Development of first lead structures for phosphoinositide 3-kinase-c2γ inhibitors

Journal of Medicinal Chemistry

Volumn 58, Issue 1, 2015, Pages 212-221

  Freitag, Anne ^a   Prajwal, Prajwal ^a   Shymanets, Aliaksei ^a   Harteneck, Christian ^a   Nürnberg, Bernd ^a   Schächtele, Christoph ^b   Kubbutat, Michael ^b   Totzke, Frank ^b   Laufer, Stefan A ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b PROQINASE GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 (ACETYLAMINO)ISONICOTINIC ACID; 3 AMINO N [3 [(2 CHLORO 5 METHOXYPHENYL)AMINO]PYRAZIN 2 YL]BENZENESULFONAMIDE; 3 CHLORO N (2 CHLORO 5 METHOXYPHENYL)PYRAZIN 2 AMINE; 3 [[[3 [(2 CHLORO 5 METHOXYPHENYL)AMINO]PYRAZIN 2 YL]AMINO]SULFONYL]BENZOIC ACID; CBZ N [3 [[[3 [(2 CHLORO 5 METHOXYPHENYL)AMINO]PYRAZIN 2 YL]AMINO]SULFONYL]PHENYL] 2 METHYLALANINAMIDE; METHYL 3 CHLOROSULFONYLBENZOATE; METHYL 3 [[[3 [(2 CHLORO 5 METHOXYPHENYL)AMINO]PYRAZIN 2 YL]AMINO]SULFONYL]BENZOATE; N (2 CHLORO 5 METHOXYPHENYL)PYRAZIN 2,3 DIAMINE; N (2 CHLORO 5 METHOXYPHENYL)TETRAZOLO[1,5A]PYRAZIN 8 AMINE; N (4 AMINOPYRIDIN 2 YL)ACETAMIDE; N [3 [(2 CHLORO 5 METHOXYPHENYL)AMINO]PYRAZIN 2 YL] 3 NITROBENZENESULFONAMIDE; N [3 [(2 CHLORO 5 METHOXYPHENYL)AMINO]PYRAZIN 2 YL]BENZENESULFONAMIDE; N [3 [[[3 [(2 CHLORO 5 METHOXYPHENYL)AMINO]PYRAZIN 2 YL]AMINO]SULFONYL]PHENYL] 2 METHYLALANINAMIDE; N [3 [[[3 [(2 CHLORO 5 METHOXYPHENYL)AMINO]PYRAZIN 2 YL]AMINO]SULFONYL]PHENYL]ACETAMIDE; PHOSPHATIDYLINOSITOL 3 KINASE C2 GAMMA INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; TERT BUTYL 2 (ACETYLAMINO)PYRIDIN 4 YLCARBAMATE; UNCLASSIFIED DRUG; BENZENESULFONAMIDE; PHOSPHATIDYLINOSITOL 4 PHOSPHATE 3 KINASE; PROTEIN KINASE INHIBITOR; PYRAZINE DERIVATIVE; SULFONAMIDE;

ARTICLE; BIOLOGICAL FUNCTIONS; DOSE RESPONSE; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; INTRACELLULAR SIGNALING; SECOND MESSENGER; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DEVELOPMENT; HUMAN; METABOLISM; SYNTHESIS;

ANIMALS; CLASS II PHOSPHATIDYLINOSITOL 3-KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; HUMANS; MODELS, CHEMICAL; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PYRAZINES; SULFONAMIDES;

EID: 84920836361     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm5006034     Document Type: Article

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