopus 로고    scopus 로고
    • Cognitive deficits and functional outcomes in major depressive disorder: determinants, substrates, and treatment interventions
    • PID: 23468126, One of the most comprehensive reviews of cognitive deficits and functional outcomes in depression
    • McIntyre RS, Cha DS, Soczynska JK, Woldeyohannes HO, Gallaugher LA, Kudlow P, et al. Cognitive deficits and functional outcomes in major depressive disorder: determinants, substrates, and treatment interventions. Depression Anxiety. 2013;30:515–27. One of the most comprehensive reviews of cognitive deficits and functional outcomes in depression.
    • (2013) Depression Anxiety , vol.30 , pp. 515-527
    • McIntyre, R.S.1    Cha, D.S.2    Soczynska, J.K.3    Woldeyohannes, H.O.4    Gallaugher, L.A.5    Kudlow, P.6
  • 42
    • 0347719366 scopus 로고    scopus 로고
    • Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer’s dementia
    • PID: 14688411, COI: 1:CAS:528:DC%2BD2cXjvFamtg%3D%3D
    • Reiman EM, Chen K, Alexander GE, et al. Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer’s dementia. Proc Natl Acad Sci U S A. 2004;101:284–9.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 284-289
    • Reiman, E.M.1    Chen, K.2    Alexander, G.E.3
  • 43
    • 76849104065 scopus 로고    scopus 로고
    • Amyloid plaques disrupt resting state default mode network connectivity in cognitively normal elderly
    • PID: 19833321, COI: 1:CAS:528:DC%2BC3cXisF2hs7g%3D
    • Sheline YI, Raichle ME, Snyder AZ, et al. Amyloid plaques disrupt resting state default mode network connectivity in cognitively normal elderly. Biol Psychiatry. 2010;67:584–7.
    • (2010) Biol Psychiatry , vol.67 , pp. 584-587
    • Sheline, Y.I.1    Raichle, M.E.2    Snyder, A.Z.3
  • 44
    • 78650188989 scopus 로고    scopus 로고
    • Regional cortical gray matter thickness differences associated with type 2 diabetes and major depression
    • PID: 20832254, Demonstrated that volumetric changes were greatest among patients with T2D + MDD compared to other groups/controls; one of only a few recent investigations to collect data from patients with both T2D + MDD
    • Ajilore O, Narr K, Rosenthal J, Pham D, Hamilton L, Watari K, et al. Regional cortical gray matter thickness differences associated with type 2 diabetes and major depression. Psychiatry Res. 2010;184(2):63–70. Demonstrated that volumetric changes were greatest among patients with T2D + MDD compared to other groups/controls; one of only a few recent investigations to collect data from patients with both T2D + MDD.
    • (2010) Psychiatry Res , vol.184 , Issue.2 , pp. 63-70
    • Ajilore, O.1    Narr, K.2    Rosenthal, J.3    Pham, D.4    Hamilton, L.5    Watari, K.6
  • 45
    • 79952985772 scopus 로고    scopus 로고
    • High-sensitivity C-reactive protein is associated with hippocampus volume in nondementia patients with type 2 diabetes
    • PID: 20537668, COI: 1:CAS:528:DC%2BC3MXjsV2gsL8%3D
    • Anan F, Masaki T, Shimomura T, Fujiki M, Umeno Y, Eshima N, et al. High-sensitivity C-reactive protein is associated with hippocampus volume in nondementia patients with type 2 diabetes. Metab Clin Exp. 2011;60:460–6.
    • (2011) Metab Clin Exp , vol.60 , pp. 460-466
    • Anan, F.1    Masaki, T.2    Shimomura, T.3    Fujiki, M.4    Umeno, Y.5    Eshima, N.6
  • 46
    • 77956083626 scopus 로고    scopus 로고
    • & jaap Kappelle, L et al.: progression of cerebral atrophy and white matter hyperintensities in patients with type 2 diabetes
    • PID: 20299484
    • de Bresser J, Tiehuis AM, van den Berg E, Reijmer YD, Jongen C. & jaap Kappelle, L et al.: progression of cerebral atrophy and white matter hyperintensities in patients with type 2 diabetes. Diabetes Care. 2010;33:1309–14.
    • (2010) Diabetes Care , vol.33 , pp. 1309-1314
    • de Bresser, J.1    Tiehuis, A.M.2    van den Berg, E.3    Reijmer, Y.D.4    Jongen, C.5
  • 47
    • 67349239395 scopus 로고    scopus 로고
    • Blunted cortisol awakening response and hippocampal atrophy in type 2 diabetes
    • COI: 1:CAS:528:DC%2BD1MXltlChsrg%3D
    • Bruehl H, Wolf OT, Convit AA. Blunted cortisol awakening response and hippocampal atrophy in type 2 diabetes. Psychoneuroendocrinology. 2009a;34(6):815–21.
