Calcium dependent FAK/CREB/TNNC1 signaling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential

Nature Communications

Volumn 5, Issue , 2014, Pages

  Leung, Cecilia S ^a,b,e   Yeung, Tsz Lun ^a,e   Yip, Kay Pong ^c   Pradeep, Sunila ^a   Balasubramanian, Lavanya ^c   Liu, Jinsong ^a   Wong, Kwong Kwok ^a,b   Mangala, Lingegowda S ^a,d   Armaiz Pena, Guillermo N ^a   Lopez Berestein, Gabriel ^a,d   Sood, Anil K ^a,b,d   Birrer, Michael J ^e   Mok, Samuel C ^a,b  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c UNIVERSITY OF SOUTH FLORIDA   (United States)

^d Center for RNA Interference and Non Coding RNA   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CHITOSAN NANOPARTICLE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; F ACTIN; FOCAL ADHESION KINASE; GLYCOPROTEIN; MICROFIBRILLAR ASSOCIATED PROTEIN 5; SMALL INTERFERING RNA; TRANSCRIPTOME; TROPONIN C; TROPONIN C TYPE 1; UNCLASSIFIED DRUG; ACTIN; CALCIUM; CONTRACTILE PROTEIN; CREB1 PROTEIN, HUMAN; MAGP2 PROTEIN, HUMAN;

CALCIUM; CANCER; CHITIN; DISEASE CONTROL; GENE EXPRESSION; GENETIC MARKER; GERM CELL; HEALTH RISK; PROTEIN; RNA; SIGNALING; SURVIVAL;

ADENOCARCINOMA CELL LINE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM DEPLETION; CALCIUM MOBILIZATION; CANCER CELL; CANCER CELL CULTURE; CANCER GENE THERAPY; CANCER INHIBITION; CANCER LOCALIZATION; CANCER SIZE; CANCER SURVIVAL; CELL ACTIVATION; CELL INVASION; CELL MOTILITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FEEDBACK SYSTEM; FEMALE; FIBROBLAST; GENE SILENCING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOLOCALIZATION; IN VITRO STUDY; IN VIVO STUDY; METASTASIS INHIBITION; METASTASIS POTENTIAL; MICRODISSECTION; MIGRATION; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; OVARY ADENOCARCINOMA; OVARY CANCER; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TREATMENT DURATION; UPREGULATION; WESTERN BLOTTING; ADENOCARCINOMA; CELL MOTION; CYTOLOGY; GENE EXPRESSION REGULATION; METABOLISM; METASTASIS; OVARY TUMOR; PROGNOSIS; STROMA CELL; TREATMENT OUTCOME; TUMOR CELL LINE;

UNITED STATES;

ACTINS; ADENOCARCINOMA; CALCIUM; CELL LINE, TUMOR; CELL MOVEMENT; CONTRACTILE PROTEINS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; FEMALE; FOCAL ADHESION PROTEIN-TYROSINE KINASES; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; GLYCOPROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; NEOPLASM METASTASIS; OVARIAN NEOPLASMS; PROGNOSIS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STROMAL CELLS; TREATMENT OUTCOME; TROPONIN C;

EID: 84920567826     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms6092     Document Type: Article

References (35)

1. Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA. 2014; 64:9-29. [PubMed: 24399786].
2. Tlsty TD, Coussens LM. Tumor stroma and regulation of cancer development. Annu Rev Pathol. 2006; 1:119-150. [PubMed: 18039110].
3. Berchuck A, et al. Patterns of gene expression that characterize long-term survival in advanced stage serous ovarian cancers. Clin Cancer Res. 2005; 11:3686-3696. [PubMed: 15897565].
4. Cancer Genome Atlas Research, N. Integrated genomic analyses of ovarian carcinoma. Nature. 2011; 474:609-615. [PubMed: 21720365].
5. Lancaster JM, et al. Gene expression patterns that characterize advanced stage serous ovarian cancers. J Soc Gynecol Investig. 2004; 11:51-59.
6. Mok SC, et al. A gene signature predictive for outcome in advanced ovarian cancer identifies a survival factor: Microfibril-associated glycoprotein 2. Cancer Cell. 2009; 16:521-532. [PubMed: 19962670].
7. Lu C, et al. Regulation of tumor angiogenesis by EZH2. Cancer Cell. 2010; 18:185-197. [PubMed: 20708159].
8. Masiero M, et al. A Core Human Primary Tumor Angiogenesis Signature Identifies the Endothelial Orphan Receptor ELTD1 as a Key Regulator of Angiogenesis. Cancer Cell. 2013; 24:229-241. [PubMed: 23871637].
9. Doyle A, Marganski W, Lee J. Calcium transients induce spatially coordinated increases in traction force during the movement of fish keratocytes. J Cell Sci. 2004; 117:2203-2214. [PubMed: 15126622].
10. Wei C, et al. Flickering calcium microdomains signal turning of migrating cells. Can J Physiol Pharmacol. 2010; 88:105-110. [PubMed: 20237584].
11. Nakamura I, Lipfert L, Rodan GA, Le TD. Convergence of alpha(v)beta(3) integrin- And macrophage colony stimulating factor-mediated signals on phospholipase Cgamma in prefusion osteoclasts. J Cell Biol. 2001; 152:361-373. [PubMed: 11266452].
12. Masson-Gadais B, Houle F, Laferriere J, Huot J. Integrin alphavbeta3, requirement for VEGFR2- mediated activation of SAPK2/p38 and for Hsp90-dependent phosphorylation of focal adhesion kinase in endothelial cells activated by VEGF. Cell Stress Chaperones. 2003; 8:37-52. [PubMed: 12820653].
13. Altman A, Villalba M. Protein kinase C-theta (PKCtheta): It's all about location, location, location. Immunol Rev. 2003; 192:53-63. [PubMed: 12670395].
14. Manicassamy S, Sadim M, Ye RD, Sun Z. Differential roles of PKC-theta in the regulation of intracellular calcium concentration in primary T cells. J Mol Biol. 2006; 355:347-359. [PubMed: 16309697].
15. 2+ mobilization and NFAT cell activation in primary mouse T cells. J Exp Med. 2003; 197:1525-1535. [PubMed: 12782715].
16. Park EM, Cho S. Enhanced ERK dependent CREB activation reduces apoptosis in staurosporinetreated human neuroblastoma SK-N-BE(2)C cells. Neurosci Lett. 2006; 402:190-194. [PubMed: 16678346].
17. Lawler J. Introduction to the tumour microenvironment review series. J Cell Mol Med. 2009; 13:1403-1404. [PubMed: 19583804].
18. Bauer EA, Uitto J, Walters RC, Eisen AZ. Enhanced collagenase production by fibroblasts derived from human basal cell carcinomas. Cancer Res. 1979; 39:4594-4599. [PubMed: 227589].
19. Knudson W, Biswas C, Toole BP. Interactions between human tumor cells and fibroblasts stimulate hyaluronate synthesis. Proc Natl Acad Sci U S A. 1984; 81:6767-6771. [PubMed: 6593727].
20. Schauer IG, Sood AK, Mok S, Liu J. Cancer-associated fibroblasts and their putative role in potentiating the initiation and development of epithelial ovarian cancer. Neoplasia. 2011; 13:393- 405. [PubMed: 21532880].
21. Gibson MA, Finnis ML, Kumaratilake JS, Cleary EG. Microfibril-associated glycoprotein-2 (MAGP-2) is specifically associated with fibrillin-containing microfibrils but exhibits more restricted patterns of tissue localization and developmental expression than its structural relative MAGP-1. J Histochem Cytochem. 1998; 46:871-886. [PubMed: 9671438].
22. Spivey KA, Banyard J. A prognostic gene signature in advanced ovarian cancer reveals a microfibril-associated protein (MAGP2) as a promoter of tumor cell survival and angiogenesis. Cell Adh Migr. 2010; 4:169-171. [PubMed: 20400864].
23. Brundage RA, Fogarty KE, Tuft RA, Fay FS. Calcium gradients underlying polarization and chemotaxis of eosinophils. Science. 1991; 254:703-706. [PubMed: 1948048].
24. Pettit EJ, Fay FS. Cytosolic free calcium and the cytoskeleton in the control of leukocyte chemotaxis. Physiol Rev. 1998; 78:949-967. [PubMed: 9790567].
25. Ridley AJ, et al. Cell migration: Integrating signals from front to back. Science. 2003; 302:1704- 1709. [PubMed: 14657486].
26. Van Haastert PJ, Devreotes PN. Chemotaxis: Signalling the way forward. Nat Rev Mol Cell Biol. 2004; 5:626-634. [PubMed: 15366706].
27. Feng M, et al. Store-independent activation of Orai1 by SPCA2 in mammary tumors. Cell. 2010; 143:84-98. [PubMed: 20887894].
28. Prevarskaya N, Skryma R, Shuba Y. Calcium in tumour metastasis: New roles for known actors. Nat Rev Cancer. 2011; 11:609-618. [PubMed: 21779011].
29. Furukawa R, et al. Calcium regulation of actin crosslinking is important for function of the actin cytoskeleton in Dictyostelium. J Cell Sci. 2003; 116:187-196. [PubMed: 12456728].
30. Tash JS, Means AR. Regulation of protein phosphorylation and motility of sperm by cyclic adenosine monophosphate and calcium. Biol Reprod. 1982; 26:745-763. [PubMed: 6282354].
31. Gahlmann R, Wade R, Gunning P, Kedes L. Differential expression of slow and fast skeletal muscle troponin C. Slow skeletal muscle troponin C is expressed in human fibroblasts. J Mol Biol. 1988; 201:379-391. [PubMed: 3166492].
32. Yeung TL, et al. TGF-beta modulates ovarian cancer invasion by upregulating CAF-derived versican in the tumor microenvironment. Cancer Res. 2013; 73:5016-5028. [PubMed: 23824740].
33. Dembo M, Wang YL. Stresses at the cell-to-substrate interface during locomotion of fibroblasts. Biophys J. 1999; 76:2307-2316. [PubMed: 10096925].
34. Lo CM, Glogauer M, Rossi M, Ferrier J. Cell-substrate separation: effect of applied force and temperature. Eur Biophys J. 1998; 27:9-17. [PubMed: 9463886].
35. Lo CM, et al. Nonmuscle myosin IIb is involved in the guidance of fibroblast migration. Mol Biol Cell. 2004; 15:982-989. [PubMed: 14699073].