메뉴 건너뛰기




Volumn 36, Issue 1, 2015, Pages 40-48

IgE responses in mouse and man and the persistence of IgE memory

Author keywords

Allergy; B cells; IgE; Immunity; Memory; Plasma cells

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; ALLERGEN; CHEMOKINE RECEPTOR CXCR5; EPITOPE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN E ANTIBODY; IMMUNOGLOBULIN E RECEPTOR; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN G4; IMMUNOGLOBULIN M; LYMPHOCYTE ANTIGEN RECEPTOR;

EID: 84919842429     PISSN: 14714906     EISSN: 14714981     Source Type: Journal    
DOI: 10.1016/j.it.2014.11.002     Document Type: Review
Times cited : (39)

References (60)
  • 1
    • 84910669251 scopus 로고    scopus 로고
    • New strategies with anti-IgE in allergic diseases
    • Holgate S.T. New strategies with anti-IgE in allergic diseases. World Allergy Organ. J. 2014, 7:17.
    • (2014) World Allergy Organ. J. , vol.7 , pp. 17
    • Holgate, S.T.1
  • 2
    • 84857802144 scopus 로고    scopus 로고
    • The who, where, and when of IgE in allergic airway disease
    • Dullaers M., et al. The who, where, and when of IgE in allergic airway disease. J. Allergy Clin. Immunol. 2012, 129:635-645.
    • (2012) J. Allergy Clin. Immunol. , vol.129 , pp. 635-645
    • Dullaers, M.1
  • 3
    • 77955859683 scopus 로고    scopus 로고
    • Plasma cell development and survival
    • Oracki S.A., et al. Plasma cell development and survival. Immunol. Rev. 2010, 237:140-159.
    • (2010) Immunol. Rev. , vol.237 , pp. 140-159
    • Oracki, S.A.1
  • 5
    • 33847273161 scopus 로고    scopus 로고
    • Unique maturation program of the IgE response in vivo
    • Erazo A., et al. Unique maturation program of the IgE response in vivo. Immunity 2007, 26:191-203.
    • (2007) Immunity , vol.26 , pp. 191-203
    • Erazo, A.1
  • 6
    • 0035158734 scopus 로고    scopus 로고
    • Hyper immunoglobulin E response in mice with monoclonal populations of B and T lymphocytes
    • Curotto de Lafaille M.A., et al. Hyper immunoglobulin E response in mice with monoclonal populations of B and T lymphocytes. J. Exp. Med. 2001, 194:1349-1359.
    • (2001) J. Exp. Med. , vol.194 , pp. 1349-1359
    • Curotto de Lafaille, M.A.1
  • 7
    • 84888120685 scopus 로고    scopus 로고
    • The distinctive germinal center phase of IgE+ B lymphocytes limits their contribution to the classical memory response
    • He J.S., et al. The distinctive germinal center phase of IgE+ B lymphocytes limits their contribution to the classical memory response. J. Exp. Med. 2013, 210:2755-2771.
    • (2013) J. Exp. Med. , vol.210 , pp. 2755-2771
    • He, J.S.1
  • 8
    • 84862777318 scopus 로고    scopus 로고
    • IgE(+) memory B cells and plasma cells generated through a germinal-center pathway
    • Talay O., et al. IgE(+) memory B cells and plasma cells generated through a germinal-center pathway. Nat. Immunol. 2012, 13:396-404.
    • (2012) Nat. Immunol. , vol.13 , pp. 396-404
    • Talay, O.1
  • 9
    • 84862777789 scopus 로고    scopus 로고
    • Fluorescent in vivo detection reveals that IgE(+) B cells are restrained by an intrinsic cell fate predisposition
    • Yang Z., et al. Fluorescent in vivo detection reveals that IgE(+) B cells are restrained by an intrinsic cell fate predisposition. Immunity 2012, 36:857-872.
    • (2012) Immunity , vol.36 , pp. 857-872
    • Yang, Z.1
  • 10
    • 84887984899 scopus 로고    scopus 로고
    • Addendum: IgE+ memory B cells and plasma cells generated through a germinal-center pathway
    • Talay O., et al. Addendum: IgE+ memory B cells and plasma cells generated through a germinal-center pathway. Nat. Immunol. 2013, 14:1302-1304.
