Validation of a gas chromatography-triple quadrupole mass spectrometry method for confirmatory analysis of dioxins and dioxin-like polychlorobiphenyls in feed following new EU Regulation 709/2014

Journal of Chromatography A

Volumn 1376, Issue , 2015, Pages 149-158

  L'Homme, B ^a   Scholl, G ^a   Eppe, G ^a   Focant, J F ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Dioxins; EU Regulation 709 2014; Gas chromatography coupled to tandem in space triple quadrupole mass spectrometry (GC QQQMS MS); Validation; Vegetable oil

Indexed keywords

CHEMICAL CONTAMINATION; COMPLIANCE CONTROL; MASS SPECTROMETRY; OIL SHALE; ORGANIC POLLUTANTS; POLYCHLORINATED BIPHENYLS; UNCERTAINTY ANALYSIS; VEGETABLE OILS;

BACKGROUND SUBTRACTION; DIOXINS; EU REGULATIONS; HIGH RESOLUTION MASS SPECTROMETRY; LIMIT OF QUANTITATIONS; MEASUREMENT UNCERTAINTY; TRIPLE-QUADRUPOLE MASS SPECTROMETRY; VALIDATION;

GAS CHROMATOGRAPHY;

DIOXIN; POLYCHLORINATED BIPHENYL; POLYCHLORINATED DIBENZODIOXIN; POLYCHLORINATED DIBENZOFURAN; VEGETABLE OIL; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; POLYCHLORODIBENZO-4-DIOXIN;

ANIMAL FOOD; ARTICLE; CONTROLLED STUDY; EUROPEAN UNION; FOOD ANALYSIS; FOOD CONTROL; GAS CHROMATOGRAPHY; LIMIT OF DETECTION; LIMIT OF QUANTITATION; MEASUREMENT ACCURACY; QUADRUPOLE MASS SPECTROMETRY; REPRODUCIBILITY; VALIDATION PROCESS; ANALOGS AND DERIVATIVES; CHEMISTRY; MASS FRAGMENTOGRAPHY; MASS SPECTROMETRY; PROCEDURES; VALIDATION STUDY;

DIOXINS; EUROPEAN UNION; FOOD ANALYSIS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; MASS SPECTROMETRY; PLANT OILS; POLYCHLORINATED BIPHENYLS; REPRODUCIBILITY OF RESULTS; TETRACHLORODIBENZODIOXIN;

EID: 84920818699     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2014.12.013     Document Type: Article

References (35)

