Meta-analysis on risk of bleeding with apixaban in patients with renal impairment

American Journal of Cardiology

Volumn 115, Issue 3, 2015, Pages 323-327

  Pathak, Ranjan ^a   Pandit, Anil ^b   Karmacharya, Paras ^a   Aryal, Madan Raj ^a   Ghimire, Sushil ^a   Poudel, Dilli Ram ^a   Shamoun, Fadi E ^b  

^a Reading Health System   (United States)

^b MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; APIXABAN; ENOXAPARIN; LOW MOLECULAR WEIGHT HEPARIN; PLACEBO; VITAMIN K GROUP; WARFARIN; BLOOD CLOTTING FACTOR 10A INHIBITOR; PYRAZOLE DERIVATIVE; PYRIDONE DERIVATIVE;

ARTICLE; BLEEDING; CREATININE CLEARANCE; HEART ATRIUM FIBRILLATION; HUMAN; LUNG EMBOLISM; META ANALYSIS; MILD RENAL IMPAIRMENT; OUTCOME ASSESSMENT; PHASE 3 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK FACTOR; SEVERE RENAL IMPAIRMENT; SYSTEMATIC REVIEW; THROMBOSIS PREVENTION; VENOUS THROMBOEMBOLISM; ATRIAL FIBRILLATION; CHEMICALLY INDUCED; COMPLICATION; KIDNEY FAILURE; RISK; SEVERITY OF ILLNESS INDEX; STROKE;

ATRIAL FIBRILLATION; FACTOR XA INHIBITORS; HEMORRHAGE; HUMANS; PYRAZOLES; PYRIDONES; RENAL INSUFFICIENCY; RISK; SEVERITY OF ILLNESS INDEX; STROKE; VENOUS THROMBOEMBOLISM;

EID: 84920728267     PISSN: 00029149     EISSN: 18791913     Source Type: Journal    
DOI: 10.1016/j.amjcard.2014.10.042     Document Type: Article

References (19)

