Expression of Ror2 mediates invasive phenotypes in renal cell carcinoma

PLoS ONE

Volumn 9, Issue 12, 2014, Pages

  Rasmussen, Neal R ^a   Debebe, Zufan ^a   Wright, Tricia M ^a   Brooks, Samira A ^a   Sendor, Adam B ^a   Brannon, A Rose ^a,b   Hakimi, A Ari ^b   Hsieh, James J ^b   Choueiri, Toni K ^c   Tamboli, Pheroze ^d   Maranchie, Jodi K ^e   Hinds, Peter ^e   Wallen, Eric M ^f,g   Simpson, Catherine ^a   Norris, Jacqueline L ^a   Janzen, William P ^a   Rathmell, W Kimryn ^a,f  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^e UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^f UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^g University of North Carolina at Chapel Hill   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GELATINASE A; PROTEIN ROR2; RECEPTOR TYROSINE KINASE LIKE ORPHAN RECEPTOR; UNCLASSIFIED DRUG; ROR2 PROTEIN, HUMAN;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GRADING; CANCER PROGNOSIS; CANCER SPECIFIC SURVIVAL; CANCER STAGING; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; KIDNEY CARCINOMA; MAJOR CLINICAL STUDY; MALE; MOUSE; MUTATION; NONHUMAN; OVERALL SURVIVAL; PROTEIN EXPRESSION; RECURRENCE FREE SURVIVAL; TUMOR GROWTH; TUMOR INVASION; VERY ELDERLY; ANIMAL; CARCINOMA, RENAL CELL; CELL MOTION; GENE EXPRESSION REGULATION; GENETICS; KIDNEY; KIDNEY NEOPLASMS; METABOLISM; NUDE MOUSE; PATHOLOGY; PROGNOSIS; TUMOR CELL LINE;

ANIMALS; CARCINOMA, RENAL CELL; CELL LINE, TUMOR; CELL MOVEMENT; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KIDNEY; KIDNEY NEOPLASMS; MICE, NUDE; MUTATION; NEOPLASM INVASIVENESS; PROGNOSIS; RECEPTOR TYROSINE KINASE-LIKE ORPHAN RECEPTORS;

EID: 84919951616     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0116101     Document Type: Article

References (33)

