Development and optimization of a high-throughput micro-computed tomography imaging method incorporating a novel analysis technique to evaluate bone mineral density of arthritic joints in a rodent model of collagen induced arthritis

Bone

Volumn 73, Issue , 2015, Pages 32-41

  Sevilla, Raquel S ^a   Cruz, Francisco ^a   Chiu, Chi Sung ^a   Xue, Dahai ^a   Bettano, Kimberly A ^a   Zhu, Joe ^a   Chakravarthy, Kalyan ^a   Faltus, Robert ^a   Wang, Shubing ^a   Vanko, Amy ^a   Robinson, Gain ^a   Zielstorff, Mark ^a   Miao, John ^a   Leccese, Erica ^a   Conway, Donald ^a   Moy, Lily Y ^a   Dogdas, Belma ^a   Cicmil, Milenko ^a   Zhang, Weisheng ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Automatic segmentation; Bone mineral density; CIA; Micro CT; Polynomial fitting; Rheumatoid arthritis

Indexed keywords

DEXAMETHASONE; PREDNISOLONE; COLLAGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANKLE; ARTHRITIS; ARTICLE; AUTOMATION; BATCH PROCESS; BONE DENSITY; BONE MASS; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG RESEARCH; EX VIVO STUDY; FEMALE; HISTOPATHOLOGY; IMAGE ANALYSIS; IMAGE CROPPING; IMAGE PROCESSING; IMAGE RECONSTRUCTION; KNEE; MICRO-COMPUTED TOMOGRAPHY; NONHUMAN; PROCESS OPTIMIZATION; RAT; THREE DIMENSIONAL IMAGING; TURNAROUND TIME; ANIMAL; ARTHRITIS, RHEUMATOID; DISEASE MODEL; LEWIS RAT; PATHOLOGY; PROCEDURES; RADIOGRAPHY;

ANIMALS; ARTHRITIS, RHEUMATOID; BONE DENSITY; COLLAGEN; DISEASE MODELS, ANIMAL; FEMALE; RATS; RATS, INBRED LEW; X-RAY MICROTOMOGRAPHY;

EID: 84919933537     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2014.11.014     Document Type: Article

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