The diagnostic utility of 99mTc-HMPAO SPECT imaging: A retrospective case series from a tertiary referral early-onset cognitive disorders clinic

Dementia and Geriatric Cognitive Disorders

Volumn 39, Issue 3-4, 2015, Pages 186-193

  Swan, Amanda ^a   Waddell, Briony ^c   Holloway, Guy ^b,d   Bak, Thomas ^b   Colville, Shuna ^b   Khan, Zubair ^d   Pal, Suvankar ^b,c  

^a College of Medicine and Veterinary Medicine ^*  (United States)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c Western General Hospital   (United States)

^d NHS LOTHIAN   (United Kingdom)

Author keywords

Alzheimer's disease; Early onset dementia; SPECT imaging; Structural imaging modalities

Indexed keywords

HEXAMETHYLPROPYLENE AMINE OXIME TECHNETIUM TC 99M; RADIOPHARMACEUTICAL AGENT;

ADULT; ALZHEIMER DISEASE; ARTICLE; BRAIN ATROPHY; BRAIN METABOLISM; BRAIN PERFUSION; CLINICAL EVALUATION; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TERTIARY CARE CENTER; AGED; ATROPHY; BRAIN; COGNITION; DEMENTIA; DIAGNOSTIC USE; IMAGE PROCESSING; PATHOLOGY; PATHOPHYSIOLOGY; SCINTISCANNING;

AGED; ALZHEIMER DISEASE; ATROPHY; BRAIN; COGNITION; DEMENTIA; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; RADIOPHARMACEUTICALS; RETROSPECTIVE STUDIES; TECHNETIUM TC 99M EXAMETAZIME; TERTIARY CARE CENTERS; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 84920861011     PISSN: 14208008     EISSN: 14219824     Source Type: Journal    
DOI: 10.1159/000369551     Document Type: Article

References (41)

