Circulating mitochondrial DNA level, a noninvasive biomarker for the early detection of gastric cancer

Cancer Epidemiology Biomarkers and Prevention

Volumn 23, Issue 11, 2014, Pages 2430-2438

  Fernandes, Julien ^a,b,e   Michel, Valérie ^a,b   Camorlinga Ponce, Margarita ^c   Gomez, Alejandro ^c   Maldonado, Carmen ^d   De Reuse, Hilde ^a,b   Torres, Javier ^c   Touati, Eliette ^a,b  

^a INSTITUT PASTEUR   (France)

^b CNRS   (France)

^c INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

^d HOSPITAL INFANTIL DE MÉXICO FEDERICO GÓMEZ   (Mexico)

^e Service de Pneumologie A Département hospitalo universitaire FIRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; MITOCHONDRIAL DNA; TUMOR MARKER;

ADULT; ARTICLE; CANCER DIAGNOSIS; CANCER PATIENT; COHORT ANALYSIS; CONTROLLED STUDY; EARLY DIAGNOSIS; FEMALE; HUMAN; HUMAN TISSUE; INTESTINE METAPLASIA; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; STOMACH CANCER; STOMACH CARCINOGENESIS; GENETICS; STOMACH TUMOR;

COHORT STUDIES; DNA, MITOCHONDRIAL; EARLY DIAGNOSIS; FEMALE; HUMANS; MALE; STOMACH NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 84920139753     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: 10.1158/1055-9965.EPI-14-0471     Document Type: Article

References (49)

