Type 2 Diabetes: Is Pancreas Transplantation an Option?

Current Diabetes Reports

Volumn 14, Issue 11, 2014, Pages

  Ciancio, Gaetano ^a   Burke, George W ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

C peptide; Pancreas transplantation; Patient candidates; Type 1 diabetes mellitus; Type 2 diabetes mellitus

Indexed keywords

CREATININE CLEARANCE; DISEASE SEVERITY; GLYCEMIC CONTROL; HUMAN; HYPOGLYCEMIA; KIDNEY FAILURE; KIDNEY FUNCTION; NON INSULIN DEPENDENT DIABETES MELLITUS; OUTCOME ASSESSMENT; PANCREAS TRANSPLANTATION; PATIENT SELECTION; POSTOPERATIVE COMPLICATION; QUALITY OF LIFE; REVIEW; BARIATRIC SURGERY; BLOOD; COMPLICATION; DIABETES MELLITUS, TYPE 2; FOLLOW UP; GLUCOSE BLOOD LEVEL; PROCEDURES; RISK REDUCTION; SECRETION (PROCESS); SURVIVAL RATE;

C PEPTIDE; GLUCOSE BLOOD LEVEL; INSULIN;

BARIATRIC SURGERY; BLOOD GLUCOSE; C-PEPTIDE; DIABETES MELLITUS, TYPE 2; FOLLOW-UP STUDIES; HUMANS; INSULIN; PANCREAS TRANSPLANTATION; PATIENT SELECTION; QUALITY OF LIFE; RISK REDUCTION BEHAVIOR; SURVIVAL RATE;

EID: 84920283256     PISSN: 15344827     EISSN: 15390829     Source Type: Journal    
DOI: 10.1007/s11892-014-0542-9     Document Type: Review

References (39)

