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Volumn 16, Issue 1, 2015, Pages 1-7

Chronic kidney disease and premature ageing of the adaptive immune response

Author keywords

Ageing; End stage renal disease; Immune system; Inflammation; Oxidative stress; Uremia

Indexed keywords

ADAPTIVE IMMUNITY; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL AGING; CELL FUNCTION; CELL POPULATION; CELLULAR IMMUNITY; CHRONIC KIDNEY DISEASE; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; DENDRITIC CELL; DISEASE ASSOCIATION; END STAGE RENAL DISEASE; EPIGENETICS; HEMATOPOIETIC STEM CELL; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; INFLAMMATION; KIDNEY FAILURE; KIDNEY FUNCTION; KIDNEY TRANSPLANTATION; LATENT PERIOD; LYMPHOID CELL; MEMORY T LYMPHOCYTE; NONHUMAN; OXIDATIVE STRESS; PREMATURE IMMUNOLOGICAL AGING; PREMATURITY; T LYMPHOCYTE; TELOMERE; THYMUS FUNCTION; UREMIA; CHRONIC KIDNEY FAILURE; GENETIC EPIGENESIS; GENETICS; IMMUNOLOGY; LYMPHOCYTE; METABOLISM; PREMATURE AGING;

EID: 84919902835     PISSN: 15272737     EISSN: 15346285     Source Type: Journal    
DOI: 10.1007/s11934-014-0471-9     Document Type: Article
Times cited : (47)

References (40)
  • 1
    • 3242816177 scopus 로고    scopus 로고
    • Peripheral blood dendritic cells and GM-CSF as an adjuvant for hepatitis B vaccination in hemodialysis patients
    • COI: 1:CAS:528:DC%2BD2cXmvVegsLY%3D, PID: 15253714
    • Verkade MA, van de Wetering J, Klepper M, Vaessen LM, Weimar W, Betjes MG. Peripheral blood dendritic cells and GM-CSF as an adjuvant for hepatitis B vaccination in hemodialysis patients. Kidney Int. 2004;66:614–21.
    • (2004) Kidney Int , vol.66 , pp. 614-621
    • Verkade, M.A.1    van de Wetering, J.2    Klepper, M.3    Vaessen, L.M.4    Weimar, W.5    Betjes, M.G.6
  • 2
    • 70349498763 scopus 로고    scopus 로고
    • The pattern of excess cancer in dialysis and transplantation
    • PID: 19589786
    • Stewart JH, Vajdic CM, van Leeuwen MT, et al. The pattern of excess cancer in dialysis and transplantation. Nephrol Dial Transplant. 2009;24:3225–31.
    • (2009) Nephrol Dial Transplant , vol.24 , pp. 3225-3231
    • Stewart, J.H.1    Vajdic, C.M.2    van Leeuwen, M.T.3
  • 3
    • 67449095324 scopus 로고    scopus 로고
    • Oxidized LDL modulates apoptosis of regulatory T cells in patients with ESRD
    • COI: 1:CAS:528:DC%2BD1MXnvF2qtrw%3D, PID: 19406979
    • Meier P, Golshayan D, Blanc E, Pascual M, Burnier M. Oxidized LDL modulates apoptosis of regulatory T cells in patients with ESRD. J Am Soc Nephrol. 2009;20:1368–84.
    • (2009) J Am Soc Nephrol , vol.20 , pp. 1368-1384
    • Meier, P.1    Golshayan, D.2    Blanc, E.3    Pascual, M.4    Burnier, M.5
  • 4
    • 4644221457 scopus 로고    scopus 로고
    • Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization
    • COI: 1:CAS:528:DC%2BD2cXnvFSgtr8%3D, PID: 15385656
    • Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. The New England journal of medicine. 2004;351:1296–305.
    • (2004) The New England journal of medicine , vol.351 , pp. 1296-1305
    • Go, A.S.1    Chertow, G.M.2    Fan, D.3    McCulloch, C.E.4    Hsu, C.Y.5
  • 5
    • 79959787164 scopus 로고    scopus 로고
    • Premature aging of circulating T cells in patients with end-stage renal disease
    • PID: 21525849, This study demonstrates significant premature immunological ageing of the T cell system in ESRD patients based on assesment of thymic function, telomere length and T cell differentiation
    • Betjes MG, Langerak AW, van der Spek A, de Wit EA, Litjens NH. Premature aging of circulating T cells in patients with end-stage renal disease. Kidney Int. 2011;80:208–17. This study demonstrates significant premature immunological ageing of the T cell system in ESRD patients based on assesment of thymic function, telomere length and T cell differentiation.