1. M.R. Lassen, G.E. Raskob, A. Gallus, G. Pineo, D. Chen, and P. Hornick Apixaban versus enoxaparin for thromboprophylaxis after knee replacement (ADVANCE-2): a randomised double-blind trial The Lancet 375 2010 807 815
2. M.R. Lassen, A. Gallus, G.E. Raskob, G. Pineo, D. Chen, and L.M. Ramirez Apixaban versus enoxaparin for thromboprophylaxis after hip replacement N Engl J Med 363 2010 2487 2498
3. C.B. Granger, J.H. Alexander, J.J.V. McMurray, R.D. Lopes, E.M. Hylek, M. Hanna, H.R. Al-Khalidi, J. Ansell, D. Atar, A. Avezum, M.C. Bahit, R. Diaz, J.D. Easton, J.A. Ezekowitz, G. Flaker, D. Garcia, M. Geraldes, B.J. Gersh, S. Golitsyn, S. Goto, A.G. Hermosillo, S.H. Hohnloser, J. Horowitz, P. Mohan, P. Jansky, B.S. Lewis, J.L. Lopez-Sendon, P. Pais, A. Parkhomenko, F.W.A. Verheugt, J. Zhu, and L. Wallentin Apixaban versus warfarin in patients with atrial fibrillation N Engl J Med 365 2011 981 992
4. S.J. Connolly, J. Eikelboom, C. Joyner, H.-C. Diener, R. Hart, S. Golitsyn, G. Flaker, A. Avezum, S.H. Hohnloser, R. Diaz, M. Talajic, J. Zhu, P. Pais, A. Budaj, A. Parkhomenko, P. Jansky, P. Commerford, R.S. Tan, K.-H. Sim, B.S. Lewis, W. Van Mieghem, G.Y.H. Lip, J.H. Kim, F. Lanas-Zanetti, A. Gonzalez-Hermosillo, A.L. Dans, M. Munawar, M. O'Donnell, J. Lawrence, G. Lewis, R. Afzal, and S. Yusuf Apixaban in patients with atrial fibrillation N Engl J Med 364 2011 806 817
5. G. Agnelli, H.R. Buller, A. Cohen, M. Curto, A.S. Gallus, M. Johnson, A. Porcari, G.E. Raskob, and J.I. Weitz Apixaban for extended treatment of venous thromboembolism N Engl J Med 368 2013 699 708
6. G. Agnelli, H.R. Buller, A. Cohen, M. Curto, A.S. Gallus, M. Johnson, U. Masiukiewicz, R. Pak, J. Thompson, G.E. Raskob, and J.I. Weitz Oral apixaban for the treatment of acute venous thromboembolism N Engl J Med 369 2013 799 808
7. H. Heidbuchel, P. Verhamme, M. Alings, M. Antz, W. Hacke, J. Oldgren, P. Sinnaeve, A.J. Camm, and P. Kirchhof EHRA practical guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation: executive summary Eur Heart J 34 2013 2094 2106
8. R.G. Hart, J.W. Eikelboom, A.J. Ingram, and C.A. Herzog Anticoagulants in atrial fibrillation patients with chronic kidney disease Nat Rev Nephrol 8 2012 569 578
9. Z. Harel, M. Sholzberg, P.S. Shah, K. Pavenski, S. Harel, R. Wald, C.M. Bell, and J. Perl Comparisons between novel oral anticoagulants and vitamin K antagonists in patients with CKD J Am Soc Nephrol 25 2014 431 442
10. P. Sardar, S. Chatterjee, E. Herzog, R. Nairooz, D. Mukherjee, and J.L. Halperin Novel oral anticoagulants in patients with renal insufficiency: a meta-analysis of randomized trials Can J Cardiol 30 2014 888 897
11. A. Liberati, D.G. Altman, J. Tetzlaff, C. Mulrow, P.C. Gøtzsche, J.P.A. Ioannidis, M. Clarke, P.J. Devereaux, J. Kleijnen, and D. Moher The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration BMJ 339 2009 b2700
12. R.M. Turner, S.M. Bird, and J.P.T. Higgins The impact of study size on meta-analyses: examination of underpowered studies in Cochrane reviews PloS One 8 2013 e59202
13. G.F. Pineo, A.S. Gallus, G.E. Raskob, D. Chen, L.-M. Ramirez, E. Ramacciotti, M.R. Lassen, and L. Wang Apixaban after hip or knee arthroplasty versus enoxaparin: efficacy and safety in key clinical subgroups J Thromb Haemost 11 2013 444 451
14. R. Providência, E. Marijon, S. Boveda, S. Barra, K. Narayanan, J.-Y. Le Heuzey, B.J. Gersh, and L. Gonçalves Meta-analysis of the Influence of chronic kidney disease on the risk of thromboembolism among patients with nonvalvular atrial fibrillation Am J Cardiol 114 2014 646 653
15. D.A. McMahan, D.M. Smith, M.A. Carey, and X.H. Zhou Risk of major hemorrhage for outpatients treated with warfarin J Gen Intern Med 13 1998 311 316
16. J.B. Olesen, G.Y.H. Lip, A.-L. Kamper, K. Hommel, L. Køber, D.A. Lane, J. Lindhardsen, G.H. Gislason, and C. Torp-Pedersen Stroke and bleeding in atrial fibrillation with chronic kidney disease N Engl J Med 367 2012 625 635
17. H. Mani, and E. Lindhoff-Last New oral anticoagulants in patients with nonvalvular atrial fibrillation: a review of pharmacokinetics, safety, efficacy, quality of life, and cost effectiveness Drug Des Devel Ther 8 2014 789 798
18. FDA Approved Drug Products: Eliquis 2012 Available at: http://www.accessdata.fda.gov/drugsatfda-docs/label/2012/202155s000lbl.pdf. Accessed on September 9, 2014.
19. W.M. Michels, D.C. Grootendorst, M. Verduijn, E.G. Elliott, F.W. Dekker, and R.T. Krediet Performance of the Cockcroft-Gault, MDRD, and new CKD-EPI formulas in relation to GFR, age, and body size Clin J Am Soc Nephrol. 2012 5 2010 1003 1009