Effects of a kefir supplement on symptoms, colonic transit, and bowel satisfaction score in patients with chronic constipation: A pilot study

Turkish Journal of Gastroenterology

Volumn 25, Issue 6, 2014, Pages 650-656

  Turan, Ilker ^a   Dedeli, Ozden ^b   Bor, Serhat ^a   Ilter, Tankut ^a  

^a EGE UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

^b CELAL BAYAR UNIVERSITY   (Turkey)

Author keywords

Constipation; Gastrointestinal transit; Kefir; Probiotic; Therapy

Indexed keywords

KEFIR; LAXATIVE; PROBIOTIC AGENT;

ADULT; AGED; ANORECTAL PRESSURE; ARTICLE; ASSESSMENT OF HUMANS; BOWEL SATISFACTION SCORE; CLINICAL ARTICLE; COMPARATIVE STUDY; CONSTIPATION; CONTROLLED STUDY; DEFECATION HABIT; DIET SUPPLEMENTATION; FECES INCONTINENCE; FEMALE; GASTROINTESTINAL TRANSIT; HUMAN; MALE; MIDDLE AGED; PILOT STUDY; VISUAL ANALOG SCALE; CHRONIC DISEASE; CLINICAL TRIAL; COLON; DAIRY PRODUCT; PATHOPHYSIOLOGY;

ADULT; AGED; CHRONIC DISEASE; COLON; CONSTIPATION; CULTURED MILK PRODUCTS; DIETARY SUPPLEMENTS; FEMALE; GASTROINTESTINAL TRANSIT; HUMANS; MALE; MIDDLE AGED; PILOT PROJECTS; PROBIOTICS;

EID: 84920438062     PISSN: 13004948     EISSN: None     Source Type: Journal    
DOI: 10.5152/tjg.2014.6990     Document Type: Article

References (32)

