Aurora kinases phosphorylate Lgl to induce mitotic spindle orientation in drosophila epithelia

Current Biology

Volumn 25, Issue 1, 2015, Pages 61-68

  Bell, Graham P ^a   Fletcher, Georgina C ^a   Brain, Ruth ^a   Thompson, Barry J ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AURORA KINASE; DROSOPHILA PROTEIN; LETHAL (2) GIANT LARVAE PROTEIN, DROSOPHILA; PKC-3 PROTEIN; PROTEIN KINASE C; TUMOR SUPPRESSOR PROTEIN;

ANIMAL; CYTOPLASM; DROSOPHILA; EPITHELIUM CELL; FORELIMB; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MITOSIS; NEURAL STEM CELL; PHOSPHORYLATION; PHYSIOLOGY; SPINDLE APPARATUS;

ANIMALS; AURORA KINASES; CYTOPLASM; DROSOPHILA; DROSOPHILA PROTEINS; EPITHELIAL CELLS; MITOSIS; NEURAL STEM CELLS; PHOSPHORYLATION; PROTEIN KINASE C; SPINDLE APPARATUS; TUMOR SUPPRESSOR PROTEINS; WINGS, ANIMAL;

EID: 84920474491     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2014.10.052     Document Type: Article

References (38)

1. P.J. Bryant, and G. Schubiger Giant and duplicated imaginal discs in a new lethal mutant of Drosophila melanogaster Dev. Biol. 24 1971 233 263
2. B.M. Mechler, W. McGinnis, and W.J. Gehring Molecular cloning of lethal(2)giant larvae, a recessive oncogene of Drosophila melanogaster EMBO J. 4 1985 1551 1557
3. L. Jacob, M. Opper, B. Metzroth, B. Phannavong, and B.M. Mechler Structure of the l(2)gl gene of Drosophila and delimitation of its tumor suppressor domain Cell 50 1987 215 225
4. R. Lützelschwab, C. Klämbt, R. Rossa, and O. Schmidt A protein product of the Drosophila recessive tumor gene, l (2) giant gl, potentially has cell adhesion properties EMBO J. 6 1987 1791 1797
5. D. Bilder, M. Li, and N. Perrimon Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors Science 289 2000 113 116
6. C.Y. Lee, R.O. Andersen, C. Cabernard, L. Manning, K.D. Tran, M.J. Lanskey, A. Bashirullah, and C.Q. Doe Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation Genes Dev. 20 2006 3464 3474
7. C.Y. Lee, K.J. Robinson, and C.Q. Doe Lgl, Pins and aPKC regulate neuroblast self-renewal versus differentiation Nature 439 2006 594 598
8. U. Tepass The apical polarity protein network in Drosophila epithelial cells: regulation of polarity, junctions, morphogenesis, cell growth, and survival Annu. Rev. Cell Dev. Biol. 28 2012 655 685
9. D. St Johnston, and J. Ahringer Cell polarity in eggs and epithelia: parallels and diversity Cell 141 2010 757 774
10. B.J. Thompson Cell polarity: models and mechanisms from yeast, worms and flies Development 140 2013 13 21
11. J. Betschinger, K. Mechtler, and J.A. Knoblich The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl Nature 422 2003 326 330
12. A. Hutterer, J. Betschinger, M. Petronczki, and J.A. Knoblich Sequential roles of Cdc42, Par-6, aPKC, and Lgl in the establishment of epithelial polarity during Drosophila embryogenesis Dev. Cell 6 2004 845 854
13. J. Betschinger, F. Eisenhaber, and J.A. Knoblich Phosphorylation-induced autoinhibition regulates the cytoskeletal protein Lethal (2) giant larvae Curr. Biol. 15 2005 276 282
14. F. Wirtz-Peitz, T. Nishimura, and J.A. Knoblich Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localization Cell 135 2008 161 173
15. C.A. Carvalho, S. Moreira, G. Ventura, C.E. Sunkel, and E. Morais-de-Sá Aurora A triggers Lgl cortical release during symmetric division to control planar spindle orientation Curr. Biol. 2014 10.1016/j.cub.2014.10.053 Published online December 4, 2014
16. J. Huang, W. Zhou, W. Dong, A.M. Watson, and Y. Hong From the cover: directed, efficient, and versatile modifications of the Drosophila genome by genomic engineering Proc. Natl. Acad. Sci. USA 106 2009 8284 8289
17. M. Carmena, S. Ruchaud, and W.C. Earnshaw Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins Curr. Opin. Cell Biol. 21 2009 796 805