1. Chan KY, Wang W, Wu JJ, Liu L, Theodoratou E, Car J, Middleton L, Russ TC, Deary IJ, Campbell H, Rudan I; Global Health Epidemiology Reference Group: Epidemiology of Alzheimer's disease and other forms of dementia in China, 1990-2010: A systematic review and analysis. Lancet 2013; 381: 2016-2023.
2. McMurtray A, Clark DG, Christine D, Mendez MF: Early-onset dementia: frequency and causes compared to late-onset dementia. Dement Geriatr Cogn Disord 2006; 21: 59-64.
3. Kelley BJ, Boeve BF, Josephs KA: Young-onset dementia demographic and etiologic characteristics of 235 patients. Arch Neurol 2008; 65: 1502-1508.
4. Schneider JA, Arvanitakis Z, Bang W, Bennett DA: Mixed brain pathologies account for most dementia cases in community-dwelling older persons. Neurology 2007; 69: 2197-2204.
5. McGinnis SM: Neuroimaging in neurodegenerative dementias. Semin Neurol 2012; 32: 347-360.
6. Masellis M, Sherborn K, Neto PR, Sadovnick DA, Hsiung GYR, Black SE, Prasad S, Williams M, Gauthier S: Early-onset dementias: diagnostic and etiological considerations. Alzheimers Res Ther 2013; 5(suppl 1):S7.
7. Greig NH, Lahiri DK, Giacobini E: Editorial: Advances in Alzheimer therapy: something old, something new, something borrowed, something blue. Curr Alzheimer Res 2005; 2: 275-279.
8. Karran E, Hardy J: Antiamyloid therapy for Alzheimer's disease-are we on the right road? N Engl J Med 2014; 370: 377-378.
9. Beach TG, Monsell SE, Phillips LE, Kukull W: Accuracy of the clinical diagnosis of Alzheimer disease at National Institute on Aging Alzheimer Disease Centers, 2005-2010. J Neuropathol Exp Neurol 2012; 71: 266-273.
10. Pimlott SL, Ebmeier KP: SPECT imaging in dementia. Br J Radiol 2007; 80:S153-S159.
11. Chen YJ, Deutsch G, Satya R, Liu HG, Mountz JM: A semi-quantitative method for correlating brain disease groups with normal controls using SPECT: Alzheimer's disease versus vascular dementia. Comput Med Imaging Graph 2013; 37: 40-47.
12. Smith GS, Deleon MJ, George AE, Kluger A, Volkow ND, McRae T, Golomb J, Ferris SH, Reisberg B, Ciaravino J, et al: Topography of cross-sectional and longitudinal glucose metabolic deficits in Alzheimer's-disease. Pathophysiologic implications. Arch Neurol 1992; 49: 1142-1150.
13. Yeo JM, Lim X, Khan Z, Pal S: Systematic review of the diagnostic utility of SPECT imaging in dementia. Eur Arch Psychiatry Clin Neurosci 2013; 263: 539-552.
14. Dougall NJ, Bruggink S, Ebmeier KP: Systematic review of the diagnostic accuracy of 99mTcm-HMPAO-SPECT in dementia. Am J Geriatr Psychiatry 2004; 12: 554-570.
15. Reiman EM, Chen KW, Alexander GE, Caselli RJ, Bandy D, Osborne D, Saunders AM, Hardy J: Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia. Proc Natl Acad Sci USA 2004; 101: 284-289.
16. Scheltens P, Launer LJ, Barkhof F, Weinstein HC, Jonker C: The diagnostic value of magnetic resonance imaging and technetium 99m HMPAO single-photon-emission computed tomography for the diagnosis of Alzheimer disease in a community-dwelling elderly population. Alzheimer Dis Assoc Disord 1997; 11: 63-70.
17. Johnson KA, Kijewski MF, Becker JA, Garada B, Satlin A, Holman BL: Quantitative brain SPECT in Alzheimer's disease and normal aging. J Nucl Med 1993; 34: 2044-2048.
18. Varma AR, Adams W, Lloyd JJ, Carson KJ, Snowden JS, Testa HJ, Jackson A, Neary D: Diagnostic patterns of regional atrophy on MRI and regional cerebral blood flow change on SPECT in young onset patients with Alzheimer's disease, frontotemporal dementia and vascular dementia. Acta Neurol Scand 2002; 105: 261-269.
19. McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR Jr, Kawas CH, Klunk WE, Koroshetz WJ, Manly JJ, Mayeux R, Mohs RC, Morris JC, Rossor MN, Scheltens P, Carrillo MC, Thies B, Weintraub S, Phelps CH: The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011; 7: 263-269.
20. Brun A, Englund B, Gustafson L, Passant U, Mann DMA, Neary D, Snowden JS: Clinical and neuropathological criteria for frontotemporal dementia. J Neurol Neurosurg Psychiatry 1994; 57: 416-418.
21. Rascovsky K, Hodges JR, Knopman D, Mendez MF, Kramer JH, Neuhaus J, van Swieten JC, Seelaar H, Dopper EGP, Onyike CU, Hillis AE, Josephs KA, Boeve BF, Kertesz A, Seeley WW, Rankin KP, Johnson JK, Gorno-Tempini ML, Rosen H, Prioleau-Latham CE, Lee A, Kipps CM, Lillo P, Piguet O, Rohrer JD, Rossor MN, Warren JD, Fox NC, Galasko D, Salmon DP, Black SE, Mesulam M, Weintraub S, Dickerson BC, Diehl-Schmid J, Pasquier F, Deramecourt V, Lebert F, Pijnenburg Y, Chow TW, Manes F, Grafman J, Cappa SF, Freedman M, Grossman M, Miller BL: Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain 2011; 134: 2456-2477.