    • (2013) Nat. Immunol. , vol.14 , pp. 1302-1304
    • Talay, O.1
  • 11
    • 84897115704 scopus 로고    scopus 로고
    • The production and regulation of IgE by the immune system
    • Wu L.C., Zarrin A.A. The production and regulation of IgE by the immune system. Nat. Rev. Immunol. 2014, 14:247-259.
    • (2014) Nat. Rev. Immunol. , vol.14 , pp. 247-259
    • Wu, L.C.1    Zarrin, A.A.2
  • 12
    • 84867377296 scopus 로고    scopus 로고
    • What is unique about the IgE response?
    • Xiong H., et al. What is unique about the IgE response?. Adv. Immunol. 2012, 116:113-141.
    • (2012) Adv. Immunol. , vol.116 , pp. 113-141
    • Xiong, H.1
  • 13
    • 84895942390 scopus 로고    scopus 로고
    • Regulatory constraints in the generation and differentiation of IgE-expressing B cells
    • Yang Z., et al. Regulatory constraints in the generation and differentiation of IgE-expressing B cells. Curr. Opin. Immunol. 2014, 28:64-70.
    • (2014) Curr. Opin. Immunol. , vol.28 , pp. 64-70
    • Yang, Z.1
  • 14
    • 68349128605 scopus 로고    scopus 로고
    • Limited humoral immunoglobulin E memory influences serum immunoglobulin E levels in blood
    • Achatz-Straussberger G., et al. Limited humoral immunoglobulin E memory influences serum immunoglobulin E levels in blood. Clin. Exp. Allergy 2009, 39:1307-1313.
    • (2009) Clin. Exp. Allergy , vol.39 , pp. 1307-1313
    • Achatz-Straussberger, G.1
  • 15
    • 0028233231 scopus 로고
    • Frequency of immunoglobulin E class switching is autonomously determined and independent of prior switching to other classes
    • Jung S., et al. Frequency of immunoglobulin E class switching is autonomously determined and independent of prior switching to other classes. J. Exp. Med. 1994, 179:2023-2026.
    • (1994) J. Exp. Med. , vol.179 , pp. 2023-2026
    • Jung, S.1
  • 16
    • 33746217857 scopus 로고    scopus 로고
    • Inefficient processing of mRNA for the membrane form of IgE is a genetic mechanism to limit recruitment of IgE-secreting cells
    • Karnowski A., et al. Inefficient processing of mRNA for the membrane form of IgE is a genetic mechanism to limit recruitment of IgE-secreting cells. Eur. J. Immunol. 2006, 36:1917-1925.
    • (2006) Eur. J. Immunol. , vol.36 , pp. 1917-1925
    • Karnowski, A.1
  • 17
    • 84856937184 scopus 로고    scopus 로고
    • Sequential class switching is required for the generation of high affinity IgE antibodies
    • Xiong H., et al. Sequential class switching is required for the generation of high affinity IgE antibodies. J. Exp. Med. 2012, 209:353-364.
    • (2012) J. Exp. Med. , vol.209 , pp. 353-364
    • Xiong, H.1
  • 18
    • 84901644301 scopus 로고    scopus 로고
    • Clonal selection in the germinal centre by regulated proliferation and hypermutation
    • Gitlin A.D., et al. Clonal selection in the germinal centre by regulated proliferation and hypermutation. Nature 2014, 509:637-640.
    • (2014) Nature , vol.509 , pp. 637-640
    • Gitlin, A.D.1
  • 19
    • 84901619694 scopus 로고    scopus 로고
    • Immunology: to affinity and beyond
    • Tarlinton D.M. Immunology: to affinity and beyond. Nature 2014, 509:573-574.
    • (2014) Nature , vol.509 , pp. 573-574
    • Tarlinton, D.M.1
  • 20
    • 0030045370 scopus 로고    scopus 로고
    • Sorting out the cytokines of asthma
    • Drazen J.M., et al. Sorting out the cytokines of asthma. J. Exp. Med. 1996, 183:1-5.