    • (2011) Kidney Int , vol.80 , pp. 208-217
    • Betjes, M.G.1    Langerak, A.W.2    van der Spek, A.3    de Wit, E.A.4    Litjens, N.H.5
  • 6
    • 78650925501 scopus 로고    scopus 로고
    • Differential effects of age, cytomegalovirus-seropositivity and end-stage renal disease (ESRD) on circulating T lymphocyte subsets
    • COI: 1:CAS:528:DC%2BC3MXhtVSjs7s%3D, PID: 21214947
    • Litjens NH, de Wit EA, Betjes MG. Differential effects of age, cytomegalovirus-seropositivity and end-stage renal disease (ESRD) on circulating T lymphocyte subsets. Immun Ageing. 2011;8:2.
    • (2011) Immun Ageing , vol.8 , pp. 2
    • Litjens, N.H.1    de Wit, E.A.2    Betjes, M.G.3
  • 7
    • 84886257843 scopus 로고    scopus 로고
    • Cytomegalovirus contributes partly to uraemia-associated premature immunological ageing of the T cell compartment
    • COI: 1:CAS:528:DC%2BC3sXhs12mtrjN, PID: 23962178
    • Meijers RW, Litjens NH, de Wit EA, et al. Cytomegalovirus contributes partly to uraemia-associated premature immunological ageing of the T cell compartment. Clin Exp Immunol. 2013;174:424–32.
    • (2013) Clin Exp Immunol , vol.174 , pp. 424-432
    • Meijers, R.W.1    Litjens, N.H.2    de Wit, E.A.3
  • 8
    • 77349101042 scopus 로고    scopus 로고
    • Features of the dendritic cell lineage
    • COI: 1:CAS:528:DC%2BC3cXjslarsbs%3D, PID: 20193008
    • Steinman RM, Idoyaga J. Features of the dendritic cell lineage. Immunol Rev. 2010;234:5–17.
    • (2010) Immunol Rev , vol.234 , pp. 5-17
    • Steinman, R.M.1    Idoyaga, J.2
  • 9
    • 29444433970 scopus 로고    scopus 로고
    • Progressive loss of renal function is associated with activation and depletion of naive T lymphocytes
    • COI: 1:CAS:528:DC%2BD2MXhtlGlsr%2FN, PID: 16257266
    • Litjens NH, van Druningen CJ, Betjes MG. Progressive loss of renal function is associated with activation and depletion of naive T lymphocytes. Clin Immunol. 2006;118:83–91.
    • (2006) Clin Immunol , vol.118 , pp. 83-91
    • Litjens, N.H.1    van Druningen, C.J.2    Betjes, M.G.3
  • 10
    • 33746165561 scopus 로고    scopus 로고
    • Naive and central memory T-cell lymphopenia in end-stage renal disease
    • COI: 1:CAS:528:DC%2BD28XmvFagsb4%3D, PID: 16738532
    • Yoon JW, Gollapudi S, Pahl MV, Vaziri ND. Naive and central memory T-cell lymphopenia in end-stage renal disease. Kidney Int. 2006;70:371–6.
    • (2006) Kidney Int , vol.70 , pp. 371-376
    • Yoon, J.W.1    Gollapudi, S.2    Pahl, M.V.3    Vaziri, N.D.4
  • 11
    • 49649087781 scopus 로고    scopus 로고
    • Impaired immune responses and antigen-specific memory CD4+ T cells in hemodialysis patients
    • COI: 1:CAS:528:DC%2BD1cXhtVWltr3M, PID: 18480314
    • Litjens NH, Huisman M, van den Dorpel M, Betjes MG. Impaired immune responses and antigen-specific memory CD4+ T cells in hemodialysis patients. J Am Soc Nephrol. 2008;19:1483–90.