22. Erkinjuntti T: Clinical criteria for vascular dementia-the NINDS-AIREN criteria. Dementia 1994; 5: 189-192.
23. McKeith IG, Galasko D, Kosaka K, Perry EK, Dickson DW, Hansen LA, Salmon DP, Lowe J, Mirra SS, Byrne EJ, Lennox G, Quinn NP, Edwardson JA, Ince PG, Bergeron C, Burns A, Miller BL, Lovestone S, Collerton D, Jansen ENH, Ballard C, de Vos RAI, Wilcock GK, Jellinger KA, Perry RH: Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology 1996; 47: 1113-1124.
24. Knopman DS, DeKosky ST, Cummings JL, Chui H, Corey-Bloom J, Relkin N, Small GW, Miller B, Stevens JC: Practice parameter: diagnosis of dementia (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2001; 56: 1143-1153.
25. Jack CR Jr, Albert MS, Knopman DS, McKhann GM, Sperling RA, Carrillo MC, Thies B, Phelps CH: Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011; 7: 257-262.
26. Jack CR, Knopman DS, Jagust WJ, Shaw LM, Aisen PS, Weiner MW, Petersen RC, Trojanowski JQ: Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade. Lancet Neurol 2010; 9: 119-128.
27. Hort J, O'Brien JT, Gainotti G, Pirttila T, Popescu BO, Rektorova I, Sorbi S, Scheltens P; EFNS Scientist Panel on Dementia: EFNS guidelines for the diagnosis and management of Alzheimer's disease. Eur J Neurol 2010; 17: 1236-1248.
28. Fairbairn A, Gould N, Kendall T, et al: Dementia-Supporting People with Dementia and Their Carers in Health and Social Care. NICE Guideline 42. London, National Institute for Health and Clinical Excellence, 2006.
29. McNeill R, Sare GM, Manoharan M, Testa HJ, Mann DMA, Neary D, Snowden JS, Varma AR: Accuracy of singlephoton emission computed tomography in differentiating frontotemporal dementia from Alzheimer's disease. J Neurol Neurosurg Psychiatry 2007; 78: 350-355.
30. deFigueiredo RJP, Shankle WR, Maccato A, Dick MB, Mundkur P, Mena I, Cotman CW: Neural-network-based classification of cognitively normal, demented, Alzheimer disease and vascular dementia from single photon emission with computed tomography image data from brain. Proc Natl Acad Sci USA 1995; 92: 5530-5534.
31. Murray ME, Graff-Radford NR, Ross OA, Petersen RC, Duara R, Dickson DW: Neuropathologically defined subtypes of Alzheimer's disease with distinct clinical characteristics: A retrospective study. Lancet Neurol 2011; 10: 785-796.
32. Jagust W, Thisted R, Devous MD, Van Heertum R, Mayberg H, Jobst K, Smith AD, Borys N: SPECT perfusion imaging in the diagnosis of Alzheimer's disease: A clinical-pathologic study. Neurology 2001; 56: 950-956.
33. Bonte FJ, Weiner MF, Bigio EH, White CL: Brain blood flow in the dementias: SPECT with histopathologic correlation in 54 patients. Radiology 1997; 202: 793-797.
34. Ebmeier KP: Is there still a place for perfusion SPECT in the diagnosis of dementia? Open Nucl Med J 2010; 2: 40-45.
35. Silverman DHS: Brain F-18-FDG PET in the diagnosis of neurodegenerative dementias: comparison with perfusion SPECT and with clinical evaluations lacking nuclear imaging. J Nucl Med 2004; 45: 594-607.
36. Murray AD: Imaging approaches for dementia. AJNR AM J Neuroradiol 2012; 33: 1836-1844.
37. Davatzikos C, Resnick SM, Wu X, Parmpi P, Clark CM: Individual patient diagnosis of AD and FTD via highdimensional pattern classification of MRI. Neuroimage 2008; 41: 1220-1227.
38. Boutoleau-Bretonnière C, Lebouvier T, Delaroche O, Lamy E, Evrard C, Charriau T, Bretonniere C, Damier P, Derkinderen P, Vercelletto M: Value of neuropsychological testing, imaging, and CSF biomarkers for the differential diagnosis and prognosis of clinically ambiguous dementia. J Alzheimers Dis 2012; 28: 323-336.
39. Pasquier F, Lavenu I, Lebert F, Jacob B, Steinling M, Petit H: The use of SPECT in a multidisciplinary memory clinic. Dement Geriatr Cogn Disord 1997; 8: 85-91.
40. Huang CR, Wahlund LO, Almkvist O, Elehu D, Svensson L, Jonsson T, Winblad B, Julin P: Voxel-and VOI-based analysis of SPECT CBF in relation to clinical and psychological heterogeneity of mild cognitive impairment. Neuroimage 2003; 19: 1137-1144.
41. Van Laere KJ, Warwick J, Versijpt J, Goethals I, Audenaert K, Van Heerden B, Dierckx R: Analysis of clinical brain SPECT data based on anatomic standardization and reference to normal data: An ROC-based comparison of visual, semiquantitative, and voxel-based methods. J Nucl Med 2002; 43: 458-469.