CD28 superagonist-mediated boost of regulatory T cells increases thrombo-inflammation and ischemic neurodegeneration during the acute phase of experimental stroke

Journal of Cerebral Blood Flow and Metabolism

Volumn 35, Issue 1, 2015, Pages 6-10

  Schuhmann, Michael K ^a   Kraft, Peter ^a   Stoll, Guido ^a   Lorenz, Kristina ^b   Meuth, Sven G ^c   Wiendl, Heinz ^c   Nieswandt, Bernhard ^d   Sparwasser, Tim ^e   Beyersdorf, Niklas ^b   Kerkau, Thomas ^b   Kleinschnitz, Christoph ^a  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c UNIVERSITY OF MÜNSTER   (Germany)

^d UNIVERSITY OF WÜRZBURG   (Germany)

^e HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

brain ischemia; inflammation; microcirculation; T cells; thrombosis

Indexed keywords

MONOCLONAL ANTIBODY CD28; CD28 ANTIGEN; HOMEODOMAIN PROTEIN; MONOCLONAL ANTIBODY; RAG-1 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD CLOTTING; BRAIN BLOOD VESSEL; BRAIN CELL; BRAIN ISCHEMIA; CELL EXPANSION; CELL INFILTRATION; CONTROLLED STUDY; EXPERIMENTAL STROKE; FUNCTIONAL STATUS; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MALE; MICROVASCULATURE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NONHUMAN; REGULATORY T LYMPHOCYTE; THROMBOSIS; AGONISTS; ANIMAL; BLOOD; BRAIN; BRAIN CIRCULATION; C57BL MOUSE; CEREBRAL ARTERY DISEASE; DISEASE MODEL; GENETICS; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; KAPLAN MEIER METHOD; KNOCKOUT MOUSE; PATHOLOGY; SURVIVAL; VASCULARIZATION;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD28; BRAIN; CEREBROVASCULAR CIRCULATION; DISEASE MODELS, ANIMAL; HOMEODOMAIN PROTEINS; IMMUNOHISTOCHEMISTRY; INFARCTION, MIDDLE CEREBRAL ARTERY; KAPLAN-MEIER ESTIMATE; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; SURVIVAL ANALYSIS; T-LYMPHOCYTES, REGULATORY; THROMBOSIS;

EID: 84920675365     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2014.175     Document Type: Article

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