    • (2008) J Am Soc Nephrol , vol.19 , pp. 1483-1490
    • Litjens, N.H.1    Huisman, M.2    van den Dorpel, M.3    Betjes, M.G.4
  • 12
    • 84876975542 scopus 로고    scopus 로고
    • Immune cell dysfunction and inflammation in end-stage renal disease
    • COI: 1:CAS:528:DC%2BC3sXmslWltb8%3D, PID: 23507826, This review is an in-depth analysis of the current knowledge on the role of inflammation, oxidative stress and dysfunction of both the adaptive and innate immune response in ESRD patients
    • Betjes MG. Immune cell dysfunction and inflammation in end-stage renal disease. Nat Rev Nephrol. 2013;9:255–65. This review is an in-depth analysis of the current knowledge on the role of inflammation, oxidative stress and dysfunction of both the adaptive and innate immune response in ESRD patients.
    • (2013) Nat Rev Nephrol , vol.9 , pp. 255-265
    • Betjes, M.G.1
  • 13
    • 72949093750 scopus 로고    scopus 로고
    • Effect of end-stage renal disease on B-lymphocyte subpopulations, IL-7, BAFF and BAFF receptor expression
    • COI: 1:CAS:528:DC%2BD1MXhs1WltLjO, PID: 19684120
    • Pahl MV, Gollapudi S, Sepassi L, Gollapudi P, Elahimehr R, Vaziri ND. Effect of end-stage renal disease on B-lymphocyte subpopulations, IL-7, BAFF and BAFF receptor expression. Nephrol Dial Transplant. 2010;25:205–12.
    • (2010) Nephrol Dial Transplant , vol.25 , pp. 205-212
    • Pahl, M.V.1    Gollapudi, S.2    Sepassi, L.3    Gollapudi, P.4    Elahimehr, R.5    Vaziri, N.D.6
  • 14
    • 33644867468 scopus 로고    scopus 로고
    • Renal transplantation reverses functional deficiencies in circulating dendritic cell subsets in chronic renal failure patients
    • PID: 16436957
    • Lim WH, Kireta S, Thomson AW, Russ GR, Coates PT. Renal transplantation reverses functional deficiencies in circulating dendritic cell subsets in chronic renal failure patients. Transplantation. 2006;81:160–8.
    • (2006) Transplantation , vol.81 , pp. 160-168
    • Lim, W.H.1    Kireta, S.2    Thomson, A.W.3    Russ, G.R.4    Coates, P.T.5
  • 16
    • 77649201737 scopus 로고    scopus 로고
    • Effects of end-stage renal disease and haemodialysis on dendritic cell subsets and basal and LPS-stimulated cytokine production
    • COI: 1:CAS:528:DC%2BC3cXislajsb0%3D, PID: 19903659
    • Agrawal S, Gollapudi P, Elahimehr R, Pahl MV, Vaziri ND. Effects of end-stage renal disease and haemodialysis on dendritic cell subsets and basal and LPS-stimulated cytokine production. Nephrol Dial Transplant. 2010;25:737–46.
    • (2010) Nephrol Dial Transplant , vol.25 , pp. 737-746
    • Agrawal, S.1    Gollapudi, P.2    Elahimehr, R.3    Pahl, M.V.4    Vaziri, N.D.5
  • 17
    • 33845990567 scopus 로고    scopus 로고
    • Functional impairment of monocyte-derived dendritic cells in patients with severe chronic kidney disease
    • COI: 1:CAS:528:DC%2BD2sXivFCrtA%3D%3D, PID: 17005525
    • Verkade MA, van Druningen CJ, Vaessen LM, Hesselink DA, Weimar W, Betjes MG. Functional impairment of monocyte-derived dendritic cells in patients with severe chronic kidney disease. Nephrol Dial Transplant. 2007;22:128–38.
    • (2007) Nephrol Dial Transplant , vol.22 , pp. 128-138
    • Verkade, M.A.1    van Druningen, C.J.2    Vaessen, L.M.3    Hesselink, D.A.4    Weimar, W.5    Betjes, M.G.6
  • 18
    • 18844471606 scopus 로고    scopus 로고
    • Advanced oxidation protein products as novel mediators of inflammation and monocyte activation in chronic renal failure
    • COI: 1:CAS:528:DyaK1cXlslanu7k%3D, PID: 9725252
    • Witko-Sarsat V, Friedlander M, Nguyen Khoa T, et al. Advanced oxidation protein products as novel mediators of inflammation and monocyte activation in chronic renal failure. J Immunol. 1998;161:2524–32.
