Patients report worse MS symptoms after menopause: Findings from an online cohort

Multiple Sclerosis and Related Disorders

Volumn 4, Issue 1, 2015, Pages 18-24

  Bove, R ^a,b   Healy, B C ^a,b,c   Secor, E ^b   Vaughan, T ^d   Katic, B ^d   Chitnis, T ^a,b   Wicks, P ^d   De Jager, P L ^a,b  

^a Partners Multiple Sclerosis Center   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d PATIENTSLIKEME INC   (United States)

Author keywords

Estrogen; Hot flashes; Menopause; Multiple sclerosis; Online communities; Patient powered research networks

Indexed keywords

ADULT; AGE; ARTICLE; COHORT ANALYSIS; DISEASE ASSOCIATION; DISEASE DURATION; DISEASE SEVERITY; FEMALE; HEALTH SURVEY; HUMAN; MAJOR CLINICAL STUDY; MULTIPLE SCLEROSIS; ONLINE ANALYSIS; POSTMENOPAUSE; REPRODUCTIVE HISTORY; SELF REPORT; SYMPTOM; ANALYSIS OF VARIANCE; DISABILITY; MIDDLE AGED; ONLINE SYSTEM; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOLOGY; QUESTIONNAIRE; SEVERITY OF ILLNESS INDEX; STATISTICAL MODEL; YOUNG ADULT;

ADULT; ANALYSIS OF VARIANCE; COHORT STUDIES; DISABILITY EVALUATION; FEMALE; HUMANS; LINEAR MODELS; MIDDLE AGED; MULTIPLE SCLEROSIS; ONLINE SYSTEMS; POSTMENOPAUSE; SEVERITY OF ILLNESS INDEX; SURVEYS AND QUESTIONNAIRES; YOUNG ADULT;

EID: 84920675967     PISSN: 22110348     EISSN: 22110356     Source Type: Journal    
DOI: 10.1016/j.msard.2014.11.009     Document Type: Article

References (22)

1. S. Alwan, I.M. Yee, M. Dybalski, C. Guimond, E. Dwosh, and T.M. Greenwood Reproductive decision making after the diagnosis of multiple sclerosis (MS) Mult Scler 19 2013 351 358
2. R. Bove Autoimmune diseases and reproductive aging Clin Immunol 149 2013 251 264
3. R. Bove, T. Chitnis, and M. Houtchens Menopause in multiple sclerosis: therapeutic considerations J Neurol 2013 (Epub 2013 Oct 8.)
4. R. Bove, E. Secor, L.B. Chibnik, L.L. Barnes, J.A. Schneider, and D.A. Bennett Age at surgical menopause influences cognitive decline and Alzheimer pathology in older women Neurology 82 2014 222 229
5. R. Bove, E. Secor, B.C. Healy, A. Musallam, T. Vaughan, and B.I. Glanz Evaluation of an online platform for multiple sclerosis research: patient description, validation of severity scale, and exploration of BMI effects on disease course PLoS One 8 2013 e59707
6. E. Cocco, C. Sardu, P. Gallo, R. Capra, M.P. Amato, and M. Trojano Frequency and risk factors of mitoxantrone-induced amenorrhea in multiple sclerosis: the FEMIMS study Mult Scler 14 2008 1225 1233
7. S.M. Gold, and R.R. Voskuhl Estrogen and testosterone therapies in multiple sclerosis Prog Brain Res 175 2009 239 251
8. S.M. Gold, and R.R. Voskuhl Estrogen treatment in multiple sclerosis J Neurol Sci 286 2009 99 103
9. O. Hadjimichael, T. Vollmer, and M. Oleen-Burkey Fatigue characteristics in multiple sclerosis: the North American research committee on multiple sclerosis (NARCOMS) survey Health Qual Life Outcomes 6 2008 100
10. S.D. Harlow, M. Gass, J.E. Hall, R. Lobo, P. Maki, and R.W. Rebar Executive summary of the stages of reproductive aging workshop +10: addressing the unfinished agenda of staging reproductive aging J Clin Endocrinol Metab 97 2012 1159 1168
11. L.E. Harward, K. Mitchell, C. Pieper, S. Copland, L.G. Criscione-Schreiber, and M.E. Clowse The impact of cyclophosphamide on menstruation and pregnancy in women with rheumatologic disease Lupus 22 2013 81 86
12. P. Holmqvist, M. Wallberg, M. Hammar, A.M. Landtblom, and J. Brynhildsen Symptoms of multiple sclerosis in women in relation to sex steroid exposure Maturitas 54 2006 149 153
13. W.H. Linssen, N.C. Notermans, O.R. Hommes, and R. Rolland Amenorrhea after immunosuppressive treatment of multiple sclerosis Acta Neurol Scand 76 1987 204 209
14. A.J. MacKenzie-Graham, G.A. Rinek, A. Avedisian, L.B. Morales, E. Umeda, and B. Boulat Estrogen treatment prevents gray matter atrophy in experimental autoimmune encephalomyelitis J Neurosci Res 90 2012 1310 1323
15. M. Mathew, J.R. Morrow, G.M. Frierson, and T.M. Bain Assessing digital literacy in web-based physical activity surveillance: the WIN study Am J Health Promot 26 2011 90 95
16. D.W. Paty, J.H. Noseworthy, and G.C. Ebers Diagnosis of multiple sclerosis D.W. Paty, G.C. Ebers, Multiple sclerosis 1997 FA Davis Company Philadelphia, PA 48 51
17. W.A. Rocca, B.R. Grossardt, and L.T. Shuster Oophorectomy, menopause, estrogen treatment, and cognitive aging: clinical evidence for a window of opportunity Brain Res 1379 2011 188 198
18. H. Shao, J.C. Breitner, R.A. Whitmer, J. Wang, K. Hayden, and H. Wengreen Hormone therapy and Alzheimer disease dementia: new findings from the Cache County study Neurology 79 2012 1846 1852
19. R. Smith, and J.W. Studd A pilot study of the effect upon multiple sclerosis of the menopause, hormone replacement therapy and the menstrual cycle J R Soc Med 85 1992 612 613
20. R.D. Spence, and R.R. Voskuhl Neuroprotective effects of estrogens and androgens in CNS inflammation and neurodegeneration Front Neuroendocrinol 33 2012 105 115
21. P. Wicks, T.E. Vaughan, and M.P. Massagli The multiple sclerosis rating scale, revised (MSRS-R): development, refinement, and psychometric validation using an online community Health Qual Life Outcomes 10 2012 70
22. A. Wundes, D. Amtmann, T. Brown, and S. Christian Menopause in women with multiple sclerosis Int J MS Care 13 2011 47