A low disposition index in adolescent offspring of mothers with gestational diabetes: a risk marker for the development of impaired glucose tolerance in youth

Diabetologia

Volumn 57, Issue 11, 2014, Pages 2413-2420

  Holder, Tara ^a   Giannini, Cosimo ^a   Santoro, Nicola ^a   Pierpont, Bridget ^a   Shaw, Melissa ^a   Duran, Elvira ^a   Caprio, Sonia ^a   Weiss, Ram ^b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HEBREW UNIVERSITY   (Israel)

Author keywords

Childhood obesity; Disposition index; Gestational diabetes mellitus

Indexed keywords

GLUCOSE; INSULIN; GLUCOSE BLOOD LEVEL;

ADOLESCENT; ADULT; ARTICLE; BLOOD SAMPLING; CELL FUNCTION; CHILD; CHILDHOOD OBESITY; CONTROLLED STUDY; DIABETIC PATIENT; DISEASE DURATION; FEMALE; FOLLOW UP; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; GLYCEMIC INDEX; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; JUVENILE; MAJOR CLINICAL STUDY; MALE; MOTHER; NON INSULIN DEPENDENT DIABETES MELLITUS; ORAL DISPOSITION INDEX; ORAL DRUG ADMINISTRATION; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET BETA CELL; PREGNANCY DIABETES MELLITUS; PRENATAL EXPOSURE; PROGENY; RECEIVER OPERATING CHARACTERISTIC; RISK FACTOR; SCHOOL CHILD; BLOOD; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; OBESITY; PATHOPHYSIOLOGY; PHYSIOLOGY; PREGNANCY; PRESCHOOL CHILD; YOUNG ADULT;

ADOLESCENT; ADULT; BLOOD GLUCOSE; CHILD; CHILD, PRESCHOOL; DIABETES, GESTATIONAL; FEMALE; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; HUMANS; MALE; OBESITY; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; YOUNG ADULT;

EID: 84919948279     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-014-3345-2     Document Type: Article

References (38)