    • (1998) J Immunol , vol.161 , pp. 2524-2532
    • Witko-Sarsat, V.1    Friedlander, M.2    Nguyen Khoa, T.3
  • 19
    • 5444257487 scopus 로고    scopus 로고
    • Oxidative stress in uremia: nature, mechanisms, and potential consequences
    • COI: 1:CAS:528:DC%2BD2cXhtVCgsrfI, PID: 15490413
    • Vaziri ND. Oxidative stress in uremia: nature, mechanisms, and potential consequences. Semin Nephrol. 2004;24:469–73.
    • (2004) Semin Nephrol , vol.24 , pp. 469-473
    • Vaziri, N.D.1
  • 21
    • 84882241031 scopus 로고    scopus 로고
    • The intestinal microbiota, a leaky gut, and abnormal immunity in kidney disease
    • COI: 1:CAS:528:DC%2BC3sXos1ymtLs%3D, PID: 23325079, This article describes a novel source of chronic inflammation, the leaky gut in uremic patients. The possible relation with abnormal immunity in these patients is discussed
    • Anders HJ, Andersen K, Stecher B. The intestinal microbiota, a leaky gut, and abnormal immunity in kidney disease. Kidney Int. 2013;83:1010–6. This article describes a novel source of chronic inflammation, the leaky gut in uremic patients. The possible relation with abnormal immunity in these patients is discussed.
    • (2013) Kidney Int , vol.83 , pp. 1010-1016
    • Anders, H.J.1    Andersen, K.2    Stecher, B.3
  • 22
    • 79952196608 scopus 로고    scopus 로고
    • Circulating pro-inflammatory CD4posCD28null T cells are independently associated with cardiovascular disease in ESRD patients
    • COI: 1:CAS:528:DC%2BC3cXhtlClurjK, PID: 20400452
    • Betjes MG, de Wit EE, Weimar W, Litjens NH. Circulating pro-inflammatory CD4posCD28null T cells are independently associated with cardiovascular disease in ESRD patients. Nephrol Dial Transplant. 2010;25:3640–6.
    • (2010) Nephrol Dial Transplant , vol.25 , pp. 3640-3646
    • Betjes, M.G.1    de Wit, E.E.2    Weimar, W.3    Litjens, N.H.4
  • 23
    • 84870428597 scopus 로고    scopus 로고
    • Kidney transplantation and the ageing immune system
    • COI: 1:CAS:528:DC%2BC38XhslGksrzF, PID: 23147756, This review describes the various aspects of the ageing immune system and the consequences thereof for immune suppressive therapy after kidney transplantation
    • McKay D, Jameson J. Kidney transplantation and the ageing immune system. Nat Rev Nephrol. 2012;8:700–8. This review describes the various aspects of the ageing immune system and the consequences thereof for immune suppressive therapy after kidney transplantation.
    • (2012) Nat Rev Nephrol , vol.8 , pp. 700-708
    • McKay, D.1    Jameson, J.2
  • 24
    • 84857416171 scopus 로고    scopus 로고
    • Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans
    • This article gives a thorough analysis of findings in mice and humans on the maintenance of peripheral naïve T cells. Based on elaborated cell labeling techniques and modelling it is clear that findings from mice studies cannot be extrapolated to explain T cell homeostasis in humans and vice versa
    • den Braber I, Mugwagwa T, Vrisekoop N, et al. Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans. Immunity. 2012;36:288–97. This article gives a thorough analysis of findings in mice and humans on the maintenance of peripheral naïve T cells. Based on elaborated cell labeling techniques and modelling it is clear that findings from mice studies cannot be extrapolated to explain T cell homeostasis in humans and vice versa.
    • (2012) Immunity , vol.36 , pp. 288-297
    • den Braber, I.1    Mugwagwa, T.2    Vrisekoop, N.3
  • 25
    • 84887335296 scopus 로고    scopus 로고
    • Closing the gap between T-cell life span estimates from stable isotope-labeling studies in mice and humans
    • COI: 1:CAS:528:DC%2BC3sXhsF2rtbrK, PID: 23945154
    • Westera L, Drylewicz J, den Braber I, et al. Closing the gap between T-cell life span estimates from stable isotope-labeling studies in mice and humans. Blood. 2013;122:2205–12.