    • (2009) Psychoneuroendocrinology , vol.34 , Issue.6 , pp. 815-821
    • Bruehl, H.1    Wolf, O.T.2    Convit, A.A.3
  • 48
    • 67649421600 scopus 로고    scopus 로고
    • Modifiers of cognitive function and brain structure in middle-aged and elderly individuals with type 2 diabetes
    • PID: 19463794, COI: 1:CAS:528:DC%2BD1MXnsFahsrw%3D
    • Bruehl H, Wolf OT, Sweat V, Tirsi A, Richardson S, Convit A. Modifiers of cognitive function and brain structure in middle-aged and elderly individuals with type 2 diabetes. Brain Res. 2009;1280:186–94.
    • (2009) Brain Res , vol.1280 , pp. 186-194
    • Bruehl, H.1    Wolf, O.T.2    Sweat, V.3    Tirsi, A.4    Richardson, S.5    Convit, A.6
  • 50
    • 84899826730 scopus 로고    scopus 로고
    • Multi-scale glycemic variability: a link to gray matter atrophy and cognitive decline in type 2 diabetes
    • PID: 24475100
    • Cui X, Abduljalil A, Manor BD, Peng C, Novak V. Multi-scale glycemic variability: a link to gray matter atrophy and cognitive decline in type 2 diabetes. PLoS One. 2014;9(1):e86284.
    • (2014) PLoS One , vol.9 , Issue.1 , pp. e86284
    • Cui, X.1    Abduljalil, A.2    Manor, B.D.3    Peng, C.4    Novak, V.5
  • 52
    • 84874443519 scopus 로고    scopus 로고
    • Macro- and microstructural magnetic resonance imaging indices associated with diabetes among community-dwelling older adults
    • PID: 23160721, Provides results on structural abnormalities in T2D patients compared to controls using one of the largest population-based studies to date, the Healthy, Aging, and Body Composition Study
    • Falvey CM, Rosano C, Simonsick EM, Harris T, Strotmeyer ES, Satterfield S. Macro- and microstructural magnetic resonance imaging indices associated with diabetes among community-dwelling older adults. Diabetes Care. 2013;36:677–82. Provides results on structural abnormalities in T2D patients compared to controls using one of the largest population-based studies to date, the Healthy, Aging, and Body Composition Study.
    • (2013) Diabetes Care , vol.36 , pp. 677-682
    • Falvey, C.M.1    Rosano, C.2    Simonsick, E.M.3    Harris, T.4    Strotmeyer, E.S.5    Satterfield, S.6
  • 53
    • 84855410053 scopus 로고    scopus 로고
    • Type 2 diabetes affects brain health differentially in men and women
    • Hapel R, Onopa R, Convit A. Type 2 diabetes affects brain health differentially in men and women. Diabetes Metab Res Rev. 2012;28(1):76–83.
    • (2012) Diabetes Metab Res Rev , vol.28 , Issue.1 , pp. 76-83
    • Hapel, R.1    Onopa, R.2    Convit, A.3
  • 54
    • 81255127489 scopus 로고    scopus 로고
    • Association of cognitive dysfunction with hippocampal atrophy in elderly Japanese people with type 2 diabetes
    • Hayaski K, Kurioka S, Yamaguchi T, Morita M, Kanazawa I, Takase H, et al. Association of cognitive dysfunction with hippocampal atrophy in elderly Japanese people with type 2 diabetes. Diabetes Res Clin Pract. 2011;94:180–5.
    • (2011) Diabetes Res Clin Pract , vol.94 , pp. 180-185
    • Hayaski, K.1    Kurioka, S.2    Yamaguchi, T.3    Morita, M.4    Kanazawa, I.5    Takase, H.6
  • 55
    • 77955477398 scopus 로고    scopus 로고
    • Potential hippocampal region atrophy in diabetes type 2: a voxel-based morphometry VSRAD study
    • PID: 20512543
    • Kamiyama K, Wada A, Suqihara M, Kurioka S, Hayashi K, Hayashi T, et al. Potential hippocampal region atrophy in diabetes type 2: a voxel-based morphometry VSRAD study. Jpn J Radiol. 2010;28(4):266–72.
    • (2010) Jpn J Radiol , vol.28 , Issue.4 , pp. 266-272
    • Kamiyama, K.1    Wada, A.2    Suqihara, M.3    Kurioka, S.4    Hayashi, K.5    Hayashi, T.6
  • 56
    • 61449087416 scopus 로고    scopus 로고
    • Focal subcortical biophysical abnormalities in patients diagnosed with type 2 diabetes and depression
    • PID: 19255382
    • Kumar A, Gupta R, Thomas A, Ajilore O, Hellemann G. Focal subcortical biophysical abnormalities in patients diagnosed with type 2 diabetes and depression. Arch Gen Psychiatry. 2009;66(3):324–30.
    • (2009) Arch Gen Psychiatry , vol.66 , Issue.3 , pp. 324-330
    • Kumar, A.1    Gupta, R.2    Thomas, A.3    Ajilore, O.4    Hellemann, G.5
  • 57
    • 84864282148 scopus 로고    scopus 로고
    • Association between hippocampal volume and serum adiponectin in patients with type 2 diabetes
    • PID: 22405025, COI: 1:CAS:528:DC%2BC38XjsFKru70%3D
    • Masaki T, Anan F, Shimomura T, Fujiki M, Saikawa T, Yoshimatsu H. Association between hippocampal volume and serum adiponectin in patients with type 2 diabetes. Metab Clin Exp. 2012;61:1197–200.