1. Stewart WF, Liberman JN, Sandler RS, et al. Epidemiology of constipation (EPOC) study in the United States: relation of clinical subtypes to sociodemographic features. Am J Gastroenterol 1999; 94: 3530-40.
2. Sonnenberg A, Koch TR. Epidemiology of constipation in the United States. Dis Colon Rectum 1989; 32: 1-8.
3. Higgins PD, Johanson JF. Epidemiology of constipation in North America: a systematic review. Am J Gastroenterol 2004; 99: 750-9.
4. Kasap E, Kitapcioglu G, Ilter T, Bor S. Turkiyede Fonksiyonel Barsak Hastaliklari Prevalansi. Turk J Gastroenterol 2006; (17 Suppl 1): 119.
5. Chang L, Toner BB, Fukudo S, et al. Gender, age, society, culture, and the patients perspective in the functional gastrointestinal disorders. Gastroenterology 2006; 130: 1435-46.
6. Lembo A, Camilleri M. Chronic constipation. N Engl J Med 2003; 349: 1360-8.
7. Ramkumar D, Rao SS. Efficacy and safety of traditional medical therapies for chronic constipation: systematic review. Am J Gastroenterol 2005; 100: 936-71.
8. Mollenbrink M, Bruckschen E. Treatment of chronic constipation with physiologic Escherichia coli bacteria. Results of a clinical study of the effectiveness and tolerance of microbiological therapy with the E. coli Nissle 1917 strain (Mutaflor). Med Klin (Munich) 1994; 89: 587-93.
9. Koebnick C, Wagner I, Leitzmann P, et al. Probiotic beverage containing Lactobacillus casei Shirota improves gastrointestinal symptoms in patients with chronic constipation. Can J Gastroenterol 2003; 17: 655-9.
10. Yang YX, He M, Hu G, et al. Effect of a fermented milk containing Bifidobacterium lactis DN-173010 on Chinese constipated women. World J Gastroenterol 2008; 14: 6237-43.
11. Bekkali NL, Bongers ME, Van den Berg MM, et al. The role of a probiotics mixture in the treatment of childhood constipation: a pilot study. Nutr J 2007; 6: 17.
12. Guzel-Seydim ZB, Kok-Tas T, Greene AK, Seydim AC. Review: Functional properties of kefir. Crit Rev Food Sci Nutr 2011; 51: 261-8.
13. Rao SS, Azpiroz F, Diamant N, et al. Minimum standards of anorectal manometry. Neurogastroenterol Motil 2002; 14: 553-9.
14. Dedeli O, Turan I, Ozturk R, Bor S. Normative values of the balloon expulsion test in healthy adults. Turk J Gastroenterol 2007; 18: 177-81.
15. Evans RC, Kamm MA, Hinton JM, Lennard-Jones JE. The normal range and a simple diagram for recording whole gut transit time. Int J Colorectal Dis 1992; 7: 15-7.
16. Toba T. Fermented milks produced with mesophilic lactic acid bacteria. Kefir and Scandinavian ropy sour milk. Jpn J Dairy Food Sci 1987; 36: 235-44.
17. Angulo L, Lopez E, Lema C. Microflora present in kefir grains of the Galician region (north-west of Spain). J Dairy Res 1992; 60: 263-7.
18. Abraham AG, De Antoni GL. Characterisation of kefir grains grown in cows milk and in soya milk. J Dairy Res 1999; 66: 327-33.
19. Talley NJ, Weaver AL, Zinsmeister AR, et al. Functional constipation and outlet delay: A population-based study. Gastroenterology 1993; 105: 781-90.
20. Johanson JF, Kralstein J. Chronic constipation: a survey of the patient perspective. Aliment Pharmacol Ther 2007; 25: 599-608.
21. Quigley EM. The enteric microbiota in the pathogenesis and management of constipation. Best Pract Res Clin Gastroenterol 2011; 25:119-26.
22. Khalif IL, Quigley EM, Konovitch EA, Maximova ID. Alterations in the colonic flora and intestinal permeability and evidence of immune activation in chronic constipation. Dig Liver Dis 2005; 37: 838-49.
23. Zoppi G, Cinquetti M, Luciano A, et al. The intestinal ecosystem in chronic functional constipation. Acta Paediatr 1998; 87: 836-41.
24. Del Piano M, Carmagnola S, Anderloni A, et al. The use of probiotics in healthy volunteers with evacuation disorders and hard stools: a double-blind, randomized, placebo-controlled study. J Clin Gastroenterol 2010; 44 Suppl 1:S30-4.
25. Chmielewska A, Szajewska H. Systematic review of randomised controlled trials: probiotics for functional constipation. World J Gastroenterol 2010; 16: 69-75.
26. Maeda H, Zhu X, Omura K, et al. Effects of an exopolysaccharide (kefiran) on lipids, blood pressure, blood glucose, and constipation. Biofactors 2004; 22: 197-200.
27. Hertzler SR, Clancy SM. Kefir improves lactose digestion and tolerance in adults with lactose maldigestion. J Am Diet Assoc 2003; 103: 582-7.
28. Picard C, Fioramonti J, Francois A, et al. Review article: bifidobacteria as probiotic agents -physiological effects and clinical benefits. Aliment Pharmacol Ther 2005; 22: 495-512.
29. Agrawal A, Houghton LA, Morris J, et al. Clinical trial: the effects of a fermented milk product containing Bifidobacterium lactis DN-173-010 on abdominal distension and gastrointestinal transit in irritable bowel syndrome with constipation. Aliment Pharmacol Ther 2009; 29: 104-14.
30. Hongisto SM, Paajanen L, Saxelin M, Korpela R. A combination of fibre-rich rye bread and yoghurt containing Lactobacillus GG improves bowel function in women with self-reported constipation. Eur J Clin Nutr 2006; 60: 319-24.
31. Cardoso LG, Ferreira MS, Schneedorf JM, Carvalho JCT. Evaluation of a soured kefir on intestinal motility of rats. Jornal Brasileiro de Fitoterapia 2003; 1: 107-9.
32. Szajewska H, Setty M, Mrukowicz J, Guandalini S. Probiotics in gastrointestinal diseases in children: hard and not-so-hard evidence of efficacy. J Pediatr Gastroenterol Nutr 2006; 42: 454-75.