Plasma miR-208 as a useful biomarker for drug-induced cardiotoxicity in rats

Journal of Applied Toxicology

Volumn 35, Issue 2, 2015, Pages 173-180

  Nishimura, Yoko ^a   Kondo, Chiaki ^a   Morikawa, Yuji ^a   Tonomura, Yutaka ^a   Torii, Mikinori ^a   Yamate, Jyoji ^b   Uehara, Takeki ^a  

^a SHIONOGI AND CO LTD   (Japan)

^b Osaka Prefecture University   (Japan)

Author keywords

Biomarker; Cardiotoxicity; MiR 208; MiRNA; Troponin

Indexed keywords

DOXORUBICIN; ISOPRENALINE; MICRORNA; MICRORNA 1; MICRORNA 133A; MICRORNA 133B; MICRORNA 206; MICRORNA 208; TROPONIN I; TROPONIN T; UNCLASSIFIED DRUG; BIOLOGICAL MARKERS; ISOPROTERENOL; MICRORNAS; MIRN208 MICRORNA, RAT; TROPONIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CARDIAC MUSCLE CELL; CARDIOTOXICITY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; LIMIT OF QUANTITATION; MALE; MICROARRAY ANALYSIS; MICRORNA BLOOD LEVEL; NONHUMAN; PROTEIN RNA BINDING; RAT; REAL TIME POLYMERASE CHAIN REACTION; ANIMALS; BLOOD; DRUG EFFECTS; HEART; MUSCLE, SKELETAL; MYOCARDIUM; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PATHOLOGY; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION;

RATTUS;

ANIMALS; BIOLOGICAL MARKERS; CARDIOTOXICITY; DOXORUBICIN; HEART; ISOPROTERENOL; MALE; MICRORNAS; MUSCLE, SKELETAL; MYOCARDIUM; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; TROPONIN;

EID: 84919866537     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.3044     Document Type: Article

References (20)

1. Ahmadi F, Dolatkhani F, Lessan-Pezeshki M, Mahdavi-Mazdeh M, Abbasi MR, Mohebi-Nejad A. 2014. Cardiac troponins in patients with chronic kidney disease and kidney transplant recipients without acute cardiac symptoms. Iran. J. Kidney Dis. 8:31-36.
2. Arroyo JD, Chevillet JR, Kroh EM, Ruf IK, Pritchard CC, Gibson DF, Mitchell PS, Bennett CF, Pogosova-Agadjanyan EL, Stirewalt DL, Tait JF, Tewari M. 2011. Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Proc. Natl. Acad. Sci. U. S. A. 108:5003-5008.
3. Bartel DP. 2004. MicroRNAs: Genomics, Biogenesis, Mechanism, and Function. Cell 116:281-297.
4. Broder H, Gottlieb RA, Lepor NE. 2008. Chemotherapy and cardiotoxicity. Rev. Cardiovasc. Med. 9:75-83.
5. Cheng Y, Wang X, Yang J, Duan X, Yao Y, Shi X, Chen Z, Fan Z, Liu X, Qin S, Tang X, Zhang C. 2012. A translational study of urine miRNAs in acute myocardial infarction. J. Mol. Cell. Cardiol. 53:668-676.
6. Haider BA, Baras AS, McCall MN, Hertel JA, Cornish TC, Halushka MK. 2014. A Critical Evaluation of microRNA Biomarkers in Non-Neoplastic Disease. PLoS One 9:e89565.
7. Ji X, Takahashi R, Hiura Y, Hirokawa G, Fukushima Y, Iwai N. 2009. Plasma miR-208 as a biomarker of myocardial injury. Clin. Chem. 55:1944-1949.
8. Li C, Fang Z, Jiang T, Zhang Q, Liu C, Zhang C, Xiang Y. 2013. Serum microRNAs profile from genome-wide serves as a fingerprint for diagnosis of acute myocardial infarction and angina pectoris. BMC Med. Genomics 6:16.
9. McNaughton R, Huet G, Shakir S. 2014. An investigation into drug products withdrawn from the EU market between 2002 and 2011 for safety reasons and the evidence used to support the decision-making. BMJ Open 4:e004221.
10. Minami K, Uehara T, Morikawa Y, Omura K, Kanki M, Horinouchi A, Ono A, Yamada H, Ohno Y, Urushidani T. 2014. miRNA Expression Atlas in Male Rat. Scientific Data 1:140005.
11. Mori Y, Kondo C, Tonomura Y, Torii M, Uehara T. Identification of potential genomic biomarkers for early detection of chemically induced cardiotoxicity in rats. 2010. Toxicology 271:36-44.
12. Nishimura Y, Morikawa Y, Kondo C, Tonomura Y, Fukushima R, Torii M, Uehara T. 2013. Genomic biomarkers for cardiotoxicity in rats as a sensitive tool in preclinical studies. J. Appl. Toxicol. 33:1120-1130.
13. O'Brien PJ. 2008. Cardiac troponin is the most effective translational safety biomarker for myocardial injury in cardiotoxicity. Toxicology 245:206-218.
14. Oliveira-Carvalho V, da Silva MM, Guimarães GV, Bacal F, Bocchi EA. 2013. MicroRNAs: new players in heart failure. Mol. Biol. Rep. 40:2663-2670.
15. Qureshi ZP, Seoane-Vazquez E, Rodriguez-Monguio R, Stevenson KB, Szeinbach SL. 2011. Market withdrawal of new molecular entities approved in the United States from 1980 to 2009. Pharmacoepidemiol. Drug Saf. 20:772-777.
16. Reagan WJ. 2010. Troponin as a biomarker of cardiac toxicity: past, present, and future. Toxicol. Pathol. 38:1134-1137.
17. Tonomura Y, Matsushima S, Kashiwagi E, Fujisawa K, Takagi S, Nishimura Y, Fukushima R, Torii M, Matsubara M. 2012. Biomarker panel of cardiac and skeletal muscle troponins, fatty acid binding protein 3 and myosin light chain 3 for the accurate diagnosis of cardiotoxicity and musculoskeletal toxicity in rats. Toxicology 302:179-189.
18. van Empel VP, De Windt LJ, da Costa Martins PA. 2012. Circulating miRNAs: reflecting or affecting cardiovascular disease? Curr. Hypertens. Rep. 14:498-509.
19. Wang D, Zhang Z, O'Loughlin E, Lee T, Houel S, O'Carroll D, Tarakhovsky A, Ahn NG, Yi R. 2012. Quantitative functions of Argonaute proteins in mammalian development. Genes Dev. 26:693-704.
20. Wang GK, Zhu JQ, Zhang JT, Li Q, Li Y, He J, Qin YW, Jing Q. 2010. Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans. Eur. Heart J. 31:659-666.