A prospective phase 2 multicenter study for the efficacy of radiation therapy following incomplete transarterial chemoembolization in unresectable hepatocellular carcinoma

International Journal of Radiation Oncology Biology Physics

Volumn 90, Issue 5, 2014, Pages 1051-1060

  Choi, Chihwan ^a   Koom, Woong Sub ^a   Kim, Tae Hyun ^b   Yoon, Sang Min ^c   Kim, Jin Hee ^d   Lee, Hyung Sik ^e   Nam, Taek Keun ^f   Seong, Jinsil ^a  

^a Yonsei University College of Medicine   (South Korea)

^b National Cancer Center   (South Korea)

^c University of Ulsan College of Medicine   (South Korea)

^d Keimyung University School of Medicine   (South Korea)

^e Dong A University College of Medicine   (South Korea)

^f Chonnam National University Medical School   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

SURVEYS; TOXICITY; TUMORS;

HEPATOCELLULAR CARCINOMA; METHODS AND MATERIALS; OVERALL SURVIVAL RATES; PATTERNS OF FAILURE; PROGNOSTIC FACTORS; PROGRESSION FREE SURVIVAL; RADIATION-INDUCED LIVER DISEASE; TRANSARTERIAL CHEMOEMBOLIZATION;

RADIOTHERAPY;

CISPLATIN; DOXORUBICIN; GELATIN SPONGE; IODINATED POPPYSEED OIL; ANTINEOPLASTIC AGENT;

ABDOMINAL PAIN; ADULT; AGED; ANOREXIA; ARTICLE; BILE DUCT FISTULA; BILOMA; BLOOD TOXICITY; CANCER PROGNOSIS; CANCER RADIOTHERAPY; CANCER STAGING; CANCER SURVIVAL; CHEMOEMBOLIZATION; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; FATIGUE; FEMALE; HUMAN; LIVER CELL CARCINOMA; MALE; MULTICENTER STUDY; MUSCLE WEAKNESS; NAUSEA; OVERALL SURVIVAL; PROGRESSION FREE SURVIVAL; RADIATION DOSE FRACTIONATION; THREE DIMENSIONAL IMAGING; TRANSARTERIAL CHEMOEMBOLIZATION; TREATMENT FAILURE; TREATMENT RESPONSE; TUMOR GROWTH; CARCINOMA, HEPATOCELLULAR; CLINICAL TRIAL; COMPUTER ASSISTED RADIOTHERAPY; DISEASE FREE SURVIVAL; LIVER NEOPLASMS; MIDDLE AGED; MORTALITY; PATHOLOGY; PHASE 2 CLINICAL TRIAL; PROCEDURES; PROSPECTIVE STUDY; RADIATION DOSE; SAMPLE SIZE;

ADULT; AGED; ANTINEOPLASTIC AGENTS; CARCINOMA, HEPATOCELLULAR; CHEMOEMBOLIZATION, THERAPEUTIC; CISPLATIN; DISEASE-FREE SURVIVAL; DOXORUBICIN; FEMALE; HUMANS; IODIZED OIL; LIVER NEOPLASMS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RADIOTHERAPY DOSAGE; RADIOTHERAPY, CONFORMAL; SAMPLE SIZE; TREATMENT FAILURE;

EID: 84920172423     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2014.08.011     Document Type: Article

References (35)