1. Zimmet P, Alberti KG, Shaw J (2001) Global and societal implications of the diabetes epidemic. Nature 414:782–787
2. Arslanian S (2002) Type 2 diabetes in children: clinical aspects and risk factors. Horm Res 57(Suppl 1):19–28
3. Fagot-Campagna A, Pettitt DJ, Engelgau MM et al (2000) Type 2 diabetes among North American children and adolescents: an epidemiologic review and a public health perspective. J Pediatr 136:664–672
4. Dabelea D, Mayer-Davis EJ, Saydah S et al (2014) Prevalence of type 1 and type 2 diabetes among children and adolescents from 2001 to 2009. JAMA 311:1778–1786
5. Sobngwi E, Boudou P, Mauvais-Jarvis F et al (2003) Effect of a diabetic environment in utero on predisposition to type 2 diabetes. Lancet 361:1861–1865
6. Pettitt DJ, Aleck KA, Baird HR, Carraher MJ, Bennett PH, Knowler WC (1988) Congenital susceptibility to NIDDM. Role of intrauterine environment. Diabetes 37:622–628
7. Silverman BL, Metzger BE, Cho NH, Loeb CA (1995) Impaired glucose tolerance in adolescent offspring of diabetic mothers. Relationship to fetal hyperinsulinism. Diabetes Care 18:611–617
8. Dabelea D, Hanson RL, Lindsay RS et al (2000) Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity: a study of discordant sibships. Diabetes 49:2208–2211
9. HAPO Study Cooperative Research Group, Metzger BE, Lowe LP et al (2008) Hyperglycemia and adverse pregnancy outcomes. N Engl J Med 358:1991–2002
10. Petitt DJ, Bennett PH, Knowler WC, Baird HR, Aleck KA (1985) Gestational diabetes mellitus and impaired glucose tolerance during pregnancy. Long-term effects on obesity and glucose tolerance in the offspring. Diabetes 34(Suppl 2):119–122
11. Tam WH, Ma RC, Yang X et al (2008) Glucose intolerance and cardiometabolic risk in children exposed to maternal gestational diabetes mellitus in utero. Pediatrics 122:1229–1234
12. Bush NC, Chandler-Laney PC, Rouse DJ, Granger WM, Oster RA, Gower BA (2011) Higher maternal gestational glucose concentration is associated with lower offspring insulin sensitivity and altered beta-cell function. J Clin Endocrinol Metab 96:E803–E809
13. Yeckel CW, Taksali SE, Dziura J et al (2005) The normal glucose tolerance continuum in obese youth: evidence for impairment in beta-cell function independent of insulin resistance. J Clin Endocrinol Metab 90:747–754
14. Kuczmarski RJ, Ogden CL, Grummer-Strawn LM et al (2000) CDC growth charts: United States. Adv Data 314:1–27
15. Gunderson EP, Lewis CE, Tsai AL et al (2007) A 20-year prospective study of childbearing and incidence of diabetes in young women, controlling for glycemia before conception: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Diabetes 56:2990–2996
16. Zeitler P, Hirst K, Pyle L et al (2012) A clinical trial to maintain glycemic control in youth with type 2 diabetes. N Engl J Med 366:2247–2256
17. Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (2003) Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 26(Suppl 1):S5–S20
18. American Diabetes Association (2004) Diagnosis and classification of diabetes mellitus. Diabetes Care 27(Suppl 1):S5–S10
19. Matsuda M, DeFronzo RA (1999) Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 22:1462–1470
20. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412–419
21. Phillips DI, Clark PM, Hales CN, Osmond C (1994) Understanding oral glucose tolerance: comparison of glucose or insulin measurements during the oral glucose tolerance test with specific measurements of insulin resistance and insulin secretion. Diabet Med J 11:286–292
22. Weiss R, Cali AM, Dziura J, Burgert TS, Tamborlane WV, Caprio S (2007) Degree of obesity and glucose allostasis are major effectors of glucose tolerance dynamics in obese youth. Diabetes Care 30:1845–1850
23. Nelder JA, Wedderburn RWM (1972) Generalized linear models. JR Statist Soc A 135:370–384
24. Metzger BE, Gabbe SG, Persson B et al (2010) International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care 33:676–682
25. International Association of Diabetes and Pregnancy Study Groups Consensus Panel, Metzger BE, Gabbe SG et al (2010) International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care 33:676–682
26. Retnakaran R, Qi Y, Goran MI, Hamilton JK (2009) Evaluation of proposed oral disposition index measures in relation to the actual disposition index. Diabet Med 26:1198–1203
27. Sjaarda LG, Bacha F, Lee S, Tfayli H, Andreatta E, Arslanian S (2012) Oral disposition index in obese youth from normal to prediabetes to diabetes: relationship to clamp disposition index. J Pediatr 161:51–57
28. Lorenzo C, Wagenknecht LE, Rewers MJ et al (2010) Disposition index, glucose effectiveness, and conversion to type 2 diabetes: the Insulin Resistance Atherosclerosis Study (IRAS). Diabetes Care 33:2098–2103
29. Giannini C, Weiss R, Cali A et al (2012) Evidence for early defects in insulin sensitivity and secretion before the onset of glucose dysregulation in obese youths: a longitudinal study. Diabetes 61:606–614
30. Kelstrup L, Damm P, Mathiesen ER et al (2013) Insulin resistance and impaired pancreatic beta-cell function in adult offspring of women with diabetes in pregnancy. J Clin Endocrinol Metab 98:3793–3801
31. Malcolm JC, Lawson ML, Gaboury I, Lough G, Keely E (2006) Glucose tolerance of offspring of mother with gestational diabetes mellitus in a low-risk population. Diabet Med 23:565–570
32. DeFronzo RA, Abdul-Ghani MA (2009) Oral disposition index predicts the development of future diabetes above and beyond fasting and 2-h glucose levels: response to Utzschneider et al. Diabetes Care 32:e86, author reply e87
33. Elbein SC, Sun J, Scroggin E, Teng K, Hasstedt SJ (2001) Role of common sequence variants in insulin secretion in familial type 2 diabetic kindreds: the sulfonylurea receptor, glucokinase, and hepatocyte nuclear factor 1alpha genes. Diabetes Care 24:472–478
34. Gjesing AP, Hornbak M, Allin KH et al (2014) High heritability and genetic correlation of intravenous glucose- and tolbutamide-induced insulin secretion among non-diabetic family members of type 2 diabetic patients. Diabetologia 57:1173–1181
35. Nolan CJ, Damm P, Prentki M (2011) Type 2 diabetes across generations: from pathophysiology to prevention and management. Lancet 378:169–181
36. Lingwood BE, Henry AM, d'Emden MC et al (2011) Determinants of body fat in infants of women with gestational diabetes mellitus differ with fetal sex. Diabetes Care 34:2581–2585
37. Pettitt DJ, Baird HR, Aleck KA, Bennett PH, Knowler WC (1983) Excessive obesity in offspring of Pima Indian women with diabetes during pregnancy. N Engl J Med 308:242–245
38. Weiss R, Dufour S, Taksali SE et al (2003) Prediabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning. Lancet 362:951–957