A pilot assessment of alpha-stat vs pH-stat arterial blood gas analysis after cardiac arrest

Journal of Critical Care

Volumn 30, Issue 1, 2015, Pages 138-144

  Eastwood, Glenn M ^a,b   Suzuki, Satoshi ^c   Lluch, Cristina ^d   Schneider, Antoine G ^e   Bellomo, Rinaldo ^b,f  

^a DEAKIN UNIVERSITY   (Australia)

^b AUSTIN HOSPITAL   (Australia)

^c OKAYAMA UNIVERSITY HOSPITAL   (Japan)

^d HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^e LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^f MONASH UNIVERSITY   (Australia)

Author keywords

Arterial blood gas; Cardiac arrest; Hyperoxemia; Hypocapnia; Hypoxemia; Intensive care

Indexed keywords

ADULT; AGED; ALPHA STAT; ARTERIAL CARBON DIOXIDE TENSION; ARTERIAL OXYGEN TENSION; ARTICLE; BLOOD GAS ANALYSIS; BODY TEMPERATURE; COMPARATIVE STUDY; FEMALE; HEART ARREST; HUMAN; HYPERCAPNIA; HYPEROXEMIA; HYPOCAPNIA; HYPOXEMIA; INDUCED HYPOTHERMIA; INTENSIVE CARE; MAJOR CLINICAL STUDY; MALE; MORTALITY; PATIENT CODING; PH STAT; PROGNOSIS; RESPIRATORY FUNCTION DISORDER; RETROSPECTIVE STUDY; RETURN OF SPONTANEOUS CIRCULATION; SURVIVAL RATE; ANOXIA; ARTERY; BLOOD; COMPLICATION; HYPEROXIA; INTENSIVE CARE UNIT; MIDDLE AGED; PILOT STUDY;

ADULT; AGED; ANOXIA; ARTERIES; BLOOD GAS ANALYSIS; BODY TEMPERATURE; FEMALE; HEART ARREST; HUMANS; HYPERCAPNIA; HYPEROXIA; HYPOTHERMIA, INDUCED; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; PILOT PROJECTS; RETROSPECTIVE STUDIES;

EID: 84920585763     PISSN: 08839441     EISSN: 15578615     Source Type: Journal    
DOI: 10.1016/j.jcrc.2014.09.022     Document Type: Article

References (31)