1. A. Jemal, F. Bray, and M.M. Center Global cancer statistics CA Cancer J Clin 61 2011 69 90
2. J. Ferlay, H.R. Shin, and F. Bray Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008 Int J Cancer 127 2010 2893 2917
3. J.F. Perz, G.L. Armstrong, and L.A. Farrington The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide J Hepatol 45 2006 529 538
4. European Association for the Study of the Liver, and European Organisation for Research, Treatment of Cancer EASL-EORTC clinical practice guidelines: Management of hepatocellular carcinoma J Hepatol 56 2012 908 943
5. C.R. de Lope, S. Tremosini, and A. Forner Management of HCC J Hepatol 56 suppl 1 2012 S75 87
6. C.M. Lo, H. Ngan, and W.K. Tso Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma Hepatology 35 2002 1164 1171
7. J.M. Llovet, M.I. Real, and X. Montana Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: A randomised controlled trial Lancet 359 2002 1734 1739
8. Y.Q. Yu, D.B. Xu, and X.D. Zhou Experience with liver resection after hepatic arterial chemoembolization for hepatocellular carcinoma Cancer 71 1993 62 65
9. T. Higuchi, M. Kikuchi, and M. Okazaki Hepatocellular carcinoma after transcatheter hepatic arterial embolization. A histopathologic study of 84 resected cases Cancer 73 1994 2259 2267
10. M. Feng, and E. Ben-Josef Radiation therapy for hepatocellular carcinoma Semin Radiat Oncol 21 2011 271 277
11. J. Klein, and L.A. Dawson Hepatocellular carcinoma radiation therapy: Review of evidence and future opportunities Int J Radiat Oncol Biol Phys 87 2013 22 32
12. J. Seong, H.C. Park, and K.H. Han Local radiotherapy for unresectable hepatocellular carcinoma patients who failed with transcatheter arterial chemoembolization Int J Radiat Oncol Biol Phys 47 2000 1331 1335
13. K. Yamada, K. Izaki, and K. Sugimoto Prospective trial of combined transcatheter arterial chemoembolization and three-dimensional conformal radiotherapy for portal vein tumor thrombus in patients with unresectable hepatocellular carcinoma Int J Radiat Oncol Biol Phys 57 2003 113 119
14. J. Seong, H.C. Park, and K.H. Han Clinical results of 3-dimensional conformal radiotherapy combined with transarterial chemoembolization for hepatocellular carcinoma in the cirrhotic patients Hepatol Res 27 2003 30 35
15. W.J. Guo, E.X. Yu, and L.M. Liu Comparison between chemoembolization combined with radiotherapy and chemoembolization alone for large hepatocellular carcinoma World J Gastroenterol 9 2003 1697 1701
16. B. Li, J. Yu, and L. Wang Study of local three-dimensional conformal radiotherapy combined with transcatheter arterial chemoembolization for patients with stage III hepatocellular carcinoma Am J Clin Oncol 26 2003 e92 e99
17. S.J. Shim, J. Seong, and K.H. Han Local radiotherapy as a complement to incomplete transcatheter arterial chemoembolization in locally advanced hepatocellular carcinoma Liver Int 25 2005 1189 1196
18. T.H. Kim, D.Y. Kim, and J.W. Park Three-dimensional conformal radiotherapy of unresectable hepatocellular carcinoma patients for whom transcatheter arterial chemoembolization was ineffective or unsuitable Am J Clin Oncol 29 2006 568 575
19. Z.H. Zhou, L.M. Liu, and W.W. Chen Combined therapy of transcatheter arterial chemoembolisation and three-dimensional conformal radiotherapy for hepatocellular carcinoma Br J Radiol 80 2007 194 201
20. D. Oh, H. Lim do, and H.C. Park Early three-dimensional conformal radiotherapy for patients with unresectable hepatocellular carcinoma after incomplete transcatheter arterial chemoembolization: A prospective evaluation of efficacy and toxicity Am J Clin Oncol 33 2010 370 375
21. M.B. Meng, Y.L. Cui, and Y. Lu Transcatheter arterial chemoembolization in combination with radiotherapy for unresectable hepatocellular carcinoma: A systematic review and meta-analysis Radiother Oncol 92 2009 184 194
22. R. Simon Optimal two-stage designs for phase II clinical trials Control Clin Trials 10 1989 1 10
23. J.M. Llovet, A.M. Di Bisceglie, and J. Bruix Design and endpoints of clinical trials in hepatocellular carcinoma J Natl Cancer Inst 100 2008 698 711
24. R. Lencioni, and J.M. Llovet Modified RECIST (mRECIST) assessment for hepatocellular carcinoma Semin Liver Dis 30 2010 52 60
25. J.C. Cheng, J.K. Wu, and C.M. Huang Radiation-induced liver disease after radiotherapy for hepatocellular carcinoma: Clinical manifestation and dosimetric description Radiother Oncol 63 2002 41 45
26. I. Sakamoto, S. Iwanaga, and K. Nagaoki Intrahepatic biloma formation (bile duct necrosis) after transcatheter arterial chemoembolization AJR Am J Roentgenol 181 2003 79 87
27. A.S. Butt, G. Mujtaba, and S. Anand Management of biliopleural fistula after transarterial chemoembolization of a liver lesion Can J Gastroenterol 24 2010 281 283
28. K.H. Han, M. Kudo, and S.L. Ye Asian consensus workshop report: Expert consensus guideline for the management of intermediate and advanced hepatocellular carcinoma in Asia Oncology 81 suppl 1 2011 158 164
29. H.C. Park, J. Seong, and M. Tanaka Multidisciplinary management of nonresectable hepatocellular carcinoma Oncology 81 Suppl 1 2011 134 140
30. Y.I. Kim, H.C. Park, and H. Lim do Changes of the liver volume and the Child-Pugh score after high dose hypofractionated radiotherapy in patients with small hepatocellular carcinoma Radiat Oncol J 30 2012 189 196
31. D.H. Wu, L. Liu, and L.H. Chen Therapeutic effects and prognostic factors in three-dimensional conformal radiotherapy combined with transcatheter arterial chemoembolization for hepatocellular carcinoma World J Gastroenterol 10 2004 2184 2189
32. J. Seong, S.H. Kim, and C.O. Suh Enhancement of tumor radioresponse by combined chemotherapy in murine hepatocarcinoma J Gastroenterol Hepatol 16 2001 883 889
33. M.A. Hawkins, and L.A. Dawson Radiation therapy for hepatocellular carcinoma: From palliation to cure Cancer 106 2006 1653 1663
34. J.H. Kim, J.W. Park, and T.H. Kim Hepatitis B virus reactivation after three-dimensional conformal radiotherapy in patients with hepatitis B virus-related hepatocellular carcinoma Int J Radiat Oncol Biol Phys 69 2007 813 819
35. I. Bargellini, E. Bozzi, and D. Campani Modified RECIST to assess tumor response after transarterial chemoembolization of hepatocellular carcinoma: CT-pathologic correlation in 178 liver explants Eur J Radiol 82 2013 e212 e218