    • (2012) Metab Clin Exp , vol.61 , pp. 1197-1200
    • Masaki, T.1    Anan, F.2    Shimomura, T.3    Fujiki, M.4    Saikawa, T.5    Yoshimatsu, H.6
  • 58
    • 84857097475 scopus 로고    scopus 로고
    • Adhesion molecules, altered vasoreactivity, and brain atrophy in type 2 diabetes
    • PID: 21926285
    • Novak V, Zhao P, Manor B, Sejdic E, Alsop D, Abduljalil A, et al. Adhesion molecules, altered vasoreactivity, and brain atrophy in type 2 diabetes. Diabetes Care. 2011;34:2438–41.
    • (2011) Diabetes Care , vol.34 , pp. 2438-2441
    • Novak, V.1    Zhao, P.2    Manor, B.3    Sejdic, E.4    Alsop, D.5    Abduljalil, A.6
  • 59
    • 80054896120 scopus 로고    scopus 로고
    • Association of metabolic dysregulation with volumetric brain magnetic resonance imaging and cognitive markers of subclinical brain aging in middle-aged adults
    • PID: 21680719
    • Tan ZS, Beiser AS, Fox CS, Au R, Himali JJ, Debette S. Association of metabolic dysregulation with volumetric brain magnetic resonance imaging and cognitive markers of subclinical brain aging in middle-aged adults. Diabetes Care. 2011;34:1766–70.
    • (2011) Diabetes Care , vol.34 , pp. 1766-1770
    • Tan, Z.S.1    Beiser, A.S.2    Fox, C.S.3    Au, R.4    Himali, J.J.5    Debette, S.6
  • 62
    • 84865467874 scopus 로고    scopus 로고
    • Resting-state brain functional connectivity is altered in type 2 diabetes
    • PID: 22664957, COI: 1:CAS:528:DC%2BC38XhtlantbfL
    • Musen G, Jacobson AM, Bolo NR, Simonson DC, Shenton ME, McCartney RL, et al. Resting-state brain functional connectivity is altered in type 2 diabetes. Diabetes. 2012;61:2375–9.
    • (2012) Diabetes , vol.61 , pp. 2375-2379
    • Musen, G.1    Jacobson, A.M.2    Bolo, N.R.3    Simonson, D.C.4    Shenton, M.E.5    McCartney, R.L.6
  • 63
    • 77950629977 scopus 로고    scopus 로고
    • Impairments in cognition and resting-state connectivity of the hippocampus in elderly subjects with type 2 diabetes
    • PID: 20123114, COI: 1:CAS:528:DC%2BC3cXjslSktbs%3D
    • Zhou H, Lu W, Shi Y, Bai F, Chang J, Yuan Y, et al. Impairments in cognition and resting-state connectivity of the hippocampus in elderly subjects with type 2 diabetes. Neurosci Lett. 2010;473:5–10.
    • (2010) Neurosci Lett , vol.473 , pp. 5-10
    • Zhou, H.1    Lu, W.2    Shi, Y.3    Bai, F.4    Chang, J.5    Yuan, Y.6
  • 65
    • 0037356826 scopus 로고    scopus 로고
    • The role of the novel adipocyte-derived hormone adiponectin in human disease
    • PID: 12611609, COI: 1:CAS:528:DC%2BD3sXis1amt7k%3D
    • Diez JJ, Iglesias P. The role of the novel adipocyte-derived hormone adiponectin in human disease. Eur J Endocrinol. 2003;148(3):293–300.
    • (2003) Eur J Endocrinol , vol.148 , Issue.3 , pp. 293-300
    • Diez, J.J.1    Iglesias, P.2
  • 66
    • 0037469177 scopus 로고    scopus 로고
    • Clinical application of C-reactive protein for cardiovascular disease detection and prevention
    • PID: 12551853
    • Ridker PM. Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Circulation. 2003;107:363–9.
    • (2003) Circulation , vol.107 , pp. 363-369
    • Ridker, P.M.1
  • 67
    • 85035889243 scopus 로고    scopus 로고
    • Wong RHX, Scholey A, Howe, PRC. Assessing premorbid cognitive ability in adults with type 2 diabetes mellitus: a review with implications for future intervention studies. (In Press)
    • Wong RHX, Scholey A, Howe, PRC. Assessing premorbid cognitive ability in adults with type 2 diabetes mellitus: a review with implications for future intervention studies. Curr Diab Rep. (In Press).
    • Curr Diab Rep.
  • 69
    • 9644291424 scopus 로고    scopus 로고
    • The relationship between impaired glucose tolerance, type 2 diabetes, and cognitive function
    • PID: 15590460
    • Awad N, Gagnon M, Messier C. The relationship between impaired glucose tolerance, type 2 diabetes, and cognitive function. J Clin Exp Neuropsychol. 2004;26(8):1044–80.
    • (2004) J Clin Exp Neuropsychol , vol.26 , Issue.8 , pp. 1044-1080
    • Awad, N.1    Gagnon, M.2    Messier, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.