Lmx1a enhances the effect of iNSCs in a PD model

Stem Cell Research

Volumn 14, Issue 1, 2015, Pages 1-9

  Wu, Jianyu ^a,b,c   Sheng, Chao ^a,d,e   Liu, Zhongfeng ^a,b   Jia, Weili ^a,b   Wang, Bin ^a,b   Li, Mo ^a,b   Fu, Linlin ^a,b   Ren, Zhenhua ^a,b   An, Jing ^a,b   Sang, Lisi ^d   Song, Gongru ^a,b   Wu, Yanchuan ^a,b   Xu, Yanling ^a,b   Wang, Shuyan ^a,b   Chen, Zhiguo ^a,b,c   Zhou, Qi ^d   Zhang, Y Alex ^a,b  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^c BEIJING INSTITUTE FOR BRAIN DISORDERS   (China)

^d INSTITUTE OF ZOOLOGY   (China)

^e UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE; NESTIN; PROTEIN; PROTEIN LMX1A; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG; GREEN FLUORESCENT PROTEIN; LENTIVIRUS VECTOR; LMX1A PROTEIN; LIM HOMEODOMAIN PROTEIN; LMX1A PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; CONVALESCENCE; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; IN VITRO STUDY; INDUCED NEURAL STEM CELL; LOCOMOTION; MALE; MOTOR PERFORMANCE; MOUSE; NEURAL STEM CELL; NEURAL STEM CELL TRANSPLANTATION; NONHUMAN; PARKINSON DISEASE; PROTEIN EXPRESSION; SERTOLI CELL; SOMATIC CELL; THERAPY EFFECT; BEHAVIOR; DOPAMINE BRAIN LEVEL; ENHANCER REGION; EXPERIMENTAL BEHAVIORAL TEST; NEWBORN; PROTEIN FUNCTION; STEM CELL TRANSPLANTATION; ANIMAL; ANIMAL BEHAVIOR; C57BL MOUSE; CELL LINE; CYTOLOGY; DISEASE MODEL; GENETICS; METABOLISM; PATHOLOGY; TRANSPLANTATION;

MUS;

ANIMALS; BEHAVIOR, ANIMAL; CELL DIFFERENTIATION; CELL LINE; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; DOPAMINERGIC NEURONS; ENHANCER ELEMENTS, GENETIC; LIM-HOMEODOMAIN PROTEINS; MALE; MICE; MICE, INBRED C57BL; NESTIN; NEURAL STEM CELLS; PARKINSON DISEASE; TRANSCRIPTION FACTORS; TYROSINE 3-MONOOXYGENASE;

EID: 84919914120     PISSN: 18735061     EISSN: 18767753     Source Type: Journal    
DOI: 10.1016/j.scr.2014.10.004     Document Type: Article

References (40)

