Vagus nerve stimulation reduces cardiac electrical instability assessed by quantitative T-wave alternans analysis in patients with drug-resistant focal epilepsy

Epilepsia

Volumn 55, Issue 12, 2014, Pages 1996-2002

  Schomer, Andrew C ^a,b   Nearing, Bruce D ^b   Schachter, Steven C ^a,b   Verrier, Richard L ^b  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Heart rate variability; Sudden unexpected death in epilepsy; T wave alternans; Vagus nerve stimulation

Indexed keywords

ADULT; ARTICLE; CLINICAL ARTICLE; DISEASE MARKER; ELECTROCARDIOGRAM; FEMALE; FOCAL EPILEPSY; HEART RATE VARIABILITY; HUMAN; MALE; PULSE GENERATOR; SUDDEN CARDIAC DEATH; T WAVE; T WAVE ALTERNANS; VAGUS NERVE STIMULATION; ARRHYTHMIAS, CARDIAC; BIOPHYSICS; COMPLICATION; ELECTROCARDIOGRAPHY; EPILEPSIES, PARTIAL; HEART RATE; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGIC MONITORING; PHYSIOLOGY; PROCEDURES;

ADULT; ARRHYTHMIAS, CARDIAC; BIOPHYSICS; ELECTROCARDIOGRAPHY, AMBULATORY; EPILEPSIES, PARTIAL; FEMALE; HEART RATE; HUMANS; MALE; MIDDLE AGED; MONITORING, PHYSIOLOGIC; VAGUS NERVE STIMULATION;

EID: 84920115037     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/epi.12855     Document Type: Article

References (40)

