Fat metaplasia and backfill are key intermediaries in the development of sacroiliac joint ankylosis in patients with ankylosing spondylitis

Arthritis and Rheumatology

Volumn 66, Issue 11, 2014, Pages 2958-2967

  Maksymowych, Walter P ^a   Wichuk, Stephanie ^a   Chiowchanwisawakit, Praveena ^b   Lambert, Robert G ^a   Pedersen, Susanne J ^a,c  

^a UNIVERSITY OF ALBERTA   (Canada)

^b MAHIDOL UNIVERSITY   (Thailand)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; NON PRESCRIPTION DRUG; NONSTEROID ANTIINFLAMMATORY AGENT; LIPID;

ADULT; ANKYLOSING SPONDYLITIS; ANKYLOSIS; ARTICLE; BATH ANKYLOSING SPONDYLITIS DISEASE ACTIVITY INDEX; EROSION; FAT METAPLASIA; FEMALE; FOLLOW UP; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; METAPLASIA; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SACROILIAC JOINT; SACROILIAC JOINT ANKYLOSIS; TISSUE REPAIR; BONE MARROW; COHORT ANALYSIS; DISEASE COURSE; LONGITUDINAL STUDY; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; REGRESSION ANALYSIS;

ADULT; ANKYLOSIS; BONE MARROW; COHORT STUDIES; DISEASE PROGRESSION; FEMALE; FOLLOW-UP STUDIES; HUMANS; INFLAMMATION; LIPIDS; LONGITUDINAL STUDIES; MAGNETIC RESONANCE IMAGING; MALE; METAPLASIA; MIDDLE AGED; REGRESSION ANALYSIS; SACROILIAC JOINT; SPONDYLITIS, ANKYLOSING;

EID: 84920481977     PISSN: 23265191     EISSN: 23265205     Source Type: Journal    
DOI: 10.1002/art.38792     Document Type: Article

References (35)