    • (2013) Blood , vol.122 , pp. 2205-2212
    • Westera, L.1    Drylewicz, J.2    den Braber, I.3
  • 26
    • 59649094871 scopus 로고    scopus 로고
    • Life after the thymus: CD31+ and CD31- human naive CD4+ T-cell subsets
    • COI: 1:CAS:528:DC%2BD1MXhtlGhsbo%3D, PID: 18583570
    • Kohler S, Thiel A. Life after the thymus: CD31+ and CD31- human naive CD4+ T-cell subsets. Blood. 2009;113:769–74.
    • (2009) Blood , vol.113 , pp. 769-774
    • Kohler, S.1    Thiel, A.2
  • 27
    • 84866050016 scopus 로고    scopus 로고
    • Uremia causes premature ageing of the T cell compartment in end-stage renal disease patients
    • COI: 1:CAS:528:DC%2BC38XhslKltLjP, PID: 22971545
    • Meijers RW, Litjens NH, de Wit EA, et al. Uremia causes premature ageing of the T cell compartment in end-stage renal disease patients. Immun Ageing. 2012;9:19.
    • (2012) Immun Ageing , vol.9 , pp. 19
    • Meijers, R.W.1    Litjens, N.H.2    de Wit, E.A.3
  • 28
    • 84863322171 scopus 로고    scopus 로고
    • A killer on the road: circulating CD4(+)CD28null T cells as cardiovascular risk factor in ESRD patients
    • COI: 1:CAS:528:DC%2BC38XntVygurs%3D, PID: 22135034
    • Betjes MG, Meijers RW, de Wit LE, Litjens NH. A killer on the road: circulating CD4(+)CD28null T cells as cardiovascular risk factor in ESRD patients. J Nephrol. 2012;25:183–91.
    • (2012) J Nephrol , vol.25 , pp. 183-191
    • Betjes, M.G.1    Meijers, R.W.2    de Wit, L.E.3    Litjens, N.H.4
  • 29
    • 50849124444 scopus 로고    scopus 로고
    • Expansion of cytolytic CD4 + CD28-T cells in end-stage renal disease
    • COI: 1:CAS:528:DC%2BD1cXhtVGgtbvE, PID: 18615000
    • Betjes MG, Huisman M, Weimar W, Litjens NH. Expansion of cytolytic CD4 + CD28-T cells in end-stage renal disease. Kidney Int. 2008;74:760–7.
    • (2008) Kidney Int , vol.74 , pp. 760-767
    • Betjes, M.G.1    Huisman, M.2    Weimar, W.3    Litjens, N.H.4
  • 30
    • 36749004391 scopus 로고    scopus 로고
    • Seropositivity for cytomegalovirus in patients with end-stage renal disease is strongly associated with atherosclerotic disease
    • PID: 17597084
    • Betjes MG, Litjens NH, Zietse R. Seropositivity for cytomegalovirus in patients with end-stage renal disease is strongly associated with atherosclerotic disease. Nephrol Dial Transplant. 2007;22:3298–303.
    • (2007) Nephrol Dial Transplant , vol.22 , pp. 3298-3303
    • Betjes, M.G.1    Litjens, N.H.2    Zietse, R.3
  • 31
    • 84876563425 scopus 로고    scopus 로고
    • Cytomegalovirus exposure and cardiovascular disease in kidney transplant recipients
    • PID: 23417659, The authors show that cytomegalovirus infections in recently transplanted patients induces an increased risk for a vascular event. This finding supports the concept of the pro-atherogenic role of CMV infection in kidney transplantation patients
    • Courivaud C, Bamoulid J, Chalopin JM, et al. Cytomegalovirus exposure and cardiovascular disease in kidney transplant recipients. J Infect Dis. 2013;207:1569–75. The authors show that cytomegalovirus infections in recently transplanted patients induces an increased risk for a vascular event. This finding supports the concept of the pro-atherogenic role of CMV infection in kidney transplantation patients.
    • (2013) J Infect Dis , vol.207 , pp. 1569-1575
    • Courivaud, C.1    Bamoulid, J.2    Chalopin, J.M.3
  • 32
    • 77955686431 scopus 로고    scopus 로고
    • Human cytomegalovirus induces systemic immune activation characterized by a type 1 cytokine signature
    • PID: 20632887
    • van de Berg PJ, Heutinck KM, Raabe R, et al. Human cytomegalovirus induces systemic immune activation characterized by a type 1 cytokine signature. J Infect Dis. 2010;202:690–9.
