MiR-145 acts as a metastasis suppressor by targeting metadherin in lung cancer

Medical Oncology

Volumn 32, Issue 1, 2015, Pages 1-8

  Wang, Mingzhi ^a   Wang, Jianhua ^a   Deng, Jianming ^a   Li, Xuejun ^a   Long, Weiguang ^a   Chang, Yongmei ^a  

^a Department of Orthopedics   (China)

Author keywords

Metadherin; Metastasis; MiR 145; Non small cell lung cancer

Indexed keywords

MESSENGER RNA; MICRORNA 145; PROTEIN; CELL ADHESION MOLECULE; MICRORNA; MIRN145 MICRORNA, HUMAN; MTDH PROTEIN, HUMAN;

ARTICLE; ASTROCYTE; ASTROCYTE ELEVATED GENE 1/ METADHERIN GENE; CANCER CELL LINE; CELL INVASION; CELL PROLIFERATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DOWN REGULATION; GENE; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG CANCER; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; METASTASIS; METASTASIS INHIBITION; NON SMALL CELL LUNG CANCER; BIOSYNTHESIS; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; IMMUNOHISTOCHEMISTRY; LUNG TUMOR; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR INVASION; WESTERN BLOTTING;

BLOTTING, WESTERN; CARCINOMA, NON-SMALL-CELL LUNG; CELL ADHESION MOLECULES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; MICRORNAS; NEOPLASM INVASIVENESS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFECTION;

EID: 84919919495     PISSN: 13570560     EISSN: 1559131X     Source Type: Journal    
DOI: 10.1007/s12032-014-0344-6     Document Type: Article

References (19)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61:69–90.
2. Gao D, Vahdat LT, Wong S, Chang JC, Mittal V. Microenvironmental regulation of epithelial–mesenchymal transitions in cancer. Cancer Res. 2012;72:4883–9.
3. Daniels MG, Bowman RV, Yang IA, Govindan R, Fong KM. An emerging place for lung cancer genomics in 2013. J Thorac Dis. 2013;5(Suppl 5):S491–7.
4. Chou J, Shahi P, Werb Z. microRNA-mediated regulation of the tumor microenvironment. Cell Cycle. 2013;12:3262–71.
5. Ai C, Jiang R, Fu L, Chen Y. MicroRNA-495 mimics delivery inhibits lung tumor progression. Tumour Biol. 2014. doi:10.1007/s13277-014-2687-1.
6. Sun Y, Chen C, Zhang P, Xie H, Hou L, Hui Z, Xu Y, Du Q, Zhou X, Su B, Gao W. Reduced miR-3127-5p expression promotes NSCLC proliferation/invasion and contributes to dasatinib sensitivity via the c-Abl/Ras/ERK pathway. Sci Rep. 2014;4:6527.
7. Zhong K, Chen K, Han L, Li B. microRNA-30b/c inhibits non-small cell lung cancer cell proliferation by targeting Rab18. BMC Cancer. 2014;14:703.
8. Zhang J, Xu L, Yang Z, Lu H, Hu D, Li W, Zhang Z, Liu B, Ma S. MicroRNA-10b indicates a poor prognosis of non-small cell lung cancer and targets E-cadherin. Clin Transl Oncol. 2014. doi:10.1007/s12094-014-1213-7.
9. Mei Z, He Y, Feng J, Shi J, Du Y, Qian L, Huang Q, Jie Z. MicroRNA-141 promotes the proliferation of non-small cell lung cancer cells by regulating expression of PHLPP1 and PHLPP2. FEBS Lett. 2014;588:3055–61.
10. Mo X, Zhang F, Liang H, Liu M, Li H, Xia H. miR-544a promotes the invasion of lung cancer cells by targeting cadherina 1 in vitro. Onco Targets Ther. 2014;7:895–900.
11. Khan S, Ebeling MC, Zaman MS, Sikander M, Yallapu MM, Chauhan N, Yacoubian AM, Behrman SW, Zafar N, Kumar D, et al. MicroRNA-145 targets MUC13 and suppresses growth and invasion of pancreatic cancer. Oncotarget. 2014;5:7599–609.
12. Eades G, Wolfson B, Zhang Y, Li Q, Yao Y, Zhou Q. lincRNA-RoR and miR-145 regulate invasion in triple-negative breast cancer via targeting ARF6. Mol Cancer Res. 2014. doi:10.1158/1541-7786.MCR-14-0251.
13. Campayo M, Navarro A, Vinolas N, Diaz T, Tejero R, Gimferrer JM, Molins L, Cabanas ML, Ramirez J, Monzo M, Marrades R. Low miR-145 and high miR-367 are associated with unfavourable prognosis in resected nonsmall cell lung cancer. Eur Respir J. 2013;41:1172–8.
14. Du L, Pertsemlidis A. microRNA regulation of cell viability and drug sensitivity in lung cancer. Expert Opin Biol Ther. 2012;12:1221–39.
15. Angulo M, Lecuona E, Sznajder JI. Role of MicroRNAs in lung disease. Arch Bronconeumol. 2012;48:325–30.
16. Chen Z, Zeng H, Guo Y, Liu P, Pan H, Deng A, Hu J. miRNA-145 inhibits non-small cell lung cancer cell proliferation by targeting c-Myc. J Exp Clin Cancer Res. 2010;29:151.
17. Zhao C, Xu Y, Zhang Y, Tan W, Xue J, Yang Z, Lu Y, Hu X. Downregulation of miR-145 contributes to lung adenocarcinoma cell growth to form brain metastases. Oncol Rep. 2013;30:2027–34.
18. Huang Y, Li LP. Progress of cancer research on astrocyte elevated gene-1/metadherin (review). Oncol Lett. 2014;8:493–501.
19. Yao Y, Gu X, Liu H, Wu G, Yuan D, Yang X, Song Y. Metadherin regulates proliferation and metastasis via actin cytoskeletal remodelling in non-small cell lung cancer. Br J Cancer. 2014;111:355–64.