18. S.G. Zeitlin, C.M. Barber, C.D. Allis, and K.F. Sullivan Differential regulation of CENP-A and histone H3 phosphorylation in G2/M J. Cell Sci. 114 2001 653 661
19. N. Kunitoku, T. Sasayama, T. Marumoto, D. Zhang, S. Honda, O. Kobayashi, K. Hatakeyama, Y. Ushio, H. Saya, and T. Hirota CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function Dev. Cell 5 2003 853 864
20. S.E. Siegrist, and C.Q. Doe Microtubule-induced Pins/Galphai cortical polarity in Drosophila neuroblasts Cell 123 2005 1323 1335
21. K.H. Siller, and C.Q. Doe Spindle orientation during asymmetric cell division Nat. Cell Biol. 11 2009 365 374
22. C. Gonzalez Spindle orientation, asymmetric division and tumour suppression in Drosophila stem cells Nat. Rev. Genet. 8 2007 462 472
23. M. Mapelli, and C. Gonzalez On the inscrutable role of Inscuteable: structural basis and functional implications for the competitive binding of NuMA and Inscuteable to LGN Open Biol. 2 2012 120102
24. D.T. Bergstralh, T. Haack, and D. St Johnston Epithelial polarity and spindle orientation: intersecting pathways Philos. Trans. R. Soc. Lond. B Biol. Sci. 368 2013 20130291
25. D.T. Bergstralh, H.E. Lovegrove, and D. St Johnston Discs large links spindle orientation to apical-basal polarity in Drosophila epithelia Curr. Biol. 23 2013 1707 1712
26. Y. Bellaïche, A. Radovic, D.F. Woods, C.D. Hough, M.L. Parmentier, C.J. O'Kane, P.J. Bryant, and F. Schweisguth The Partner of Inscuteable/Discs-large complex is required to establish planar polarity during asymmetric cell division in Drosophila Cell 106 2001 355 366
27. C.A. Johnston, K. Hirono, K.E. Prehoda, and C.Q. Doe Identification of an Aurora-A/PinsLINKER/Dlg spindle orientation pathway using induced cell polarity in S2 cells Cell 138 2009 1150 1163
28. B. Egger, J.Q. Boone, N.R. Stevens, A.H. Brand, and C.Q. Doe Regulation of spindle orientation and neural stem cell fate in the Drosophila optic lobe Neural Dev. 2 2007 1
29. Y. Nakajima, E.J. Meyer, A. Kroesen, S.A. McKinney, and M.C. Gibson Epithelial junctions maintain tissue architecture by directing planar spindle orientation Nature 500 2013 359 362
30. J. Zhu, Y. Shang, Q. Wan, Y. Xia, J. Chen, Q. Du, and M. Zhang Phosphorylation-dependent interaction between tumor suppressors Dlg and Lgl Cell Res. 24 2014 451 463
31. S. Kim, I. Gailite, B. Moussian, S. Luschnig, M. Goette, K. Fricke, M. Honemann-Capito, H. Grubmüller, and A. Wodarz Kinase-activity-independent functions of atypical protein kinase C in Drosophila J. Cell Sci. 122 2009 3759 3771
32. J. Huang, W. Zhou, W. Dong, and Y. Hong Targeted engineering of the Drosophila genome Fly (Austin) 3 2009 274 277
33. K.L. Pope, and T.J. Harris Control of cell flattening and junctional remodeling during squamous epithelial morphogenesis in Drosophila Development 135 2008 2227 2238
34. A.G. Tian, and W.M. Deng Lgl and its phosphorylation by aPKC regulate oocyte polarity formation in Drosophila Development 135 2008 463 471
35. Y.H. Koh, E. Popova, U. Thomas, L.C. Griffith, and V. Budnik Regulation of DLG localization at synapses by CaMKII-dependent phosphorylation Cell 98 1999 353 363
36. D.J. David, A. Tishkina, and T.J. Harris The PAR complex regulates pulsed actomyosin contractions during amnioserosa apical constriction in Drosophila Development 137 2010 1645 1655
37. K.J. Venken, K.L. Schulze, N.A. Haelterman, H. Pan, Y. He, M. Evans-Holm, J.W. Carlson, R.W. Levis, A.C. Spradling, R.A. Hoskins, and H.J. Bellen MiMIC: a highly versatile transposon insertion resource for engineering Drosophila melanogaster genes Nat. Methods 8 2011 737 743
38. D. Berdnik, and J.A. Knoblich Drosophila Aurora-A is required for centrosome maturation and actin-dependent asymmetric protein localization during mitosis Curr. Biol. 12 2002 640 647