    • (2010) J Infect Dis , vol.202 , pp. 690-699
    • van de Berg, P.J.1    Heutinck, K.M.2    Raabe, R.3
  • 33
    • 77951637832 scopus 로고    scopus 로고
    • Cytomegalovirus infection reduces telomere length of the circulating T cell pool
    • PID: 20176738
    • van de Berg PJ, Griffiths SJ, Yong SL, et al. Cytomegalovirus infection reduces telomere length of the circulating T cell pool. J Immunol. 2010;184:3417–23.
    • (2010) J Immunol , vol.184 , pp. 3417-3423
    • van de Berg, P.J.1    Griffiths, S.J.2    Yong, S.L.3
  • 34
    • 84873910693 scopus 로고    scopus 로고
    • SuperTAG Methylation-Specific Digital Karyotyping (SMSDK) Reveals Uremia Induced Epigenetic Dysregulation of Atherosclerosis-Related Genes
    • Zawada AM, Rogacev KS, Hummel B, et al. SuperTAG Methylation-Specific Digital Karyotyping (SMSDK) Reveals Uremia Induced Epigenetic Dysregulation of Atherosclerosis-Related Genes. Circ Cardiovasc Genet. 2012;5:611–20.
    • (2012) Circ Cardiovasc Genet , vol.5 , pp. 611-620
    • Zawada, A.M.1    Rogacev, K.S.2    Hummel, B.3
  • 35
    • 0032918601 scopus 로고    scopus 로고
    • CD14++ monocytes, CD14+/CD16+ subset and soluble CD14 as biological markers of inflammatory systemic diseases and monitoring immunosuppressive therapy
    • COI: 1:CAS:528:DyaK1MXivVWhtbs%3D, PID: 10353463
    • Scherberich JE, Nockher WA. CD14++ monocytes, CD14+/CD16+ subset and soluble CD14 as biological markers of inflammatory systemic diseases and monitoring immunosuppressive therapy. Clin Chem Lab Med. 1999;37:209–13.
    • (1999) Clin Chem Lab Med , vol.37 , pp. 209-213
    • Scherberich, J.E.1    Nockher, W.A.2
  • 37
    • 84911423053 scopus 로고    scopus 로고
    • Circulating CD4(+)CD28null T Cells May Increase the Risk of an Atherosclerotic Vascular Event Shortly after Kidney Transplantation
    • PID: 24288592
    • Betjes MG, Weimar W, Litjens NH. Circulating CD4(+)CD28null T Cells May Increase the Risk of an Atherosclerotic Vascular Event Shortly after Kidney Transplantation. J Transplant. 2013;2013:841430.
    • (2013) J Transplant , vol.2013 , pp. 841430
    • Betjes, M.G.1    Weimar, W.2    Litjens, N.H.3
  • 38
    • 84863720724 scopus 로고    scopus 로고
    • Terminally differentiated CD8+ Temra cells are associated with the risk for acute kidney allograft rejection
    • COI: 1:CAS:528:DC%2BC38XhtVSqu7jE, PID: 22691956
    • Betjes MG, Meijers RW, de Wit EA, Weimar W, Litjens NH. Terminally differentiated CD8+ Temra cells are associated with the risk for acute kidney allograft rejection. Transplantation. 2012;94:63–9.
    • (2012) Transplantation , vol.94 , pp. 63-69
    • Betjes, M.G.1    Meijers, R.W.2    de Wit, E.A.3    Weimar, W.4    Litjens, N.H.5
  • 39
    • 46949105036 scopus 로고    scopus 로고
    • Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets
    • COI: 1:CAS:528:DC%2BD1cXosVKktLs%3D, PID: 18573906
    • Sportes C, Hakim FT, Memon SA, et al. Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets. J Exp Med. 2008;205:1701–14.
    • (2008) J Exp Med , vol.205 , pp. 1701-1714
    • Sportes, C.1    Hakim, F.T.2    Memon, S.A.3
  • 40
    • 84882236393 scopus 로고    scopus 로고
    • Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease
    • COI: 1:CAS:528:DC%2BC3sXos1ymtL0%3D, PID: 23325084
    • Ruiz S, Pergola PE, Zager RA, Vaziri ND. Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease. Kidney Int. 2013;83:1029–41.
    • (2013) Kidney Int , vol.83 , pp. 1029-1041
    • Ruiz, S.1    Pergola, P.E.2    Zager, R.A.3    Vaziri, N.D.4


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