    • (1996) J. Exp. Med. , vol.183 , pp. 1-5
    • Drazen, J.M.1
  • 21
    • 84890059710 scopus 로고    scopus 로고
    • Allergen immunotherapy and tolerance
    • Matsuoka T., et al. Allergen immunotherapy and tolerance. Allergol. Int. 2013, 62:403-413.
    • (2013) Allergol. Int. , vol.62 , pp. 403-413
    • Matsuoka, T.1
  • 22
  • 23
    • 0032970154 scopus 로고    scopus 로고
    • The high-affinity IgE receptor (Fc epsilon RI): from physiology to pathology
    • Kinet J.P. The high-affinity IgE receptor (Fc epsilon RI): from physiology to pathology. Annu. Rev. Immunol. 1999, 17:931-972.
    • (1999) Annu. Rev. Immunol. , vol.17 , pp. 931-972
    • Kinet, J.P.1
  • 24
    • 0030772226 scopus 로고    scopus 로고
    • Mast cells
    • Metcalfe D.D., et al. Mast cells. Physiol. Rev. 1997, 77:1033-1079.
    • (1997) Physiol. Rev. , vol.77 , pp. 1033-1079
    • Metcalfe, D.D.1
  • 25
    • 0035664093 scopus 로고    scopus 로고
    • Persistent IgE synthesis in the nasal mucosa of hay fever patients
    • Smurthwaite L., et al. Persistent IgE synthesis in the nasal mucosa of hay fever patients. Eur. J. Immunol. 2001, 31:3422-3431.
    • (2001) Eur. J. Immunol. , vol.31 , pp. 3422-3431
    • Smurthwaite, L.1
  • 26
    • 84872797554 scopus 로고    scopus 로고
    • Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E
    • Cheng L.E., et al. Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E. Immunity 2013, 38:166-175.
    • (2013) Immunity , vol.38 , pp. 166-175
    • Cheng, L.E.1
  • 27
    • 80051930931 scopus 로고    scopus 로고
    • Orchestrating house dust mite-associated allergy in the lung
    • Gregory L.G., Lloyd C.M. Orchestrating house dust mite-associated allergy in the lung. Trends Immunol. 2011, 32:402-411.
    • (2011) Trends Immunol. , vol.32 , pp. 402-411
    • Gregory, L.G.1    Lloyd, C.M.2
  • 28
    • 70449732274 scopus 로고    scopus 로고
    • Induction of long-lived allergen-specific plasma cells by mucosal allergen challenge
    • e814
    • Luger E.O., et al. Induction of long-lived allergen-specific plasma cells by mucosal allergen challenge. J. Allergy Clin. Immunol. 2009, 124:819-826. e814.
    • (2009) J. Allergy Clin. Immunol. , vol.124 , pp. 819-826
    • Luger, E.O.1
  • 29
    • 0030456345 scopus 로고    scopus 로고
    • Germinal center formation and local immunoglobulin E (IgE) production in the lung after an airway antigenic challenge
    • Chvatchko Y., et al. Germinal center formation and local immunoglobulin E (IgE) production in the lung after an airway antigenic challenge. J. Exp. Med. 1996, 184:2353-2360.
    • (1996) J. Exp. Med. , vol.184 , pp. 2353-2360
    • Chvatchko, Y.1
  • 30
  • 31
    • 8944239404 scopus 로고    scopus 로고
    • Peripheral blood dendritic cells express Fc epsilon RI as a complex composed of Fc epsilon RI alpha- and Fc epsilon RI gamma-chains and can use this receptor for IgE-mediated allergen presentation
    • Maurer D., et al. Peripheral blood dendritic cells express Fc epsilon RI as a complex composed of Fc epsilon RI alpha- and Fc epsilon RI gamma-chains and can use this receptor for IgE-mediated allergen presentation. J. Immunol. 1996, 157:607-616.
    • (1996) J. Immunol. , vol.157 , pp. 607-616
    • Maurer, D.1
  • 32
    • 0039820128 scopus 로고
    • High-affinity IgE receptor on eosinophils is involved in defence against parasites
    • Gounni A.S., et al. High-affinity IgE receptor on eosinophils is involved in defence against parasites. Nature 1994, 367:183-186.
