Circulating pro-inflammatory CD4posCD28null T cells are independently associated with cardiovascular disease in ESRD patients

Nephrology Dialysis Transplantation

Volumn 25, Issue 11, 2010, Pages 3640-3646

  Betjes, Michiel G H ^a   De Wit, Elly E A ^a   Weimar, Willem ^a   Litjens, Nicolle H R ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Atherosclerosis; Cytomegalovirus; Inflammation; Kidney; T cells

Indexed keywords

ADULT; AGE; AGED; ARTICLE; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CD4POSCD28NULL T CELL; CIGARETTE SMOKING; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; DIABETES MELLITUS; DISEASE CONTROL; FEMALE; HUMAN; HUMAN CELL; HYPERCHOLESTEROLEMIA; KIDNEY FAILURE; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; NULL CELL; PREVALENCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; SEROLOGY; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; BIOSYNTHESIS; CHRONIC KIDNEY FAILURE; IMMUNOLOGY; MIDDLE AGED; PHYSIOLOGY; RISK FACTOR;

CD28 ANTIGEN; CD4 ANTIGEN; GAMMA INTERFERON; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD28; ANTIGENS, CD4; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASES; CYTOMEGALOVIRUS INFECTIONS; FEMALE; HUMANS; INTERFERON-GAMMA; KIDNEY FAILURE, CHRONIC; MALE; MIDDLE AGED; RISK FACTORS; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79952196608     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfq203     Document Type: Article

References (38)