1. Gupta K, Miller JD, Li JZ, Russell MW, Charbonneau C (2008) Epidemiologic and socioeconomic burden of metastatic renal cell carcinoma (mRCC): a literature review. Cancer Treatment Reviews 34: 193-205.
2. (2013) Cancer Facts and Figures 2013. American Cancer Society, Inc: 64.
3. Eggener SE, Yossepowitch O, Pettus JA, Snyder ME, Motzer RJ, et al. (2006) Renal cell carcinoma recurrence after nephrectomy for localized disease: predicting survival from time of recurrence. Journal of clinical oncology: official journal of the American Society of Clinical Oncology 24: 3101-3106.
4. Wright TM, Brannon AR, Gordan JD, Mikels AJ, Mitchell C, et al. (2009) Ror2, a developmentally regulated kinase, promotes tumor growth potential in renal cell carcinoma. Oncogene 28: 2513-2523.
5. Takeuchi S, Takeda K, Oishi I, Nomi M, Ikeya M, et al. (2000) Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation. Genes to Cells 5: 71-78.
6. Afzal AR, Rajab A, Fenske CD, Oldridge M, Elanko N, et al. (2000) Recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by mutation of ROR2. Nature Genetics 25: 419-422.
7. Oldridge M, Fortuna AM, Maringa M, Propping P, Mansour S, et al. (2000) Dominant mutations in ROR2, encoding an orphan receptor tyrosine kinase, cause brachydactyly type B. Nature Genetics 24: 275-278.
8. Enomoto M, Hayakawa S, Itsukushima S, Ren DY, Matsuo M, et al. (2009) Autonomous regulation of osteosarcoma cell invasiveness by Wnt5a/Ror2 signaling. Oncogene 28: 3197-3208.
9. Morioka K, Tanikawa C, Ochi K, Daigo Y, Katagiri T, et al. (2009) Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for osteosarcoma. Cancer Sci.
10. O'Connell MP, Fiori JL, Xu M, Carter AD, Frank BP, et al. (2009) The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma. Oncogene.
11. Edris B, Espinosa I, Muhlenberg T, Mikels A, Lee CH, et al. (2012) ROR2 is a novel prognostic biomarker and a potential therapeutic target in leiomyosarcoma and gastrointestinal stromal tumour. Journal of Pathology 227: 223-233.
12. Kobayashi M, Shibuya Y, Takeuchi J, Murata M, Suzuki H, et al. (2009) Ror2 expression in squamous cell carcinoma and epithelial dysplasia of the oral cavity. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107: 398-406.
13. Yamamoto H, Oue N, Sato A, Hasegawa Y, Matsubara A, et al. (2010) Wnt5a signaling is involved in the aggressiveness of prostate cancer and expression of metalloproteinase. Oncogene 29: 2036-2046.
14. Kubo T, Kuroda Y, Shimizu H, Kokubu A, Okada N, et al. (2009) Resequencing and copy number analysis of the human tyrosine kinase gene family in poorly differentiated gastric cancer. Carcinogenesis 30: 1857-1864.
15. Ohta H, Aoyagi K, Fukaya M, Danjoh I, Ohta A, et al. (2009) Cross talk between hedgehog and epithelial-mesenchymal transition pathways in gastric pit cells and in diffuse-type gastric cancers. British Journal of Cancer 100: 389-398.
16. Mei H, Lian S, Zhang S, Wang W, Mao Q, et al. (2014) High expression of ROR2 in cancer cell correlates with unfavorable prognosis in colorectal cancer. Biochemical and biophysical research communications.
17. Rasmussen NR, Wright TM, Brooks SA, Hacker KE, Debebe Z, et al. (2013) Receptor tyrosine kinase-like orphan receptor 2 (Ror2) expression creates a poised state of Wnt signaling in renal cancer. The Journal of biological chemistry.
18. Yamagata K, Li X, Ikegaki S, Oneyama C, Okada M, et al. (2012) Dissection of Wnt5a-Ror2 signaling leading to matrix metalloproteinase (MMP-13) expression. The Journal of biological chemistry 287: 1588-1599.
19. O'Connell MP, Fiori JL, Xu M, Carter AD, Frank BP, et al. (2010) The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma. Oncogene 29: 34-44.
20. Ren D, Minami Y, Nishita M (2011) Critical role of Wnt5a-Ror2 signaling in motility and invasiveness of carcinoma cells following Snail-mediated epithelial-mesenchymal transition. Genes to Cells 16: 304-315.
21. Lu BJ, Wang YQ, Wei XJ, Rong LQ, Wei D, et al. (2012) Expression of WNT-5a and ROR2 correlates with disease severity in osteosarcoma. Mol Med Report 5: 1033-1036.
22. Lai SS, Xue B, Yang Y, Zhao L, Chu CS, et al. (2012) Ror2-Src signaling in metastasis of mouse melanoma cells is inhibited by NRAGE. Cancer genetics 205: 552-562.
23. Choi H, Chun YS, Kim TY, Park JW (2010) HIF-2alpha enhances beta-catenin/TCF-driven transcription by interacting with beta-catenin. Cancer Res 70: 10101-10111.
24. Li X, Yamagata K, Nishita M, Endo M, Arfian N, et al. (2013) Activation of Wnt5a-Ror2 signaling associated with epithelial-to-mesenchymal transition of tubular epithelial cells during renal fibrosis. Genes to cells: devoted to molecular & cellular mechanisms 18: 608-619.
25. (2013) Comprehensive molecular characterization of clear cell renal cell carcinoma. Nature 499: 43-49.
26. Brooks SA, Brannon AR, Parker JS, Fisher JC, Sen O, et al. (2014) ClearCode34: A Prognostic Risk Predictor for Localized Clear Cell Renal Cell Carcinoma. European Urology.
27. Gentile A, Lazzari L, Benvenuti S, Trusolino L, Comoglio PM (2011) Ror1 is a pseudokinase that is crucial for Met-driven tumorigenesis. Cancer Research 71: 3132-3141.
28. Mendrola JM, Shi F, Park JH, Lemmon MA (2013) Receptor tyrosine kinases with intracellular pseudokinase domains. Biochemical Society Transactions 41: 1029-1036.
29. O'Connell MP, Marchbank K, Webster MR, Valiga AA, Kaur A, et al. (2013) Hypoxia induces phenotypic plasticity and therapy resistance in melanoma via the tyrosine kinase receptors ROR1 and ROR2. Cancer discovery 3: 1378-1393.
30. Brannon AR, Reddy A, Seiler M, Arreola A, Moore DT, et al. (2010) Molecular Stratification of Clear Cell Renal Cell Carcinoma by Consensus Clustering Reveals Distinct Subtypes and Survival Patterns. Genes & cancer 1: 152-163.
31. Iliopoulos O, Kibel A, Gray S, Kaelin WG Jr (1995) Tumour suppression by the human von Hippel-Lindau gene product. Nature Medicine 1: 822-826.
32. Liotta LA, Stetler-Stevenson WG (1990) Metalloproteinases and cancer invasion. Seminars in Cancer Biology 1: 99-106.
33. Li B, Dewey CN (2011) RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. BMC bioinformatics 12: 323.