1. Commission Regulation (EC) No 850/2004 of 29 April 2004 on persistent organic pollutants and amending Directive 79/117/EEC. Offic. J. Eur. Commun. 2004, L158/7-49.
2. Travis C.C., Hattemer-Frey H.A. Human exposure to dioxin. Sci. Total Environ. 1991, 104:97-127.
3. Fries G.F. A review of the significance of animal food products as potential pathways of human exposures to dioxins. J. Anim. Sci. 1995, 73:1639-1650.
4. Focant J.-F., Eppe G., Pirard C., Massart A.-C., André J.-E., De Pauw E. Levels and congener distributions of PCDDs, PCDFs and non-ortho PCBs in Belgian foodstuffs: assessment of dietary intake. Chemosphere 2002, 48:167-179.
5. Windal I., Vandevijvere S., Maleki M., Goscinny S., Vinkx C., Focant J.-F., Eppe G., Hanot V., Van Loco J. Dietary intake of PCDD/Fs and dioxin-like PCBs of the Belgian population. Chemosphere 2010, 79:334-340.
6. Van Larebeke N., Hens L., Schepens P., Covaci A., Baeyens J., Everaert K., Bernheim J.L., Vlietinck R., De Poorter G. The Belgian PCB and dioxin incident of January-June 1999: exposure data and potential impact on health. Environ. Health Perspect. 2001, 109:265-273.
7. Focant J.-F. Dioxin food crises and new POPs: challenges in analysis. Anal. Bioanal. Chem. 2012, 403:2797-2800.
8. Council Directive 2001/102/EC of 27 November 2001 amending Directive 1999/29/EC on the undesirable substances and products in animal nutrition. Offic. J. Eur. Commun. 2002, L6/45-49.
9. Council Regulation (EC) No 2375/2001 of 29 November 2001 amending Commission Regulation (EC) No 466/2001 setting maximum levels for certain contaminants in foodstuffs. Offic. J. Eur. Commun. 2001, L321/1-5.
10. Commission Regulation (EC) No 277/2012 of 28 March 2012 amending Annexes I and II to Directive 2002/32/EC of the European Parliament and of the Council as regards maximum levels and action thresholds for dioxins and polychlorinated biphenyls. Offic. J. Eur. Commun. 2012, L91/1-7.
11. Commission Regulation (EU) No 1259/2011 of 2 December 2011 amending Regulation (EC) No 1881/2006 as regards maximum levels for dioxins, dioxin-like PCBs and non dioxin-like PCBs in foodstuffs. Offic. J. Eur. Commun. 2011, L320/18-23.
12. Council Directive 2006/88/EC of 24 October 2006 on animal health requirements for aquaculture animals and products thereof, and on prevention and control of certain diseases in aquatic animals. Offic. J. Eur. Commun. 2006, L328/14-56.
13. Commission Directive 2002/70/EC of 26 July 2002 establishing requirements for the determination of levels of dioxins and dioxin-like PCBs in feedingstuffs. Offic. J. Eur. Commun. 2002, L209/15-21.
14. Commission Regulation (EC) 1881/2006 of 19 December 2006 setting maximum levels for certain contaminants in foodstuffs. Offic. J. Eur. Commun. 2006, L364/5-24.
15. Focant J.-F., Eppe G. Screening and confirmatory methods for the detection of dioxins and polychlorinated biphenyls (PCB) in foods. Persistent Organic Pollutants and Toxic Metals in Foods 2013, 47-80. Woodhead Publishing, Cambridge. M. Rose, A. Fernandes (Eds.).
16. Malisch R., Baumann B., Behnisch P.A., Canady R., Fraisse D., Fürst P., Hayward D., Hoogenboom R., Hoogerbrugge R., Liem D., Päpke O., Traag W., Wiesmüller T. Harmonised quality criteria for chemical and bioassays analyses of PCDDs/PCDFs in feed and food. Part 1: General considerations, GC/MS methods. Organohalogen Compd. 2001, 50:53-58.
17. Behnisch P.A., Allen R., Anderson J., Brouwer A., Brown D.J., Campbell T.C., Goeyens L., Harrison R.O., Hoogenboom R., Van Overmeire I., Traag W., Malisch R. Harmonised quality criteria for chemical and bioassays analyses of PCDDs/PCDFs in feed and food. Part 2: General considerations, bioassay methods. Organohalogen Compd. 2001, 50:59-63.
18. Focant J.-F., Pirard C., Eppe G., De Pauw E. Recent advances in mass spectrometric measurement of dioxins. J. Chromatogr. A 2005, 1067:265-275.
19. Focant J.-F., Eppe G., De Pauw E. Optimisation and use of tandem-in-time mass spectrometry in comparison with immunoassay and HRGC/HRMS for PCDD/F screening. Chemosphere 2001, 43:417-424.