1. Leichtman AB, Cohen D, Keith D, et al. Kidney and pancreas transplantation in the United States, 1997–2006: the HRSA Breakthrough Collaboratives and the 58 DSA Challenge. Am J Transplant. 2008;8(4 Pt 2):946–57.
2. Burke GW, Ciancio G, Sollinger HW. Advances in pancreas transplantation. Transplantation. 2004;77(9 Suppl):S62–7.
3. Ciancio G, Burke GW, Miller J. Current treatment practices in immunosuppression. Expert Opin Pharmacother. 2000;1:1307–30.
4. Ciancio G, Mattiazzi A, Roth D, Kupin W, Miller J, Burke GW. The use of daclizumab as induction therapy in combination with tacrolimus and mycophenolate mofetil in recipients with previous transplants. Clin Transplant. 2003;17(5):428–32.
5. Burke GW, Ciancio G. Critical care issues in the renal and pancreatic allograft recipient. In: Civetta JM, Taylor RW, Kirby RR, editors. Critical care. 3rd ed. Philadelphia: J.B. Lippincott Company; 1997. p. 1311–5.
6. White SA, Shaw JA, Sutherland DE. Pancreas transplantation. Lancet. 2009;373(9677):1808–17.
7. Stumvoll M, Goldstein BJ, Van Haeften TW. Type 2 diabetes: pathogenesis and treatment. Lancet. 2008;371(9631):2153–6.
8. Ferchak CV, Meneghini LF. Obesity, bariatric surgery, and type 2 diabetes. Diabetes Metab Res Rev. 2004;6:438–45.
9. Sampaio MS, Kuo HT, Bunnapradist S. Outcomes of simultaneous pancreas-kidney transplantation in type 2 diabetic recipients. Clin J Am Soc Nephrol. 2011;6:1198–206.
10. Wiseman AC, Gralla J. Simulatenous pancreas kidney transplant versus other kidney options in patients with type 2 diabetes. Clin J Am Soc Nephrol. 2012;7:656–64.
11. Gruessner AC. 2011 update on pancreas transplantation: comprehensive trend analysis of 25,000 cases followed up over the course of twenty-four years at the International Pancreas Transplant Registry (IPTR). Rev Diabet Stud. 2011;8:6–16.
12. Scalea JR, Cooper M. Surgical strategies for type II diabetes. Transplant Rev. 2012;26:177–82.
13. American Diabetes Association Expert Committee. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care. 2003;26:S5–20.
14. Ciancio G, Sageshima J, Chen L, et al. Advantage of rapamycin over mycophenolate mofetil when used with tacrolimus for simultaneous kidney transplant recipients: randomized, single-center trial at 10 years. Am J Transplant. 2012;2:3363–76. This paper illustrates long-term survival of pancreas transplantation in a randomized prospective trial.
15. Nath DS, Gruessner AC, Kandaswamy R, et al. Outcomes of pancreas transplants for patients with type 2 diabetes mellitus. Clin Transplant. 2005;19:792–7.
16. Orlando G, Stratta RJ, Light J. Pancreas transplantation for type 2 diabetes mellitus. Curr Opin Organ Transplant. 2010;16:110–5. This paper provides evidence that some patients with T2D will benefit from pancreas transplantation.
17. Singh RP, Rogers J, Farney A, et al. Do pretransplant C-peptide levels influence outcomes in simultaneous kidney-pancreas transplantation? Transplant Proc. 2008;40:510–2.
18. Light JA, Barhyte DY. Simultaneous pancreas-kidney transplants in type I and type II diabetic patients with end-stage renal disease. Similar 10-year outcomes. Transplant Proc. 2005;37:1283–4.
19. Esmatjes E, Fernandez C, Rueda S, et al. The utility of the C-peptide in the phenotyping of patient candidates for pancreas transplantation. Clin Transplant. 2007;21:358–62.
20. Burke GW, Ciancio G, Olson L, Roth D, Miller J. Ten-year survival after simultaneous pancreas/kidney transplantation with bladder drainage and tacrolimus-based immunosuppression. Transplant Proc. 2001;33(1–2):1681–3.
21. White SA, Shaw JA, Sutherland DE. Pancreas transplantation. Lancet. 2009;373(9677):1808–17.
22. Nathan DM, Cleary PA, Backlund JY, et al. Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. NEJM. 2005;353:2643–53.
23. Friedman AL, Friedman EA. Pancreas transplantation for type 2 diabetes at U.S. transplant centers. Diabetes Care. 2002;25:1896.
24. Sasaki TM, Gray RS, Ratner RE, et al. Successful long-term kidney-pancreas transplants in diabetic patients with high C-peptide levels. Transplantation. 1998;65:1510–2.
25. Light JA, Sasaki TM, Currier CB, Barhyte DY. Successful long term kidney-pancreas transplants regardless of C-peptide status and race. Transplantation. 2001;71:152–4.
26. Nath DS, Gruessner AC, Kandaswamy R, Gruessner RW, Sutherland DER, Humar A. Outcomes of pancreas transplants for patients with type 2 diabetes mellitus. Clin Transplant. 2005;19:792–7.
27. Margreiter C, Resch T, Oberhuber R, Aigner F, Maier H, Sucher R, et al. Combined pancreas-kidney transplantation for patients with end-stage nephropathy caused by type-2 diabetes mellitus. Transplantation. 2013;95:1030–6. This paper reports recent experience with pancreas transplantation in T2D patients.
28. Vendrame F, Pileggi A, Laughlin E, et al. Recurrence of type 1 diabetes after simultaneous pancreas-kidney transplantatiom, despite immunosuppression, is associated with autoantibodies and pathogenic autoreactive CD4 T-cells. Diabetes. 2010;59:947–57.
29. Coppelli A, Giannarelli R, Vistoli F, et al. The beneficial effects of pancreas transplant alone on diabetic nephropathy. Diabetes Care. 2005;28(6):1366–70.
30. Fioretto P, Mauer SM, Bilous RW, Goetz FC, Sutherland DE, Steffes MW. Effects of pancreas transplantation on glomerular structure in insulin-dependent diabetic patients with their own kidneys. Lancet. 1993;342(8881):1193–6.
31. Fioretto P, Steffes MW, De Sutherland, Goetz FC, Mauer M. Reversal of lesions of diabetic nephropathy after pancreas transplantation. N Eng J Med. 1998;339(2):69–75.
32. Fioretto P, Sutherland DE, Najafian B, Mauer M. Remodeling of renal interstitial and tubular lesions in pancreas transplant recipients. Kidney Int. 2006;69(5):907–12.
33. Giannarelli R, Coppelli A, Sartini MS, et al. Pancreas transplant alone has beneficial effects on retinopathy in type 1 diabetic patients. Diabetologia. 2006;49(12):2977–82.
34. Pearce IA, Ilango B, Sells RA, Wong D. Stabilisation of diabetic retinopathy following simultaneous pancreas and kidney transplant. Br J Ophthalmol. 2000;84(7):736–40.
35. Hathaway DK, Hartwig MS, Milstead J, Elmer D, Evans S, Gaber AO. Improvement in quality of life reported by diabetic recipients of kidney-only and pancreas-kidney allografts. Transplant Proc. 1994;26(2):512–4.
36. Navarro X, Sutherland DE, Kennedy WR. Long-term effects of pancreatic transplantation on diabetic neuropathy. Ann Neurol. 1997;42(5):727–36.
37. Guerra G, Ilahe A, Ciancio G. Diabetes and kidney transplantation: past, present, and future. Curr Diab Rep. 2012;12(5):597–603.
38. Meier-Kriesche HU, Stegall MD. Should we be performing pancreas transplants? Am J Transplant. 2004;4(12):1935–6.
39. Dean PG, Kudva YC, Larson TS, Kremers WK, Stegall MD. Posttransplant diabetes mellitus after pancreas transplantation. Am J Transplant. 2008;8(1):175–82.