Formulation and evaluation of new long acting metoprolol tartrate ophthalmic gels

Saudi Pharmaceutical Journal

Volumn 22, Issue 6, 2014, Pages 555-563

  Abou el Ela, Amal El Sayeh F ^a,b   Khatib, Mona Mohamed El ^a,c  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b Assiut University   (Egypt)

^c CAIRO UNIVERSITY   (Egypt)

Author keywords

Carbopol 934; IOP; Metoprolol tartrate; Ocular gel delivery; Pluronic F127

Indexed keywords

CARBOPOL 934; METOPROLOL TARTRATE; POLOXAMER;

ALBINO RABBIT; ANIMAL EXPERIMENT; ARTICLE; BIOAVAILABILITY; BIOCOMPATIBILITY; CHEMICAL STRUCTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORNEA; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG MECHANISM; DRUG PENETRATION; DRUG RELEASE; DRUG RESPONSE; DRUG SCREENING; GEL; IN VITRO STUDY; IN VIVO STUDY; INTRAOCULAR PRESSURE; MALE; NONHUMAN; OCULAR GEL DRUG DELIVERY SYSTEM; PH MEASUREMENT; PUPIL; RESPONSE TIME; SHEAR RATE; VISCOSITY;

EID: 84920679304     PISSN: 13190164     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsps.2014.03.003     Document Type: Article

References (26)

1. Abou el Ela A.E.F., Ibrahim E.H., Allam A.A. Bucco-adhesive tablets containing metoprololtartarate: formulation, in vitro and in vivo characterization. J. Drug Deliv. Sci. Tech. 2013, 23:171-179.
2. Alm A., Wickström C.P. Effects of systemic and topical administration of metoprolol on intraocular pressure in healthy subjects. Acta Ophthalmol. 1980, 58:740-747.
3. British Pharmacopeia 2007, vol. IV. The Stationary Office, London, UK, Appendix ID, A140.
4. Bucheli J., Aeschlimann J., Gloor B. The influence of metoprolol eye drops on intraocular pressure. Klin. Monbl. Augenheilkd. 1980, 177:146-150.
5. Deshmukh P.K., Gattani S.G. In vitro and in vivo consideration of novel environmentally responsive ophthalmic drug delivery system. Pharm. Dev. Technol. 2013, 18:950-956.
6. El-Gendy A.M., Jun H.W., Kassem A.A. In vitro release studies of flurbiprofen from different topical formulations. Drug. Dev. Ind. Pharm. 2002, 28:823-831.
7. El-Kamel A.H. In vitro and in vivo evaluation of Pluronic F127-based ocular delivery system for timolol maleate. Int. J. Pharm. 2002, 24:47-55.
8. French D.L., Haglund B.O., Himmelstein K.J., Mauger J.W. Controlled release of substituted benzoic and naphthoic acids using Carbopol gels: measurement of drug concentration profiles and correlation to release rate kinetics. Pharm. Res. 1995, 12:1513-1520.
9. Gratieri T., Gelfuso G.M., Rocha E.M., Sarmento V.H., Freitas O.d., Lopez R.F.V. A poloxamer/chitosan in situ forming gel with prolonged retention time for ocular delivery. Eur. J. Pharm. Biopharm. 2010, 75:186-193.
10. Habib F.S., Attia M.A. Comparative study of the ocular activity in rabbit eyes of adrenaline bitartrate formulated in carbopolamdpoloxamers gels. Arch. Pharm. Chem. Sci. 1984, 12:91-96.
11. Hassan M.A. A long acting ophthalmic gel formulations of Atenolol. Drug. Dev. Ind. Pharm. 2007, 33:1192-1198.
12. Jain N., Aswal V., Goyal P., Bahadur P. Micellar structure of an ethylene oxide-propylene oxide block copolymer: a small-angle neutron scattering study. J. Phys. Chem. 1998, 102:8452-8458.
13. Karthikeyan J., Janardhan S., Saravanakumar N., Selvaraj S., Sivasakthi R., Mennakumari R. Formulation and in vitro evaluation of sustained release microspheres of metoprolol tartrate loaded eudragit-RS100. Der Pharmacia Lettre 2010, 2:261-275.
14. Kaur I.P., Kanwar M. Ocular preparations: the formulation approach. Drug Dev. Ind. Pharm. 2002, 28:473-493.
15. Krieglstein G.K. The long-term ocular and systemic effects of topically applied metoprolol tartrate in glaucoma and ocular hypertension. Acta Ophthalmol. 1981, 59:15-20.
16. Luch J.R. Metoprolol tartrate. Analytical Profiles of Drug Substances 1983, vol. 12:326-354. Academic Press Inc, New York, London.
17. Ma W., Xu H., Wang C., Nie S., Pan W. Pluronic F127-g-poly (acrylic acid) copolymers as in situ gelling vehicle for ophthalmic drug delivery system. Int. J. Pharm. 2008, 350:247-256.
18. Mansour M., Mansour S., Mortada N.D., AbdElhady S.S. Ocular poloxamer-based ciprofloxacin hydrochloride in situ forming gels. Drug Dev. Ind. Pharm. 2008, 34:744-752.
19. Martin A. Physical Pharmacy, Physical Chemical Principles in the Pharmaceutical Sciences 1993, Lea & Febiger, London, pp. 182-185. fourth ed.
20. Mayol L., Quaglia F., Borzacchiello A., Ambrosio L., LaRotonda M.I. A novel poloxamers/hyaluronic acid in situ forming hydrogel for drug delivery: rheological, mucoadhesive and in vitro release properties. Eur. J. Pharm. Biopharm. 2008, 70:199-206.
21. Plummer C.E., MacKay E.O., Gelatt K.N. Comparison of the effects of topical administration of a fixed combination of dorzolamide-timolol to monotherapy with timolol or dorzolamide on IOP, pupil size, and heart rate in glaucomatous dogs. Vet. Ophthalmol. 2006, 9:245-249.
22. Ramana M.V., Nagda C., Himaja M. Design and evaluation of mucoadhesive buccal drug delivery systems containing metoprolol tartrate. Ind. J. Pharm. Sci. 2007, 69:515-518.
23. Ricci E.J., Lunardi L.O., Nanclares D.M., Marchetti J.M. Sustained release of lidocaine from Poloxamer 407 gels. Int. J. Pharm. 2005, 288:235-244.
24. Schmolka I.R. Artificial skin. Preparation and properties of Pluronic F127 gels for the treatment of burns. J. Biomed. Mater. Res. 1972, 6:571-582.
25. Waring G.O., Harris R.R. Sympotoms on Ocular Therapy 1979, vol. 11:127-140. John Wiley, New York.
26. Zaki R., Hosny K.M., Khames A., Abd-elbary A. Ketorolac tromethamine in-situ ocular hydrogel: Preparation, characterization and in vivo evaluation. Int. J. Drug Del. 2011, 3:535-545.