20. Eppe G., Focant J.-F., Pirard C., De Pauw E. PTV-LV-GC/MS/MS as screening and complementary method to HRMS for the monitoring of dioxin levels in food and feed. Talanta 2004, 63:1135-1146.
21. Focant J.-F., Eppe G., Scippo M.-L., Massart A.-C., Pirard C., Maghuin-Rogister G., De Pauw E. Comprehensive two-dimensional gas chromatography with isotope dilution time-of-flight mass spectrometry for the measurement of dioxins and polychlorinated biphenyls in foodstuffs. Comparison with other methods. J. Chromatogr. A 2005, 1086:45-60.
22. Pirard C., De Pauw E., Focant J.-F. Suitability of tandem-in-time mass spectrometry for polybrominated diphenylether measurement in fish and shellfish samples: comparison with high resolution mass spectrometry. J. Chromatogr. A 2006, 1115:125-132.
23. Ingelido A.M., Brambilla G., Abballe A., Di Domenico A., Fulgenzi A.R., Iacovella N., Iamiceli A.L., Valentini S., De Felip E. PCDD, PCDF, AND. DL-PCB analysis in food: performance evaluation of the high-resolution gas chromatography/low-resolution tandem mass spectrometry technique using consensus-based samples. Rapid Commun. Mass Spectrom. 2012, 26:236-242.
24. Garcia-Bermejo A., Abalos M., Saulo J., Abad E., Gonzalez M.J., Gomara B. Feasibility of triple-quadrupole GC-MS/MS as an alternative technique to GC-HRMS for the analysis of PCDD/Fs and DL-PCBs in food and feedstuff samples. Organohalogen Compd. 2011, 73:653-656.
25. Sandy C., Fürst P., Bernsmann T., Baumeister D. Determination of polychlorinated biphenyl congeners in foodstuffs and animal feed using a triple quadrupole GC-MS/MS instrument. Organohalogen Compd. 2011, 73:1370-1371.
26. Kotz A., Malisch R., Wahl K., Bitomsky N., Adamovic K., Gerteisen I., Leswal S., Schächtele J., Tritschler R., Winterhalter H. GC-MS/MS determination of PCDD/Fs and PCBs in feed and food - comparison with GC-HRMS. Organohalogen Compd. 2011, 73:688-691.
27. Kotz A., Malisch R., Focant J.-F., Eppe G., Cederberg T.L., Rantakokko P., Fürst P., Bernsmann T., Leondiadis L., Lovasz C., Scortichini G., Diletti G., Di Domenico A., Ingelido A.M., Traag W., Smith F., Fernandez A. Analytical criteria for use of MS/MS for determination of dioxins and dioxin-like PCBs in feed and food. Organohalogen Compd. 2012, 74:156-159.
28. Commission Regulation (EU) No 252/2012 of 21 March 2012 laying down methods of sampling and analysis for the official control of levels of dioxins, dioxin-like PCBs and non-dioxin-like PCBs in certain foodstuffs and repealing Regulation (EC) No 1883/2006. Offic. J. Eur. Commun. 2012, L84/1-22.
29. Commission Regulation (EC) No 152/2009 of 27 January 2009 laying down the methods of sampling and analysis for the official control of feed. Offic. J. Eur. Commun. 2009, L54/1-130.
30. Commission Regulation (EU) No 589/2014 of 2 June 2014 laying down methods of sampling and analysis for the control of levels of dioxins, dioxin-like PCBs and non-dioxin-like PCBs in certain foodstuffs and repealing Regulation (EU) No 252/2012. Offic. J. Eur. Commun. 2014, L164/18-40.
31. Commission Regulation (EU) No 709/2014 of 20 June 2014 amending Regulation (EC) No 152/2009 as regards the determination of the levels of dioxins and polychlorinated biphenyls. Offic. J. Eur. Commun. 2014, L188/1-18.
32. Focant J.-F., Eppe G., Pirard C., De Pauw E. Fast clean-up for polychlorinated dibenzo-p-dioxins, dibenzofurans and coplanar polychlorinated biphenyls analysis of high-fat-content biological samples. J. Chromatogr. A 2001, 925:207-221.
33. Focant J.-F., Eppe G., Massart A.-C., Scholl G., Pirard C., De Pauw E. High-throughput biomonitoring of dioxins and polychlorinated biphenyls at the sub-picogram level in human serum. J. Chromatogr. A 2006, 1130:97-107.
34. Eppe G., Diletti G., Fernandes A., Haedrich J., Hart J., Hove H., Iamiceli A.L., Kotz A., Malisch R., Marchand P., Moche W., Scholl G., Scortichini G., Bernsmann T., Tondeur Y., Traag W. Measurement uncertainty for persistent organic pollutants by isotope-dilution mass spectroscopy. Organohalogen Compd. 2014, (in press).
35. Eurachem/CITAC Guide: Quantifying Uncertainty in Analytical Measurement 2012, ISBN 978-0-948926-30-3. 3rd ed. S.L.R. Ellison, A. Williams (Eds.).