1. Shlipak MG, Fried LF, Cushman M et al. Cardiovascular mortality risk in chronic kidney disease: Comparison of traditional and novel risk factors. JAMA 2005; 293: 1737-1745
2. Muntner P, He J, Astor BC et al. Traditional and nontraditional risk factors predict coronary heart disease in chronic kidney disease: Results from the Atherosclerosis Risk in Communities Study. J Am Soc Nephrol 2005; 16: 529-538 (Pubitemid 41725151)
3. Fellstrom BC, Jardine AG, Schmieder RE et al. Rosuvastatin and cardiovascular events in patients undergoing hemodialysis. N Engl J Med 2009; 360: 1395-1407
4. Navaneethan SD, Nigwekar SU, Perkovic Vet al. HMG CoA reductase inhibitors (statins) for dialysis patients. Cochrane Database Syst Rev 2009; 3: CD004289
5. Wanner C, Krane V, Marz Wet al. Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis. N Engl J Med 2005; 353: 238-248 (Pubitemid 41058323)
6. Betjes MG, Litjens NH, Zietse R. Seropositivity for cytomegalovirus in patients with end-stage renal disease is strongly associated with atherosclerotic disease. Nephrol Dial Transplant 2007; 22: 3298-3303 (Pubitemid 350202544)
7. Blankenberg S, Rupprecht HJ, Bickel C et al. Cytomegalovirus infection with interleukin-6 response predicts cardiac mortality in patients with coronary artery disease. Circulation 2001; 103: 2915-2921 (Pubitemid 32578128)
8. Muhlestein JB, Anderson JL. Infectious serology and atherosclerosis: How burdensome is the risk? Circulation 2003; 107: 220-222 (Pubitemid 36135213)
9. Muhlestein JB, Horne BD, Carlquist JF et al. Cytomegalovirus seropositivity and C-reactive protein have independent and combined predictive value for mortality in patients with angiographically demonstrated coronary artery disease. Circulation 2000; 102: 1917-1923
10. Zhu J, Quyyumi AA, Norman JE et al. Cytomegalovirus in the pathogenesis of atherosclerosis: The role of inflammation as reflected by elevated C-reactive protein levels. J Am Coll Cardiol 1999; 34: 1738-1743
11. Stassen FR, Vega-Cordova X, Vliegen I et al. Immune activation following cytomegalovirus infection: More important than direct viral effects in cardiovascular disease? J Clin Virol 2006; 35: 349-353 (Pubitemid 43188987)
12. Zhou YF, Shou M, Guetta E et al. Cytomegalovirus infection of rats increases the neointimal response to vascular injury without consistent evidence of direct infection of the vascular wall. Circulation 1999; 100: 1569-1575 (Pubitemid 29461471)
13. Betjes MG, Huisman M, Weimar W et al. Expansion of cytolytic CD4+CD28- T cells in end-stage renal disease. Kidney Int 2008; 74: 760-767
14. Betjes MG, Weimar W, Litjens NH. CMV seropositivity determines epoetin dose and hemoglobin levels in patients with CKD. J Am Soc Nephrol 2009; 20: 2661-2666
15. Nadareishvili ZG, Li H, Wright V et al. Elevated pro-inflammatory CD4+CD28- Lymphocytes and stroke recurrence and death. Neurology 2004; 63: 1446-1451 (Pubitemid 39426279)
16. Nowik M, Nowacki P, Grabarek J et al. Can we talk about CD4+CD28- Lymphocytes as a risk factor for ischemic stroke? Eur Neurol 2007; 58: 26-33 (Pubitemid 47038157)
17. Zal B, Kaski JC, Arno G et al. Heat-shock protein 60-reactive CD4+CD28null T cells in patients with acute coronary syndromes. Circulation 2004; 109: 1230-1235 (Pubitemid 38372781)
18. Liuzzo G, Biasucci LM, Trotta G et al. Unusual CD4+CD28null T lymphocytes and recurrence of acute coronary events. J Am Coll Cardiol 2007; 50: 1450-1458 (Pubitemid 47494592)
19. Liuzzo G, Goronzy JJ, Yang H et al. Monoclonal T-cell proliferation and plaque instability in acute coronary syndromes. Circulation 2000; 101: 2883-2888 (Pubitemid 30415876)
20. Sato K, Niessner A, Kopecky SL et al. TRAIL-expressing T cells induce apoptosis of vascular smooth muscle cells in the atherosclerotic plaque. J Exp Med 2006; 203: 239-250 (Pubitemid 43139661)
21. Falagas ME, Griffiths J, Prekezes J et al. Cytomegalovirus colitis mimicking colon carcinoma in an HIV-negative patient with chronic renal failure. Am J Gastroenterol 1996; 91: 168-169 (Pubitemid 26026065)
22. Quintana LF, Collado S, Coll E et al. Cytomegalovirus esophagitis in a patient on peritoneal dialysis. Nefrologia 2005; 25: 201-204
23. Verkade MA, van de Wetering J, Klepper M et al. Peripheral blood dendritic cells and GM-CSF as an adjuvant for hepatitis B vaccination in hemodialysis patients. Kidney Int 2004; 66: 614-621 (Pubitemid 38982003)
24. van Leeuwen EM, Remmerswaal EB, Vossen MTet al. Emergence of a CD4+CD28- granzyme B+, cytomegalovirus-specific T cell subset after recovery of primary cytomegalovirus infection. J Immunol 2004; 173: 1834-1841 (Pubitemid 38971617)
25. Appay V, Dunbar PR, Callan M et al. Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections. Nat Med 2002; 8: 379-385 (Pubitemid 34407033)
26. Litjens NHR, van Druningen CJ, Betjes MGH. Progressive loss of renal function is associated with activation and depletion of naive T lymphocytes. Clin Immunol 2006; 118: 83-91 (Pubitemid 43012050)
27. Full LE, Ruisanchez C, Monaco C. The inextricable link between atherosclerosis and prototypical inflammatory diseases rheumatoid arthritis and systemic lupus erythematosus. Arthritis Res Ther 2009; 11: 217
28. Martens PB, Goronzy JJ, Schaid D et al. Expansion of unusual CD4+ T cells in severe rheumatoid arthritis. Arthritis Rheum 1997; 40: 1106-1114 (Pubitemid 27242298)
29. Waldrop SL, Pitcher CJ, Peterson DM et al. Determination of antigenspecific memory/effector CD4+ T cell frequencies by flow cytometry: Evidence for a novel, antigen-specific homeostatic mechanism in HIVassociated immunodeficiency. J Clin Invest 1997; 99: 1739-1750 (Pubitemid 27163826)
30. Avalos I, Rho YH, Chung CP et al. Atherosclerosis in rheumatoid arthritis and systemic lupus erythematosus. Clin Exp Rheumatol 2008; 26: S5-S13
31. Calza L, Manfredi R, Pocaterra D et al. Risk of premature atherosclerosis and ischemic heart disease associated with HIV infection and antiretroviral therapy. J Infect 2008; 57: 16-32
32. Olsson J, Wikby A, Johansson B et al. Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: The Swedish longitudinal OCTO immune study. Mech Ageing Dev 2000; 121: 187-201 (Pubitemid 32115413)
33. Wikby A, Johansson B, Olsson J et al. Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: The Swedish NONA immune study. Exp Gerontol 2002; 37: 445-453 (Pubitemid 34073563)
34. Fletcher JM, Vukmanovic-Stejic M, Dunne PJ et al. Cytomegalovirus- specific CD4+ T cells in healthy carriers are continuously driven to replicative exhaustion. J Immunol 2005; 175: 8218-8225 (Pubitemid 41798386)
35. Spyridopoulos I, Hoffmann J, Aicher A et al. Accelerated telomere shortening in leukocyte subpopulations of patients with coronary heart disease: Role of cytomegalovirus seropositivity. Circulation 2009; 120: 1364-1372
36. Hummel M, Abecassis MM. A model for reactivation of CMV from latency. J Clin Virol 2002; 25: S123-S136 (Pubitemid 35287198)
37. Brugaletta S, Biasucci LM, Pinnelli M et al. Novel anti-inflammatory effect of statins: Reduction of CD4+CD28null T lymphocyte frequency in patients with unstable angina. Heart 2006; 92: 249-250 (Pubitemid 43131971)
38. Dumitriu IE, Araguas ET, Baboonian C et al. CD4+ CD28 null T cells in coronary artery disease: When helpers become killers. Cardiovasc Res 2009; 81: 11-19