1. Elliott RE, Morsi A, Kalhorn SP, et al. Vagus nerve stimulation in 436 consecutive patients with treatment-resistant epilepsy: long-term outcomes and predictors of response. Epilepsy Behav 2011; 20: 57-63.
2. Englot DJ, Chang EF, Auguste KI,. Vagus nerve stimulation for epilepsy: a meta-analysis of efficacy and predictors of response. J Neurosurg 2011; 115: 1248-1255.
3. DiCarlo L, Libbus I, Amurthur B, et al. Autonomic regulation therapy for the improvement of left ventricular function and heart failure symptoms: the ANTHEM-HF Study. J Card Fail 2013; 19: 655-660.
4. Conway CR, Colijn MA, Schachter SC,. Vagus nerve stimulation for epilepsy and depression. In, Reti IM, (Ed) Brain stimulation: methodologies and interventions. John Wiley & Sons Ltd, West Sussex, UK, 2015. (in press).
5. Annegers JF, Coan SP, Hauser WA, et al. Epilepsy, vagal nerve stimulation by the NCP system, all-cause mortality, and sudden, unexpected, unexplained death. Epilepsia 2000; 41: 549-553.
6. Strzelczyk A, Adjei P, Scott CA, et al. Postictal increase in T-wave alternans after generalized tonic-clonic seizures. Epilepsia 2011; 52: 2112-2117.
7. Verrier RL, Klingenheben T, Malik M, et al. Microvolt T-wave alternans: physiologic basis, methods of measurement, and clinical utility. Consensus guideline by the International Society for Holter and Noninvasive Electrocardiology. J Am Coll Cardiol 2011; 44: 1309-1324.
8. Lotufo PA, Valiengo L, Bensenor IM, et al. A systematic review and meta-analysis of heart rate variability in epilepsy and antiepileptic drugs. Epilepsia 2012; 53: 272-282.
9. Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation 1996; 93: 1043-1065.
10. Shorvon S, Tomson T,. Sudden unexpected death in epilepsy. Lancet 2011; 378: 2028-2038.
11. Bardai A, Lamberts RJ, Blom MT, et al. Epilepsy is a risk factor for sudden cardiac arrest in the general population. PLoS One 2012; 7: e42749.
12. Possusamy A, Marques JL, Reuber M,. Comparison of heart rate variability parameters during complex partial seizures and psychogenic nonepileptic seizures. Epilepsia 2012; 53: 1314-1321.
13. Moseley B, Bateman L, Millichap JJ, et al. Autonomic epileptic seizures, autonomic effects of seizures, and SUDEP. Epilepsy Behav 2013; 26: 375-385.
14. Falconer B, Rajs J,. Post-mortem findings of cardiac lesions in epileptics: a preliminary report. Forensic Sci 1976; 8: 63-71.
15. Natelson BH, Suarez RV, Terrence CF, et al. Patients with epilepsy who die suddenly have cardiac disease. Arch Neurol 1998; 55: 857-860.
16. Hajsadeghi S, Afsharian S, Fereshtehnejad SM, et al. Serum levels of cardiac troponin I in patients with uncomplicated epileptic seizure. Arch Med Res 2009; 40: 24-28.
17. Annegers JF, Hauser WA, Shirts SB,. Heart disease mortality and morbidity in patients with epilepsy. Epilepsia 1984; 25: 699-704.
18. Janszky I, Hallqvist J, Tomson T, et al. Increased risk and worse prognosis of myocardial infarction in patients with prior hospitalization for epilepsy: the Stockholm Heart Epidemiology Program. Brain 2009; 132 (Pt 10): 2798-2804.
19. Tigaran S, Molgaard H, McClelland R, et al. Evidence of cardiac ischemia during seizures in drug refractory epilepsy patients. Neurology 2003; 60: 492-495.
20. Nei M, Ho RT, Abou-Khalil BW, et al. EEG and ECG in sudden unexplained death in epilepsy. Epilepsia 2004; 45: 338-345.
21. Eggleston KS, Olin BD, Fisher RS,. Ictal tachycardia: the head-heart connection. Seizure 2014; 23: 496-505.
22. Espinosa PS, Lee JW, Tedrow UB, et al. Sudden unexpected near death in epilepsy: malignant arrhythmia from a partial seizure. Neurology 2009; 72: 1702-1703.
23. Ferlisi M, Tomei R, Carletti M, et al. Seizure induced ventricular fibrillation: a case of near-SUDEP. Seizure 2013; 22: 249-251.
24. Hocker S, Prasad A, Rabinstein AA,. Cardiac injury in refractory status epilepticus. Epilepsia 2013; 54: 518-522.
25. Verrier RL, Schachter SC,. Neurocardiac interactions in sudden unexpected death in epilepsy: can ambulatory electrocardiogram-based assessment of autonomic function and T-wave alternans help to evaluate risk? In, Lathers CM, Schraeder PL, Bungo MW, Leestma JE, Wannamaker BB, Verrier RL, Schachter SC, (Eds). Sudden death in epilepsy: risk analyses, SUDEP cluster risk factor classification and identification. Taylor Publishing Company, Boca Raton FL (in press).
26. Lown B, Verrier RL,. Neural activity and ventricular fibrillation. N Engl J Med 1976; 294: 1165-1170.
27. Verrier RL, Ikeda T,. Ambulatory ECG-based T-wave alternans monitoring for risk assessment and guiding medical therapy: mecha-nisms and clinical applications. Prog Cardiovasc Dis 2013; 56: 172-185.
28. Hesdorffer DC, Tomson T, Benn E, et al. Do antiepileptic drugs or generalized tonic-clonic seizure frequency increase SUDEP risk? A combined analysis. Epilepsia 2012; 53: 249-252.
29. DeGiorgio CM, Miller P, Meymandi S, et al. RMSSD, a measure of vagus-mediated heart rate variability, is associated with risk factors for SUDEP: the SUDEP-7 inventory. Epilepsy Behav 2010; 19: 78-81.
30. Galli R, Limbruno U, Pizzanelli C, et al. Analysis of RR variability in drug-resistant epilepsy patients chronically treated with vagus nerve stimulation. Auton Neurosci 2003; 107: 52-59.
31. Ronkainen E, Korpelainen JT, Heikkinen E, et al. Cardiac autonomic control in patients with refractory epilepsy before and during vagus nerve stimulation treatment: a one-year follow-up study. Epilepsia 2006; 47: 556-562.
32. Hallioglu O, Okuyaz C, Mert E, et al. Effects of antiepileptic drug therapy on heart rate variability in children with epilepsy. Epilepsy Res 2008; 79: 49-54.
33. Hamann JJ, Ruble SB, Stolen C, et al. Vagus nerve stimulation improves left ventricular function in a canine model of chronic heart failure. Eur J Heart Fail 2013; 15: 1319-1326.
34. Zhang Y, Popovic ZB, Bibevski S, et al. Chronic vagus nerve stimulation improves autonomic control and attenuates systemic inflammation and heart failure progression in a canine high-rate pacing model. Circ Heart Fail 2009; 2: 692-699.
35. Shen MJ, Shinohara T, Park HW, et al. Continuous low-level vagus nerve stimulation reduces stellate ganglion nerve activity and paroxysmal atrial tachyarrhythmias in ambulatory canines. Circulation 2011; 123: 2204-2212.
36. Shen MJ, Chang H-C, Park HW, et al. Low-level vagus nerve stimulation upregulates small conductance calcium-activated potassium channels in the stellate ganglion. Heart Rhythm 2013; 10: 910-915.
37. Schwartz PJ, De Ferrari GM,. Vagal stimulation for heart failure: background and first in-man study. Heart Rhythm 2009; 6: S76-S81.
38. De Ferrari GM, Schwartz PJ,. Vagus nerve stimulation: from pre-clinical to clinical application: challenges and future directions. Heart Fail Rev 2011; 16: 195-203.
39. Handforth A, DeGiorgio CM, Schachter SC, et al. Vagus nerve stimulation therapy for partial-onset seizures: a randomized active-control trial. Neurology 1998; 51: 48-55.
40. Verrier RL, Nearing BD,. Electrophysiologic basis for T-wave alternans as an index of vulnerability to ventricular fibrillation. J Cardiovasc Electrophysiol 1994; 5: 445-461.