DNAJB1 destabilizes PDCD5 to suppress p53-mediated apoptosis

Cancer Letters

Volumn 357, Issue 1, 2015, Pages 307-315

  Cui, Xiandan ^a   Choi, Hyo Kyoung ^a   Choi, Young Seok ^b   Park, Soo Yeon ^a   Sung, Gi Jun ^c   Lee, Yoo Hyun ^d   Lee, Jeongmin ^e   Jun, Woo Jin ^f   Kim, Kyungsup ^a   Choi, Kyung Chul ^c   Yoon, Ho Geun ^a  

^a Yonsei University College of Medicine   (South Korea)

^b CHA University   (South Korea)

^c University of Ulsan College of Medicine   (South Korea)

^d Suwon University   (South Korea)

^e Kyung Hee University   (South Korea)

^f Chonnam National University   (South Korea)

Author keywords

Apoptosis; DNAJB1; P53; PDCD5; Ubiquitination

Indexed keywords

ETOPOSIDE; HEAT SHOCK PROTEIN 40; PROTEIN DNAJB1; PROTEIN P53; PROTEIN PDCD5; TUMOR SUPPRESSOR PROTEIN; UBIQUITIN; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; DNAJB1 PROTEIN, HUMAN; PDCD5 PROTEIN, HUMAN; TP53 PROTEIN, HUMAN; TUMOR PROTEIN;

A549 CELL LINE; ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CELL; CANCER GROWTH; CONTROLLED STUDY; EMBRYO; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; LUNG CANCER; MOUSE; NONHUMAN; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; TRANSCRIPTION REGULATION; UBIQUITINATION; CELL PROLIFERATION; COLON TUMOR; GENETIC TRANSFECTION; GENETICS; HCT116 CELL LINE; HEK293 CELL LINE; LUNG TUMOR; METABOLISM; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; COLONIC NEOPLASMS; HCT116 CELLS; HEK293 CELLS; HSP40 HEAT-SHOCK PROTEINS; HUMANS; LUNG NEOPLASMS; NEOPLASM PROTEINS; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITINATION;

EID: 84920380990     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2014.11.041     Document Type: Article

References (19)

1. Saibil H. Chaperone machines for protein folding, unfolding and disaggregation. Nat. Rev. Mol. Cell Biol 2013, 14:630-642.
2. Rylander M.N., Feng Y., Bass J., Diller K.R. Thermally induced injury and heat-shock protein expression in cells and tissues. Ann. N. Y. Acad. Sci 2005, 1066:222-242.
3. Gottesman S., Wickner S., Maurizi M.R. Protein quality control: triage by chaperones and proteases. Genes Dev 1997, 11:815-823.
4. Hartl F.U. Molecular chaperones in cellular protein folding. Nature 1996, 381:571-579.
5. Bohen S.P., Kralli A., Yamamoto K.R. Hold 'em and fold 'em: chaperones and signal transduction. Science 1995, 268:1303-1304.
6. Mitra A., Shevde L.A., Samant R.S. Multi-faceted role of HSP40 in cancer. Clin. Exp. Metastasis 2009, 26:559-567.
7. King F.W., Wawrzynow A., Hohfeld J., Zylicz M. Co-chaperones Bag-1, Hop and Hsp40 regulate Hsc70 and Hsp90 interactions with wild-type or mutant p53. EMBO J. 2001, 20:6297-6305.
8. Powers M.V., Clarke P.A., Workman P. Dual targeting of HSC70 and HSP72 inhibits HSP90 function and induces tumor-specific apoptosis. Cancer Cell 2008, 14:250-262.
9. Soti C., Nagy E., Giricz Z., Vigh L., Csermely P., Ferdinandy P. Heat shock proteins as emerging therapeutic targets. Br. J. Pharmacol 2005, 146:769-780.
10. Jego G., Hazoume A., Seigneuric R., Garrido C. Targeting heat shock proteins in cancer. Cancer Lett 2013, 332:275-285.
11. Gotoh T., Terada K., Mori M. hsp70-DnaJ chaperone pairs prevent nitric oxide-mediated apoptosis in RAW 264.7 macrophages. Cell Death Differ 2001, 8:357-366.
12. Gotoh T., Terada K., Oyadomari S., Mori M. hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria. Cell Death Differ 2004, 11:390-402.
13. Velichko A.K., Markova E.N., Petrova N.V., Razin S.V., Kantidze O.L. Mechanisms of heat shock response in mammals. Cell. Mol. Life Sci 2013, 70:4229-4241.
14. Li X., Srinivasan S.R., Connarn J., Ahmad A., Young Z.T., Kabza A.M., et al. Analogs of the allosteric Heat Shock Protein 70 (Hsp70) inhibitor, MKT-077, as anti-cancer agents. ACS Med. Chem. Lett 2013, 4.
15. Maloney A., Workman P. HSP90 as a new therapeutic target for cancer therapy: the story unfolds. Expert Opin. Biol. Ther 2002, 2:3-24.
16. De Bessa S.A., Salaorni S., Patrao D.F., Neto M.M., Brentani M.M., Nagai M.A. JDP1 (DNAJC12/Hsp40) expression in breast cancer and its association with estrogen receptor status. Int. J. Mol. Med 2006, 17:363-367.
17. Tsai M.F., Wang C.C., Chang G.C., Chen C.Y., Chen H.Y., Cheng C.L., et al. A new tumor suppressor DnaJ-like heat shock protein, HLJ1, and survival of patients with non-small-cell lung carcinoma. J. Natl. Cancer Inst 2006, 98:825-838.
18. Witham J., Vidot S., Agarwal R., Kaye S.B., Richardson A. Transient ectopic expression as a method to detect genes conferring drug resistance. Int. J. Cancer 2008, 122:2641-2645.
19. Laufen T., Mayer M.P., Beisel C., Klostermeier D., Mogk A., Reinstein J., et al. Mechanism of regulation of hsp70 chaperones by DnaJ cochaperones. Proc. Natl. Acad. Sci. U.S.A. 1999, 96:5452-5457.