1. Andersson E., Tryggvason U., Deng Q., Friling S., Alekseenko Z., Robert B., Perlmann T., Ericson J. Identification of intrinsic determinants of midbrain dopamine neurons. Cell 2006, 124:393-405.
2. Blurton-Jones M., Kitazawa M., Martinez-Coria H., Castello N.A., Muller F.J., Loring J.F., Yamasaki T.R., Poon W.W., Green K.N., LaFerla F.M. Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:13594-13599.
3. Buttery P.C., Barker R.A. Treating Parkinson's disease in the 21st century: can stem cell transplantation compete?. J. Comp. Neurol. 2014, 522:2802-2816.
4. Caiazzo M., Dell'Anno M.T., Dvoretskova E., Lazarevic D., Taverna S., Leo D., Sotnikova T.D., Menegon A., Roncaglia P., Colciago G., Russo G., Carninci P., Pezzoli G., Gainetdinov R.R., Gustincich S., Dityatev A., Broccoli V. Direct generation of functional dopaminergic neurons from mouse and human fibroblasts. Nature 2011, 476:224-227.
5. Chen Z., Palmer T.D. Cellular repair of CNS disorders: an immunological perspective. Hum. Mol. Genet. 2008, 17:R84-R92.
6. Chen Z., Phillips L.K., Gould E., Campisi J., Lee S.W., Ormerod B.K., Zwierzchoniewska M., Martinez O.M., Palmer T.D. MHC mismatch inhibits neurogenesis and neuron maturation in stem cell allografts. PLoS ONE 2011, 6:e14787.
7. Cheng L. Novel strategy for treating neural disease. Sci. China Life Sci. 2014, 57:947-948.
8. Cheng F., Lu X.C., Hao H.Y., Dai X.L., Qian T.D., Huang B.S., Tang L.J., Yu W., Li L.X. Neurogenin 2 converts mesenchymal stem cells into a neural precursor fate and improves functional recovery after experimental stroke. Cell. Physiol. Biochem. 2014, 33:847-858.
9. Cheng L., Hu W., Qiu B., Zhao J., Yu Y., Guan W., Wang M., Yang W., Pei G. Generation of neural progenitor cells by chemical cocktails and hypoxia. Cell Res. 2014, 24:665-679.
10. Conner J.M., Lauterborn J.C., Yan Q., Gall C.M., Varon S. Distribution of brain-derived neurotrophic factor (BDNF) protein and mRNA in the normal adult rat CNS: evidence for anterograde axonal transport. J. Neurosci. 1997, 17:2295-2313.
11. Deng Q., Andersson E., Hedlund E., Alekseenko Z., Coppola E., Panman L., Millonig J.H., Brunet J.F., Ericson J., Perlmann T. Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development. Development 2011, 138:3399-3408.
12. Freed C.R., Greene P.E., Breeze R.E., Tsai W.Y., DuMouchel W., Kao R., Dillon S., Winfield H., Culver S., Trojanowski J.Q., Eidelberg D., Fahn S. Transplantation of embryonic dopamine neurons for severe Parkinson's disease. N. Engl. J. Med. 2001, 344:710-719.
13. Friling S., Andersson E., Thompson L.H., Jonsson M.E., Hebsgaard J.B., Nanou E., Alekseenko Z., Marklund U., Kjellander S., Volakakis N., Hovatta O., El Manira A., Bjorklund A., Perlmann T., Ericson J. Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cells. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:7613-7618.
14. Han D.W., Tapia N., Hermann A., Hemmer K., Hoing S., Arauzo-Bravo M.J., Zaehres H., Wu G., Frank S., Moritz S., Greber B., Yang J.H., Lee H.T., Schwamborn J.C., Storch A., Scholer H.R. Direct reprogramming of fibroblasts into neural stem cells by defined factors. Cell Stem Cell 2012, 10:465-472.
15. Hyman C., Hofer M., Barde Y.A., Juhasz M., Yancopoulos G.D., Squinto S.P., Lindsay R.M. BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Nature 1991, 350:230-232.
16. Kim J., Su S.C., Wang H., Cheng A.W., Cassady J.P., Lodato M.A., Lengner C.J., Chung C.Y., Dawlaty M.M., Tsai L.H., Jaenisch R. Functional integration of dopaminergic neurons directly converted from mouse fibroblasts. Cell Stem Cell 2011, 9:413-419.
17. Kim S.M., Flasskamp H., Hermann A., Arauzo-Bravo M.J., Lee S.C., Lee S.H., Seo E.H., Storch A., Lee H.T., Scholer H.R., Tapia N., Han D.W. Direct conversion of mouse fibroblasts into induced neural stem cells. Nat. Protoc. 2014, 9:871-881.
18. Kuric E., Wieloch T., Ruscher K. Dopamine receptor activation increases glial cell line-derived neurotrophic factor in experimental stroke. Exp. Neurol. 2013, 247:202-208.
19. Legutko B., Li X., Skolnick P. Regulation of BDNF expression in primary neuron culture by LY392098, a novel AMPA receptor potentiator. Neuropharmacology 2001, 40:1019-1027.
