Regulation of influenza A virus nucleoprotein oligomerization by phosphorylation

Journal of Virology

Volumn 89, Issue 2, 2015, Pages 1452-1455

  Turrell, Lauren ^a   Hutchinson, Edward C ^a   Vreede, Frank T ^a   Fodor, Ervin ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; OLIGORIBONUCLEOTIDE; PLASMID DNA; RNA POLYMERASE; SERINE; VIRUS NUCLEOPROTEIN; VIRUS RNA; CORE PROTEIN; NP PROTEIN, INFLUENZA A VIRUS; RNA BINDING PROTEIN;

AMINO ACID ANALYSIS; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; BACULOVIRUS EXPRESSION SYSTEM; CONTROLLED STUDY; GENE CONTROL; INFLUENZA VIRUS A; MUTATIONAL ANALYSIS; NONHUMAN; OLIGOMERIZATION; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; RESIDUE ANALYSIS; RNA BINDING; VIROGENESIS; VIRUS CELL INTERACTION; VIRUS GENE; VIRUS RECOMBINANT; VNP GENE; WILD TYPE; HUMAN; INFLUENZA A VIRUS (H3N2); METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN MULTIMERIZATION; VIRUS REPLICATION;

INFLUENZA A VIRUS; ORTHOMYXOVIRIDAE;

HUMANS; INFLUENZA A VIRUS, H3N2 SUBTYPE; PHOSPHORYLATION; PROTEIN MULTIMERIZATION; RNA-BINDING PROTEINS; VIRAL CORE PROTEINS; VIRUS REPLICATION;

EID: 84920771817     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02332-14     Document Type: Article

References (19)

1. Arranz R, Coloma R, Chichon FJ, Conesa JJ, Carrascosa JL, Valpuesta JM, Ortin J, Martin-Benito J. 2012. The structure of native influenza virion ribonucleoproteins. Science 338:1634-1637. http://dx.doi.org/10.1126/science.1228172.
2. Moeller A, Kirchdoerfer RN, Potter CS, Carragher B, Wilson IA. 2012. Organization of the influenza virus replication machinery. Science 338: 1631-1634. http://dx.doi.org/10.1126/science.1227270.
3. Fodor E. 2013. The RNA polymerase of influenza a virus: mechanisms of viral transcription and replication. Acta Virol 57:113-122. http://dx.doi.org/10.4149/av_2013_02_113.
4. Resa-Infante P, Jorba N, Coloma R, Ortin J. 2011. The influenza virus RNA synthesis machine: advances in its structure and function. RNA Biol 8:207-215. http://dx.doi.org/10.4161/rna.8.2.14513.
5. Turrell L, Lyall JW, Tiley LS, Fodor E, Vreede FT. 2013. The role and assembly mechanism of nucleoprotein in influenza A virus ribonucleoprotein complexes. Nat Commun 4:1591. http://dx.doi.org/10.1038/ncomms2589.
6. Ng AK, Zhang H, Tan K, Li Z, Liu JH, Chan PK, Li SM, Chan WY, Au SW, Joachimiak A, Walz T, Wang JH, Shaw PC. 2008. Structure of the influenza virus A H5N1 nucleoprotein: implications for RNA binding, oligomerization, and vaccine design. FASEB J 22:3638-3647. http://dx.doi.org/10.1096/fj.08-112110.
7. Ye Q, Krug RM, Tao YJ. 2006. The mechanism by which influenza A virus nucleoprotein forms oligomers and binds RNA. Nature 444:1078-1082. http://dx.doi.org/10.1038/nature05379.
8. Chan WH, Ng AK, Robb NC, Lam MK, Chan PK, Au SW, Wang JH, Fodor E, Shaw PC. 2010. Functional analysis of the influenza virus H5N1 nucleoprotein tail loop reveals amino acids that are crucial for oligomerization and ribonucleoprotein activities. J Virol 84:7337-7345. http://dx.doi.org/10.1128/JVI.02474-09.
9. Elton D, Medcalf E, Bishop K, Digard P. 1999. Oligomerization of the influenza virus nucleoprotein: identification of positive and negative sequence elements. Virology 260:190-200. http://dx.doi.org/10.1006/viro.1999.9818.
10. Chenavas S, Estrozi LF, Slama-Schwok A, Delmas B, Di Primo C, Baudin F, Li X, Crepin T, Ruigrok RW. 2013. Monomeric nucleoprotein of influenza A virus. PLoS Pathog 9:e1003275. http://dx.doi.org/10.1371/journal.ppat.1003275.
11. Tarus B, Bakowiez O, Chenavas S, Duchemin L, Estrozi LF, Bourdieu C, Lejal N, Bernard J, Moudjou M, Chevalier C, Delmas B, Ruigrok RW, Di Primo C, Slama-Schwok A. 2012. Oligomerization paths of the nucleoprotein of influenza A virus. Biochimie 94:776-785. http://dx.doi.org/10.1016/j.biochi.2011.11.009.
12. Hutchinson EC, Denham EM, Thomas B, Trudgian DC, Hester SS, Ridlova G, York A, Turrell L, Fodor E. 2012. Mapping the phosphoproteome of influenza A and B viruses by mass spectrometry. PLoS Pathog 8:e1002993. http://dx.doi.org/10.1371/journal.ppat.1002993.
13. Bieniossek C, Imasaki T, Takagi Y, Berger I. 2012. MultiBac: expanding the research toolbox for multiprotein complexes. Trends Biochem Sci 37:49-57. http://dx.doi.org/10.1016/j.tibs.2011.10.005.
14. O'Reilly DR, Miller LK, Luckow VA. 1994. Post-translational modification, p 216-236. In Baculovirus expression vectors: a laboratory manual. Oxford University Press, Oxford, United Kingdom.
15. Ye Q, Guu TS, Mata DA, Kuo RL, Smith B, Krug RM, Tao YJ. 2012. Biochemical and structural evidence in support of a coherent model for the formation of the double-helical influenza A virus ribonucleoprotein. mBio 4:e00467-12. http://dx.doi.org/10.1128/mBio.00467-12.
16. Hoffmann E, Neumann G, Kawaoka Y, Hobom G, Webster RG. 2000. A DNA transfection system for generation of influenza A virus from eight plasmids. Proc Natl Acad Sci USA 97:6108-6113. http://dx.doi.org/10.1073/pnas.100133697.
17. Fodor E, Crow M, Mingay LJ, Deng T, Sharps J, Fechter P, Brownlee GG. 2002. A single amino acid mutation in the PA subunit of the influenza virus RNA polymerase inhibits endonucleolytic cleavage of capped RNAs. J Virol 76:8989-9001. http://dx.doi.org/10.1128/JVI.76.18.8989-9001.2002.
18. Fodor E, Devenish L, Engelhardt OG, Palese P, Brownlee GG, Garcia-Sastre A. 1999. Rescue of influenza A virus from recombinant DNA. J Virol 73:9679-9682.
19. Robb NC, Smith M, Vreede FT, Fodor E. 2009. NS2/NEP protein regulates transcription and replication of the influenza virus RNA genome. J Gen Virol 90:1398-1407. http://dx.doi.org/10.1099/vir.0.009639-0.