1. de Jonge E., Peelen L., Keijzers P.J., et al. Association between administered oxygen, arterial partial oxygen pressure and mortality in mechanically ventilated intensive care unit patients. Crit Care 2008, 12:R156. 10.1186/cc7150.
2. Kilgannon J.H., Jones A.E., Shapiro N.I., et al. Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality. JAMA 2010, 303:2165-2171.
3. Bellomo R., Bailey M., Eastwood G.M., et al. Arterial hyperoxia and in-hospital mortality after resuscitation from cardiac arrest. Crit Care 2011, 15:R90. 10.1186/cc10090.
4. Schneider A.G., Eastwood G.M., Bellomo R., et al. Arterial carbon dioxide tension and outcome in patients admitted to the intensive care unit after cardiac arrest. Resuscitation 2013, 84:927-934.
5. Kilgannon J.H., Jones A.E., Parrillo J.E., et al. Relationship between supranormal oxygen tension and outcome after resuscitation from cardiac arrest. Circulation 2011, 123(23):2717-2722.
6. Bacher A. Effects of body temperature on blood gases. Intensive Care Med 2005, 31:24-27.
7. Falkenbach P., Kamarainen A., Makela A., et al. Incidence of iatrogenic dyscarbia during mild therapeutic hypothermia after successful resuscitation from out-of-hospital cardiac arrest. Resuscitation 2008, 80:990-993.
8. Zimmerman J.E., Wagner D.P., Draper E.A., Wright L., Alzola C., Knaus W.A. Evaluation of acute physiology and chronic health evaluation III predictions of hospital mortality in an independent database. Crit Care Med 1998, 26:1317-1326.
9. Clinical and Laboratory Standards Institute (CLSI) Blood gas and pH Analysis and Related Measurements: Approved Guideline. CLSI document C46-A [ISBN 1-56238-444-9] 2001, CLSI, 940 West Valley Road, Suite 1400, Wayne, Pennsylvania 19087-1898 USA.
10. Knaus W.A., Wagner D.P., Draper E.A., et al. The APACHE III prognostic system. Risk prediction of hospital mortality for critically ill hospitalized adults. Chest 1991, 100:1619-1636.
11. Douzinas E.E., Patsouris E., Kypriades E.M., et al. Hypoxaemic reperfusion ameliorates the histopathological changes in the pig brain after a severe global cerebral ischaemic insult. Intensive Care Med 2001, 27:905-910.
12. Balan I.S., Fiskum G., Hazelton J., Cotto-Cumba C., Rosenthal R.E. Oximetry-guided reoxygenation improves neurological outcome after experimental cardiac arrest. Stroke 2006, 37:3008-3013.
13. Vannucci R.C., Towfighi J., Heitjan D.R., et al. Carbon dioxide protects the perinatal brain from hypoxic-ischemic damage: an experimental study in the immature rat. Pediatrics 1995, 95:868-874.
14. Safar P., Xiao F., Radovsky A., et al. Improved cerebral resuscitation from cardiac arrest in dogs with mild hypothermia plus blood flow promotion. Stroke 1996, 27:105-113.
15. Pilcher J., Weatherall M., Shirtcliffe P., Bellomo R., Young P., Beasley R. The effect of hyperoxia following cardiac arrest-a systematic review and meta-analysis. Resuscitation 2000, 83:417-422.
16. Steiner L.A., Balestreri M., Johnston A.J., et al. Sustained moderate reduction in arterial CO2 after brain trauma time-course of cerebral blood flow velocity and intracranial pressure. Intensive Care Med 2004, 30:2180-2187.
17. Tsui S.S., Schultz J.M., Shen I., Ungerleider R.M. Postoperative hypoxaemia exacerbates potential brain injury after deep hypothermic circulatory arrest. Ann Thorac Surg 2004, 78:188-196.
18. Martin L.J., Brambrink A.M., Lehmann C., et al. Hypoxia-ischemia causes abnormalities in glutamate transporters and death of astroglia and neurons in newborn striatum. Ann Neurol 1997, 42:335-348.
19. Eastwood G.M., Young P.J., Bellomo R. The impact of oxygen and carbon dioxide management on outcome after cardiac arrest. Curr Opin Crit Care 2014, 20(3):266-272.
20. Coles J.P., Fryer T.D., Coleman M.R., et al. Hyperventilation following head injury: effect on ischemic burden and cerebral oxidative metabolism. Crit Care Med 2007, 35:568-578.
21. Davis D.P., Idris A.H., Sise M.J., et al. Early ventilation and outcome in patients with moderate to severe traumatic brain injury. Crit Care Med 2006, 34:1202-1208.
22. Aufderheide T.P., Lurie K.G. Death by hyperventilation: a common and life-threatening problem during cardiopulmonary resuscitation. Crit Care Med 2004, 32:S345-S351.
23. Peberdy M.A., Callaway C.W., Neurmar R.W., et al. Post-cardiac arrest care: 2010 American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation 2010, 122(Suppl. 3):S768-S786. [Errata, Circulation 2011;123(6):e237, 124(15)e403].
24. Cortes D.O., Creteur J., Vincent J., Taccone F.S. Carbon dioxide management after cardiac arrest: quite a complex issue. Resuscitation 2013, 84:e103.
25. Absalom A.R., Scheeren T.W.L. NIRS during therapeutic hypothermia: cool or hot?. Resuscitation 2013, 84:720-721.
26. Pynnonen L., Falkenback P., Kamarainen A., Lonnrot K., Yli-Hankala A., Tenhunen J. Therapeutic hypothermia after cardiac arrest-cerebral perfusion and metabolism during upper and lower threshold normocapnia. Resuscitation 2011, 82:1174-1179.
27. Voicu S., Deye N., Malissin I., et al. Influence of α-stat and pH-stat blood gas management strategies on cerebral blood flow and oxygenation in patients treated with therapeutic hypothermia after out-of-hospital cardiac arrest: a crossover study. Crit Care Med 2014, 42:1849-1861.
28. Meex I., Dens J., Jans F., Boer W., et al. Cerebral tissue oxygen saturation during therapeutic hypothermia in post-cardiac arrest patients. Resuscitation 2013, 84:788-799.
29. The Hypothermia after Cardiac Arrest Study Group Mild therapeutic hypothermia to improve the neurological outcome after cardiac arrest. N Engl J Med 2002, 346:549-556. [Erratum, N Engl J Med 2002;346:1756.].
30. Bernard S.A., Gray T.W., Buist M.D., et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with inducted hypothermia. N Engl J Med 2002, 346:557-563.
31. Nielsen N., Wetterselev J., Cronberg T., et al. Targeted temperature management at 33°C versus 36°C after cardiac arrest. N Engl J Med 2013, 369:2197-2206.