20. Lin L.F., Doherty D.H., Lile J.D., Bektesh S., Collins F. GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 1993, 260:1130-1132.
21. Lindvall O., Brundin P., Widner H., Rehncrona S., Gustavii B., Frackowiak R., Leenders K.L., Sawle G., Rothwell J.C., Marsden C.D., et al. Grafts of fetal dopamine neurons survive and improve motor function in Parkinson's disease. Science 1990, 247:574-577.
22. Lujan E., Chanda S., Ahlenius H., Sudhof T.C., Wernig M. Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:2527-2532.
23. Maucksch C., Firmin E., Butler-Munro C., Montgomery J.M., Dottori M., Connor B. Non-viral generation of neural precursor-like cells from adult human fibroblasts. J. Stem Cells Regen. Med. 2012, 8:162-170.
24. Marsden C.D., Parkes J.D. "On-off" effects in patients with Parkinson's disease on chronic levodopa therapy. Lancet 1976, 1:292-296.
25. Mitchell R., Szabo E., Benoit Y.D., Case D., Mechael R., Alamilla J., Lee J.H., Fibig-Comyn A., Gillespie D., Bhatia M. Activation of neural cell fate programs towards direct conversion of adult human fibroblasts to tri-potent neural progenitors using Oct-4. Stem Cells Dev. 2014, 23:1937-1946.
26. Olanow C.W., Goetz C.G., Kordower J.H., Stoessl A.J., Sossi V., Brin M.F., Shannon K.M., Nauert G.M., Perl D.P., Godbold J., Freeman T.B. A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease. Ann. Neurol. 2003, 54:403-414.
27. Pfisterer U., Kirkeby A., Torper O., Wood J., Nelander J., Dufour A., Bjorklund A., Lindvall O., Jakobsson J., Parmar M. Direct conversion of human fibroblasts to dopaminergic neurons. Proc. Natl. Acad. Sci. U. S. A. 2011, 108:10343-10348.
28. Ren Z., Wang J., Wang S., Zou C., Li X., Guan Y., Chen Z., Zhang Y.A. Autologous transplantation of GDNF-expressing mesenchymal stem cells protects against MPTP-induced damage in cynomolgus monkeys. Sci. Rep. 2013, 3:2786.
29. Roy N.S., Cleren C., Singh S.K., Yang L., Beal M.F., Goldman S.A. Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes. Nat. Med. 2006, 12:1259-1268.
30. Sheng C., Zheng Q., Wu J., Xu Z., Wang L., Li W., Zhang H., Zhao X.Y., Liu L., Wang Z., Guo C., Wu H.J., Liu Z., He S., Wang X.J., Chen Z., Zhou Q. Direct reprogramming of Sertoli cells into multipotent neural stem cells by defined factors. Cell Res. 2012, 22:208-218.
31. Sheng C., Zheng Q., Wu J., Xu Z., Sang L., Wang L., Guo C., Zhu W., Tong M., Liu L., Li W., Liu Z.H., Zhao X.Y., Chen Z., Zhou Q. Generation of dopaminergic neurons directly from mouse fibroblasts and fibroblast-derived neural progenitors. Cell Res. 2012, 22:769-772.
32. Spina M.B., Squinto S.P., Miller J., Lindsay R.M., Hyman C. Brain-derived neurotrophic factor protects dopamine neurons against 6-hydroxydopamine and N-methyl-4-phenylpyridinium ion toxicity: involvement of the glutathione system. J. Neurochem. 1992, 59:99-106.
33. Tabar V., Tomishima M., Panagiotakos G., Wakayama S., Menon J., Chan B., Mizutani E., Al-Shamy G., Ohta H., Wakayama T., Studer L. Therapeutic cloning in individual parkinsonian mice. Nat. Med. 2008, 14:379-381.
34. Takahashi K., Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006, 126:663-676.
35. Takahashi K., Tanabe K., Ohnuki M., Narita M., Ichisaka T., Tomoda K., Yamanaka S. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007, 131:861-872.
36. Vierbuchen T., Ostermeier A., Pang Z.P., Kokubu Y., Sudhof T.C., Wernig M. Direct conversion of fibroblasts to functional neurons by defined factors. Nature 2010, 463:1035-1041.
37. Wernig M., Zhao J.P., Pruszak J., Hedlund E., Fu D., Soldner F., Broccoli V., Constantine-Paton M., Isacson O., Jaenisch R. Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:5856-5861.
38. Ying Q.L., Stavridis M., Griffiths D., Li M., Smith A. Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture. Nat. Biotechnol. 2003, 21:183-186.
39. Yu J., Vodyanik M.A., Smuga-Otto K., Antosiewicz-Bourget J., Frane J.L., Tian S., Nie J., Jonsdottir G.A., Ruotti V., Stewart R., Slukvin, Thomson J.A. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007, 318:1917-1920.
40. Zou Q., Yan Q., Zhong J., Wang K., Sun H., Yi X., Lai L. Direct conversion of human fibroblasts into neuronal restricted progenitors. J. Biol. Chem. 2014, 289:5250-5260.