    • (1994) Nature , vol.367 , pp. 183-186
    • Gounni, A.S.1
  • 33
    • 84892595674 scopus 로고    scopus 로고
    • IgE immunotherapy: a novel concept with promise for the treatment of cancer
    • Josephs D.H., et al. IgE immunotherapy: a novel concept with promise for the treatment of cancer. MAbs 2014, 6:54-72.
    • (2014) MAbs , vol.6 , pp. 54-72
    • Josephs, D.H.1
  • 34
    • 84869128517 scopus 로고    scopus 로고
    • Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever
    • e895
    • Hatzler L., et al. Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever. J. Allergy Clin. Immunol. 2012, 130:894-901. e895.
    • (2012) J. Allergy Clin. Immunol. , vol.130 , pp. 894-901
    • Hatzler, L.1
  • 35
    • 17044377561 scopus 로고    scopus 로고
    • Allergen drives class switching to IgE in the nasal mucosa in allergic rhinitis
    • Takhar P., et al. Allergen drives class switching to IgE in the nasal mucosa in allergic rhinitis. J. Immunol. 2005, 174:5024-5032.
    • (2005) J. Immunol. , vol.174 , pp. 5024-5032
    • Takhar, P.1
  • 36
    • 0028984059 scopus 로고
    • Human Ig S gamma regions and their participation in sequential switching to IgE
    • Mills F.C., et al. Human Ig S gamma regions and their participation in sequential switching to IgE. J. Immunol. 1995, 155:3021-3036.
    • (1995) J. Immunol. , vol.155 , pp. 3021-3036
    • Mills, F.C.1
  • 37
    • 84862597176 scopus 로고    scopus 로고
    • On the differentiation of mouse IgE(+) cells
    • author reply 623-624
    • Lafaille J.J., et al. On the differentiation of mouse IgE(+) cells. Nat. Immunol. 2012, 13:623. author reply 623-624.
    • (2012) Nat. Immunol. , vol.13 , pp. 623
    • Lafaille, J.J.1
  • 38
    • 0030469752 scopus 로고    scopus 로고
    • The two membrane isoforms of human IgE assemble into functionally distinct B cell antigen receptors
    • Batista F.D., et al. The two membrane isoforms of human IgE assemble into functionally distinct B cell antigen receptors. J. Exp. Med. 1996, 184:2197-2205.
    • (1996) J. Exp. Med. , vol.184 , pp. 2197-2205
    • Batista, F.D.1
  • 39
    • 33748482189 scopus 로고    scopus 로고
    • The extracellular membrane-proximal domain of human membrane IgE controls apoptotic signaling of the B cell receptor in the mature B cell line A20
    • Poggianella M., et al. The extracellular membrane-proximal domain of human membrane IgE controls apoptotic signaling of the B cell receptor in the mature B cell line A20. J. Immunol. 2006, 177:3597-3605.
    • (2006) J. Immunol. , vol.177 , pp. 3597-3605
    • Poggianella, M.1
  • 40
    • 77953195601 scopus 로고    scopus 로고
    • Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice
    • Brightbill H.D., et al. Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice. J. Clin. Invest. 2010, 120:2218-2229.
    • (2010) J. Clin. Invest. , vol.120 , pp. 2218-2229
    • Brightbill, H.D.1
  • 41
    • 84904490534 scopus 로고    scopus 로고
    • Targeting membrane-expressed IgE B cell receptor with an antibody to the M1 prime epitope reduces IgE production
    • Gauvreau G.M., et al. Targeting membrane-expressed IgE B cell receptor with an antibody to the M1 prime epitope reduces IgE production. Sci. Transl. Med. 2014, 6:243ra285.
    • (2014) Sci. Transl. Med. , vol.6 , pp. 243ra285
    • Gauvreau, G.M.1
  • 42
    • 33748469406 scopus 로고    scopus 로고
    • Germinal-centre reactions in allergic inflammation
    • Gould H.J., et al. Germinal-centre reactions in allergic inflammation. Trends Immunol. 2006, 27:446-452.
