Restoring visual function to blind mice with a photoswitch that exploits electrophysiological remodeling of retinal ganglion cells

Neuron

Volumn 81, Issue 4, 2014, Pages 800-813

  Tochitsky, Ivan ^a   Polosukhina, Aleksandra ^a   Degtyar, Vadim E ^a   Gallerani, Nicholas ^a   Smith, Caleb M ^a   Friedman, Aaron ^a   Van Gelder, Russell N ^b   Trauner, Dirk ^c   Kaufer, Daniela ^a   Kramer, Richard H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DENAQ; PHOTOSENSITIZING AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLINDNESS; CONDITIONING; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG SPECIFICITY; EXPLORATORY BEHAVIOR TEST; HYPERPOLARIZATION; MOUSE; MOUSE STRAIN; NEUROTRANSMISSION; NONHUMAN; PHOTOSENSITIZATION; PHOTOSTIMULATION; PRIORITY JOURNAL; RETINA CONE; RETINA DEGENERATION; RETINA GANGLION CELL; RETINA MACULA AGE RELATED DEGENERATION; RETINA ROD; RETINITIS PIGMENTOSA; SENSORY SYSTEM ELECTROPHYSIOLOGY; TOXICITY TESTING; VISION; WHITE LIGHT; AGE RELATED MACULAR DEGENERATION; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL MODEL; DRUG EFFECT; DRUG STRUCTURE; ISOMERIZATION; LIGHT INTENSITY; NERVOUS SYSTEM ELECTROPHYSIOLOGY; PHARMACOLOGICAL BLOCKING; PHOTORECEPTOR; SENSITIVITY ANALYSIS; SPECTRAL SENSITIVITY; TREATMENT RESPONSE;

ANIMALS; BLINDNESS; DISEASE MODELS, ANIMAL; ELECTROPHYSIOLOGICAL PHENOMENA; LIGHT; MICE; MICE, INBRED C57BL; PHOTORECEPTOR CELLS; PHOTOSENSITIZING AGENTS; RETINA; RETINAL DEGENERATION; RETINAL GANGLION CELLS; TREATMENT OUTCOME; VISION, OCULAR;

EID: 84896702144     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2014.01.003     Document Type: Article

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