Adaptive amino acid substitutions enhance the virulence of a reassortant H7N1 avian influenza virus isolated from wild waterfowl in mice

Virology

Volumn 476, Issue , 2015, Pages 233-239

  Yu, Zhijun ^a,b   Sun, Weiyang ^b   Li, Xue ^b,e   Chen, Qiang ^c,d   Chai, Hongliang ^c   Gao, Xiaolong ^b   Guo, Jiao ^b   Zhang, Kun ^b   Wang, Tiecheng ^b   Feng, Na ^b   Zheng, Xuexing ^b   Wang, Hualei ^b   Zhao, Yongkun ^b   Qin, Chuan ^a   Huang, Geng ^b   Yang, Songtao ^b   Hua, Yuping ^c   Zhang, Xuemei ^e   Gao, Yuwei ^b,f   Xia, Xianzhu ^a,b,f  

^a INSTITUTE OF LABORATORY ANIMAL SCIENCE   (China)

^b BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^c NORTHEAST FORESTRY UNIVERSITY   (China)

^d JINZHOU MEDICAL UNIVERSITY   (China)

^e Changchun Institute of Biological Products   (China)

^f YANGZHOU UNIVERSITY   (China)

Author keywords

Adaptation; Avian influenza virus; H7N1; Mice; Wild waterfowl

Indexed keywords

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GENETIC REASSORTMENT; GENOME ANALYSIS; IN VITRO STUDY; IN VIVO STUDY; INFLUENZA VIRUS A H7N1; LETHAL DOSE; LUNG INFECTION; MOUSE; NONHUMAN; SEQUENCE ANALYSIS; STRAIN IDENTIFICATION; VIRAL TROPISM; VIRUS GENOME; VIRUS ISOLATION; VIRUS LOAD; VIRUS REPLICATION; VIRUS STRAIN; VIRUS VIRULENCE; WATERFOWL; ADAPTATION; ANIMAL; AVIAN INFLUENZA; BAGG ALBINO MOUSE; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; PATHOGENICITY; PHYSIOLOGY; VIROLOGY; VIRULENCE; WILD ANIMAL;

ANATIDAE; AVES; AVIAN INFLUENZA VIRUS; MAMMALIA; MUS;

INFLUENZA VIRUS HEMAGGLUTININ; NA PROTEIN, INFLUENZA A VIRUS; PB2 PROTEIN, INFLUENZAVIRUS A; RNA DIRECTED RNA POLYMERASE; SIALIDASE; VIRUS PROTEIN;

ADAPTATION, BIOLOGICAL; AMINO ACID SUBSTITUTION; ANIMALS; ANIMALS, WILD; ANSERIFORMES; FEMALE; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; INFLUENZA A VIRUS, H7N1 SUBTYPE; INFLUENZA IN BIRDS; MICE; MICE, INBRED BALB C; NEURAMINIDASE; REASSORTANT VIRUSES; RNA REPLICASE; VIRAL PROTEINS; VIRULENCE;

EID: 84920202365     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2014.11.031     Document Type: Article

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