    • (2006) Trends Immunol. , vol.27 , pp. 446-452
    • Gould, H.J.1
  • 43
    • 0034114471 scopus 로고    scopus 로고
    • Local production and detection of (specific) IgE in nasal B-cells and plasma cells of allergic rhinitis patients
    • KleinJan A., et al. Local production and detection of (specific) IgE in nasal B-cells and plasma cells of allergic rhinitis patients. Eur. Respir. J. 2000, 15:491-497.
    • (2000) Eur. Respir. J. , vol.15 , pp. 491-497
    • KleinJan, A.1
  • 44
    • 0025969722 scopus 로고
    • Frequency analysis of IgE-secreting B lymphocytes in persons with normal or elevated serum IgE levels
    • King C.L., et al. Frequency analysis of IgE-secreting B lymphocytes in persons with normal or elevated serum IgE levels. J. Immunol. 1991, 146:1478-1483.
    • (1991) J. Immunol. , vol.146 , pp. 1478-1483
    • King, C.L.1
  • 45
    • 0038152342 scopus 로고    scopus 로고
    • The biology of IGE and the basis of allergic disease
    • Gould H.J., et al. The biology of IGE and the basis of allergic disease. Annu. Rev. Immunol. 2003, 21:579-628.
    • (2003) Annu. Rev. Immunol. , vol.21 , pp. 579-628
    • Gould, H.J.1
  • 46
    • 0141955063 scopus 로고    scopus 로고
    • S epsilon S mu and S epsilon S gamma switch circles in human nasal mucosa following ex vivo allergen challenge: evidence for direct as well as sequential class switch recombination
    • Cameron L., et al. S epsilon S mu and S epsilon S gamma switch circles in human nasal mucosa following ex vivo allergen challenge: evidence for direct as well as sequential class switch recombination. J. Immunol. 2003, 171:3816-3822.
    • (2003) J. Immunol. , vol.171 , pp. 3816-3822
    • Cameron, L.1
  • 47
    • 84899522492 scopus 로고    scopus 로고
    • Generation of memory B cells inside and outside germinal centers
    • Takemori T., et al. Generation of memory B cells inside and outside germinal centers. Eur. J. Immunol. 2014, 44:1258-1264.
    • (2014) Eur. J. Immunol. , vol.44 , pp. 1258-1264
    • Takemori, T.1
  • 48
    • 12444251056 scopus 로고    scopus 로고
    • Organization of secondary lymphoid tissue and local IgE formation to Staphylococcus aureus enterotoxins in nasal polyp tissue
    • Gevaert P., et al. Organization of secondary lymphoid tissue and local IgE formation to Staphylococcus aureus enterotoxins in nasal polyp tissue. Allergy 2005, 60:71-79.
    • (2005) Allergy , vol.60 , pp. 71-79
    • Gevaert, P.1
  • 49
    • 84870579024 scopus 로고    scopus 로고
    • Local receptor revision and class switching to IgE in chronic rhinosinusitis with nasal polyps
    • Gevaert P., et al. Local receptor revision and class switching to IgE in chronic rhinosinusitis with nasal polyps. Allergy 2013, 68:55-63.
    • (2013) Allergy , vol.68 , pp. 55-63
    • Gevaert, P.1
  • 50
    • 33646026384 scopus 로고    scopus 로고
    • IgE memory: persistence of antigen-specific IgE responses years after treatment of human filarial infections
    • Mitre E., Nutman T.B. IgE memory: persistence of antigen-specific IgE responses years after treatment of human filarial infections. J. Allergy Clin. Immunol. 2006, 117:939-945.
    • (2006) J. Allergy Clin. Immunol. , vol.117 , pp. 939-945
    • Mitre, E.1    Nutman, T.B.2
  • 51
    • 33845952641 scopus 로고    scopus 로고
    • Class switch recombination to IgE in the bronchial mucosa of atopic and nonatopic patients with asthma
    • Takhar P., et al. Class switch recombination to IgE in the bronchial mucosa of atopic and nonatopic patients with asthma. J. Allergy Clin. Immunol. 2007, 119:213-218.
