Metallo-β-lactamase-producing Bacteroides species can shield other members of the gut microbiota from antibiotics

Antimicrobial Agents and Chemotherapy

Volumn 59, Issue 1, 2015, Pages 650-653

  Stiefel, Usha ^a,b   Tima, Mary Ann ^a   Nerzic, Michelle M ^a  

^a LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BETA LACTAM; CEFTRIAXONE; CEPHALOSPORIN; METALLO BETA LACTAMASE; NITROCEFIN; BACTERIAL PROTEIN; BETA LACTAMASE; CARBAPENEMASE;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL STRAIN; BACTERICIDAL ACTIVITY; BACTEROIDES; COMMENSAL; CONTROLLED STUDY; ENZYME SYNTHESIS; ESCHERICHIA COLI; HUMAN; INCUBATION TIME; INTESTINE FLORA; MINIMUM BACTERICIDAL CONCENTRATION; NONHUMAN; ORGANISMAL INTERACTION; PATHOGENESIS; BACTEROIDES FRAGILIS; BIOSYNTHESIS; DRUG EFFECTS; GASTROINTESTINAL TRACT; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MICROFLORA; PHYSIOLOGY;

BACTERIAL PROTEINS; BACTEROIDES; BACTEROIDES FRAGILIS; BETA-LACTAM RESISTANCE; BETA-LACTAMASES; CEFTRIAXONE; ESCHERICHIA COLI; GASTROINTESTINAL TRACT; HUMANS; MICROBIAL SENSITIVITY TESTS; MICROBIOTA;

EID: 84920160757     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.03719-14     Document Type: Article

References (19)

1. Vollaard EJ, Clasener HAL. 1994. Colonization resistance. Antimicrob Agents Chemother 38:409-414. http://dx.doi.org/10.1128/AAC.38.3.409.
2. Sullivan A, Edlund C, Nord CE. 2001. Effect of antimicrobial agents on the ecological balance of human microbiota. Lancet Infect Dis 1:101-114. http://dx.doi.org/10.1016/S1473-3099(01)00066-4.
3. Donskey CJ, Chowdhry TK, Hecker MT, Hoyen CK, Hanrahan JA, Hujer AM, Hutton-Thomas RA, Whalen CC, Bonomo RA, Rice LB. 2000. Effect of antibiotic therapy on the density of vancomycin-resistant enterococci in the stool of colonized patients. N Engl J Med 343:1925-1932. http://dx.doi.org/10.1056/NEJM200012283432604.
4. Stiefel U, Pultz NJ, Harmoinen J, Koski P, Lindevall K, Helfand MS, Donskey CJ. 2003. Oral administration of β-lactamase preserves colonization resistance of piperacillin-treated mice. J Infect Dis 188:1605-1609. http://dx.doi.org/10.1086/379153.
5. Stiefel U, Harmoinen J, Koski P, Kaariainen S, Wickstrand B, Lindevall K, Pultz NJ, Bonomo RA, Helfand MS, Donskey CJ. 2005. Orally administered recombinant metallo-β-lactamase preserves colonization resistance of pip-eracillin- tazobactam-treated mice. Antimicrob Agents Chemother 49:5190-5191. http://dx.doi.org/10.1128/AAC.49.12.5190-5191.2005.
6. Stiefel U, Nerandzic MM, Koski P, Donskey CJ. 2008. Orally administered β-lactamase enzymes represent a novel strategy to prevent colonization by Clostridium difficile. J Antimicrob Chemother 62:1105-1108. http://dx.doi.org/10.1093/jac/dkn298.
7. Harmoinen J, Vaali K, Koski P, Syrjänen K, Laitinen O, Lindevall K, Westermarck E. 2003. Enzymic degradation of a beta-lactam antibiotic, ampicillin, in the gut: a novel treatment modality. J Antimicrob Chemother 51:361-365. http://dx.doi.org/10.1093/jac/dkg095.
8. Stiefel U, Tima MA, Nerandzic MM. 2014. Gastrointestinal colonization with a cephalosporinase-producing Bacteroides species preserves colonization resistance against vancomycin-resistant Enterococcus and Clostridium difficile in cephalosporin-treated mice. Antimicrob Agents Chemother 58:4535-4542. http://dx.doi.org/10.1128/AAC.02782-14.
9. Rogers MB, Parker AC, Smith CJ. 1993. Cloning and characterization of the endogenous cephalosporinase gene, cepA, from Bacteroides fragilis reveals a new subgroup of Ambler class A β-lactamases. Antimicrob Agents Chemother 37:2391-2400. http://dx.doi.org/10.1128/AAC.37.11.2391.
10. Smith CJ, Bennett TK, Parker AC. 1994. Molecular and genetic analysis of the Bacteroides uniformis cephalosporinase gene, cblA, encoding the species-specific β-lactamase. Antimicrob Agents Chemother 38:1711-1715.
11. Giraud-Morin C, Madinier I, Fosse T. 2003. Sequence analysis of cfxA2- like β-lactamases in Prevotella species. J Antimicrob Chemother 51:1293-1296. http://dx.doi.org/10.1093/jac/dkg221.
12. Thompson JS, Malamy MH. 1990. Sequencing the gene for an imipenem-cefoxitin- hydrolyzing enzyme (cfiA) from Bacteroides fragilis TAL2480 reveals strong similarity between cfiA and Bacillus cereus β-lactamase II. J Bacteriol 172:2584-2593.
13. Hujer KM, Hujer AM, Hulten E, Bajaksouzian S, Adams JM, Donskey CJ, Ecker DJ, Massire C, Eshoo MW, Sampath R, Thomson JM, Rather PN, Craft DW, Fishbain JT, Ewell AJ, Jacobs MR, Paterson DL, Bonomo RA. 2006. Analysis of antibiotic resistance genes in multidrug resistant Acinetobacter sp. isolates from military and civilian patients treated at the Walter Reed Army Medical Center. Antimicrob Agents Chemother 50:4114-4123. http://dx.doi.org/10.1128/AAC.00778-06.
14. O'Callaghan CH, Morris A, Kirby SM. 1972. Novel method for detection of β-lactamases by using a chromogenic cephalosporin substrate. Antimicrob Agents Chemother 1:283-288. http://dx.doi.org/10.1128/AAC.1.4 .283.
15. th ed. NCCLS document M11-A8. National Committee for Clinical Laboratory Standards, Wayne, PA.
16. th ed. Star Publishing Co, Belmont, CA.
17. Sader HS, Fritsche TR, Jones RN. 2006. Daptomycin bactericidal activity and correlation between disk and broth microdilution method results in testing of Staphylococcus aureus strains with decreased susceptibility to vancomycin. Antimicrob Agents Chemother 50:2330-2336. http://dx.doi .org/10.1128/AAC.01491-05.
18. Yang Y, Rasmussen BA, Bush K. 1992. Biochemical characterization of the metallo-β-lactamase CcrA from Bacteroides fragilis TAL3636. Antimicrob Agents Chemother 36:1155-1157. http://dx.doi.org/10.1128/AAC .36.5.1155.
19. Wexler H. 2007. Bacteroides: the good, the bad, and the nitty-gritty. Clin Microbiol Rev 20:593-621. http://dx.doi.org/10.1128/CMR.00008-07.