1. Weber U, Maksymowych WP,. Advances and challenges in spondyloarthritis imaging for diagnosis and assessment of disease. Curr Rheumatol Rep 2013; 25: 345-53.
2. Ostergaard M, Maksymowych WP, Pedersen SJ, Chiowchanwisawakit P, Lambert RG,. Structural lesions detected by magnetic resonance imaging in the spine of patients with spondyloarthritis: definitions, assessment system, and reference image set. J Rheumatol 2009; 36 Suppl 84: 18-34.
3. Rudwaleit M, Landewe R, van der Linden S, Dougados M, Sieper J, Braun J, et al., Defining active sacroiliitis on magnetic resonance imaging (MRI) for classification of axial spondyloarthritis: a consensual approach by the ASAS/OMERACT MRI group. Ann Rheum Dis 2009; 68: 1520-7.
4. Hermann KG, Baraliakos X, van der Heijde D, Jurik AG, Landewe R, Marzo-Ortega H, et al., Descriptions of spinal MRI lesions and definition of a positive MRI of the spine in axial SpA. Ann Rheum Dis 2012; 71: 1278-88.
5. Chiowchanwisawakit P, Lambert RG, Conner-Spady B, Maksymowych WP,. Focal fat lesions at vertebral corners on magnetic resonance imaging predict the development of new syndesmophytes in ankylosing spondylitis. Arthritis Rheum 2011; 63: 2215-25.
6. Maksymowych WP, Morency N, Conner-Spady B, Lambert RG,. Suppression of inflammation and effects on new bone formation in ankylosing spondylitis: evidence for a window of opportunity in disease modification. Ann Rheum Dis 2013; 72: 23-8.
7. Song IH, Hermann KG, Haibel H, Althoff CE, Poddubnyy D, Listing J, et al., Relationship between active inflammatory lesions in the spine and sacroiliac joints and new development of chronic lesions on whole-body MRI in early axial spondyloarthritis: results of the ESTHER trial at week 48. Ann Rheum Dis 2011; 70: 1257-63.
8. Weber U, Pedersen SJ, Ostergaard M, Rufibach K, Lambert R, Maksymowych WP,. Can erosions on MRI of the sacroiliac joints be reliably detected in patients with ankylosing spondylitis? A cross-sectional study. Arthritis Res Ther 2012; 14: R124.
9. Gladman DD, Rahman P, Cook RJ, Shen H, Zummer M, Thomson G, et al., The Spondyloarthritis Research Consortium of Canada registry for spondyloarthritis. J Rheumatol 2011; 38: 1343-8.
10. Van der Linden S, Valkenburg HA, Cats A,. Evaluation of diagnostic criteria for ankylosing spondylitis: a proposal for modification of the New York criteria. Arthritis Rheum 1984; 27: 361-8.
11. Maksymowych WP, Inman RD, Salonen D, Dhillon SS, Williams M, Stone M, et al., Development and preliminary validation of the Spondyloarthritis Research Consortium of Canada MRI sacroiliac joint structural score. J Rheumatol. In press.
12. Maksymowych WP, Wichuk S, Chiowchanwisawakit P, Lambert RG, Pedersen SJ,. The Spondyloarthritis Research Consortium of Canada MRI sacroiliac joint structural score: a method for reliable detection of structural progression [abstract]. Arthritis Rheum 2013; 65 Suppl: S1239.
13. Weber U, Lambert RG, Ostergaard M, Hodler J, Pedersen SJ, Maksymowych WP,. The diagnostic utility of magnetic resonance imaging in spondylarthritis: an international multicenter evaluation of one hundred eighty-seven subjects. Arthritis Rheum 2010; 62: 3048-58.
14. Sieper J, Appel H, Braun J, Rudwaleit M,. Critical appraisal of assessment of structural damage in ankylosing spondylitis: implications for treatment outcomes [review]. Arthritis Rheum 2008; 58: 649-56.
15. Bennett AN, Rehman A, Hensor EM, Marzo-Ortega H, Emery P, McGonagle D,. The fatty Romanus lesion: a noninflammatory spinal MRI lesion specific for axial spondyloarthropathy [published erratum appears in Ann Rheum Dis 2011;70:1519]. Ann Rheum Dis 2010; 69: 89-4.
16. Bennett AN, Rehman A, Hensor EM, Marzo-Ortega H, Emery P, McGonagle D,. Evaluation of the diagnostic utility of spinal magnetic resonance imaging in axial spondylarthritis [published erratum appears in Arthritis Rheum 2010;62:3005]. Arthritis Rheum 2009; 60: 1331-41.
17. Weber U, Pedersen SJ, Zubler V, Rufibach K, Chan SM, Lambert RG, et al., Fat infiltration on magnetic resonance imaging of the sacroiliac joints has limited diagnostic utility in nonradiographic axial spondyloarthritis. J Rheumatol 2014; 41: 75-83.
18. Baraliakos X, Heldmann F, Callhoff J, Listing J, Appelboom T, Brandt J, et al., Which spinal lesions are associated with new bone formation in patients with ankylosing spondylitis treated with anti-TNF agents? A long-term observational study using MRI and conventional radiography. Ann Rheum Dis 2013. E-pub ahead of print.
19. James AW,. Review of signaling pathways governing MSC osteogenic and adipogenic differentiation. Scientifica (Cairo) 2013; 2013: 684736.
20. Noel D, Gazit D, Bouquet C, Apparailly F, Bony C, Plence P, et al., Short-term BMP-2 expression is sufficient for in vivo osteochondral differentiation of mesenchymal stem cells. Stem Cells 2004; 22: 74-85.
21. Wang S, Mu J, Fan Z, Yu Y, Yan M, L, ei G, et al., Insulin-like growth factor 1 can promote the osteogenic differentiation and osteogenesis of stem cells from apical papilla. Stem Cell Res 2012; 8: 346-56.
22. Teruel T, Valverde AM, Benito M, Lorenzo M,. Insulin-like growth factor I and insulin induce adipogenic-related gene expression in fetal brown adipocyte primary cultures. Biochem J 1996; 319: 627-32.
23. Wang EA, Israel DI, Kelly S, Luxenberg DP,. Bone morphogenetic protein-2 causes commitment and differentiation in C3H10T1/2 and 3T3 cells. Growth Factors 1993; 9: 57-71.
24. Kruth HS,. Receptor-independent fluid-phase pinocytosis mechanisms for induction of foam cell formation with native low-density lipoprotein particles. Curr Opin Lipidol 2011; 22: 386-93.
25. Mattila JT, Ojo OO, Kepka-Lenhart D, Marino S, Kim JH, Eum SY, et al., Microenvironments in tuberculous granulomas are delineated by distinct populations of macrophage subsets and expression of nitric oxide synthase and arginase isoforms. J Immunol 2013; 191: 773-84.
26. Sica A, Montovani A,. Macrophage plasticity and polarization: in vivo veritas. J Clin Invest 2012; 122: 787-95.
27. Serhan CN, Brain SD, Buckley CD, Gilroy DW, Haslett C, O'Neill LA, et al., Resolution of inflammation: state of the art, definitions and terms. FASEB J 2007; 21: 325-32.
28. Levy BD, Clish CB, Schmidt B, Gronert K, Serhan CN,. Lipid mediator class switching during acute inflammation: signals in resolution. Nat Immunol 2001; 2: 612-9.
29. Serhan CN,. Lipoxins and aspirin-triggered 15-epi-lipoxins are the first lipid mediators of endogenous anti-inflammation and resolution. Prostaglandins Leukot Essent Fatty Acids 2005; 73: 141-62.
30. Ariel A, Serhan CN,. Resolvins and protectins in the termination program of acute inflammation. Trends Immunol 2007; 28: 176-83.
31. Serhan CN, Clish CB, Brannon J, Colgan SP, Chiang N, Gronert K, et al., Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing. J Exp Med 2000; 192: 1197-204.
32. Hasturk H, Kantarci A, Goguet-Surmenian E, Blackwood A, Andry C, Serhan CN, et al., Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivo. J Immunol 2007; 179: 7021-9.
33. Gao L, Faibish D, Fredman G, Herrera BS, Chiang N, Serhan CN, et al., Resolvin E1 and chemokine-like receptor 1 mediate bone preservation. J Immunol 2013; 190: 689-94.
34. Hong S, Gronert K, Devchand P, Moussignac RL, Serhan CN,. Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood and glial cells: autacoids in antiinflammation. J Biol Chem 2003; 278: 14677-87.
35. Freire-de-Lima CG, Xiao YQ, Gardai SJ, Bratton DL, Schiemann WP, Henson PM,. Apoptotic cells, through transforming growth factor-β, coordinately induce anti-inflammatory and suppress pro-inflammatory eicosanoid and NO synthesis in murine macrophages. J Biol Chem 2006; 281: 38376-84.