    • (2007) J. Allergy Clin. Immunol. , vol.119 , pp. 213-218
    • Takhar, P.1
  • 52
    • 0031681234 scopus 로고    scopus 로고
    • Clonally related IgE and IgG4 transcripts in blood lymphocytes of patients with asthma reveal differing patterns of somatic mutation
    • Snow R.E., et al. Clonally related IgE and IgG4 transcripts in blood lymphocytes of patients with asthma reveal differing patterns of somatic mutation. Eur. J. Immunol. 1998, 28:3354-3361.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 3354-3361
    • Snow, R.E.1
  • 53
    • 84906835232 scopus 로고    scopus 로고
    • Influence of seasonal exposure to grass pollen on local and peripheral blood IgE repertoires in patients with allergic rhinitis
    • Wu Y.C., et al. Influence of seasonal exposure to grass pollen on local and peripheral blood IgE repertoires in patients with allergic rhinitis. J. Allergy Clin. Immunol. 2014, 134:604-612.
    • (2014) J. Allergy Clin. Immunol. , vol.134 , pp. 604-612
    • Wu, Y.C.1
  • 54
    • 0242494188 scopus 로고    scopus 로고
    • Local somatic hypermutation and class switch recombination in the nasal mucosa of allergic rhinitis patients
    • Coker H.A., et al. Local somatic hypermutation and class switch recombination in the nasal mucosa of allergic rhinitis patients. J. Immunol. 2003, 171:5602-5610.
    • (2003) J. Immunol. , vol.171 , pp. 5602-5610
    • Coker, H.A.1
  • 55
    • 0033407143 scopus 로고    scopus 로고
    • Analysis of immunoglobulin E VH transcripts in a bronchial biopsy of an asthmatic patient confirms bias towards VH5, and indicates local clonal expansion, somatic mutation and isotype switch events
    • Snow R.E., et al. Analysis of immunoglobulin E VH transcripts in a bronchial biopsy of an asthmatic patient confirms bias towards VH5, and indicates local clonal expansion, somatic mutation and isotype switch events. Immunology 1999, 98:646-651.
    • (1999) Immunology , vol.98 , pp. 646-651
    • Snow, R.E.1
  • 56
    • 77949675996 scopus 로고    scopus 로고
    • Allergy for a lifetime?
    • Luger E.O., et al. Allergy for a lifetime?. Allergol. Int. 2010, 59:1-8.
    • (2010) Allergol. Int. , vol.59 , pp. 1-8
    • Luger, E.O.1
  • 57
    • 23244457657 scopus 로고    scopus 로고
    • Biased use of VH5 IgE-positive B cells in the nasal mucosa in allergic rhinitis
    • Coker H.A., et al. Biased use of VH5 IgE-positive B cells in the nasal mucosa in allergic rhinitis. J. Allergy Clin. Immunol. 2005, 116:445-452.
    • (2005) J. Allergy Clin. Immunol. , vol.116 , pp. 445-452
    • Coker, H.A.1
  • 58
    • 84896135804 scopus 로고    scopus 로고
    • IgE-associated IGHV genes from venom and peanut allergic individuals lack mutational evidence of antigen selection
    • Wang Y., et al. IgE-associated IGHV genes from venom and peanut allergic individuals lack mutational evidence of antigen selection. PLoS ONE 2014, 9:e89730.
    • (2014) PLoS ONE , vol.9 , pp. e89730
    • Wang, Y.1
  • 59
    • 33750502877 scopus 로고    scopus 로고
    • High affinity germinal center B cells are actively selected into the plasma cell compartment
    • Phan T.G., et al. High affinity germinal center B cells are actively selected into the plasma cell compartment. J. Exp. Med. 2006, 203:2419-2424.
    • (2006) J. Exp. Med. , vol.203 , pp. 2419-2424
    • Phan, T.G.1
  • 60
    • 58149337005 scopus 로고    scopus 로고
    • Migration of antibody secreting cells towards CXCL12 depends on the isotype that forms the BCR
    • Achatz-Straussberger G., et al. Migration of antibody secreting cells towards CXCL12 depends on the isotype that forms the BCR. Eur. J. Immunol. 2008, 38:3167-3177.
    • (2008) Eur. J. Immunol. , vol.38 , pp. 3167-3177
    • Achatz-Straussberger, G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.