1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin 2005;55:74-108.
2. o 11. Lyon, France: International Agency for Research on Cancer; 2013. Available from http://globocan.iarc.fr.
3. Kamangar F, Dawsey SM, Blaser MJ, Perez-Perez GI, Pietinen P, Newschaffer CJ, et al. Opposing risks of gastric cardia and noncardia gastric adenocarcinomas associated with Helicobacter pylori seropositivity. J Natl Cancer Inst 2006;98:1445-52.
4. Roukos DH. Early-stage gastric cancer: a highly treatable disease. Ann Surg Oncol 2003;11:127-9.
5. Asaka M. A new approach for elimination of gastric cancer deaths in Japan. Int J Cancer 2013;132:1272-6.
6. Resende C, Thiel A, Machado JC, Ristmäki A. Gastric cancer: basic aspects. Helicobacter 2011;16:38-44.
7. Bornschein J, Rokkas T, Selgrad M, Malfertheimer P. Gastric cancer: clinical aspects, epidemiology and molecular background. Helicobacter 2011;16:45-52.
8. de Martel C, Ferlay J, Franceschi S, Vignat J, Bray F, Forman D, et al. Global burden of cancers attributable to infections in 2008: a review and synthetic analysis. Lancet Oncol 2012;13:607-15.
9. Blaser MJ, Atherton JC. Helicobacter pylori persistence: biology and disease. J Clin Invest 2004;113:321-33.
10. Atherton JC. The pathogenesis of Helicobacter pylori-induced gastroduodenal diseases. Ann Rev Pathol Mech Dis 2006;1:63-96.
11. Correa P. Human gastric carcinogenesis: a multistep and multifactorial process. First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. Cancer Re 1992;52:6735-40.
12. Zhou L, Sung JJ, Lin S. A five-year follow-up study on the pathological changes of gastric mucosa after H. pylori eradication. Chin Med J 2003;116:11-4.
13. Ley C, Mohar A, Guarner J. Helicobacter pylori eradication and gastric preneoplastic conditions: a randomized, double-blind, placebo-controlled trial. Cancer Epidemiol Biomarkers 2004;13:4-10.
14. Fukase K, Kato M, Kikuchi S, Inoue K, Uemura N, Okamoto S, et al. Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trial. Lancet 2008;372:392-7.
15. di Mario F, Cavallaro LG. Non-invasive tests in gastric diseases. Dig Liver Dis 2008;40:523-30.
16. Cooke CL, Torres J, Solnick JV. Biomarkers of Helicobacter pylori-associated gastric cancer. Gut Microbes 2013;4:532-40.
17. Wallace DC. Mitochondrial DNA sequence variation in human evolution and disease. Proc Natl Acad Sci U S A 1994;91:8739-46.
18. Meng S, Han J. Mitochondrial DNA copy number alteration in human cancers. North Am J of Med Sci 2013;6:22-5.
19. Yu M. Mitochondrial DNA copy number alterations in human cancers. Chichester, England: John Wiley and Sons, Ltd:; 2012.
20. Carew JS, Huang P. Mitochondrial defects in cancer. Mol Cancer 2002;1:9.
21. Kamalidehghan B, Houshmand M, Shafa Shariat Panahi M, Rezza Abbaszadegan M, Ismail P, Bagher Shiroudi M. Tumoral cell mtDNA approximately 8.9kb deletion is more common than other deletions in gastric cancer. Arch Med Res 2006;37:848-53.
22. Maximo V, Soares P, Seruca R, Rocha AS, Castro P, Sobrinho-Simoes M. Microsatellite instability, mitochondrial DNA large deletions and mitochondrial DNA mutations in gastric carcinoma. Genes Chromosomes Cancer 2001;32:136-43.
23. Hiyama T, Tanaka S, Shima H, Kose K, Kitadai Y, Ito M, et al. Somatic mutation of mitochondrial DNA in Helicobacter pylori-associated chronic gastritis in patients with and without gastric cancer. Int J Mol Med 2003;12:169-74.
24. Machado A, Figuereido C, Touati E, Maximo V, Sousa S, Michel V, et al. Helicobacter pylori infection downregulates nuclear and mitochondrial DNA repair in gastric cells. Clin Cancer Res 2009;15: 2995-3002.
25. Touati E. When bacteria become mutagenic and carcinogenic: lessons from H. pylori . Mutat Res 2010;703:66-70.
26. Lee HC, Yin PH, Lin JC, Wu CC, Chen CY, Wu CW, et al. Mitochondrial genome instability and mtDNA depletion in human cancers. Ann N Y Acad Sci 2005;1042:109-22.
27. Zhang G, Qu Y, Dang S, Yang Q, Shi B, Hou P. Variable copy number of mitochondrial DNA (mtDNA) predicts worse prognosis in advanced gastric cancer patients. Diagn Pathol 2013;8:173.
28. Wen SL, Zhang F, Feng S. Decreased copy number of mitochondrial DNA: a potential diagnostic criterion for gastric cancer. Oncol Lett 2013;6:1098-102.
29. Ellinger J, Muller DC, Muller SC, Hauser S, Heukamp LC, von Ruecker A, et al. Circulating mitochondrial DNA in serum: a universal diagnostic biomarker for patients with urological malignancies. Urol Oncol 2012;30:509-15.
30. Shen J, Platek M, Mahasneh A, Ambrosone CB, Zhao H. Mitochondrial copy number and risk of breast cancer: a pilot study. Mitochondrion 2010;10:62-8.
31. Qu F, Liu X, Zhou F, Yang H, Bao G, He X, et al. Association between mitochondrial DNA content in leukocytes and colorectal cancer risk: a case-control analysis. Cancer 2011;117:3148-55.
32. Bonner MR, Shen M, Liu CS, Divita M, He X, Lan Q. Mitochondrial DNA content and lung cancer risk in Xuan Wei, China. Lung Cancer 2009;63:331-4.
33. Hosgood HD III, Liu CS, Rothman N, Weinstein SJ, Bonner MR, Shen M, et al. Mitochondrial DNA copy number and lung cancer risk in a prospective cohort study. Carcinogenesis 2010;31:847-9.
34. Xia P, An H, Dang C, Radpour R, Kohler C, Fokas E, et al. Decreased mitochondrial DNA content in blood samples of patients with stage I breast cancer. BMC Cancer 2009;21:454.
35. Liao LM, Baccarelli A, Shu XO, Gao YT, Ji BT, Yang GZ, et al. Mitochondrial DNA copy number and risk of gastric cancer: a report from the Shanghai Women's Health Study. Cancer Epidemiol Biomarkers Prev 2011;20:1944-9.
36. Camorlinga-Ponce M, Flores-Luna L, Lazcano-Ponce E, Herrero R, Bernal-Sahagun F, Abdo-Francis JM, et al. Age and severity of mucosal lesions influence the performance of serologic markers in Helicobacter pylori-associated gastroduodenal pathologies. Cancer Epidemiol Biomarkers Prev 2008;17:2498-504.
37. Camorlinga-Ponce M, Torres J, Perez-Perez G, Leal-Herrera Y, Gon-zalez-Ortiz B, Madrazo de la Garza A, et al. Validation of a serologic test for the diagnosis of Helicobacter pylori infection and the immune response to urease and CagA in children.Am J Gastroenterol 1998;93:1264-70.
38. Chatre L, Ricchetti M. Large heterogeneity of mitochondrial DNA transcription and initiation of replication exposed by single-cell imaging. J Cell Sci 2013;126:914-26.
39. Parone PA, Da Cruz S, Tondera D, Mattenberger Y, James DI, Maechler P, et al. Preventing mitochondrial fission impairs mitochondrial function and leads to loss of mitochondrial DNA. PLoS ONE 2008;3:e3257.
40. Fan AX, Radpour R, Haghighi MM, Kohler C, Xia P, Hahn S, et al. Mitochondrial DNA content in paired normal and cancerous breast tissue samples from patients with breast cancer. J Cancer Res Clin Oncol 2009;135:983-9.
41. Woolf B. On estimating the relation between blood group and disease. Ann Hum Genet 1955;19:251-3.
42. Delacour H, Servonnet A, Perrot A, Vigezzi JF, Ramirez JM. [ROC (receiver operating characteristics) curve: principles and application in biology]. Ann Biol Clin (Paris) 2005;63:145-54.
43. Cossarizza A, Pinti M, Nasi M, Gibellini L, Manzini S, Roat E, et al. Increased plasma levels of extracellular mitochondrial DNA during HIV infection: a new role for mitochondrial damage-associated molecular patterns during inflammation. Mitochondrion 2013;11:750-5.
44. Xu E, Sun W, Gu J, Chow WH, Ajani JA, Wu X. Association of mitochondrial DNA copy number in peripheral blood leukocytes with risk of esophageal adenocarcinoma. Carcinogenesis 2013;34:2521-4.
45. Warburg O. On respiratory impairment in cancer cells. Science 1956;124:269-70.
46. Purdue MP, Hofmann JN, Colt JS, Hoxha M, Ruterbusch JJ, Davis FG, et al. A case-control study of peripheral blood mitochondrialDNA copy number and risk of renal cell carcinoma. PLoS ONE 2012;7:e43149.
47. Xing J, Chen M, Wood C, Lin J, Spitz MR, Ma J, et al. Mitochondrial DNA content: Its genetic heritability and association with renal cell carcinoma. J Natl Cancer Inst 2008;100:1104-12.
48. Epplein M, Xiang YB, Cai Q, Peek RM Jr, Li H, Correa P, et al. Circulating cytokines and gastric cancer risk. Cancer Causes Control 2013;24:2245-50.
49. Zhao S, Yang Y, Liu J, Liu H, Ge N, Yang H, et al. Association of mitochondrial DNA content in peripheral blood leukocyte with hepatitis B virus-related hepatocellular carcinoma in a Chinese Han population. Cancer Sci 2011;102:1553-8.